Macarron is a workflow to systematically annotate and prioritize potentially bioactive (and often unannotated) small molecules in microbial community metabolomic datasets. Macarron prioritizes metabolic features as potentially bioactive in a phenotype/condition of interest using a combination of (a) covariance with annotated metabolites, (b) ecological properties such as abundance with respect to covarying annotated compounds, and (c) differential abundance in the phenotype/condition of interest.
If you have questions, please direct it to: Macarron Forum
Macarron requires R version 4.2.0 or higher. Install Bioconductor and then install Macarron:
if(!requireNamespace("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("Macarron")
Macarron can be run from the command line or as an R function. Both methods require the same
arguments, have the same options, and use the same default settings. The package includes the
wrapper Macarron()
as well as functions which perform different steps in the Macarron
framework.
Macarron requires 4 comma-separated, appropriately formatted input files. The files and their formatting constraints are described below.
If you do not have the chemical taxonomy file, you can generate this file using the annotation dataframe and Macarron utility decorate_ID
(see Advanced Topics).
By default, all files will be stored in a folder named Macarron_output inside the current working directory. The main prioritization results are stored in prioritized_metabolites_all.csv
. Another file, prioritized_metabolites_characterizable.csv
is a subset of prioritized_metabolites_all.csv
and only contains metabolic features which covary with at least one annotated metabolite.
The columns in these output files are:
Maaslin2
.Example (demo) input files can be found under inst/extdata
folder of the Macarron
source. These files were generated from the PRISM study of stool metabolomes of individuals with inflammatory bowel disease (IBD) and healthy “Control” individuals. Control and IBD are the two phenotypes in this example. Macarron will be applied to prioritize metabolic features with respect to their bioactivity in IBD. Therefore, in this example, the phenotype of interest is “IBD” and the reference phenotype is “Control”. The four input files are demo_abundances.csv
, demo_annotations.csv
, demo_metadata.csv
, and demo_taxonomy.csv
.
library(Macarron)
## Loading required package: SummarizedExperiment
## Loading required package: MatrixGenerics
## Loading required package: matrixStats
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## Attaching package: 'MatrixGenerics'
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## Welcome to Bioconductor
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## Vignettes contain introductory material; view with
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## Attaching package: 'Biobase'
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prism_abundances <- system.file(
'extdata','demo_abundances.csv', package="Macarron")
prism_annotations <-system.file(
'extdata','demo_annotations.csv', package="Macarron")
prism_metadata <-system.file(
'extdata','demo_metadata.csv', package="Macarron")
mets_taxonomy <-system.file(
'extdata','demo_taxonomy.csv', package="Macarron")
prism_prioritized <- Macarron::Macarron(input_abundances = prism_abundances,
input_annotations = prism_annotations,
input_metadata = prism_metadata,
input_taxonomy = mets_taxonomy)
## 2024-07-16 19:23:09.485769 INFO::Creating output folder.
## 2024-07-16 19:23:09.498765 INFO::Writing function arguments to log file
## Samples with both abundances and metadata: 102
## 2024-07-16 19:23:09.5662 INFO::Summarized Experiment created.
## 2024-07-16 19:23:09.568832 INFO::Metadata chosen for prevalence filtering: diagnosis
## 869 features pass chosen minimum prevalence threshold of 0.7.
## Calculating pairwise correlations in phenotype: IBD
##
## Calculating pairwise correlations in phenotype: Control
## Distance matrix with 869 features created.
## 2024-07-16 19:23:16.709974 INFO::Distance matrix with 869 metabolic features created.
## Initiating module detection
## 2024-07-16 19:23:16.713287 INFO::Minimum module size used for this dataset: 10
## Tree constructed
## Evaluating measures of success
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## 2024-07-16 19:23:18.698314 INFO::Total number of modules detected: 30
## Initiating AVA calculations
## Finding anchors
## Calculating AVA
## Initiating q-value calculations
## [1] "Creating output folder"
## [1] "Creating output feature tables folder"
## [1] "Creating output fits folder"
## [1] "Creating output figures folder"
## 2024-07-16 19:23:21.512807 INFO::Writing function arguments to log file
## 2024-07-16 19:23:21.530454 INFO::Verifying options selected are valid
## 2024-07-16 19:23:21.578278 INFO::Determining format of input files
## 2024-07-16 19:23:21.580198 INFO::Input format is data samples as columns and metadata samples as rows
## 2024-07-16 19:23:21.611039 INFO::Formula for fixed effects: expr ~ diagnosis + age + antibiotics
## 2024-07-16 19:23:21.615118 INFO::Filter data based on min abundance and min prevalence
## 2024-07-16 19:23:21.617384 INFO::Total samples in data: 102
## 2024-07-16 19:23:21.618991 INFO::Min samples required with min abundance for a feature not to be filtered: 0.000000
## 2024-07-16 19:23:21.631928 INFO::Total filtered features: 0
## 2024-07-16 19:23:21.633994 INFO::Filtered feature names from abundance and prevalence filtering:
## 2024-07-16 19:23:21.658603 INFO::Total filtered features with variance filtering: 0
## 2024-07-16 19:23:21.660625 INFO::Filtered feature names from variance filtering:
## 2024-07-16 19:23:21.662379 INFO::Running selected normalization method: NONE
## 2024-07-16 19:23:21.664551 INFO::Applying z-score to standardize continuous metadata
## 2024-07-16 19:23:21.702705 INFO::Running selected transform method: NONE
## 2024-07-16 19:23:21.705776 INFO::Running selected analysis method: LM
## 2024-07-16 19:23:21.720102 INFO::Fitting model to feature number 1, F1
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## 2024-07-16 19:23:23.103905 INFO::Fitting model to feature number 184, F190
## 2024-07-16 19:23:23.111982 INFO::Fitting model to feature number 185, F191
## 2024-07-16 19:23:23.119858 INFO::Fitting model to feature number 186, F192
## 2024-07-16 19:23:23.127324 INFO::Fitting model to feature number 187, F193
## 2024-07-16 19:23:23.135009 INFO::Fitting model to feature number 188, F194
## 2024-07-16 19:23:23.142751 INFO::Fitting model to feature number 189, F195
## 2024-07-16 19:23:23.150755 INFO::Fitting model to feature number 190, F196
## 2024-07-16 19:23:23.159116 INFO::Fitting model to feature number 191, F197
## 2024-07-16 19:23:23.167517 INFO::Fitting model to feature number 192, F198
## 2024-07-16 19:23:23.174995 INFO::Fitting model to feature number 193, F199
## 2024-07-16 19:23:23.182826 INFO::Fitting model to feature number 194, F200
## 2024-07-16 19:23:23.188594 INFO::Fitting model to feature number 195, F201
## 2024-07-16 19:23:23.194969 INFO::Fitting model to feature number 196, F202
## 2024-07-16 19:23:23.200542 INFO::Fitting model to feature number 197, F203
## 2024-07-16 19:23:23.206632 INFO::Fitting model to feature number 198, F204
## 2024-07-16 19:23:23.212683 INFO::Fitting model to feature number 199, F206
## 2024-07-16 19:23:23.218804 INFO::Fitting model to feature number 200, F207
## 2024-07-16 19:23:23.22457 INFO::Fitting model to feature number 201, F208
## 2024-07-16 19:23:23.23139 INFO::Fitting model to feature number 202, F209
## 2024-07-16 19:23:23.239169 INFO::Fitting model to feature number 203, F210
## 2024-07-16 19:23:23.246416 INFO::Fitting model to feature number 204, F211
## 2024-07-16 19:23:23.253823 INFO::Fitting model to feature number 205, F212
## 2024-07-16 19:23:23.261179 INFO::Fitting model to feature number 206, F213
## 2024-07-16 19:23:23.268439 INFO::Fitting model to feature number 207, F214
## 2024-07-16 19:23:23.275743 INFO::Fitting model to feature number 208, F215
## 2024-07-16 19:23:23.28304 INFO::Fitting model to feature number 209, F216
## 2024-07-16 19:23:23.290288 INFO::Fitting model to feature number 210, F217
## 2024-07-16 19:23:23.297497 INFO::Fitting model to feature number 211, F218
## 2024-07-16 19:23:23.30475 INFO::Fitting model to feature number 212, F219
## 2024-07-16 19:23:23.311974 INFO::Fitting model to feature number 213, F220
## 2024-07-16 19:23:23.319113 INFO::Fitting model to feature number 214, F221
## 2024-07-16 19:23:23.32656 INFO::Fitting model to feature number 215, F222
## 2024-07-16 19:23:23.333896 INFO::Fitting model to feature number 216, F223
## 2024-07-16 19:23:23.341189 INFO::Fitting model to feature number 217, F224
## 2024-07-16 19:23:23.3484 INFO::Fitting model to feature number 218, F225
## 2024-07-16 19:23:23.355801 INFO::Fitting model to feature number 219, F226
## 2024-07-16 19:23:23.36418 INFO::Fitting model to feature number 220, F227
## 2024-07-16 19:23:23.373512 INFO::Fitting model to feature number 221, F228
## 2024-07-16 19:23:23.382082 INFO::Fitting model to feature number 222, F229
## 2024-07-16 19:23:23.39073 INFO::Fitting model to feature number 223, F230
## 2024-07-16 19:23:23.399221 INFO::Fitting model to feature number 224, F231
## 2024-07-16 19:23:23.404617 INFO::Fitting model to feature number 225, F232
## 2024-07-16 19:23:23.409246 INFO::Fitting model to feature number 226, F233
## 2024-07-16 19:23:23.413778 INFO::Fitting model to feature number 227, F234
## 2024-07-16 19:23:23.420911 INFO::Fitting model to feature number 228, F235
## 2024-07-16 19:23:23.428341 INFO::Fitting model to feature number 229, F236
## 2024-07-16 19:23:23.435732 INFO::Fitting model to feature number 230, F237
## 2024-07-16 19:23:23.443144 INFO::Fitting model to feature number 231, F238
## 2024-07-16 19:23:23.450575 INFO::Fitting model to feature number 232, F239
## 2024-07-16 19:23:23.458138 INFO::Fitting model to feature number 233, F240
## 2024-07-16 19:23:23.46581 INFO::Fitting model to feature number 234, F241
## 2024-07-16 19:23:23.473375 INFO::Fitting model to feature number 235, F242
## 2024-07-16 19:23:23.481065 INFO::Fitting model to feature number 236, F243
## 2024-07-16 19:23:23.488645 INFO::Fitting model to feature number 237, F244
## 2024-07-16 19:23:23.496005 INFO::Fitting model to feature number 238, F245
## 2024-07-16 19:23:23.503336 INFO::Fitting model to feature number 239, F246
## 2024-07-16 19:23:23.51071 INFO::Fitting model to feature number 240, F247
## 2024-07-16 19:23:23.518259 INFO::Fitting model to feature number 241, F248
## 2024-07-16 19:23:23.525837 INFO::Fitting model to feature number 242, F249
## 2024-07-16 19:23:23.533295 INFO::Fitting model to feature number 243, F250
## 2024-07-16 19:23:23.540905 INFO::Fitting model to feature number 244, F252
## 2024-07-16 19:23:23.548234 INFO::Fitting model to feature number 245, F253
## 2024-07-16 19:23:23.55537 INFO::Fitting model to feature number 246, F254
## 2024-07-16 19:23:23.562956 INFO::Fitting model to feature number 247, F255
## 2024-07-16 19:23:23.570527 INFO::Fitting model to feature number 248, F256
## 2024-07-16 19:23:23.578019 INFO::Fitting model to feature number 249, F257
## 2024-07-16 19:23:23.585523 INFO::Fitting model to feature number 250, F259
## 2024-07-16 19:23:23.59315 INFO::Fitting model to feature number 251, F260
## 2024-07-16 19:23:23.600733 INFO::Fitting model to feature number 252, F261
## 2024-07-16 19:23:23.608427 INFO::Fitting model to feature number 253, F262
## 2024-07-16 19:23:23.616043 INFO::Fitting model to feature number 254, F263
## 2024-07-16 19:23:23.623607 INFO::Fitting model to feature number 255, F264
## 2024-07-16 19:23:23.631074 INFO::Fitting model to feature number 256, F265
## 2024-07-16 19:23:23.638493 INFO::Fitting model to feature number 257, F266
## 2024-07-16 19:23:23.645886 INFO::Fitting model to feature number 258, F267
## 2024-07-16 19:23:23.653237 INFO::Fitting model to feature number 259, F269
## 2024-07-16 19:23:23.660539 INFO::Fitting model to feature number 260, F270
## 2024-07-16 19:23:23.668237 INFO::Fitting model to feature number 261, F271
## 2024-07-16 19:23:23.675884 INFO::Fitting model to feature number 262, F272
## 2024-07-16 19:23:23.682274 INFO::Fitting model to feature number 263, F273
## 2024-07-16 19:23:23.687344 INFO::Fitting model to feature number 264, F274
## 2024-07-16 19:23:23.692438 INFO::Fitting model to feature number 265, F276
## 2024-07-16 19:23:23.69901 INFO::Fitting model to feature number 266, F277
## 2024-07-16 19:23:23.706127 INFO::Fitting model to feature number 267, F278
## 2024-07-16 19:23:23.713142 INFO::Fitting model to feature number 268, F279
## 2024-07-16 19:23:23.723365 INFO::Fitting model to feature number 269, F280
## 2024-07-16 19:23:23.730743 INFO::Fitting model to feature number 270, F281
## 2024-07-16 19:23:23.738515 INFO::Fitting model to feature number 271, F282
## 2024-07-16 19:23:23.74656 INFO::Fitting model to feature number 272, F283
## 2024-07-16 19:23:23.754229 INFO::Fitting model to feature number 273, F284
## 2024-07-16 19:23:23.761842 INFO::Fitting model to feature number 274, F285
## 2024-07-16 19:23:23.769427 INFO::Fitting model to feature number 275, F286
## 2024-07-16 19:23:23.775762 INFO::Fitting model to feature number 276, F287
## 2024-07-16 19:23:23.780499 INFO::Fitting model to feature number 277, F288
## 2024-07-16 19:23:23.785214 INFO::Fitting model to feature number 278, F289
## 2024-07-16 19:23:23.789913 INFO::Fitting model to feature number 279, F290
## 2024-07-16 19:23:23.794578 INFO::Fitting model to feature number 280, F292
## 2024-07-16 19:23:23.799269 INFO::Fitting model to feature number 281, F293
## 2024-07-16 19:23:23.804044 INFO::Fitting model to feature number 282, F294
## 2024-07-16 19:23:23.808873 INFO::Fitting model to feature number 283, F295
## 2024-07-16 19:23:23.813565 INFO::Fitting model to feature number 284, F296
## 2024-07-16 19:23:23.81814 INFO::Fitting model to feature number 285, F297
## 2024-07-16 19:23:23.822779 INFO::Fitting model to feature number 286, F298
## 2024-07-16 19:23:23.827461 INFO::Fitting model to feature number 287, F299
## 2024-07-16 19:23:23.832453 INFO::Fitting model to feature number 288, F300
## 2024-07-16 19:23:23.837798 INFO::Fitting model to feature number 289, F301
## 2024-07-16 19:23:23.842611 INFO::Fitting model to feature number 290, F302
## 2024-07-16 19:23:23.847496 INFO::Fitting model to feature number 291, F303
## 2024-07-16 19:23:23.853438 INFO::Fitting model to feature number 292, F304
## 2024-07-16 19:23:23.859375 INFO::Fitting model to feature number 293, F305
## 2024-07-16 19:23:23.864239 INFO::Fitting model to feature number 294, F306
## 2024-07-16 19:23:23.869111 INFO::Fitting model to feature number 295, F307
## 2024-07-16 19:23:23.874014 INFO::Fitting model to feature number 296, F308
## 2024-07-16 19:23:23.878823 INFO::Fitting model to feature number 297, F309
## 2024-07-16 19:23:23.88371 INFO::Fitting model to feature number 298, F310
## 2024-07-16 19:23:23.888504 INFO::Fitting model to feature number 299, F311
## 2024-07-16 19:23:23.893283 INFO::Fitting model to feature number 300, F312
## 2024-07-16 19:23:23.898105 INFO::Fitting model to feature number 301, F313
## 2024-07-16 19:23:23.903066 INFO::Fitting model to feature number 302, F315
## 2024-07-16 19:23:23.907966 INFO::Fitting model to feature number 303, F316
## 2024-07-16 19:23:23.914564 INFO::Fitting model to feature number 304, F317
## 2024-07-16 19:23:23.920979 INFO::Fitting model to feature number 305, F318
## 2024-07-16 19:23:23.928045 INFO::Fitting model to feature number 306, F319
## 2024-07-16 19:23:23.935146 INFO::Fitting model to feature number 307, F320
## 2024-07-16 19:23:23.94303 INFO::Fitting model to feature number 308, F321
## 2024-07-16 19:23:23.950748 INFO::Fitting model to feature number 309, F322
## 2024-07-16 19:23:23.958575 INFO::Fitting model to feature number 310, F323
## 2024-07-16 19:23:23.966709 INFO::Fitting model to feature number 311, F324
## 2024-07-16 19:23:23.974961 INFO::Fitting model to feature number 312, F325
## 2024-07-16 19:23:23.982916 INFO::Fitting model to feature number 313, F326
## 2024-07-16 19:23:23.98939 INFO::Fitting model to feature number 314, F327
## 2024-07-16 19:23:23.995573 INFO::Fitting model to feature number 315, F328
## 2024-07-16 19:23:24.003664 INFO::Fitting model to feature number 316, F329
## 2024-07-16 19:23:24.011715 INFO::Fitting model to feature number 317, F330
## 2024-07-16 19:23:24.019778 INFO::Fitting model to feature number 318, F331
## 2024-07-16 19:23:24.027779 INFO::Fitting model to feature number 319, F332
## 2024-07-16 19:23:24.035601 INFO::Fitting model to feature number 320, F333
## 2024-07-16 19:23:24.043587 INFO::Fitting model to feature number 321, F334
## 2024-07-16 19:23:24.05128 INFO::Fitting model to feature number 322, F335
## 2024-07-16 19:23:24.058854 INFO::Fitting model to feature number 323, F336
## 2024-07-16 19:23:24.066341 INFO::Fitting model to feature number 324, F337
## 2024-07-16 19:23:24.074299 INFO::Fitting model to feature number 325, F338
## 2024-07-16 19:23:24.082218 INFO::Fitting model to feature number 326, F339
## 2024-07-16 19:23:24.090451 INFO::Fitting model to feature number 327, F340
## 2024-07-16 19:23:24.098185 INFO::Fitting model to feature number 328, F342
## 2024-07-16 19:23:24.10612 INFO::Fitting model to feature number 329, F343
## 2024-07-16 19:23:24.113619 INFO::Fitting model to feature number 330, F344
## 2024-07-16 19:23:24.121696 INFO::Fitting model to feature number 331, F345
## 2024-07-16 19:23:24.129771 INFO::Fitting model to feature number 332, F346
## 2024-07-16 19:23:24.136026 INFO::Fitting model to feature number 333, F347
## 2024-07-16 19:23:24.141434 INFO::Fitting model to feature number 334, F348
## 2024-07-16 19:23:24.146921 INFO::Fitting model to feature number 335, F350
## 2024-07-16 19:23:24.152556 INFO::Fitting model to feature number 336, F351
## 2024-07-16 19:23:24.158083 INFO::Fitting model to feature number 337, F352
## 2024-07-16 19:23:24.163401 INFO::Fitting model to feature number 338, F353
## 2024-07-16 19:23:24.170966 INFO::Fitting model to feature number 339, F355
## 2024-07-16 19:23:24.179032 INFO::Fitting model to feature number 340, F356
## 2024-07-16 19:23:24.18462 INFO::Fitting model to feature number 341, F357
## 2024-07-16 19:23:24.189857 INFO::Fitting model to feature number 342, F358
## 2024-07-16 19:23:24.195073 INFO::Fitting model to feature number 343, F359
## 2024-07-16 19:23:24.200267 INFO::Fitting model to feature number 344, F360
## 2024-07-16 19:23:24.205323 INFO::Fitting model to feature number 345, F361
## 2024-07-16 19:23:24.210436 INFO::Fitting model to feature number 346, F362
## 2024-07-16 19:23:24.217808 INFO::Fitting model to feature number 347, F363
## 2024-07-16 19:23:24.22288 INFO::Fitting model to feature number 348, F364
## 2024-07-16 19:23:24.227939 INFO::Fitting model to feature number 349, F365
## 2024-07-16 19:23:24.233425 INFO::Fitting model to feature number 350, F366
## 2024-07-16 19:23:24.238921 INFO::Fitting model to feature number 351, F367
## 2024-07-16 19:23:24.246275 INFO::Fitting model to feature number 352, F368
## 2024-07-16 19:23:24.254463 INFO::Fitting model to feature number 353, F369
## 2024-07-16 19:23:24.262743 INFO::Fitting model to feature number 354, F370
## 2024-07-16 19:23:24.270963 INFO::Fitting model to feature number 355, F371
## 2024-07-16 19:23:24.278444 INFO::Fitting model to feature number 356, F372
## 2024-07-16 19:23:24.283809 INFO::Fitting model to feature number 357, F373
## 2024-07-16 19:23:24.289088 INFO::Fitting model to feature number 358, F374
## 2024-07-16 19:23:24.297144 INFO::Fitting model to feature number 359, F375
## 2024-07-16 19:23:24.305701 INFO::Fitting model to feature number 360, F376
## 2024-07-16 19:23:24.314058 INFO::Fitting model to feature number 361, F377
## 2024-07-16 19:23:24.322091 INFO::Fitting model to feature number 362, F378
## 2024-07-16 19:23:24.329899 INFO::Fitting model to feature number 363, F379
## 2024-07-16 19:23:24.337909 INFO::Fitting model to feature number 364, F380
## 2024-07-16 19:23:24.345912 INFO::Fitting model to feature number 365, F381
## 2024-07-16 19:23:24.354072 INFO::Fitting model to feature number 366, F382
## 2024-07-16 19:23:24.362369 INFO::Fitting model to feature number 367, F383
## 2024-07-16 19:23:24.370645 INFO::Fitting model to feature number 368, F384
## 2024-07-16 19:23:24.378666 INFO::Fitting model to feature number 369, F386
## 2024-07-16 19:23:24.385795 INFO::Fitting model to feature number 370, F387
## 2024-07-16 19:23:24.391246 INFO::Fitting model to feature number 371, F388
## 2024-07-16 19:23:24.396591 INFO::Fitting model to feature number 372, F389
## 2024-07-16 19:23:24.40209 INFO::Fitting model to feature number 373, F390
## 2024-07-16 19:23:24.409724 INFO::Fitting model to feature number 374, F391
## 2024-07-16 19:23:24.417126 INFO::Fitting model to feature number 375, F392
## 2024-07-16 19:23:24.424382 INFO::Fitting model to feature number 376, F393
## 2024-07-16 19:23:24.431501 INFO::Fitting model to feature number 377, F394
## 2024-07-16 19:23:24.439097 INFO::Fitting model to feature number 378, F395
## 2024-07-16 19:23:24.446972 INFO::Fitting model to feature number 379, F396
## 2024-07-16 19:23:24.454788 INFO::Fitting model to feature number 380, F397
## 2024-07-16 19:23:24.462541 INFO::Fitting model to feature number 381, F398
## 2024-07-16 19:23:24.470348 INFO::Fitting model to feature number 382, F399
## 2024-07-16 19:23:24.47827 INFO::Fitting model to feature number 383, F400
## 2024-07-16 19:23:24.486116 INFO::Fitting model to feature number 384, F401
## 2024-07-16 19:23:24.493942 INFO::Fitting model to feature number 385, F402
## 2024-07-16 19:23:24.501788 INFO::Fitting model to feature number 386, F403
## 2024-07-16 19:23:24.51055 INFO::Fitting model to feature number 387, F404
## 2024-07-16 19:23:24.516814 INFO::Fitting model to feature number 388, F406
## 2024-07-16 19:23:24.523293 INFO::Fitting model to feature number 389, F407
## 2024-07-16 19:23:24.529795 INFO::Fitting model to feature number 390, F408
## 2024-07-16 19:23:24.53696 INFO::Fitting model to feature number 391, F409
## 2024-07-16 19:23:24.542794 INFO::Fitting model to feature number 392, F410
## 2024-07-16 19:23:24.54956 INFO::Fitting model to feature number 393, F411
## 2024-07-16 19:23:24.557438 INFO::Fitting model to feature number 394, F412
## 2024-07-16 19:23:24.56522 INFO::Fitting model to feature number 395, F413
## 2024-07-16 19:23:24.573089 INFO::Fitting model to feature number 396, F414
## 2024-07-16 19:23:24.58161 INFO::Fitting model to feature number 397, F415
## 2024-07-16 19:23:24.589451 INFO::Fitting model to feature number 398, F416
## 2024-07-16 19:23:24.597071 INFO::Fitting model to feature number 399, F417
## 2024-07-16 19:23:24.605208 INFO::Fitting model to feature number 400, F418
## 2024-07-16 19:23:24.612944 INFO::Fitting model to feature number 401, F419
## 2024-07-16 19:23:24.620183 INFO::Fitting model to feature number 402, F420
## 2024-07-16 19:23:24.625469 INFO::Fitting model to feature number 403, F421
## 2024-07-16 19:23:24.630989 INFO::Fitting model to feature number 404, F422
## 2024-07-16 19:23:24.638136 INFO::Fitting model to feature number 405, F423
## 2024-07-16 19:23:24.646445 INFO::Fitting model to feature number 406, F425
## 2024-07-16 19:23:24.654905 INFO::Fitting model to feature number 407, F426
## 2024-07-16 19:23:24.663334 INFO::Fitting model to feature number 408, F428
## 2024-07-16 19:23:24.670663 INFO::Fitting model to feature number 409, F429
## 2024-07-16 19:23:24.676788 INFO::Fitting model to feature number 410, F430
## 2024-07-16 19:23:24.684064 INFO::Fitting model to feature number 411, F431
## 2024-07-16 19:23:24.689638 INFO::Fitting model to feature number 412, F432
## 2024-07-16 19:23:24.696334 INFO::Fitting model to feature number 413, F433
## 2024-07-16 19:23:24.703538 INFO::Fitting model to feature number 414, F434
## 2024-07-16 19:23:24.710312 INFO::Fitting model to feature number 415, F435
## 2024-07-16 19:23:24.715977 INFO::Fitting model to feature number 416, F436
## 2024-07-16 19:23:24.721322 INFO::Fitting model to feature number 417, F437
## 2024-07-16 19:23:24.727027 INFO::Fitting model to feature number 418, F438
## 2024-07-16 19:23:24.733002 INFO::Fitting model to feature number 419, F439
## 2024-07-16 19:23:24.739462 INFO::Fitting model to feature number 420, F440
## 2024-07-16 19:23:24.744665 INFO::Fitting model to feature number 421, F441
## 2024-07-16 19:23:24.749928 INFO::Fitting model to feature number 422, F442
## 2024-07-16 19:23:24.755146 INFO::Fitting model to feature number 423, F443
## 2024-07-16 19:23:24.760376 INFO::Fitting model to feature number 424, F444
## 2024-07-16 19:23:24.765525 INFO::Fitting model to feature number 425, F445
## 2024-07-16 19:23:24.770819 INFO::Fitting model to feature number 426, F446
## 2024-07-16 19:23:24.775937 INFO::Fitting model to feature number 427, F447
## 2024-07-16 19:23:24.783023 INFO::Fitting model to feature number 428, F448
## 2024-07-16 19:23:24.78913 INFO::Fitting model to feature number 429, F449
## 2024-07-16 19:23:24.795933 INFO::Fitting model to feature number 430, F450
## 2024-07-16 19:23:24.803147 INFO::Fitting model to feature number 431, F451
## 2024-07-16 19:23:24.810359 INFO::Fitting model to feature number 432, F452
## 2024-07-16 19:23:24.817692 INFO::Fitting model to feature number 433, F454
## 2024-07-16 19:23:24.825137 INFO::Fitting model to feature number 434, F455
## 2024-07-16 19:23:24.832543 INFO::Fitting model to feature number 435, F456
## 2024-07-16 19:23:24.839977 INFO::Fitting model to feature number 436, F457
## 2024-07-16 19:23:24.847424 INFO::Fitting model to feature number 437, F458
## 2024-07-16 19:23:24.854769 INFO::Fitting model to feature number 438, F459
## 2024-07-16 19:23:24.862517 INFO::Fitting model to feature number 439, F461
## 2024-07-16 19:23:24.870332 INFO::Fitting model to feature number 440, F462
## 2024-07-16 19:23:24.878121 INFO::Fitting model to feature number 441, F463
## 2024-07-16 19:23:24.88594 INFO::Fitting model to feature number 442, F464
## 2024-07-16 19:23:24.893609 INFO::Fitting model to feature number 443, F465
## 2024-07-16 19:23:24.901042 INFO::Fitting model to feature number 444, F466
## 2024-07-16 19:23:24.907693 INFO::Fitting model to feature number 445, F467
## 2024-07-16 19:23:24.915391 INFO::Fitting model to feature number 446, F468
## 2024-07-16 19:23:24.920779 INFO::Fitting model to feature number 447, F469
## 2024-07-16 19:23:24.926289 INFO::Fitting model to feature number 448, F470
## 2024-07-16 19:23:24.931722 INFO::Fitting model to feature number 449, F471
## 2024-07-16 19:23:24.936691 INFO::Fitting model to feature number 450, F474
## 2024-07-16 19:23:24.941797 INFO::Fitting model to feature number 451, F475
## 2024-07-16 19:23:24.946883 INFO::Fitting model to feature number 452, F476
## 2024-07-16 19:23:24.951971 INFO::Fitting model to feature number 453, F477
## 2024-07-16 19:23:24.957104 INFO::Fitting model to feature number 454, F478
## 2024-07-16 19:23:24.962697 INFO::Fitting model to feature number 455, F479
## 2024-07-16 19:23:24.967817 INFO::Fitting model to feature number 456, F480
## 2024-07-16 19:23:24.972851 INFO::Fitting model to feature number 457, F481
## 2024-07-16 19:23:24.977878 INFO::Fitting model to feature number 458, F482
## 2024-07-16 19:23:24.982871 INFO::Fitting model to feature number 459, F483
## 2024-07-16 19:23:24.987844 INFO::Fitting model to feature number 460, F484
## 2024-07-16 19:23:24.992768 INFO::Fitting model to feature number 461, F485
## 2024-07-16 19:23:24.997947 INFO::Fitting model to feature number 462, F486
## 2024-07-16 19:23:25.003076 INFO::Fitting model to feature number 463, F487
## 2024-07-16 19:23:25.007954 INFO::Fitting model to feature number 464, F488
## 2024-07-16 19:23:25.015688 INFO::Fitting model to feature number 465, F489
## 2024-07-16 19:23:25.023808 INFO::Fitting model to feature number 466, F490
## 2024-07-16 19:23:25.031906 INFO::Fitting model to feature number 467, F491
## 2024-07-16 19:23:25.039927 INFO::Fitting model to feature number 468, F492
## 2024-07-16 19:23:25.046118 INFO::Fitting model to feature number 469, F493
## 2024-07-16 19:23:25.053581 INFO::Fitting model to feature number 470, F494
## 2024-07-16 19:23:25.061033 INFO::Fitting model to feature number 471, F495
## 2024-07-16 19:23:25.091016 INFO::Fitting model to feature number 472, F496
## 2024-07-16 19:23:25.096639 INFO::Fitting model to feature number 473, F497
## 2024-07-16 19:23:25.101732 INFO::Fitting model to feature number 474, F498
## 2024-07-16 19:23:25.106919 INFO::Fitting model to feature number 475, F499
## 2024-07-16 19:23:25.111999 INFO::Fitting model to feature number 476, F500
## 2024-07-16 19:23:25.117828 INFO::Fitting model to feature number 477, F501
## 2024-07-16 19:23:25.123308 INFO::Fitting model to feature number 478, F502
## 2024-07-16 19:23:25.13283 INFO::Fitting model to feature number 479, F503
## 2024-07-16 19:23:25.141204 INFO::Fitting model to feature number 480, F504
## 2024-07-16 19:23:25.149257 INFO::Fitting model to feature number 481, F505
## 2024-07-16 19:23:25.156771 INFO::Fitting model to feature number 482, F506
## 2024-07-16 19:23:25.164244 INFO::Fitting model to feature number 483, F507
## 2024-07-16 19:23:25.171555 INFO::Fitting model to feature number 484, F508
## 2024-07-16 19:23:25.179062 INFO::Fitting model to feature number 485, F509
## 2024-07-16 19:23:25.186385 INFO::Fitting model to feature number 486, F510
## 2024-07-16 19:23:25.193833 INFO::Fitting model to feature number 487, F511
## 2024-07-16 19:23:25.201342 INFO::Fitting model to feature number 488, F512
## 2024-07-16 19:23:25.20886 INFO::Fitting model to feature number 489, F513
## 2024-07-16 19:23:25.216456 INFO::Fitting model to feature number 490, F514
## 2024-07-16 19:23:25.224017 INFO::Fitting model to feature number 491, F515
## 2024-07-16 19:23:25.231699 INFO::Fitting model to feature number 492, F516
## 2024-07-16 19:23:25.239165 INFO::Fitting model to feature number 493, F517
## 2024-07-16 19:23:25.246595 INFO::Fitting model to feature number 494, F518
## 2024-07-16 19:23:25.254055 INFO::Fitting model to feature number 495, F519
## 2024-07-16 19:23:25.261754 INFO::Fitting model to feature number 496, F520
## 2024-07-16 19:23:25.267836 INFO::Fitting model to feature number 497, F521
## 2024-07-16 19:23:25.275445 INFO::Fitting model to feature number 498, F522
## 2024-07-16 19:23:25.282716 INFO::Fitting model to feature number 499, F523
## 2024-07-16 19:23:25.288466 INFO::Fitting model to feature number 500, F524
## 2024-07-16 19:23:25.29517 INFO::Fitting model to feature number 501, F525
## 2024-07-16 19:23:25.302093 INFO::Fitting model to feature number 502, F526
## 2024-07-16 19:23:25.307996 INFO::Fitting model to feature number 503, F527
## 2024-07-16 19:23:25.312836 INFO::Fitting model to feature number 504, F528
## 2024-07-16 19:23:25.317502 INFO::Fitting model to feature number 505, F529
## 2024-07-16 19:23:25.322546 INFO::Fitting model to feature number 506, F530
## 2024-07-16 19:23:25.329161 INFO::Fitting model to feature number 507, F531
## 2024-07-16 19:23:25.336591 INFO::Fitting model to feature number 508, F532
## 2024-07-16 19:23:25.344116 INFO::Fitting model to feature number 509, F533
## 2024-07-16 19:23:25.351499 INFO::Fitting model to feature number 510, F534
## 2024-07-16 19:23:25.358975 INFO::Fitting model to feature number 511, F535
## 2024-07-16 19:23:25.366994 INFO::Fitting model to feature number 512, F536
## 2024-07-16 19:23:25.374767 INFO::Fitting model to feature number 513, F537
## 2024-07-16 19:23:25.382459 INFO::Fitting model to feature number 514, F539
## 2024-07-16 19:23:25.389926 INFO::Fitting model to feature number 515, F540
## 2024-07-16 19:23:25.397774 INFO::Fitting model to feature number 516, F541
## 2024-07-16 19:23:25.405375 INFO::Fitting model to feature number 517, F543
## 2024-07-16 19:23:25.412636 INFO::Fitting model to feature number 518, F544
## 2024-07-16 19:23:25.419857 INFO::Fitting model to feature number 519, F545
## 2024-07-16 19:23:25.42705 INFO::Fitting model to feature number 520, F546
## 2024-07-16 19:23:25.43428 INFO::Fitting model to feature number 521, F547
## 2024-07-16 19:23:25.441707 INFO::Fitting model to feature number 522, F548
## 2024-07-16 19:23:25.449678 INFO::Fitting model to feature number 523, F549
## 2024-07-16 19:23:25.45651 INFO::Fitting model to feature number 524, F550
## 2024-07-16 19:23:25.463145 INFO::Fitting model to feature number 525, F551
## 2024-07-16 19:23:25.469931 INFO::Fitting model to feature number 526, F552
## 2024-07-16 19:23:25.476971 INFO::Fitting model to feature number 527, F553
## 2024-07-16 19:23:25.485149 INFO::Fitting model to feature number 528, F554
## 2024-07-16 19:23:25.493597 INFO::Fitting model to feature number 529, F555
## 2024-07-16 19:23:25.501742 INFO::Fitting model to feature number 530, F556
## 2024-07-16 19:23:25.509911 INFO::Fitting model to feature number 531, F557
## 2024-07-16 19:23:25.51758 INFO::Fitting model to feature number 532, F558
## 2024-07-16 19:23:25.525312 INFO::Fitting model to feature number 533, F559
## 2024-07-16 19:23:25.532725 INFO::Fitting model to feature number 534, F560
## 2024-07-16 19:23:25.540545 INFO::Fitting model to feature number 535, F561
## 2024-07-16 19:23:25.548237 INFO::Fitting model to feature number 536, F562
## 2024-07-16 19:23:25.555883 INFO::Fitting model to feature number 537, F563
## 2024-07-16 19:23:25.5635 INFO::Fitting model to feature number 538, F564
## 2024-07-16 19:23:25.571364 INFO::Fitting model to feature number 539, F566
## 2024-07-16 19:23:25.579121 INFO::Fitting model to feature number 540, F567
## 2024-07-16 19:23:25.586784 INFO::Fitting model to feature number 541, F568
## 2024-07-16 19:23:25.594283 INFO::Fitting model to feature number 542, F569
## 2024-07-16 19:23:25.601643 INFO::Fitting model to feature number 543, F570
## 2024-07-16 19:23:25.609158 INFO::Fitting model to feature number 544, F571
## 2024-07-16 19:23:25.616696 INFO::Fitting model to feature number 545, F572
## 2024-07-16 19:23:25.624415 INFO::Fitting model to feature number 546, F573
## 2024-07-16 19:23:25.632143 INFO::Fitting model to feature number 547, F574
## 2024-07-16 19:23:25.639832 INFO::Fitting model to feature number 548, F575
## 2024-07-16 19:23:25.647531 INFO::Fitting model to feature number 549, F576
## 2024-07-16 19:23:25.655043 INFO::Fitting model to feature number 550, F577
## 2024-07-16 19:23:25.66259 INFO::Fitting model to feature number 551, F578
## 2024-07-16 19:23:25.668455 INFO::Fitting model to feature number 552, F579
## 2024-07-16 19:23:25.673357 INFO::Fitting model to feature number 553, F580
## 2024-07-16 19:23:25.678374 INFO::Fitting model to feature number 554, F581
## 2024-07-16 19:23:25.684509 INFO::Fitting model to feature number 555, F582
## 2024-07-16 19:23:25.691458 INFO::Fitting model to feature number 556, F583
## 2024-07-16 19:23:25.698859 INFO::Fitting model to feature number 557, F584
## 2024-07-16 19:23:25.706277 INFO::Fitting model to feature number 558, F585
## 2024-07-16 19:23:25.713915 INFO::Fitting model to feature number 559, F586
## 2024-07-16 19:23:25.721797 INFO::Fitting model to feature number 560, F587
## 2024-07-16 19:23:25.729349 INFO::Fitting model to feature number 561, F588
## 2024-07-16 19:23:25.736747 INFO::Fitting model to feature number 562, F589
## 2024-07-16 19:23:25.744283 INFO::Fitting model to feature number 563, F590
## 2024-07-16 19:23:25.751706 INFO::Fitting model to feature number 564, F591
## 2024-07-16 19:23:25.759062 INFO::Fitting model to feature number 565, F592
## 2024-07-16 19:23:25.766575 INFO::Fitting model to feature number 566, F593
## 2024-07-16 19:23:25.7741 INFO::Fitting model to feature number 567, F594
## 2024-07-16 19:23:25.781613 INFO::Fitting model to feature number 568, F595
## 2024-07-16 19:23:25.789058 INFO::Fitting model to feature number 569, F596
## 2024-07-16 19:23:25.796577 INFO::Fitting model to feature number 570, F597
## 2024-07-16 19:23:25.80414 INFO::Fitting model to feature number 571, F598
## 2024-07-16 19:23:25.811653 INFO::Fitting model to feature number 572, F599
## 2024-07-16 19:23:25.819126 INFO::Fitting model to feature number 573, F600
## 2024-07-16 19:23:25.826554 INFO::Fitting model to feature number 574, F601
## 2024-07-16 19:23:25.833908 INFO::Fitting model to feature number 575, F602
## 2024-07-16 19:23:25.841295 INFO::Fitting model to feature number 576, F603
## 2024-07-16 19:23:25.848716 INFO::Fitting model to feature number 577, F605
## 2024-07-16 19:23:25.856213 INFO::Fitting model to feature number 578, F606
## 2024-07-16 19:23:25.863614 INFO::Fitting model to feature number 579, F607
## 2024-07-16 19:23:25.871119 INFO::Fitting model to feature number 580, F608
## 2024-07-16 19:23:25.87865 INFO::Fitting model to feature number 581, F609
## 2024-07-16 19:23:25.886619 INFO::Fitting model to feature number 582, F610
## 2024-07-16 19:23:25.894243 INFO::Fitting model to feature number 583, F611
## 2024-07-16 19:23:25.902257 INFO::Fitting model to feature number 584, F612
## 2024-07-16 19:23:25.908998 INFO::Fitting model to feature number 585, F613
## 2024-07-16 19:23:25.914022 INFO::Fitting model to feature number 586, F614
## 2024-07-16 19:23:25.920596 INFO::Fitting model to feature number 587, F615
## 2024-07-16 19:23:25.926094 INFO::Fitting model to feature number 588, F616
## 2024-07-16 19:23:25.931803 INFO::Fitting model to feature number 589, F617
## 2024-07-16 19:23:25.940173 INFO::Fitting model to feature number 590, F618
## 2024-07-16 19:23:25.948111 INFO::Fitting model to feature number 591, F619
## 2024-07-16 19:23:25.955178 INFO::Fitting model to feature number 592, F620
## 2024-07-16 19:23:25.962131 INFO::Fitting model to feature number 593, F621
## 2024-07-16 19:23:25.969529 INFO::Fitting model to feature number 594, F622
## 2024-07-16 19:23:25.975879 INFO::Fitting model to feature number 595, F623
## 2024-07-16 19:23:25.983957 INFO::Fitting model to feature number 596, F624
## 2024-07-16 19:23:25.991699 INFO::Fitting model to feature number 597, F625
## 2024-07-16 19:23:25.999611 INFO::Fitting model to feature number 598, F626
## 2024-07-16 19:23:26.007452 INFO::Fitting model to feature number 599, F627
## 2024-07-16 19:23:26.014956 INFO::Fitting model to feature number 600, F628
## 2024-07-16 19:23:26.02261 INFO::Fitting model to feature number 601, F629
## 2024-07-16 19:23:26.031195 INFO::Fitting model to feature number 602, F630
## 2024-07-16 19:23:26.037195 INFO::Fitting model to feature number 603, F631
## 2024-07-16 19:23:26.044291 INFO::Fitting model to feature number 604, F632
## 2024-07-16 19:23:26.051888 INFO::Fitting model to feature number 605, F633
## 2024-07-16 19:23:26.059329 INFO::Fitting model to feature number 606, F634
## 2024-07-16 19:23:26.066974 INFO::Fitting model to feature number 607, F635
## 2024-07-16 19:23:26.075013 INFO::Fitting model to feature number 608, F636
## 2024-07-16 19:23:26.082917 INFO::Fitting model to feature number 609, F637
## 2024-07-16 19:23:26.091376 INFO::Fitting model to feature number 610, F638
## 2024-07-16 19:23:26.099793 INFO::Fitting model to feature number 611, F639
## 2024-07-16 19:23:26.107069 INFO::Fitting model to feature number 612, F640
## 2024-07-16 19:23:26.115109 INFO::Fitting model to feature number 613, F641
## 2024-07-16 19:23:26.123372 INFO::Fitting model to feature number 614, F642
## 2024-07-16 19:23:26.131384 INFO::Fitting model to feature number 615, F643
## 2024-07-16 19:23:26.139678 INFO::Fitting model to feature number 616, F644
## 2024-07-16 19:23:26.147391 INFO::Fitting model to feature number 617, F645
## 2024-07-16 19:23:26.152599 INFO::Fitting model to feature number 618, F646
## 2024-07-16 19:23:26.157668 INFO::Fitting model to feature number 619, F647
## 2024-07-16 19:23:26.162695 INFO::Fitting model to feature number 620, F648
## 2024-07-16 19:23:26.167835 INFO::Fitting model to feature number 621, F649
## 2024-07-16 19:23:26.173057 INFO::Fitting model to feature number 622, F650
## 2024-07-16 19:23:26.178104 INFO::Fitting model to feature number 623, F651
## 2024-07-16 19:23:26.185443 INFO::Fitting model to feature number 624, F652
## 2024-07-16 19:23:26.192603 INFO::Fitting model to feature number 625, F653
## 2024-07-16 19:23:26.198158 INFO::Fitting model to feature number 626, F654
## 2024-07-16 19:23:26.203489 INFO::Fitting model to feature number 627, F655
## 2024-07-16 19:23:26.208661 INFO::Fitting model to feature number 628, F656
## 2024-07-16 19:23:26.213903 INFO::Fitting model to feature number 629, F657
## 2024-07-16 19:23:26.219074 INFO::Fitting model to feature number 630, F658
## 2024-07-16 19:23:26.22446 INFO::Fitting model to feature number 631, F659
## 2024-07-16 19:23:26.229832 INFO::Fitting model to feature number 632, F660
## 2024-07-16 19:23:26.234675 INFO::Fitting model to feature number 633, F661
## 2024-07-16 19:23:26.239836 INFO::Fitting model to feature number 634, F662
## 2024-07-16 19:23:26.246606 INFO::Fitting model to feature number 635, F663
## 2024-07-16 19:23:26.251948 INFO::Fitting model to feature number 636, F664
## 2024-07-16 19:23:26.257055 INFO::Fitting model to feature number 637, F665
## 2024-07-16 19:23:26.262965 INFO::Fitting model to feature number 638, F666
## 2024-07-16 19:23:26.26806 INFO::Fitting model to feature number 639, F667
## 2024-07-16 19:23:26.273713 INFO::Fitting model to feature number 640, F668
## 2024-07-16 19:23:26.278833 INFO::Fitting model to feature number 641, F669
## 2024-07-16 19:23:26.284013 INFO::Fitting model to feature number 642, F670
## 2024-07-16 19:23:26.290408 INFO::Fitting model to feature number 643, F671
## 2024-07-16 19:23:26.298188 INFO::Fitting model to feature number 644, F672
## 2024-07-16 19:23:26.306279 INFO::Fitting model to feature number 645, F673
## 2024-07-16 19:23:26.314128 INFO::Fitting model to feature number 646, F674
## 2024-07-16 19:23:26.321421 INFO::Fitting model to feature number 647, F675
## 2024-07-16 19:23:26.329494 INFO::Fitting model to feature number 648, F676
## 2024-07-16 19:23:26.335201 INFO::Fitting model to feature number 649, F677
## 2024-07-16 19:23:26.341202 INFO::Fitting model to feature number 650, F678
## 2024-07-16 19:23:26.348268 INFO::Fitting model to feature number 651, F679
## 2024-07-16 19:23:26.356036 INFO::Fitting model to feature number 652, F680
## 2024-07-16 19:23:26.364269 INFO::Fitting model to feature number 653, F681
## 2024-07-16 19:23:26.372122 INFO::Fitting model to feature number 654, F682
## 2024-07-16 19:23:26.379926 INFO::Fitting model to feature number 655, F683
## 2024-07-16 19:23:26.387109 INFO::Fitting model to feature number 656, F684
## 2024-07-16 19:23:26.394316 INFO::Fitting model to feature number 657, F685
## 2024-07-16 19:23:26.402304 INFO::Fitting model to feature number 658, F686
## 2024-07-16 19:23:26.410557 INFO::Fitting model to feature number 659, F687
## 2024-07-16 19:23:26.418687 INFO::Fitting model to feature number 660, F688
## 2024-07-16 19:23:26.425858 INFO::Fitting model to feature number 661, F689
## 2024-07-16 19:23:26.434233 INFO::Fitting model to feature number 662, F690
## 2024-07-16 19:23:26.442518 INFO::Fitting model to feature number 663, F691
## 2024-07-16 19:23:26.451066 INFO::Fitting model to feature number 664, F692
## 2024-07-16 19:23:26.459552 INFO::Fitting model to feature number 665, F693
## 2024-07-16 19:23:26.467705 INFO::Fitting model to feature number 666, F694
## 2024-07-16 19:23:26.475789 INFO::Fitting model to feature number 667, F695
## 2024-07-16 19:23:26.483052 INFO::Fitting model to feature number 668, F696
## 2024-07-16 19:23:26.490774 INFO::Fitting model to feature number 669, F697
## 2024-07-16 19:23:26.498824 INFO::Fitting model to feature number 670, F698
## 2024-07-16 19:23:26.506627 INFO::Fitting model to feature number 671, F699
## 2024-07-16 19:23:26.511919 INFO::Fitting model to feature number 672, F700
## 2024-07-16 19:23:26.517269 INFO::Fitting model to feature number 673, F701
## 2024-07-16 19:23:26.522496 INFO::Fitting model to feature number 674, F702
## 2024-07-16 19:23:26.527548 INFO::Fitting model to feature number 675, F704
## 2024-07-16 19:23:26.532868 INFO::Fitting model to feature number 676, F705
## 2024-07-16 19:23:26.538149 INFO::Fitting model to feature number 677, F706
## 2024-07-16 19:23:26.544132 INFO::Fitting model to feature number 678, F707
## 2024-07-16 19:23:26.550791 INFO::Fitting model to feature number 679, F708
## 2024-07-16 19:23:26.558675 INFO::Fitting model to feature number 680, F709
## 2024-07-16 19:23:26.56665 INFO::Fitting model to feature number 681, F710
## 2024-07-16 19:23:26.572916 INFO::Fitting model to feature number 682, F711
## 2024-07-16 19:23:26.581028 INFO::Fitting model to feature number 683, F712
## 2024-07-16 19:23:26.589221 INFO::Fitting model to feature number 684, F713
## 2024-07-16 19:23:26.597358 INFO::Fitting model to feature number 685, F714
## 2024-07-16 19:23:26.605725 INFO::Fitting model to feature number 686, F715
## 2024-07-16 19:23:26.613957 INFO::Fitting model to feature number 687, F716
## 2024-07-16 19:23:26.621691 INFO::Fitting model to feature number 688, F717
## 2024-07-16 19:23:26.627375 INFO::Fitting model to feature number 689, F718
## 2024-07-16 19:23:26.632787 INFO::Fitting model to feature number 690, F719
## 2024-07-16 19:23:26.63824 INFO::Fitting model to feature number 691, F720
## 2024-07-16 19:23:26.64361 INFO::Fitting model to feature number 692, F721
## 2024-07-16 19:23:26.648778 INFO::Fitting model to feature number 693, F722
## 2024-07-16 19:23:26.654204 INFO::Fitting model to feature number 694, F723
## 2024-07-16 19:23:26.6592 INFO::Fitting model to feature number 695, F724
## 2024-07-16 19:23:26.664189 INFO::Fitting model to feature number 696, F725
## 2024-07-16 19:23:26.669214 INFO::Fitting model to feature number 697, F726
## 2024-07-16 19:23:26.674274 INFO::Fitting model to feature number 698, F727
## 2024-07-16 19:23:26.67941 INFO::Fitting model to feature number 699, F728
## 2024-07-16 19:23:26.684513 INFO::Fitting model to feature number 700, F729
## 2024-07-16 19:23:26.689629 INFO::Fitting model to feature number 701, F730
## 2024-07-16 19:23:26.694738 INFO::Fitting model to feature number 702, F731
## 2024-07-16 19:23:26.700025 INFO::Fitting model to feature number 703, F732
## 2024-07-16 19:23:26.705546 INFO::Fitting model to feature number 704, F733
## 2024-07-16 19:23:26.711148 INFO::Fitting model to feature number 705, F734
## 2024-07-16 19:23:26.719281 INFO::Fitting model to feature number 706, F735
## 2024-07-16 19:23:26.726107 INFO::Fitting model to feature number 707, F736
## 2024-07-16 19:23:26.731949 INFO::Fitting model to feature number 708, F737
## 2024-07-16 19:23:26.737878 INFO::Fitting model to feature number 709, F739
## 2024-07-16 19:23:26.744464 INFO::Fitting model to feature number 710, F740
## 2024-07-16 19:23:26.752573 INFO::Fitting model to feature number 711, F741
## 2024-07-16 19:23:26.758649 INFO::Fitting model to feature number 712, F742
## 2024-07-16 19:23:26.764256 INFO::Fitting model to feature number 713, F743
## 2024-07-16 19:23:26.769509 INFO::Fitting model to feature number 714, F744
## 2024-07-16 19:23:26.774748 INFO::Fitting model to feature number 715, F745
## 2024-07-16 19:23:26.782247 INFO::Fitting model to feature number 716, F746
## 2024-07-16 19:23:26.789774 INFO::Fitting model to feature number 717, F747
## 2024-07-16 19:23:26.797295 INFO::Fitting model to feature number 718, F748
## 2024-07-16 19:23:26.804984 INFO::Fitting model to feature number 719, F749
## 2024-07-16 19:23:26.81258 INFO::Fitting model to feature number 720, F750
## 2024-07-16 19:23:26.820923 INFO::Fitting model to feature number 721, F751
## 2024-07-16 19:23:26.829234 INFO::Fitting model to feature number 722, F752
## 2024-07-16 19:23:26.837511 INFO::Fitting model to feature number 723, F753
## 2024-07-16 19:23:26.842847 INFO::Fitting model to feature number 724, F754
## 2024-07-16 19:23:26.848261 INFO::Fitting model to feature number 725, F755
## 2024-07-16 19:23:26.853709 INFO::Fitting model to feature number 726, F756
## 2024-07-16 19:23:26.858768 INFO::Fitting model to feature number 727, F757
## 2024-07-16 19:23:26.863922 INFO::Fitting model to feature number 728, F758
## 2024-07-16 19:23:26.869016 INFO::Fitting model to feature number 729, F759
## 2024-07-16 19:23:26.874428 INFO::Fitting model to feature number 730, F760
## 2024-07-16 19:23:26.882389 INFO::Fitting model to feature number 731, F761
## 2024-07-16 19:23:26.890526 INFO::Fitting model to feature number 732, F762
## 2024-07-16 19:23:26.897769 INFO::Fitting model to feature number 733, F763
## 2024-07-16 19:23:26.903091 INFO::Fitting model to feature number 734, F764
## 2024-07-16 19:23:26.908264 INFO::Fitting model to feature number 735, F765
## 2024-07-16 19:23:26.916533 INFO::Fitting model to feature number 736, F766
## 2024-07-16 19:23:26.924657 INFO::Fitting model to feature number 737, F767
## 2024-07-16 19:23:26.932342 INFO::Fitting model to feature number 738, F768
## 2024-07-16 19:23:26.937775 INFO::Fitting model to feature number 739, F769
## 2024-07-16 19:23:26.943316 INFO::Fitting model to feature number 740, F770
## 2024-07-16 19:23:26.948825 INFO::Fitting model to feature number 741, F771
## 2024-07-16 19:23:26.954105 INFO::Fitting model to feature number 742, F772
## 2024-07-16 19:23:26.959318 INFO::Fitting model to feature number 743, F773
## 2024-07-16 19:23:26.964482 INFO::Fitting model to feature number 744, F774
## 2024-07-16 19:23:26.969635 INFO::Fitting model to feature number 745, F775
## 2024-07-16 19:23:26.974738 INFO::Fitting model to feature number 746, F776
## 2024-07-16 19:23:26.981089 INFO::Fitting model to feature number 747, F777
## 2024-07-16 19:23:26.989519 INFO::Fitting model to feature number 748, F778
## 2024-07-16 19:23:26.99793 INFO::Fitting model to feature number 749, F779
## 2024-07-16 19:23:27.005463 INFO::Fitting model to feature number 750, F780
## 2024-07-16 19:23:27.032594 INFO::Fitting model to feature number 751, F781
## 2024-07-16 19:23:27.03787 INFO::Fitting model to feature number 752, F782
## 2024-07-16 19:23:27.042946 INFO::Fitting model to feature number 753, F783
## 2024-07-16 19:23:27.047927 INFO::Fitting model to feature number 754, F784
## 2024-07-16 19:23:27.052837 INFO::Fitting model to feature number 755, F785
## 2024-07-16 19:23:27.058224 INFO::Fitting model to feature number 756, F786
## 2024-07-16 19:23:27.063861 INFO::Fitting model to feature number 757, F787
## 2024-07-16 19:23:27.068755 INFO::Fitting model to feature number 758, F788
## 2024-07-16 19:23:27.073631 INFO::Fitting model to feature number 759, F789
## 2024-07-16 19:23:27.07838 INFO::Fitting model to feature number 760, F790
## 2024-07-16 19:23:27.083263 INFO::Fitting model to feature number 761, F791
## 2024-07-16 19:23:27.088198 INFO::Fitting model to feature number 762, F792
## 2024-07-16 19:23:27.093345 INFO::Fitting model to feature number 763, F793
## 2024-07-16 19:23:27.099518 INFO::Fitting model to feature number 764, F794
## 2024-07-16 19:23:27.106468 INFO::Fitting model to feature number 765, F795
## 2024-07-16 19:23:27.113857 INFO::Fitting model to feature number 766, F796
## 2024-07-16 19:23:27.119832 INFO::Fitting model to feature number 767, F797
## 2024-07-16 19:23:27.124899 INFO::Fitting model to feature number 768, F798
## 2024-07-16 19:23:27.129784 INFO::Fitting model to feature number 769, F799
## 2024-07-16 19:23:27.134802 INFO::Fitting model to feature number 770, F800
## 2024-07-16 19:23:27.142482 INFO::Fitting model to feature number 771, F801
## 2024-07-16 19:23:27.147635 INFO::Fitting model to feature number 772, F802
## 2024-07-16 19:23:27.152988 INFO::Fitting model to feature number 773, F803
## 2024-07-16 19:23:27.158049 INFO::Fitting model to feature number 774, F804
## 2024-07-16 19:23:27.163013 INFO::Fitting model to feature number 775, F805
## 2024-07-16 19:23:27.167943 INFO::Fitting model to feature number 776, F806
## 2024-07-16 19:23:27.172769 INFO::Fitting model to feature number 777, F808
## 2024-07-16 19:23:27.177657 INFO::Fitting model to feature number 778, F809
## 2024-07-16 19:23:27.182601 INFO::Fitting model to feature number 779, F810
## 2024-07-16 19:23:27.187487 INFO::Fitting model to feature number 780, F811
## 2024-07-16 19:23:27.192355 INFO::Fitting model to feature number 781, F812
## 2024-07-16 19:23:27.19721 INFO::Fitting model to feature number 782, F813
## 2024-07-16 19:23:27.20201 INFO::Fitting model to feature number 783, F814
## 2024-07-16 19:23:27.206711 INFO::Fitting model to feature number 784, F815
## 2024-07-16 19:23:27.211358 INFO::Fitting model to feature number 785, F816
## 2024-07-16 19:23:27.21611 INFO::Fitting model to feature number 786, F817
## 2024-07-16 19:23:27.220793 INFO::Fitting model to feature number 787, F818
## 2024-07-16 19:23:27.225424 INFO::Fitting model to feature number 788, F819
## 2024-07-16 19:23:27.230087 INFO::Fitting model to feature number 789, F820
## 2024-07-16 19:23:27.234657 INFO::Fitting model to feature number 790, F821
## 2024-07-16 19:23:27.239344 INFO::Fitting model to feature number 791, F822
## 2024-07-16 19:23:27.24403 INFO::Fitting model to feature number 792, F823
## 2024-07-16 19:23:27.249014 INFO::Fitting model to feature number 793, F824
## 2024-07-16 19:23:27.253839 INFO::Fitting model to feature number 794, F825
## 2024-07-16 19:23:27.258717 INFO::Fitting model to feature number 795, F826
## 2024-07-16 19:23:27.263703 INFO::Fitting model to feature number 796, F827
## 2024-07-16 19:23:27.268592 INFO::Fitting model to feature number 797, F828
## 2024-07-16 19:23:27.27358 INFO::Fitting model to feature number 798, F829
## 2024-07-16 19:23:27.279489 INFO::Fitting model to feature number 799, F830
## 2024-07-16 19:23:27.286913 INFO::Fitting model to feature number 800, F831
## 2024-07-16 19:23:27.294709 INFO::Fitting model to feature number 801, F832
## 2024-07-16 19:23:27.301857 INFO::Fitting model to feature number 802, F833
## 2024-07-16 19:23:27.307386 INFO::Fitting model to feature number 803, F834
## 2024-07-16 19:23:27.3152 INFO::Fitting model to feature number 804, F835
## 2024-07-16 19:23:27.321123 INFO::Fitting model to feature number 805, F836
## 2024-07-16 19:23:27.328172 INFO::Fitting model to feature number 806, F837
## 2024-07-16 19:23:27.335685 INFO::Fitting model to feature number 807, F838
## 2024-07-16 19:23:27.34338 INFO::Fitting model to feature number 808, F839
## 2024-07-16 19:23:27.351259 INFO::Fitting model to feature number 809, F840
## 2024-07-16 19:23:27.358987 INFO::Fitting model to feature number 810, F841
## 2024-07-16 19:23:27.366793 INFO::Fitting model to feature number 811, F842
## 2024-07-16 19:23:27.374051 INFO::Fitting model to feature number 812, F843
## 2024-07-16 19:23:27.381193 INFO::Fitting model to feature number 813, F844
## 2024-07-16 19:23:27.38826 INFO::Fitting model to feature number 814, F845
## 2024-07-16 19:23:27.395319 INFO::Fitting model to feature number 815, F846
## 2024-07-16 19:23:27.402726 INFO::Fitting model to feature number 816, F847
## 2024-07-16 19:23:27.41 INFO::Fitting model to feature number 817, F848
## 2024-07-16 19:23:27.416968 INFO::Fitting model to feature number 818, F849
## 2024-07-16 19:23:27.423567 INFO::Fitting model to feature number 819, F850
## 2024-07-16 19:23:27.428521 INFO::Fitting model to feature number 820, F851
## 2024-07-16 19:23:27.433472 INFO::Fitting model to feature number 821, F852
## 2024-07-16 19:23:27.4384 INFO::Fitting model to feature number 822, F853
## 2024-07-16 19:23:27.443259 INFO::Fitting model to feature number 823, F854
## 2024-07-16 19:23:27.448229 INFO::Fitting model to feature number 824, F855
## 2024-07-16 19:23:27.453024 INFO::Fitting model to feature number 825, F856
## 2024-07-16 19:23:27.457965 INFO::Fitting model to feature number 826, F857
## 2024-07-16 19:23:27.462918 INFO::Fitting model to feature number 827, F858
## 2024-07-16 19:23:27.470531 INFO::Fitting model to feature number 828, F859
## 2024-07-16 19:23:27.478463 INFO::Fitting model to feature number 829, F860
## 2024-07-16 19:23:27.485703 INFO::Fitting model to feature number 830, F861
## 2024-07-16 19:23:27.490648 INFO::Fitting model to feature number 831, F862
## 2024-07-16 19:23:27.495651 INFO::Fitting model to feature number 832, F863
## 2024-07-16 19:23:27.501723 INFO::Fitting model to feature number 833, F864
## 2024-07-16 19:23:27.508836 INFO::Fitting model to feature number 834, F865
## 2024-07-16 19:23:27.516666 INFO::Fitting model to feature number 835, F866
## 2024-07-16 19:23:27.524243 INFO::Fitting model to feature number 836, F867
## 2024-07-16 19:23:27.53161 INFO::Fitting model to feature number 837, F868
## 2024-07-16 19:23:27.539249 INFO::Fitting model to feature number 838, F869
## 2024-07-16 19:23:27.546822 INFO::Fitting model to feature number 839, F870
## 2024-07-16 19:23:27.554322 INFO::Fitting model to feature number 840, F871
## 2024-07-16 19:23:27.561868 INFO::Fitting model to feature number 841, F872
## 2024-07-16 19:23:27.569469 INFO::Fitting model to feature number 842, F873
## 2024-07-16 19:23:27.577236 INFO::Fitting model to feature number 843, F874
## 2024-07-16 19:23:27.584754 INFO::Fitting model to feature number 844, F875
## 2024-07-16 19:23:27.592121 INFO::Fitting model to feature number 845, F876
## 2024-07-16 19:23:27.600066 INFO::Fitting model to feature number 846, F877
## 2024-07-16 19:23:27.60774 INFO::Fitting model to feature number 847, F878
## 2024-07-16 19:23:27.615582 INFO::Fitting model to feature number 848, F879
## 2024-07-16 19:23:27.623834 INFO::Fitting model to feature number 849, F880
## 2024-07-16 19:23:27.631597 INFO::Fitting model to feature number 850, F881
## 2024-07-16 19:23:27.639399 INFO::Fitting model to feature number 851, F882
## 2024-07-16 19:23:27.647684 INFO::Fitting model to feature number 852, F883
## 2024-07-16 19:23:27.655527 INFO::Fitting model to feature number 853, F884
## 2024-07-16 19:23:27.663358 INFO::Fitting model to feature number 854, F885
## 2024-07-16 19:23:27.671177 INFO::Fitting model to feature number 855, F886
## 2024-07-16 19:23:27.679118 INFO::Fitting model to feature number 856, F887
## 2024-07-16 19:23:27.687187 INFO::Fitting model to feature number 857, F888
## 2024-07-16 19:23:27.695209 INFO::Fitting model to feature number 858, F889
## 2024-07-16 19:23:27.703226 INFO::Fitting model to feature number 859, F890
## 2024-07-16 19:23:27.70871 INFO::Fitting model to feature number 860, F891
## 2024-07-16 19:23:27.714235 INFO::Fitting model to feature number 861, F892
## 2024-07-16 19:23:27.722201 INFO::Fitting model to feature number 862, F893
## 2024-07-16 19:23:27.730139 INFO::Fitting model to feature number 863, F894
## 2024-07-16 19:23:27.738219 INFO::Fitting model to feature number 864, F895
## 2024-07-16 19:23:27.746403 INFO::Fitting model to feature number 865, F896
## 2024-07-16 19:23:27.754555 INFO::Fitting model to feature number 866, F897
## 2024-07-16 19:23:27.76275 INFO::Fitting model to feature number 867, F898
## 2024-07-16 19:23:27.770912 INFO::Fitting model to feature number 868, F899
## 2024-07-16 19:23:27.775907 INFO::Fitting model to feature number 869, F900
## 2024-07-16 19:23:27.960391 INFO::Counting total values for each feature
## 2024-07-16 19:23:28.159445 INFO::Writing filtered data to file Macarron_output/maaslin2_results/features/filtered_data.tsv
## 2024-07-16 19:23:28.494736 INFO::Writing filtered, normalized data to file Macarron_output/maaslin2_results/features/filtered_data_norm.tsv
## 2024-07-16 19:23:28.844089 INFO::Writing filtered, normalized, transformed data to file Macarron_output/maaslin2_results/features/filtered_data_norm_transformed.tsv
## 2024-07-16 19:23:29.189252 INFO::Writing residuals to file Macarron_output/maaslin2_results/fits/residuals.rds
## 2024-07-16 19:23:29.242791 INFO::Writing fitted values to file Macarron_output/maaslin2_results/fits/fitted.rds
## 2024-07-16 19:23:29.28505 INFO::Writing all results to file (ordered by increasing q-values): Macarron_output/maaslin2_results/all_results.tsv
## 2024-07-16 19:23:29.363907 INFO::Writing the significant results (those which are less than or equal to the threshold of 0.250000 ) to file (ordered by increasing q-values): Macarron_output/maaslin2_results/significant_results.tsv
## 2024-07-16 19:23:29.403746 INFO::Writing association plots (one for each significant association) to output folder: Macarron_output/maaslin2_results
## 2024-07-16 19:23:29.582235 INFO::Plotting associations from most to least significant, grouped by metadata
## 2024-07-16 19:23:29.584487 INFO::Plotting data for metadata number 1, diagnosis
## 2024-07-16 19:23:29.641382 INFO::Creating boxplot for categorical data, diagnosis vs F504
## 2024-07-16 19:23:30.08676 INFO::Creating boxplot for categorical data, diagnosis vs F859
## 2024-07-16 19:23:30.365165 INFO::Creating boxplot for categorical data, diagnosis vs F533
## 2024-07-16 19:23:30.652286 INFO::Creating boxplot for categorical data, diagnosis vs F587
## 2024-07-16 19:23:30.850518 INFO::Creating boxplot for categorical data, diagnosis vs F584
## 2024-07-16 19:23:31.089575 INFO::Creating boxplot for categorical data, diagnosis vs F197
## 2024-07-16 19:23:31.373016 INFO::Creating boxplot for categorical data, diagnosis vs F380
## 2024-07-16 19:23:31.595768 INFO::Creating boxplot for categorical data, diagnosis vs F829
## 2024-07-16 19:23:31.770518 INFO::Creating boxplot for categorical data, diagnosis vs F664
## 2024-07-16 19:23:32.062596 INFO::Creating boxplot for categorical data, diagnosis vs F93
## 2024-07-16 19:23:32.343267 INFO::Creating boxplot for categorical data, diagnosis vs F15
## 2024-07-16 19:23:32.526739 INFO::Creating boxplot for categorical data, diagnosis vs F881
## 2024-07-16 19:23:32.764105 INFO::Creating boxplot for categorical data, diagnosis vs F806
## 2024-07-16 19:23:32.950449 INFO::Creating boxplot for categorical data, diagnosis vs F78
## 2024-07-16 19:23:33.205585 INFO::Creating boxplot for categorical data, diagnosis vs F189
## 2024-07-16 19:23:33.402235 INFO::Creating boxplot for categorical data, diagnosis vs F369
## 2024-07-16 19:23:33.571055 INFO::Creating boxplot for categorical data, diagnosis vs F623
## 2024-07-16 19:23:33.74271 INFO::Creating boxplot for categorical data, diagnosis vs F710
## 2024-07-16 19:23:33.926361 INFO::Creating boxplot for categorical data, diagnosis vs F851
## 2024-07-16 19:23:34.09211 INFO::Creating boxplot for categorical data, diagnosis vs F257
## 2024-07-16 19:23:34.260266 INFO::Creating boxplot for categorical data, diagnosis vs F330
## 2024-07-16 19:23:34.429095 INFO::Creating boxplot for categorical data, diagnosis vs F344
## 2024-07-16 19:23:34.597612 INFO::Creating boxplot for categorical data, diagnosis vs F696
## 2024-07-16 19:23:34.76391 INFO::Creating boxplot for categorical data, diagnosis vs F741
## 2024-07-16 19:23:34.942554 INFO::Creating boxplot for categorical data, diagnosis vs F509
## 2024-07-16 19:23:35.105675 INFO::Creating boxplot for categorical data, diagnosis vs F479
## 2024-07-16 19:23:35.27677 INFO::Creating boxplot for categorical data, diagnosis vs F550
## 2024-07-16 19:23:35.509052 INFO::Creating boxplot for categorical data, diagnosis vs F640
## 2024-07-16 19:23:35.992079 INFO::Creating boxplot for categorical data, diagnosis vs F281
## 2024-07-16 19:23:36.181531 INFO::Creating boxplot for categorical data, diagnosis vs F80
## 2024-07-16 19:23:36.428526 INFO::Creating boxplot for categorical data, diagnosis vs F285
## 2024-07-16 19:23:36.618218 INFO::Creating boxplot for categorical data, diagnosis vs F531
## 2024-07-16 19:23:36.857121 INFO::Creating boxplot for categorical data, diagnosis vs F737
## 2024-07-16 19:23:37.055333 INFO::Creating boxplot for categorical data, diagnosis vs F875
## 2024-07-16 19:23:37.233238 INFO::Creating boxplot for categorical data, diagnosis vs F864
## 2024-07-16 19:23:37.448304 INFO::Creating boxplot for categorical data, diagnosis vs F379
## 2024-07-16 19:23:37.627001 INFO::Creating boxplot for categorical data, diagnosis vs F190
## 2024-07-16 19:23:37.881503 INFO::Creating boxplot for categorical data, diagnosis vs F4
## 2024-07-16 19:23:38.056201 INFO::Creating boxplot for categorical data, diagnosis vs F591
## 2024-07-16 19:23:38.229878 INFO::Creating boxplot for categorical data, diagnosis vs F773
## 2024-07-16 19:23:38.432099 INFO::Creating boxplot for categorical data, diagnosis vs F283
## 2024-07-16 19:23:38.731447 INFO::Creating boxplot for categorical data, diagnosis vs F233
## 2024-07-16 19:23:38.979431 INFO::Creating boxplot for categorical data, diagnosis vs F420
## 2024-07-16 19:23:39.149081 INFO::Creating boxplot for categorical data, diagnosis vs F5
## 2024-07-16 19:23:39.3164 INFO::Creating boxplot for categorical data, diagnosis vs F137
## 2024-07-16 19:23:39.511633 INFO::Creating boxplot for categorical data, diagnosis vs F215
## 2024-07-16 19:23:39.69506 INFO::Creating boxplot for categorical data, diagnosis vs F489
## 2024-07-16 19:23:39.860395 INFO::Creating boxplot for categorical data, diagnosis vs F220
## 2024-07-16 19:23:40.027178 INFO::Creating boxplot for categorical data, diagnosis vs F691
## 2024-07-16 19:23:40.204214 INFO::Creating boxplot for categorical data, diagnosis vs F381
## 2024-07-16 19:23:40.394807 INFO::Creating boxplot for categorical data, diagnosis vs F539
## 2024-07-16 19:23:40.600406 INFO::Creating boxplot for categorical data, diagnosis vs F490
## 2024-07-16 19:23:40.785795 INFO::Creating boxplot for categorical data, diagnosis vs F832
## 2024-07-16 19:23:40.973816 INFO::Creating boxplot for categorical data, diagnosis vs F396
## 2024-07-16 19:23:41.256139 INFO::Creating boxplot for categorical data, diagnosis vs F528
## 2024-07-16 19:23:41.485989 INFO::Creating boxplot for categorical data, diagnosis vs F234
## 2024-07-16 19:23:41.769064 INFO::Creating boxplot for categorical data, diagnosis vs F178
## 2024-07-16 19:23:41.971623 INFO::Creating boxplot for categorical data, diagnosis vs F761
## 2024-07-16 19:23:42.210087 INFO::Creating boxplot for categorical data, diagnosis vs F2
## 2024-07-16 19:23:42.427312 INFO::Creating boxplot for categorical data, diagnosis vs F260
## 2024-07-16 19:23:42.613966 INFO::Creating boxplot for categorical data, diagnosis vs F734
## 2024-07-16 19:23:42.793307 INFO::Creating boxplot for categorical data, diagnosis vs F429
## 2024-07-16 19:23:42.975764 INFO::Creating boxplot for categorical data, diagnosis vs F630
## 2024-07-16 19:23:43.184514 INFO::Creating boxplot for categorical data, diagnosis vs F817
## 2024-07-16 19:23:43.419733 INFO::Creating boxplot for categorical data, diagnosis vs F847
## 2024-07-16 19:23:43.656765 INFO::Creating boxplot for categorical data, diagnosis vs F896
## 2024-07-16 19:23:43.832723 INFO::Creating boxplot for categorical data, diagnosis vs F81
## 2024-07-16 19:23:44.001247 INFO::Creating boxplot for categorical data, diagnosis vs F110
## 2024-07-16 19:23:44.169203 INFO::Creating boxplot for categorical data, diagnosis vs F3
## 2024-07-16 19:23:44.357026 INFO::Creating boxplot for categorical data, diagnosis vs F33
## 2024-07-16 19:23:44.531271 INFO::Creating boxplot for categorical data, diagnosis vs F270
## 2024-07-16 19:23:44.697246 INFO::Creating boxplot for categorical data, diagnosis vs F278
## 2024-07-16 19:23:44.86656 INFO::Creating boxplot for categorical data, diagnosis vs F264
## 2024-07-16 19:23:45.03965 INFO::Creating boxplot for categorical data, diagnosis vs F90
## 2024-07-16 19:23:45.233204 INFO::Creating boxplot for categorical data, diagnosis vs F403
## 2024-07-16 19:23:45.426163 INFO::Creating boxplot for categorical data, diagnosis vs F727
## 2024-07-16 19:23:45.598063 INFO::Creating boxplot for categorical data, diagnosis vs F394
## 2024-07-16 19:23:45.791196 INFO::Creating boxplot for categorical data, diagnosis vs F800
## 2024-07-16 19:23:45.967239 INFO::Creating boxplot for categorical data, diagnosis vs F439
## 2024-07-16 19:23:46.149938 INFO::Creating boxplot for categorical data, diagnosis vs F554
## 2024-07-16 19:23:46.403293 INFO::Creating boxplot for categorical data, diagnosis vs F559
## 2024-07-16 19:23:46.647304 INFO::Creating boxplot for categorical data, diagnosis vs F548
## 2024-07-16 19:23:46.884938 INFO::Creating boxplot for categorical data, diagnosis vs F794
## 2024-07-16 19:23:47.158275 INFO::Creating boxplot for categorical data, diagnosis vs F45
## 2024-07-16 19:23:47.552644 INFO::Creating boxplot for categorical data, diagnosis vs F158
## 2024-07-16 19:23:47.73011 INFO::Creating boxplot for categorical data, diagnosis vs F477
## 2024-07-16 19:23:47.923357 INFO::Creating boxplot for categorical data, diagnosis vs F1
## 2024-07-16 19:23:48.090992 INFO::Creating boxplot for categorical data, diagnosis vs F862
## 2024-07-16 19:23:48.266517 INFO::Creating boxplot for categorical data, diagnosis vs F803
## 2024-07-16 19:23:48.462317 INFO::Creating boxplot for categorical data, diagnosis vs F751
## 2024-07-16 19:23:48.646276 INFO::Creating boxplot for categorical data, diagnosis vs F98
## 2024-07-16 19:23:48.841578 INFO::Creating boxplot for categorical data, diagnosis vs F22
## 2024-07-16 19:23:49.028511 INFO::Creating boxplot for categorical data, diagnosis vs F625
## 2024-07-16 19:23:49.193112 INFO::Creating boxplot for categorical data, diagnosis vs F206
## 2024-07-16 19:23:49.364171 INFO::Creating boxplot for categorical data, diagnosis vs F779
## 2024-07-16 19:23:49.543473 INFO::Creating boxplot for categorical data, diagnosis vs F532
## 2024-07-16 19:23:49.711224 INFO::Creating boxplot for categorical data, diagnosis vs F676
## 2024-07-16 19:23:49.903701 INFO::Creating boxplot for categorical data, diagnosis vs F644
## 2024-07-16 19:23:50.183112 INFO::Creating boxplot for categorical data, diagnosis vs F7
## 2024-07-16 19:23:50.425889 INFO::Creating boxplot for categorical data, diagnosis vs F596
## 2024-07-16 19:23:50.741334 INFO::Creating boxplot for categorical data, diagnosis vs F250
## 2024-07-16 19:23:51.054604 INFO::Creating boxplot for categorical data, diagnosis vs F462
## 2024-07-16 19:23:51.327299 INFO::Creating boxplot for categorical data, diagnosis vs F516
## 2024-07-16 19:23:51.622238 INFO::Creating boxplot for categorical data, diagnosis vs F659
## 2024-07-16 19:23:51.832611 INFO::Creating boxplot for categorical data, diagnosis vs F663
## 2024-07-16 19:23:52.084371 INFO::Creating boxplot for categorical data, diagnosis vs F837
## 2024-07-16 19:23:52.300377 INFO::Creating boxplot for categorical data, diagnosis vs F138
## 2024-07-16 19:23:52.563154 INFO::Creating boxplot for categorical data, diagnosis vs F445
## 2024-07-16 19:23:52.97325 INFO::Creating boxplot for categorical data, diagnosis vs F697
## 2024-07-16 19:23:53.153296 INFO::Creating boxplot for categorical data, diagnosis vs F225
## 2024-07-16 19:23:53.323304 INFO::Creating boxplot for categorical data, diagnosis vs F148
## 2024-07-16 19:23:53.555551 INFO::Creating boxplot for categorical data, diagnosis vs F448
## 2024-07-16 19:23:53.745234 INFO::Creating boxplot for categorical data, diagnosis vs F91
## 2024-07-16 19:23:53.975273 INFO::Creating boxplot for categorical data, diagnosis vs F123
## 2024-07-16 19:23:54.245797 INFO::Creating boxplot for categorical data, diagnosis vs F665
## 2024-07-16 19:23:54.463468 INFO::Creating boxplot for categorical data, diagnosis vs F845
## 2024-07-16 19:23:54.726254 INFO::Creating boxplot for categorical data, diagnosis vs F331
## 2024-07-16 19:23:55.010706 INFO::Creating boxplot for categorical data, diagnosis vs F361
## 2024-07-16 19:23:55.220844 INFO::Creating boxplot for categorical data, diagnosis vs F421
## 2024-07-16 19:23:55.439775 INFO::Creating boxplot for categorical data, diagnosis vs F277
## 2024-07-16 19:23:55.615957 INFO::Creating boxplot for categorical data, diagnosis vs F307
## 2024-07-16 19:23:55.8644 INFO::Creating boxplot for categorical data, diagnosis vs F503
## 2024-07-16 19:23:56.162175 INFO::Creating boxplot for categorical data, diagnosis vs F34
## 2024-07-16 19:23:56.442459 INFO::Creating boxplot for categorical data, diagnosis vs F649
## 2024-07-16 19:23:56.72684 INFO::Creating boxplot for categorical data, diagnosis vs F825
## 2024-07-16 19:23:57.015009 INFO::Creating boxplot for categorical data, diagnosis vs F298
## 2024-07-16 19:23:57.239997 INFO::Creating boxplot for categorical data, diagnosis vs F461
## 2024-07-16 19:23:57.412738 INFO::Creating boxplot for categorical data, diagnosis vs F242
## 2024-07-16 19:23:57.591417 INFO::Creating boxplot for categorical data, diagnosis vs F375
## 2024-07-16 19:23:57.75645 INFO::Creating boxplot for categorical data, diagnosis vs F648
## 2024-07-16 19:23:58.039252 INFO::Creating boxplot for categorical data, diagnosis vs F724
## 2024-07-16 19:23:58.22103 INFO::Creating boxplot for categorical data, diagnosis vs F678
## 2024-07-16 19:23:58.399957 INFO::Creating boxplot for categorical data, diagnosis vs F290
## 2024-07-16 19:23:58.857617 INFO::Creating boxplot for categorical data, diagnosis vs F743
## 2024-07-16 19:23:59.093583 INFO::Creating boxplot for categorical data, diagnosis vs F495
## 2024-07-16 19:23:59.316188 INFO::Creating boxplot for categorical data, diagnosis vs F261
## 2024-07-16 19:23:59.543441 INFO::Creating boxplot for categorical data, diagnosis vs F43
## 2024-07-16 19:23:59.721403 INFO::Creating boxplot for categorical data, diagnosis vs F714
## 2024-07-16 19:23:59.892496 INFO::Creating boxplot for categorical data, diagnosis vs F131
## 2024-07-16 19:24:00.073679 INFO::Creating boxplot for categorical data, diagnosis vs F150
## 2024-07-16 19:24:00.254753 INFO::Creating boxplot for categorical data, diagnosis vs F651
## 2024-07-16 19:24:00.442824 INFO::Creating boxplot for categorical data, diagnosis vs F798
## 2024-07-16 19:24:00.660773 INFO::Creating boxplot for categorical data, diagnosis vs F289
## 2024-07-16 19:24:00.859354 INFO::Creating boxplot for categorical data, diagnosis vs F661
## 2024-07-16 19:24:01.05868 INFO::Creating boxplot for categorical data, diagnosis vs F199
## 2024-07-16 19:24:01.236993 INFO::Creating boxplot for categorical data, diagnosis vs F406
## 2024-07-16 19:24:01.425065 INFO::Creating boxplot for categorical data, diagnosis vs F139
## 2024-07-16 19:24:01.618528 INFO::Creating boxplot for categorical data, diagnosis vs F506
## 2024-07-16 19:24:01.818041 INFO::Creating boxplot for categorical data, diagnosis vs F552
## 2024-07-16 19:24:02.002516 INFO::Creating boxplot for categorical data, diagnosis vs F94
## 2024-07-16 19:24:02.185118 INFO::Creating boxplot for categorical data, diagnosis vs F430
## 2024-07-16 19:24:02.362351 INFO::Creating boxplot for categorical data, diagnosis vs F639
## 2024-07-16 19:24:02.602726 INFO::Creating boxplot for categorical data, diagnosis vs F500
## 2024-07-16 19:24:02.818292 INFO::Creating boxplot for categorical data, diagnosis vs F609
## 2024-07-16 19:24:03.04696 INFO::Creating boxplot for categorical data, diagnosis vs F306
## 2024-07-16 19:24:03.275736 INFO::Creating boxplot for categorical data, diagnosis vs F507
## 2024-07-16 19:24:03.469514 INFO::Creating boxplot for categorical data, diagnosis vs F671
## 2024-07-16 19:24:03.703876 INFO::Creating boxplot for categorical data, diagnosis vs F894
## 2024-07-16 19:24:03.999571 INFO::Creating boxplot for categorical data, diagnosis vs F345
## 2024-07-16 19:24:04.290118 INFO::Creating boxplot for categorical data, diagnosis vs F801
## 2024-07-16 19:24:04.488281 INFO::Creating boxplot for categorical data, diagnosis vs F194
## 2024-07-16 19:24:04.697521 INFO::Creating boxplot for categorical data, diagnosis vs F195
## 2024-07-16 19:24:04.961772 INFO::Creating boxplot for categorical data, diagnosis vs F119
## 2024-07-16 19:24:05.187794 INFO::Creating boxplot for categorical data, diagnosis vs F120
## 2024-07-16 19:24:05.37734 INFO::Creating boxplot for categorical data, diagnosis vs F231
## 2024-07-16 19:24:05.598213 INFO::Creating boxplot for categorical data, diagnosis vs F311
## 2024-07-16 19:24:05.779657 INFO::Creating boxplot for categorical data, diagnosis vs F646
## 2024-07-16 19:24:05.974742 INFO::Creating boxplot for categorical data, diagnosis vs F814
## 2024-07-16 19:24:06.218747 INFO::Creating boxplot for categorical data, diagnosis vs F510
## 2024-07-16 19:24:06.492834 INFO::Creating boxplot for categorical data, diagnosis vs F398
## 2024-07-16 19:24:06.711826 INFO::Creating boxplot for categorical data, diagnosis vs F60
## 2024-07-16 19:24:06.91613 INFO::Creating boxplot for categorical data, diagnosis vs F153
## 2024-07-16 19:24:07.142285 INFO::Creating boxplot for categorical data, diagnosis vs F858
## 2024-07-16 19:24:07.404561 INFO::Creating boxplot for categorical data, diagnosis vs F775
## 2024-07-16 19:24:07.617331 INFO::Creating boxplot for categorical data, diagnosis vs F684
## 2024-07-16 19:24:07.788404 INFO::Creating boxplot for categorical data, diagnosis vs F384
## 2024-07-16 19:24:07.995013 INFO::Creating boxplot for categorical data, diagnosis vs F134
## 2024-07-16 19:24:08.170491 INFO::Creating boxplot for categorical data, diagnosis vs F670
## 2024-07-16 19:24:08.36995 INFO::Creating boxplot for categorical data, diagnosis vs F632
## 2024-07-16 19:24:08.545247 INFO::Creating boxplot for categorical data, diagnosis vs F721
## 2024-07-16 19:24:08.723335 INFO::Creating boxplot for categorical data, diagnosis vs F700
## 2024-07-16 19:24:08.931199 INFO::Creating boxplot for categorical data, diagnosis vs F376
## 2024-07-16 19:24:09.159319 INFO::Creating boxplot for categorical data, diagnosis vs F301
## 2024-07-16 19:24:09.431878 INFO::Creating boxplot for categorical data, diagnosis vs F27
## 2024-07-16 19:24:09.698913 INFO::Creating boxplot for categorical data, diagnosis vs F280
## 2024-07-16 19:24:09.985681 INFO::Creating boxplot for categorical data, diagnosis vs F391
## 2024-07-16 19:24:10.207711 INFO::Creating boxplot for categorical data, diagnosis vs F725
## 2024-07-16 19:24:10.456308 INFO::Creating boxplot for categorical data, diagnosis vs F186
## 2024-07-16 19:24:10.635614 INFO::Creating boxplot for categorical data, diagnosis vs F481
## 2024-07-16 19:24:10.804613 INFO::Creating boxplot for categorical data, diagnosis vs F333
## 2024-07-16 19:24:10.979845 INFO::Creating boxplot for categorical data, diagnosis vs F720
## 2024-07-16 19:24:11.260484 INFO::Creating boxplot for categorical data, diagnosis vs F520
## 2024-07-16 19:24:11.53116 INFO::Creating boxplot for categorical data, diagnosis vs F129
## 2024-07-16 19:24:11.74594 INFO::Creating boxplot for categorical data, diagnosis vs F204
## 2024-07-16 19:24:11.954343 INFO::Creating boxplot for categorical data, diagnosis vs F259
## 2024-07-16 19:24:12.178295 INFO::Creating boxplot for categorical data, diagnosis vs F831
## 2024-07-16 19:24:12.345456 INFO::Creating boxplot for categorical data, diagnosis vs F891
## 2024-07-16 19:24:12.517353 INFO::Creating boxplot for categorical data, diagnosis vs F262
## 2024-07-16 19:24:12.729791 INFO::Creating boxplot for categorical data, diagnosis vs F592
## 2024-07-16 19:24:12.981794 INFO::Creating boxplot for categorical data, diagnosis vs F343
## 2024-07-16 19:24:13.22739 INFO::Creating boxplot for categorical data, diagnosis vs F505
## 2024-07-16 19:24:13.50008 INFO::Creating boxplot for categorical data, diagnosis vs F622
## 2024-07-16 19:24:13.781825 INFO::Creating boxplot for categorical data, diagnosis vs F348
## 2024-07-16 19:24:14.041426 INFO::Creating boxplot for categorical data, diagnosis vs F133
## 2024-07-16 19:24:14.315732 INFO::Creating boxplot for categorical data, diagnosis vs F371
## 2024-07-16 19:24:14.607598 INFO::Creating boxplot for categorical data, diagnosis vs F113
## 2024-07-16 19:24:14.79358 INFO::Creating boxplot for categorical data, diagnosis vs F336
## 2024-07-16 19:24:14.967706 INFO::Creating boxplot for categorical data, diagnosis vs F399
## 2024-07-16 19:24:15.150078 INFO::Creating boxplot for categorical data, diagnosis vs F416
## 2024-07-16 19:24:15.389237 INFO::Creating boxplot for categorical data, diagnosis vs F657
## 2024-07-16 19:24:15.668012 INFO::Creating boxplot for categorical data, diagnosis vs F241
## 2024-07-16 19:24:15.90223 INFO::Creating boxplot for categorical data, diagnosis vs F95
## 2024-07-16 19:24:16.124997 INFO::Creating boxplot for categorical data, diagnosis vs F128
## 2024-07-16 19:24:16.373021 INFO::Creating boxplot for categorical data, diagnosis vs F595
## 2024-07-16 19:24:16.607794 INFO::Creating boxplot for categorical data, diagnosis vs F428
## 2024-07-16 19:24:16.884486 INFO::Creating boxplot for categorical data, diagnosis vs F796
## 2024-07-16 19:24:17.15768 INFO::Creating boxplot for categorical data, diagnosis vs F709
## 2024-07-16 19:24:17.372715 INFO::Creating boxplot for categorical data, diagnosis vs F602
## 2024-07-16 19:24:17.593481 INFO::Creating boxplot for categorical data, diagnosis vs F293
## 2024-07-16 19:24:17.80359 INFO::Creating boxplot for categorical data, diagnosis vs F867
## 2024-07-16 19:24:18.028433 INFO::Creating boxplot for categorical data, diagnosis vs F108
## 2024-07-16 19:24:18.259594 INFO::Creating boxplot for categorical data, diagnosis vs F846
## 2024-07-16 19:24:18.513705 INFO::Creating boxplot for categorical data, diagnosis vs F633
## 2024-07-16 19:24:18.687373 INFO::Creating boxplot for categorical data, diagnosis vs F564
## 2024-07-16 19:24:18.956983 INFO::Creating boxplot for categorical data, diagnosis vs F183
## 2024-07-16 19:24:19.124692 INFO::Creating boxplot for categorical data, diagnosis vs F647
## 2024-07-16 19:24:19.326472 INFO::Creating boxplot for categorical data, diagnosis vs F288
## 2024-07-16 19:24:19.592195 INFO::Creating boxplot for categorical data, diagnosis vs F159
## 2024-07-16 19:24:19.841506 INFO::Creating boxplot for categorical data, diagnosis vs F638
## 2024-07-16 19:24:20.030756 INFO::Creating boxplot for categorical data, diagnosis vs F484
## 2024-07-16 19:24:20.269721 INFO::Creating boxplot for categorical data, diagnosis vs F20
## 2024-07-16 19:24:20.488403 INFO::Creating boxplot for categorical data, diagnosis vs F19
## 2024-07-16 19:24:20.74577 INFO::Creating boxplot for categorical data, diagnosis vs F897
## 2024-07-16 19:24:20.983262 INFO::Creating boxplot for categorical data, diagnosis vs F442
## 2024-07-16 19:24:21.251052 INFO::Creating boxplot for categorical data, diagnosis vs F372
## 2024-07-16 19:24:21.433705 INFO::Creating boxplot for categorical data, diagnosis vs F771
## 2024-07-16 19:24:21.603678 INFO::Creating boxplot for categorical data, diagnosis vs F370
## 2024-07-16 19:24:21.835403 INFO::Creating boxplot for categorical data, diagnosis vs F620
## 2024-07-16 19:24:22.011119 INFO::Creating boxplot for categorical data, diagnosis vs F753
## 2024-07-16 19:24:22.187204 INFO::Creating boxplot for categorical data, diagnosis vs F568
## 2024-07-16 19:24:22.387397 INFO::Creating boxplot for categorical data, diagnosis vs F312
## 2024-07-16 19:24:22.559974 INFO::Creating boxplot for categorical data, diagnosis vs F485
## 2024-07-16 19:24:22.840011 INFO::Creating boxplot for categorical data, diagnosis vs F627
## 2024-07-16 19:24:23.120922 INFO::Creating boxplot for categorical data, diagnosis vs F72
## 2024-07-16 19:24:23.347302 INFO::Creating boxplot for categorical data, diagnosis vs F575
## 2024-07-16 19:24:23.630916 INFO::Creating boxplot for categorical data, diagnosis vs F332
## 2024-07-16 19:24:23.803897 INFO::Creating boxplot for categorical data, diagnosis vs F674
## 2024-07-16 19:24:23.981313 INFO::Creating boxplot for categorical data, diagnosis vs F537
## 2024-07-16 19:24:25.107041 INFO::Creating boxplot for categorical data, diagnosis vs F839
## 2024-07-16 19:24:25.317275 INFO::Creating boxplot for categorical data, diagnosis vs F715
## 2024-07-16 19:24:25.565593 INFO::Creating boxplot for categorical data, diagnosis vs F768
## 2024-07-16 19:24:25.796318 INFO::Creating boxplot for categorical data, diagnosis vs F202
## 2024-07-16 19:24:26.051561 INFO::Creating boxplot for categorical data, diagnosis vs F756
## 2024-07-16 19:24:26.323751 INFO::Creating boxplot for categorical data, diagnosis vs F536
## 2024-07-16 19:24:26.535113 INFO::Creating boxplot for categorical data, diagnosis vs F677
## 2024-07-16 19:24:26.73701 INFO::Creating boxplot for categorical data, diagnosis vs F435
## 2024-07-16 19:24:27.01689 INFO::Creating boxplot for categorical data, diagnosis vs F574
## 2024-07-16 19:24:27.244788 INFO::Creating boxplot for categorical data, diagnosis vs F70
## 2024-07-16 19:24:27.492183 INFO::Creating boxplot for categorical data, diagnosis vs F146
## 2024-07-16 19:24:27.746827 INFO::Creating boxplot for categorical data, diagnosis vs F236
## 2024-07-16 19:24:27.984874 INFO::Creating boxplot for categorical data, diagnosis vs F527
## 2024-07-16 19:24:28.211994 INFO::Creating boxplot for categorical data, diagnosis vs F624
## 2024-07-16 19:24:28.417032 INFO::Creating boxplot for categorical data, diagnosis vs F426
## 2024-07-16 19:24:28.626298 INFO::Creating boxplot for categorical data, diagnosis vs F880
## 2024-07-16 19:24:28.793468 INFO::Creating boxplot for categorical data, diagnosis vs F549
## 2024-07-16 19:24:28.970883 INFO::Creating boxplot for categorical data, diagnosis vs F49
## 2024-07-16 19:24:29.196089 INFO::Creating boxplot for categorical data, diagnosis vs F67
## 2024-07-16 19:24:29.463441 INFO::Creating boxplot for categorical data, diagnosis vs F491
## 2024-07-16 19:24:29.643321 INFO::Creating boxplot for categorical data, diagnosis vs F174
## 2024-07-16 19:24:29.84644 INFO::Creating boxplot for categorical data, diagnosis vs F254
## 2024-07-16 19:24:30.103148 INFO::Creating boxplot for categorical data, diagnosis vs F112
## 2024-07-16 19:24:30.4015 INFO::Creating boxplot for categorical data, diagnosis vs F235
## 2024-07-16 19:24:30.613964 INFO::Creating boxplot for categorical data, diagnosis vs F833
## 2024-07-16 19:24:30.894273 INFO::Creating boxplot for categorical data, diagnosis vs F752
## 2024-07-16 19:24:31.166613 INFO::Creating boxplot for categorical data, diagnosis vs F792
## 2024-07-16 19:24:31.38391 INFO::Creating boxplot for categorical data, diagnosis vs F422
## 2024-07-16 19:24:31.567343 INFO::Creating boxplot for categorical data, diagnosis vs F6
## 2024-07-16 19:24:31.869337 INFO::Creating boxplot for categorical data, diagnosis vs F463
## 2024-07-16 19:24:32.148837 INFO::Creating boxplot for categorical data, diagnosis vs F706
## 2024-07-16 19:24:32.315827 INFO::Creating boxplot for categorical data, diagnosis vs F642
## 2024-07-16 19:24:32.485661 INFO::Creating boxplot for categorical data, diagnosis vs F65
## 2024-07-16 19:24:32.652711 INFO::Creating boxplot for categorical data, diagnosis vs F102
## 2024-07-16 19:24:32.87169 INFO::Creating boxplot for categorical data, diagnosis vs F783
## 2024-07-16 19:24:33.162199 INFO::Creating boxplot for categorical data, diagnosis vs F478
## 2024-07-16 19:24:33.411567 INFO::Creating boxplot for categorical data, diagnosis vs F889
## 2024-07-16 19:24:33.634315 INFO::Creating boxplot for categorical data, diagnosis vs F350
## 2024-07-16 19:24:33.806053 INFO::Creating boxplot for categorical data, diagnosis vs F681
## 2024-07-16 19:24:33.970338 INFO::Creating boxplot for categorical data, diagnosis vs F748
## 2024-07-16 19:24:34.151175 INFO::Creating boxplot for categorical data, diagnosis vs F762
## 2024-07-16 19:24:34.315451 INFO::Creating boxplot for categorical data, diagnosis vs F852
## 2024-07-16 19:24:34.524997 INFO::Creating boxplot for categorical data, diagnosis vs F180
## 2024-07-16 19:24:34.719596 INFO::Creating boxplot for categorical data, diagnosis vs F248
## 2024-07-16 19:24:34.883678 INFO::Creating boxplot for categorical data, diagnosis vs F759
## 2024-07-16 19:24:35.049122 INFO::Creating boxplot for categorical data, diagnosis vs F824
## 2024-07-16 19:24:35.229313 INFO::Creating boxplot for categorical data, diagnosis vs F145
## 2024-07-16 19:24:35.403167 INFO::Creating boxplot for categorical data, diagnosis vs F16
## 2024-07-16 19:24:35.570295 INFO::Creating boxplot for categorical data, diagnosis vs F169
## 2024-07-16 19:24:35.739287 INFO::Creating boxplot for categorical data, diagnosis vs F392
## 2024-07-16 19:24:35.923915 INFO::Creating boxplot for categorical data, diagnosis vs F468
## 2024-07-16 19:24:36.210107 INFO::Creating boxplot for categorical data, diagnosis vs F476
## 2024-07-16 19:24:36.508405 INFO::Creating boxplot for categorical data, diagnosis vs F699
## 2024-07-16 19:24:36.776483 INFO::Creating boxplot for categorical data, diagnosis vs F735
## 2024-07-16 19:24:37.027557 INFO::Creating boxplot for categorical data, diagnosis vs F182
## 2024-07-16 19:24:37.307045 INFO::Creating boxplot for categorical data, diagnosis vs F64
## 2024-07-16 19:24:37.586212 INFO::Creating boxplot for categorical data, diagnosis vs F203
## 2024-07-16 19:24:37.886899 INFO::Creating boxplot for categorical data, diagnosis vs F877
## 2024-07-16 19:24:38.159963 INFO::Creating boxplot for categorical data, diagnosis vs F433
## 2024-07-16 19:24:38.405002 INFO::Creating boxplot for categorical data, diagnosis vs F739
## 2024-07-16 19:24:38.594943 INFO::Creating boxplot for categorical data, diagnosis vs F749
## 2024-07-16 19:24:38.877389 INFO::Creating boxplot for categorical data, diagnosis vs F382
## 2024-07-16 19:24:39.123872 INFO::Creating boxplot for categorical data, diagnosis vs F162
## 2024-07-16 19:24:39.378058 INFO::Creating boxplot for categorical data, diagnosis vs F438
## 2024-07-16 19:24:39.60709 INFO::Creating boxplot for categorical data, diagnosis vs F360
## 2024-07-16 19:24:39.83836 INFO::Creating boxplot for categorical data, diagnosis vs F56
## 2024-07-16 19:24:40.073162 INFO::Creating boxplot for categorical data, diagnosis vs F529
## 2024-07-16 19:24:40.318452 INFO::Creating boxplot for categorical data, diagnosis vs F48
## 2024-07-16 19:24:40.539354 INFO::Creating boxplot for categorical data, diagnosis vs F826
## 2024-07-16 19:24:40.732413 INFO::Creating boxplot for categorical data, diagnosis vs F488
## 2024-07-16 19:24:40.904947 INFO::Creating boxplot for categorical data, diagnosis vs F309
## 2024-07-16 19:24:41.068479 INFO::Creating boxplot for categorical data, diagnosis vs F834
## 2024-07-16 19:24:41.235367 INFO::Creating boxplot for categorical data, diagnosis vs F449
## 2024-07-16 19:24:41.433686 INFO::Creating boxplot for categorical data, diagnosis vs F77
## 2024-07-16 19:24:41.62432 INFO::Creating boxplot for categorical data, diagnosis vs F365
## 2024-07-16 19:24:41.793384 INFO::Creating boxplot for categorical data, diagnosis vs F346
## 2024-07-16 19:24:41.976031 INFO::Creating boxplot for categorical data, diagnosis vs F654
## 2024-07-16 19:24:42.149158 INFO::Creating boxplot for categorical data, diagnosis vs F79
## 2024-07-16 19:24:42.31604 INFO::Creating boxplot for categorical data, diagnosis vs F785
## 2024-07-16 19:24:42.537802 INFO::Creating boxplot for categorical data, diagnosis vs F415
## 2024-07-16 19:24:42.81992 INFO::Creating boxplot for categorical data, diagnosis vs F466
## 2024-07-16 19:24:43.097484 INFO::Creating boxplot for categorical data, diagnosis vs F643
## 2024-07-16 19:24:43.363306 INFO::Creating boxplot for categorical data, diagnosis vs F160
## 2024-07-16 19:24:43.635713 INFO::Creating boxplot for categorical data, diagnosis vs F69
## 2024-07-16 19:24:43.81843 INFO::Creating boxplot for categorical data, diagnosis vs F498
## 2024-07-16 19:24:44.023437 INFO::Creating boxplot for categorical data, diagnosis vs F207
## 2024-07-16 19:24:44.30884 INFO::Creating boxplot for categorical data, diagnosis vs F679
## 2024-07-16 19:24:44.512989 INFO::Creating boxplot for categorical data, diagnosis vs F618
## 2024-07-16 19:24:44.756968 INFO::Creating boxplot for categorical data, diagnosis vs F255
## 2024-07-16 19:24:44.997652 INFO::Creating boxplot for categorical data, diagnosis vs F267
## 2024-07-16 19:24:45.253141 INFO::Creating boxplot for categorical data, diagnosis vs F143
## 2024-07-16 19:24:45.510155 INFO::Creating boxplot for categorical data, diagnosis vs F286
## 2024-07-16 19:24:45.743321 INFO::Creating boxplot for categorical data, diagnosis vs F562
## 2024-07-16 19:24:46.007911 INFO::Creating boxplot for categorical data, diagnosis vs F100
## 2024-07-16 19:24:46.224849 INFO::Creating boxplot for categorical data, diagnosis vs F374
## 2024-07-16 19:24:46.41191 INFO::Creating boxplot for categorical data, diagnosis vs F535
## 2024-07-16 19:24:46.691915 INFO::Creating boxplot for categorical data, diagnosis vs F658
## 2024-07-16 19:24:46.962566 INFO::Creating boxplot for categorical data, diagnosis vs F707
## 2024-07-16 19:24:47.153002 INFO::Creating boxplot for categorical data, diagnosis vs F325
## 2024-07-16 19:24:47.433941 INFO::Creating boxplot for categorical data, diagnosis vs F89
## 2024-07-16 19:24:47.679752 INFO::Creating boxplot for categorical data, diagnosis vs F214
## 2024-07-16 19:24:47.849676 INFO::Creating boxplot for categorical data, diagnosis vs F578
## 2024-07-16 19:24:48.038885 INFO::Creating boxplot for categorical data, diagnosis vs F790
## 2024-07-16 19:24:48.207284 INFO::Creating boxplot for categorical data, diagnosis vs F265
## 2024-07-16 19:24:48.399367 INFO::Creating boxplot for categorical data, diagnosis vs F253
## 2024-07-16 19:24:48.636889 INFO::Creating boxplot for categorical data, diagnosis vs F294
## 2024-07-16 19:24:48.855349 INFO::Creating boxplot for categorical data, diagnosis vs F410
## 2024-07-16 19:24:49.028367 INFO::Creating boxplot for categorical data, diagnosis vs F614
## 2024-07-16 19:24:49.218024 INFO::Creating boxplot for categorical data, diagnosis vs F764
## 2024-07-16 19:24:49.384149 INFO::Creating boxplot for categorical data, diagnosis vs F59
## 2024-07-16 19:24:49.551367 INFO::Creating boxplot for categorical data, diagnosis vs F675
## 2024-07-16 19:24:49.724736 INFO::Creating boxplot for categorical data, diagnosis vs F441
## 2024-07-16 19:24:49.92996 INFO::Creating boxplot for categorical data, diagnosis vs F193
## 2024-07-16 19:24:50.119927 INFO::Creating boxplot for categorical data, diagnosis vs F689
## 2024-07-16 19:24:50.30158 INFO::Creating boxplot for categorical data, diagnosis vs F249
## 2024-07-16 19:24:50.468211 INFO::Creating boxplot for categorical data, diagnosis vs F821
## 2024-07-16 19:24:50.667985 INFO::Creating boxplot for categorical data, diagnosis vs F351
## 2024-07-16 19:24:50.899123 INFO::Creating boxplot for categorical data, diagnosis vs F66
## 2024-07-16 19:24:51.10179 INFO::Creating boxplot for categorical data, diagnosis vs F413
## 2024-07-16 19:24:51.34766 INFO::Creating boxplot for categorical data, diagnosis vs F172
## 2024-07-16 19:24:51.590626 INFO::Creating boxplot for categorical data, diagnosis vs F317
## 2024-07-16 19:24:51.777503 INFO::Creating boxplot for categorical data, diagnosis vs F167
## 2024-07-16 19:24:52.029434 INFO::Creating boxplot for categorical data, diagnosis vs F229
## 2024-07-16 19:24:52.214645 INFO::Creating boxplot for categorical data, diagnosis vs F243
## 2024-07-16 19:24:52.476769 INFO::Creating boxplot for categorical data, diagnosis vs F732
## 2024-07-16 19:24:52.806957 INFO::Creating boxplot for categorical data, diagnosis vs F467
## 2024-07-16 19:24:53.089004 INFO::Creating boxplot for categorical data, diagnosis vs F474
## 2024-07-16 19:24:53.352473 INFO::Creating boxplot for categorical data, diagnosis vs F156
## 2024-07-16 19:24:53.536658 INFO::Creating boxplot for categorical data, diagnosis vs F786
## 2024-07-16 19:24:53.775193 INFO::Creating boxplot for categorical data, diagnosis vs F216
## 2024-07-16 19:24:54.006892 INFO::Creating boxplot for categorical data, diagnosis vs F85
## 2024-07-16 19:24:54.182351 INFO::Creating boxplot for categorical data, diagnosis vs F621
## 2024-07-16 19:24:54.349517 INFO::Creating boxplot for categorical data, diagnosis vs F558
## 2024-07-16 19:24:54.579781 INFO::Creating boxplot for categorical data, diagnosis vs F582
## 2024-07-16 19:24:54.850964 INFO::Creating boxplot for categorical data, diagnosis vs F898
## 2024-07-16 19:24:55.028346 INFO::Creating boxplot for categorical data, diagnosis vs F402
## 2024-07-16 19:24:55.229889 INFO::Creating boxplot for categorical data, diagnosis vs F71
## 2024-07-16 19:24:55.405144 INFO::Creating boxplot for categorical data, diagnosis vs F99
## 2024-07-16 19:24:55.575962 INFO::Creating boxplot for categorical data, diagnosis vs F366
## 2024-07-16 19:24:55.74319 INFO::Creating boxplot for categorical data, diagnosis vs F778
## 2024-07-16 19:24:55.937033 INFO::Creating boxplot for categorical data, diagnosis vs F188
## 2024-07-16 19:24:56.111936 INFO::Creating boxplot for categorical data, diagnosis vs F857
## 2024-07-16 19:24:56.306777 INFO::Creating boxplot for categorical data, diagnosis vs F440
## 2024-07-16 19:24:56.505904 INFO::Creating boxplot for categorical data, diagnosis vs F799
## 2024-07-16 19:24:56.70803 INFO::Creating boxplot for categorical data, diagnosis vs F482
## 2024-07-16 19:24:56.909097 INFO::Creating boxplot for categorical data, diagnosis vs F212
## 2024-07-16 19:24:57.130207 INFO::Creating boxplot for categorical data, diagnosis vs F882
## 2024-07-16 19:24:57.402386 INFO::Creating boxplot for categorical data, diagnosis vs F599
## 2024-07-16 19:24:57.610066 INFO::Creating boxplot for categorical data, diagnosis vs F302
## 2024-07-16 19:24:57.78584 INFO::Creating boxplot for categorical data, diagnosis vs F543
## 2024-07-16 19:24:57.9504 INFO::Creating boxplot for categorical data, diagnosis vs F269
## 2024-07-16 19:24:58.116582 INFO::Creating boxplot for categorical data, diagnosis vs F650
## 2024-07-16 19:24:58.281249 INFO::Creating boxplot for categorical data, diagnosis vs F456
## 2024-07-16 19:24:58.519978 INFO::Creating boxplot for categorical data, diagnosis vs F573
## 2024-07-16 19:24:58.697751 INFO::Creating boxplot for categorical data, diagnosis vs F8
## 2024-07-16 19:24:58.866475 INFO::Creating boxplot for categorical data, diagnosis vs F810
## 2024-07-16 19:24:59.032698 INFO::Creating boxplot for categorical data, diagnosis vs F401
## 2024-07-16 19:24:59.206982 INFO::Creating boxplot for categorical data, diagnosis vs F606
## 2024-07-16 19:24:59.39246 INFO::Creating boxplot for categorical data, diagnosis vs F662
## 2024-07-16 19:24:59.841237 INFO::Creating boxplot for categorical data, diagnosis vs F765
## 2024-07-16 19:25:00.116211 INFO::Creating boxplot for categorical data, diagnosis vs F887
## 2024-07-16 19:25:00.389863 INFO::Creating boxplot for categorical data, diagnosis vs F770
## 2024-07-16 19:25:00.621795 INFO::Creating boxplot for categorical data, diagnosis vs F469
## 2024-07-16 19:25:00.873491 INFO::Creating boxplot for categorical data, diagnosis vs F86
## 2024-07-16 19:25:01.134002 INFO::Creating boxplot for categorical data, diagnosis vs F400
## 2024-07-16 19:25:01.416446 INFO::Creating boxplot for categorical data, diagnosis vs F579
## 2024-07-16 19:25:01.617379 INFO::Creating boxplot for categorical data, diagnosis vs F871
## 2024-07-16 19:25:01.781325 INFO::Creating boxplot for categorical data, diagnosis vs F37
## 2024-07-16 19:25:01.946522 INFO::Creating boxplot for categorical data, diagnosis vs F446
## 2024-07-16 19:25:02.113729 INFO::Creating boxplot for categorical data, diagnosis vs F218
## 2024-07-16 19:25:02.311331 INFO::Creating boxplot for categorical data, diagnosis vs F321
## 2024-07-16 19:25:02.561011 INFO::Creating boxplot for categorical data, diagnosis vs F487
## 2024-07-16 19:25:02.801981 INFO::Creating boxplot for categorical data, diagnosis vs F740
## 2024-07-16 19:25:03.00328 INFO::Creating boxplot for categorical data, diagnosis vs F141
## 2024-07-16 19:25:03.226335 INFO::Creating boxplot for categorical data, diagnosis vs F327
## 2024-07-16 19:25:03.444228 INFO::Creating boxplot for categorical data, diagnosis vs F196
## 2024-07-16 19:25:03.671868 INFO::Creating boxplot for categorical data, diagnosis vs F883
## 2024-07-16 19:25:03.85527 INFO::Creating boxplot for categorical data, diagnosis vs F279
## 2024-07-16 19:25:04.034084 INFO::Creating boxplot for categorical data, diagnosis vs F838
## 2024-07-16 19:25:04.249926 INFO::Creating boxplot for categorical data, diagnosis vs F451
## 2024-07-16 19:25:04.526636 INFO::Creating boxplot for categorical data, diagnosis vs F854
## 2024-07-16 19:25:04.751288 INFO::Creating boxplot for categorical data, diagnosis vs F434
## 2024-07-16 19:25:05.04944 INFO::Creating boxplot for categorical data, diagnosis vs F519
## 2024-07-16 19:25:05.231522 INFO::Creating boxplot for categorical data, diagnosis vs F694
## 2024-07-16 19:25:05.430033 INFO::Creating boxplot for categorical data, diagnosis vs F561
## 2024-07-16 19:25:05.617459 INFO::Creating boxplot for categorical data, diagnosis vs F10
## 2024-07-16 19:25:05.797374 INFO::Creating boxplot for categorical data, diagnosis vs F303
## 2024-07-16 19:25:06.010992 INFO::Creating boxplot for categorical data, diagnosis vs F512
## 2024-07-16 19:25:06.226723 INFO::Creating boxplot for categorical data, diagnosis vs F645
## 2024-07-16 19:25:06.461157 INFO::Creating boxplot for categorical data, diagnosis vs F793
## 2024-07-16 19:25:06.634635 INFO::Creating boxplot for categorical data, diagnosis vs F404
## 2024-07-16 19:25:06.80555 INFO::Creating boxplot for categorical data, diagnosis vs F362
## 2024-07-16 19:25:06.977998 INFO::Creating boxplot for categorical data, diagnosis vs F525
## 2024-07-16 19:25:07.179995 INFO::Creating boxplot for categorical data, diagnosis vs F742
## 2024-07-16 19:25:07.354628 INFO::Creating boxplot for categorical data, diagnosis vs F276
## 2024-07-16 19:25:07.530243 INFO::Creating boxplot for categorical data, diagnosis vs F499
## 2024-07-16 19:25:07.733693 INFO::Creating boxplot for categorical data, diagnosis vs F328
## 2024-07-16 19:25:07.920422 INFO::Creating boxplot for categorical data, diagnosis vs F787
## 2024-07-16 19:25:08.150471 INFO::Creating boxplot for categorical data, diagnosis vs F30
## 2024-07-16 19:25:08.347283 INFO::Creating boxplot for categorical data, diagnosis vs F122
## 2024-07-16 19:25:08.560448 INFO::Creating boxplot for categorical data, diagnosis vs F619
## 2024-07-16 19:25:08.804727 INFO::Creating boxplot for categorical data, diagnosis vs F572
## 2024-07-16 19:25:09.07984 INFO::Creating boxplot for categorical data, diagnosis vs F47
## 2024-07-16 19:25:09.347594 INFO::Creating boxplot for categorical data, diagnosis vs F570
## 2024-07-16 19:25:09.550732 INFO::Creating boxplot for categorical data, diagnosis vs F26
## 2024-07-16 19:25:09.775789 INFO::Creating boxplot for categorical data, diagnosis vs F252
## 2024-07-16 19:25:10.006922 INFO::Creating boxplot for categorical data, diagnosis vs F117
## 2024-07-16 19:25:10.259397 INFO::Creating boxplot for categorical data, diagnosis vs F683
## 2024-07-16 19:25:10.505243 INFO::Creating boxplot for categorical data, diagnosis vs F395
## 2024-07-16 19:25:10.73387 INFO::Creating boxplot for categorical data, diagnosis vs F822
## 2024-07-16 19:25:11.005811 INFO::Creating boxplot for categorical data, diagnosis vs F46
## 2024-07-16 19:25:11.228123 INFO::Creating boxplot for categorical data, diagnosis vs F154
## 2024-07-16 19:25:11.507783 INFO::Creating boxplot for categorical data, diagnosis vs F540
## 2024-07-16 19:25:11.774297 INFO::Creating boxplot for categorical data, diagnosis vs F884
## 2024-07-16 19:25:12.020422 INFO::Creating boxplot for categorical data, diagnosis vs F368
## 2024-07-16 19:25:12.307525 INFO::Creating boxplot for categorical data, diagnosis vs F607
## 2024-07-16 19:25:12.588833 INFO::Creating boxplot for categorical data, diagnosis vs F111
## 2024-07-16 19:25:12.820007 INFO::Creating boxplot for categorical data, diagnosis vs F745
## 2024-07-16 19:25:13.040345 INFO::Creating boxplot for categorical data, diagnosis vs F673
## 2024-07-16 19:25:13.306993 INFO::Creating boxplot for categorical data, diagnosis vs F92
## 2024-07-16 19:25:13.541924 INFO::Creating boxplot for categorical data, diagnosis vs F493
## 2024-07-16 19:25:13.818097 INFO::Creating boxplot for categorical data, diagnosis vs F835
## 2024-07-16 19:25:14.080594 INFO::Creating boxplot for categorical data, diagnosis vs F872
## 2024-07-16 19:25:14.296405 INFO::Creating boxplot for categorical data, diagnosis vs F879
## 2024-07-16 19:25:14.564063 INFO::Creating boxplot for categorical data, diagnosis vs F432
## 2024-07-16 19:25:14.813969 INFO::Creating boxplot for categorical data, diagnosis vs F518
## 2024-07-16 19:25:15.079093 INFO::Creating boxplot for categorical data, diagnosis vs F44
## 2024-07-16 19:25:15.316732 INFO::Creating boxplot for categorical data, diagnosis vs F240
## 2024-07-16 19:25:15.565468 INFO::Creating boxplot for categorical data, diagnosis vs F819
## 2024-07-16 19:25:15.73628 INFO::Creating boxplot for categorical data, diagnosis vs F411
## 2024-07-16 19:25:15.937677 INFO::Creating boxplot for categorical data, diagnosis vs F353
## 2024-07-16 19:25:16.188447 INFO::Creating boxplot for categorical data, diagnosis vs F763
## 2024-07-16 19:25:16.467425 INFO::Creating boxplot for categorical data, diagnosis vs F97
## 2024-07-16 19:25:16.640975 INFO::Creating boxplot for categorical data, diagnosis vs F40
## 2024-07-16 19:25:16.838098 INFO::Creating boxplot for categorical data, diagnosis vs F652
## 2024-07-16 19:25:17.02697 INFO::Creating boxplot for categorical data, diagnosis vs F789
## 2024-07-16 19:25:17.227662 INFO::Creating boxplot for categorical data, diagnosis vs F25
## 2024-07-16 19:25:17.574002 INFO::Creating boxplot for categorical data, diagnosis vs F256
## 2024-07-16 19:25:17.838041 INFO::Creating boxplot for categorical data, diagnosis vs F423
## 2024-07-16 19:25:18.025028 INFO::Creating boxplot for categorical data, diagnosis vs F594
## 2024-07-16 19:25:18.235834 INFO::Creating boxplot for categorical data, diagnosis vs F201
## 2024-07-16 19:25:18.474464 INFO::Creating boxplot for categorical data, diagnosis vs F813
## 2024-07-16 19:25:18.648738 INFO::Creating boxplot for categorical data, diagnosis vs F653
## 2024-07-16 19:25:18.937963 INFO::Creating boxplot for categorical data, diagnosis vs F524
## 2024-07-16 19:25:19.20067 INFO::Creating boxplot for categorical data, diagnosis vs F777
## 2024-07-16 19:25:19.437991 INFO::Creating boxplot for categorical data, diagnosis vs F226
## 2024-07-16 19:25:19.738386 INFO::Creating boxplot for categorical data, diagnosis vs F227
## 2024-07-16 19:25:20.026448 INFO::Creating boxplot for categorical data, diagnosis vs F521
## 2024-07-16 19:25:20.300215 INFO::Creating boxplot for categorical data, diagnosis vs F14
## 2024-07-16 19:25:20.596274 INFO::Creating boxplot for categorical data, diagnosis vs F310
## 2024-07-16 19:25:20.790869 INFO::Creating boxplot for categorical data, diagnosis vs F452
## 2024-07-16 19:25:20.997609 INFO::Creating boxplot for categorical data, diagnosis vs F52
## 2024-07-16 19:25:21.222755 INFO::Creating boxplot for categorical data, diagnosis vs F53
## 2024-07-16 19:25:21.444071 INFO::Creating boxplot for categorical data, diagnosis vs F844
## 2024-07-16 19:25:21.752817 INFO::Creating boxplot for categorical data, diagnosis vs F31
## 2024-07-16 19:25:22.02304 INFO::Creating boxplot for categorical data, diagnosis vs F795
## 2024-07-16 19:25:22.295619 INFO::Creating boxplot for categorical data, diagnosis vs F766
## 2024-07-16 19:25:22.57685 INFO::Creating boxplot for categorical data, diagnosis vs F342
## 2024-07-16 19:25:22.845528 INFO::Creating boxplot for categorical data, diagnosis vs F408
## 2024-07-16 19:25:23.030262 INFO::Creating boxplot for categorical data, diagnosis vs F282
## 2024-07-16 19:25:23.235277 INFO::Creating boxplot for categorical data, diagnosis vs F508
## 2024-07-16 19:25:23.495232 INFO::Creating boxplot for categorical data, diagnosis vs F805
## 2024-07-16 19:25:23.707248 INFO::Creating boxplot for categorical data, diagnosis vs F337
## 2024-07-16 19:25:23.895565 INFO::Creating boxplot for categorical data, diagnosis vs F820
## 2024-07-16 19:25:24.077043 INFO::Creating boxplot for categorical data, diagnosis vs F593
## 2024-07-16 19:25:24.254017 INFO::Creating boxplot for categorical data, diagnosis vs F701
## 2024-07-16 19:25:24.501149 INFO::Creating boxplot for categorical data, diagnosis vs F459
## 2024-07-16 19:25:24.774358 INFO::Creating boxplot for categorical data, diagnosis vs F305
## 2024-07-16 19:25:25.009545 INFO::Creating boxplot for categorical data, diagnosis vs F142
## 2024-07-16 19:25:25.181336 INFO::Creating boxplot for categorical data, diagnosis vs F534
## 2024-07-16 19:25:25.348315 INFO::Creating boxplot for categorical data, diagnosis vs F135
## 2024-07-16 19:25:25.56131 INFO::Creating boxplot for categorical data, diagnosis vs F702
## 2024-07-16 19:25:25.744141 INFO::Creating boxplot for categorical data, diagnosis vs F776
## 2024-07-16 19:25:25.954622 INFO::Creating boxplot for categorical data, diagnosis vs F295
## 2024-07-16 19:25:26.130151 INFO::Creating boxplot for categorical data, diagnosis vs F355
## 2024-07-16 19:25:26.341423 INFO::Creating boxplot for categorical data, diagnosis vs F797
## 2024-07-16 19:25:26.518228 INFO::Creating boxplot for categorical data, diagnosis vs F13
## 2024-07-16 19:25:26.726741 INFO::Creating boxplot for categorical data, diagnosis vs F356
## 2024-07-16 19:25:26.970054 INFO::Creating boxplot for categorical data, diagnosis vs F359
## 2024-07-16 19:25:27.145031 INFO::Creating boxplot for categorical data, diagnosis vs F121
## 2024-07-16 19:25:27.364179 INFO::Creating boxplot for categorical data, diagnosis vs F850
## 2024-07-16 19:25:27.633182 INFO::Creating boxplot for categorical data, diagnosis vs F899
## 2024-07-16 19:25:27.898068 INFO::Creating boxplot for categorical data, diagnosis vs F628
## 2024-07-16 19:25:28.119814 INFO::Creating boxplot for categorical data, diagnosis vs F843
## 2024-07-16 19:25:28.343843 INFO::Creating boxplot for categorical data, diagnosis vs F107
## 2024-07-16 19:25:28.647034 INFO::Creating boxplot for categorical data, diagnosis vs F287
## 2024-07-16 19:25:28.929642 INFO::Creating boxplot for categorical data, diagnosis vs F165
## 2024-07-16 19:25:29.242124 INFO::Creating boxplot for categorical data, diagnosis vs F557
## 2024-07-16 19:25:29.587681 INFO::Creating boxplot for categorical data, diagnosis vs F127
## 2024-07-16 19:25:29.907187 INFO::Creating boxplot for categorical data, diagnosis vs F299
## 2024-07-16 19:25:30.17202 INFO::Creating boxplot for categorical data, diagnosis vs F497
## 2024-07-16 19:25:30.429514 INFO::Creating boxplot for categorical data, diagnosis vs F711
## 2024-07-16 19:25:30.666115 INFO::Creating boxplot for categorical data, diagnosis vs F319
## 2024-07-16 19:25:30.914977 INFO::Creating boxplot for categorical data, diagnosis vs F271
## 2024-07-16 19:25:31.164983 INFO::Creating boxplot for categorical data, diagnosis vs F157
## 2024-07-16 19:25:31.380809 INFO::Creating boxplot for categorical data, diagnosis vs F560
## 2024-07-16 19:25:31.638622 INFO::Creating boxplot for categorical data, diagnosis vs F680
## 2024-07-16 19:25:31.925083 INFO::Creating boxplot for categorical data, diagnosis vs F580
## 2024-07-16 19:25:32.128779 INFO::Creating boxplot for categorical data, diagnosis vs F152
## 2024-07-16 19:25:32.411687 INFO::Creating boxplot for categorical data, diagnosis vs F12
## 2024-07-16 19:25:32.606592 INFO::Creating boxplot for categorical data, diagnosis vs F324
## 2024-07-16 19:25:32.847364 INFO::Creating boxplot for categorical data, diagnosis vs F893
## 2024-07-16 19:25:33.145308 INFO::Creating boxplot for categorical data, diagnosis vs F318
## 2024-07-16 19:25:33.457815 INFO::Creating boxplot for categorical data, diagnosis vs F784
## 2024-07-16 19:25:33.709951 INFO::Creating boxplot for categorical data, diagnosis vs F567
## 2024-07-16 19:25:33.988934 INFO::Creating boxplot for categorical data, diagnosis vs F457
## 2024-07-16 19:25:34.270447 INFO::Creating boxplot for categorical data, diagnosis vs F708
## 2024-07-16 19:25:34.459444 INFO::Creating boxplot for categorical data, diagnosis vs F669
## 2024-07-16 19:25:34.657686 INFO::Creating boxplot for categorical data, diagnosis vs F87
## 2024-07-16 19:25:37.428564 INFO::Plotting data for metadata number 2, antibiotics
## 2024-07-16 19:25:37.433223 INFO::Creating boxplot for categorical data, antibiotics vs F663
## 2024-07-16 19:25:37.696145 INFO::Creating boxplot for categorical data, antibiotics vs F838
## 2024-07-16 19:25:38.005587 INFO::Creating boxplot for categorical data, antibiotics vs F764
## 2024-07-16 19:25:38.268507 INFO::Creating boxplot for categorical data, antibiotics vs F880
## 2024-07-16 19:25:38.614292 INFO::Creating boxplot for categorical data, antibiotics vs F751
## 2024-07-16 19:25:38.850216 INFO::Creating boxplot for categorical data, antibiotics vs F288
## 2024-07-16 19:25:39.032933 INFO::Creating boxplot for categorical data, antibiotics vs F65
## 2024-07-16 19:25:39.218656 INFO::Creating boxplot for categorical data, antibiotics vs F742
## 2024-07-16 19:25:39.462721 INFO::Creating boxplot for categorical data, antibiotics vs F528
## 2024-07-16 19:25:39.720012 INFO::Creating boxplot for categorical data, antibiotics vs F790
## 2024-07-16 19:25:40.062258 INFO::Creating boxplot for categorical data, antibiotics vs F777
## 2024-07-16 19:25:40.347528 INFO::Creating boxplot for categorical data, antibiotics vs F178
## 2024-07-16 19:25:40.571621 INFO::Creating boxplot for categorical data, antibiotics vs F139
## 2024-07-16 19:25:40.793437 INFO::Creating boxplot for categorical data, antibiotics vs F202
## 2024-07-16 19:25:41.120787 INFO::Creating boxplot for categorical data, antibiotics vs F220
## 2024-07-16 19:25:41.323036 INFO::Creating boxplot for categorical data, antibiotics vs F397
## 2024-07-16 19:25:41.61514 INFO::Creating boxplot for categorical data, antibiotics vs F882
## 2024-07-16 19:25:41.83714 INFO::Creating boxplot for categorical data, antibiotics vs F446
## 2024-07-16 19:25:42.109486 INFO::Creating boxplot for categorical data, antibiotics vs F418
## 2024-07-16 19:25:42.435795 INFO::Creating boxplot for categorical data, antibiotics vs F133
## 2024-07-16 19:25:42.692645 INFO::Creating boxplot for categorical data, antibiotics vs F696
## 2024-07-16 19:25:42.94797 INFO::Creating boxplot for categorical data, antibiotics vs F548
## 2024-07-16 19:25:43.261717 INFO::Creating boxplot for categorical data, antibiotics vs F536
## 2024-07-16 19:25:43.567473 INFO::Creating boxplot for categorical data, antibiotics vs F194
## 2024-07-16 19:25:43.890074 INFO::Creating boxplot for categorical data, antibiotics vs F34
## 2024-07-16 19:25:44.158489 INFO::Creating boxplot for categorical data, antibiotics vs F153
## 2024-07-16 19:25:44.443649 INFO::Creating boxplot for categorical data, antibiotics vs F400
## 2024-07-16 19:25:44.701632 INFO::Creating boxplot for categorical data, antibiotics vs F794
## 2024-07-16 19:25:45.000503 INFO::Creating boxplot for categorical data, antibiotics vs F396
## 2024-07-16 19:25:45.322289 INFO::Creating boxplot for categorical data, antibiotics vs F182
## 2024-07-16 19:25:45.678384 INFO::Creating boxplot for categorical data, antibiotics vs F719
## 2024-07-16 19:25:45.897068 INFO::Creating boxplot for categorical data, antibiotics vs F109
## 2024-07-16 19:25:46.098725 INFO::Creating boxplot for categorical data, antibiotics vs F180
## 2024-07-16 19:25:46.304028 INFO::Creating boxplot for categorical data, antibiotics vs F552
## 2024-07-16 19:25:46.542634 INFO::Creating boxplot for categorical data, antibiotics vs F789
## 2024-07-16 19:25:46.843629 INFO::Creating boxplot for categorical data, antibiotics vs F893
## 2024-07-16 19:25:47.049335 INFO::Creating boxplot for categorical data, antibiotics vs F834
## 2024-07-16 19:25:47.369867 INFO::Creating boxplot for categorical data, antibiotics vs F889
## 2024-07-16 19:25:47.62829 INFO::Creating boxplot for categorical data, antibiotics vs F143
## 2024-07-16 19:25:47.898702 INFO::Creating boxplot for categorical data, antibiotics vs F224
## 2024-07-16 19:25:48.220301 INFO::Creating boxplot for categorical data, antibiotics vs F5
## 2024-07-16 19:25:48.529573 INFO::Creating boxplot for categorical data, antibiotics vs F873
## 2024-07-16 19:25:48.803617 INFO::Creating boxplot for categorical data, antibiotics vs F452
## 2024-07-16 19:25:49.08284 INFO::Creating boxplot for categorical data, antibiotics vs F681
## 2024-07-16 19:25:49.387867 INFO::Creating boxplot for categorical data, antibiotics vs F468
## 2024-07-16 19:25:49.619722 INFO::Creating boxplot for categorical data, antibiotics vs F731
## 2024-07-16 19:25:49.828295 INFO::Creating boxplot for categorical data, antibiotics vs F479
## 2024-07-16 19:25:50.042769 INFO::Creating boxplot for categorical data, antibiotics vs F520
## 2024-07-16 19:25:50.306408 INFO::Creating boxplot for categorical data, antibiotics vs F649
## 2024-07-16 19:25:50.605294 INFO::Creating boxplot for categorical data, antibiotics vs F259
## 2024-07-16 19:25:50.804049 INFO::Creating boxplot for categorical data, antibiotics vs F186
## 2024-07-16 19:25:51.147338 INFO::Creating boxplot for categorical data, antibiotics vs F312
## 2024-07-16 19:25:51.446614 INFO::Creating boxplot for categorical data, antibiotics vs F477
## 2024-07-16 19:25:51.738528 INFO::Creating boxplot for categorical data, antibiotics vs F4
## 2024-07-16 19:25:52.010046 INFO::Creating boxplot for categorical data, antibiotics vs F632
## 2024-07-16 19:25:52.33625 INFO::Creating boxplot for categorical data, antibiotics vs F31
## 2024-07-16 19:25:52.681455 INFO::Creating boxplot for categorical data, antibiotics vs F184
## 2024-07-16 19:25:52.979991 INFO::Creating boxplot for categorical data, antibiotics vs F7
## 2024-07-16 19:25:53.2858 INFO::Creating boxplot for categorical data, antibiotics vs F213
## 2024-07-16 19:25:53.584218 INFO::Creating boxplot for categorical data, antibiotics vs F691
## 2024-07-16 19:25:53.858128 INFO::Creating boxplot for categorical data, antibiotics vs F828
## 2024-07-16 19:25:54.178254 INFO::Creating boxplot for categorical data, antibiotics vs F831
## 2024-07-16 19:25:54.462219 INFO::Creating boxplot for categorical data, antibiotics vs F315
## 2024-07-16 19:25:54.696001 INFO::Creating boxplot for categorical data, antibiotics vs F159
## 2024-07-16 19:25:54.917203 INFO::Creating boxplot for categorical data, antibiotics vs F331
## 2024-07-16 19:25:55.103705 INFO::Creating boxplot for categorical data, antibiotics vs F757
## 2024-07-16 19:25:55.352945 INFO::Creating boxplot for categorical data, antibiotics vs F167
## 2024-07-16 19:25:55.563528 INFO::Creating boxplot for categorical data, antibiotics vs F85
## 2024-07-16 19:25:55.779697 INFO::Creating boxplot for categorical data, antibiotics vs F80
## 2024-07-16 19:25:56.010088 INFO::Creating boxplot for categorical data, antibiotics vs F105
## 2024-07-16 19:25:56.231239 INFO::Creating boxplot for categorical data, antibiotics vs F674
## 2024-07-16 19:25:56.498925 INFO::Creating boxplot for categorical data, antibiotics vs F50
## 2024-07-16 19:25:56.850882 INFO::Creating boxplot for categorical data, antibiotics vs F164
## 2024-07-16 19:25:57.15177 INFO::Creating boxplot for categorical data, antibiotics vs F840
## 2024-07-16 19:25:57.365853 INFO::Creating boxplot for categorical data, antibiotics vs F232
## 2024-07-16 19:25:57.676942 INFO::Creating boxplot for categorical data, antibiotics vs F872
## 2024-07-16 19:25:57.965036 INFO::Creating boxplot for categorical data, antibiotics vs F54
## 2024-07-16 19:25:58.312145 INFO::Creating boxplot for categorical data, antibiotics vs F365
## 2024-07-16 19:25:58.538663 INFO::Creating boxplot for categorical data, antibiotics vs F499
## 2024-07-16 19:25:58.778606 INFO::Creating boxplot for categorical data, antibiotics vs F510
## 2024-07-16 19:25:59.062081 INFO::Creating boxplot for categorical data, antibiotics vs F716
## 2024-07-16 19:25:59.332806 INFO::Creating boxplot for categorical data, antibiotics vs F454
## 2024-07-16 19:25:59.630239 INFO::Creating boxplot for categorical data, antibiotics vs F52
## 2024-07-16 19:25:59.854385 INFO::Creating boxplot for categorical data, antibiotics vs F273
## 2024-07-16 19:26:00.118766 INFO::Creating boxplot for categorical data, antibiotics vs F474
## 2024-07-16 19:26:00.329733 INFO::Creating boxplot for categorical data, antibiotics vs F267
## 2024-07-16 19:26:00.616689 INFO::Creating boxplot for categorical data, antibiotics vs F253
## 2024-07-16 19:26:00.955578 INFO::Creating boxplot for categorical data, antibiotics vs F247
## 2024-07-16 19:26:01.256813 INFO::Creating boxplot for categorical data, antibiotics vs F708
## 2024-07-16 19:26:01.496747 INFO::Creating boxplot for categorical data, antibiotics vs F438
## 2024-07-16 19:26:01.767675 INFO::Creating boxplot for categorical data, antibiotics vs F450
## 2024-07-16 19:26:02.009156 INFO::Creating boxplot for categorical data, antibiotics vs F666
## 2024-07-16 19:26:02.288799 INFO::Creating boxplot for categorical data, antibiotics vs F720
## 2024-07-16 19:26:02.601288 INFO::Creating boxplot for categorical data, antibiotics vs F48
## 2024-07-16 19:26:02.909378 INFO::Creating boxplot for categorical data, antibiotics vs F371
## 2024-07-16 19:26:03.217547 INFO::Creating boxplot for categorical data, antibiotics vs F423
## 2024-07-16 19:26:03.496376 INFO::Creating boxplot for categorical data, antibiotics vs F190
## 2024-07-16 19:26:03.779454 INFO::Creating boxplot for categorical data, antibiotics vs F351
## 2024-07-16 19:26:04.110115 INFO::Creating boxplot for categorical data, antibiotics vs F394
## 2024-07-16 19:26:04.429489 INFO::Creating boxplot for categorical data, antibiotics vs F581
## 2024-07-16 19:26:04.730315 INFO::Creating boxplot for categorical data, antibiotics vs F276
## 2024-07-16 19:26:04.943064 INFO::Creating boxplot for categorical data, antibiotics vs F608
## 2024-07-16 19:26:05.125663 INFO::Creating boxplot for categorical data, antibiotics vs F28
## 2024-07-16 19:26:05.346511 INFO::Creating boxplot for categorical data, antibiotics vs F805
## 2024-07-16 19:26:05.634466 INFO::Creating boxplot for categorical data, antibiotics vs F249
## 2024-07-16 19:26:05.917609 INFO::Creating boxplot for categorical data, antibiotics vs F776
## 2024-07-16 19:26:06.1515 INFO::Creating boxplot for categorical data, antibiotics vs F755
## 2024-07-16 19:26:06.446627 INFO::Creating boxplot for categorical data, antibiotics vs F68
## 2024-07-16 19:26:06.777625 INFO::Creating boxplot for categorical data, antibiotics vs F78
## 2024-07-16 19:26:07.036377 INFO::Creating boxplot for categorical data, antibiotics vs F381
## 2024-07-16 19:26:07.494819 INFO::Creating boxplot for categorical data, antibiotics vs F644
## 2024-07-16 19:26:07.817479 INFO::Creating boxplot for categorical data, antibiotics vs F358
## 2024-07-16 19:26:08.13537 INFO::Creating boxplot for categorical data, antibiotics vs F344
## 2024-07-16 19:26:08.490577 INFO::Creating boxplot for categorical data, antibiotics vs F209
## 2024-07-16 19:26:08.811899 INFO::Creating boxplot for categorical data, antibiotics vs F898
## 2024-07-16 19:26:09.129456 INFO::Creating boxplot for categorical data, antibiotics vs F51
## 2024-07-16 19:26:09.455843 INFO::Creating boxplot for categorical data, antibiotics vs F149
## 2024-07-16 19:26:09.894323 INFO::Creating boxplot for categorical data, antibiotics vs F108
## 2024-07-16 19:26:10.199238 INFO::Creating boxplot for categorical data, antibiotics vs F255
## 2024-07-16 19:26:10.51643 INFO::Creating boxplot for categorical data, antibiotics vs F823
## 2024-07-16 19:26:10.783305 INFO::Creating boxplot for categorical data, antibiotics vs F864
## 2024-07-16 19:26:11.063096 INFO::Creating boxplot for categorical data, antibiotics vs F214
## 2024-07-16 19:26:11.358687 INFO::Creating boxplot for categorical data, antibiotics vs F76
## 2024-07-16 19:26:11.646659 INFO::Creating boxplot for categorical data, antibiotics vs F575
## 2024-07-16 19:26:11.968645 INFO::Creating boxplot for categorical data, antibiotics vs F13
## 2024-07-16 19:26:12.281196 INFO::Creating boxplot for categorical data, antibiotics vs F389
## 2024-07-16 19:26:12.550569 INFO::Creating boxplot for categorical data, antibiotics vs F556
## 2024-07-16 19:26:12.853557 INFO::Creating boxplot for categorical data, antibiotics vs F49
## 2024-07-16 19:26:13.164674 INFO::Creating boxplot for categorical data, antibiotics vs F436
## 2024-07-16 19:26:13.452049 INFO::Creating boxplot for categorical data, antibiotics vs F378
## 2024-07-16 19:26:13.67395 INFO::Creating boxplot for categorical data, antibiotics vs F682
## 2024-07-16 19:26:13.902263 INFO::Creating boxplot for categorical data, antibiotics vs F47
## 2024-07-16 19:26:14.094989 INFO::Creating boxplot for categorical data, antibiotics vs F429
## 2024-07-16 19:26:14.358389 INFO::Creating boxplot for categorical data, antibiotics vs F588
## 2024-07-16 19:26:14.637897 INFO::Creating boxplot for categorical data, antibiotics vs F616
## 2024-07-16 19:26:14.834444 INFO::Creating boxplot for categorical data, antibiotics vs F323
## 2024-07-16 19:26:15.02701 INFO::Creating boxplot for categorical data, antibiotics vs F409
## 2024-07-16 19:26:15.215027 INFO::Creating boxplot for categorical data, antibiotics vs F326
## 2024-07-16 19:26:15.525453 INFO::Creating boxplot for categorical data, antibiotics vs F698
## 2024-07-16 19:26:15.773482 INFO::Creating boxplot for categorical data, antibiotics vs F567
## 2024-07-16 19:26:15.994792 INFO::Creating boxplot for categorical data, antibiotics vs F179
## 2024-07-16 19:26:16.187392 INFO::Creating boxplot for categorical data, antibiotics vs F787
## 2024-07-16 19:26:16.371193 INFO::Creating boxplot for categorical data, antibiotics vs F79
## 2024-07-16 19:26:16.577833 INFO::Creating boxplot for categorical data, antibiotics vs F335
## 2024-07-16 19:26:16.907095 INFO::Creating boxplot for categorical data, antibiotics vs F576
## 2024-07-16 19:26:17.103022 INFO::Creating boxplot for categorical data, antibiotics vs F667
## 2024-07-16 19:26:17.303129 INFO::Creating boxplot for categorical data, antibiotics vs F694
## 2024-07-16 19:26:17.512016 INFO::Creating boxplot for categorical data, antibiotics vs F297
## 2024-07-16 19:26:17.740709 INFO::Creating boxplot for categorical data, antibiotics vs F569
## 2024-07-16 19:26:18.028601 INFO::Creating boxplot for categorical data, antibiotics vs F138
## 2024-07-16 19:26:18.286863 INFO::Creating boxplot for categorical data, antibiotics vs F611
## 2024-07-16 19:26:18.54766 INFO::Creating boxplot for categorical data, antibiotics vs F810
## 2024-07-16 19:26:18.817804 INFO::Creating boxplot for categorical data, antibiotics vs F746
## 2024-07-16 19:26:19.069841 INFO::Creating boxplot for categorical data, antibiotics vs F23
## 2024-07-16 19:26:19.324683 INFO::Creating boxplot for categorical data, antibiotics vs F135
## 2024-07-16 19:26:19.54738 INFO::Creating boxplot for categorical data, antibiotics vs F411
## 2024-07-16 19:26:19.758246 INFO::Creating boxplot for categorical data, antibiotics vs F489
## 2024-07-16 19:26:19.999466 INFO::Creating boxplot for categorical data, antibiotics vs F492
## 2024-07-16 19:26:20.18952 INFO::Creating boxplot for categorical data, antibiotics vs F844
## 2024-07-16 19:26:20.489376 INFO::Creating boxplot for categorical data, antibiotics vs F586
## 2024-07-16 19:26:20.695862 INFO::Creating boxplot for categorical data, antibiotics vs F11
## 2024-07-16 19:26:21.052157 INFO::Creating boxplot for categorical data, antibiotics vs F900
## 2024-07-16 19:26:21.273885 INFO::Creating boxplot for categorical data, antibiotics vs F21
## 2024-07-16 19:26:21.574638 INFO::Creating boxplot for categorical data, antibiotics vs F736
## 2024-07-16 19:26:21.801704 INFO::Creating boxplot for categorical data, antibiotics vs F408
## 2024-07-16 19:26:22.122509 INFO::Creating boxplot for categorical data, antibiotics vs F788
## 2024-07-16 19:26:22.407592 INFO::Creating boxplot for categorical data, antibiotics vs F66
## 2024-07-16 19:26:22.619677 INFO::Creating boxplot for categorical data, antibiotics vs F493
## 2024-07-16 19:26:22.841015 INFO::Creating boxplot for categorical data, antibiotics vs F343
## 2024-07-16 19:26:23.136436 INFO::Creating boxplot for categorical data, antibiotics vs F352
## 2024-07-16 19:26:23.468475 INFO::Creating boxplot for categorical data, antibiotics vs F677
## 2024-07-16 19:26:23.672259 INFO::Creating boxplot for categorical data, antibiotics vs F816
## 2024-07-16 19:26:23.862355 INFO::Creating boxplot for categorical data, antibiotics vs F457
## 2024-07-16 19:26:24.046354 INFO::Creating boxplot for categorical data, antibiotics vs F330
## 2024-07-16 19:26:24.232701 INFO::Creating boxplot for categorical data, antibiotics vs F293
## 2024-07-16 19:26:24.496264 INFO::Creating boxplot for categorical data, antibiotics vs F725
## 2024-07-16 19:26:24.752654 INFO::Creating boxplot for categorical data, antibiotics vs F813
## 2024-07-16 19:26:24.947164 INFO::Creating boxplot for categorical data, antibiotics vs F295
## 2024-07-16 19:26:25.20084 INFO::Creating boxplot for categorical data, antibiotics vs F656
## 2024-07-16 19:26:25.397135 INFO::Creating boxplot for categorical data, antibiotics vs F669
## 2024-07-16 19:26:25.726295 INFO::Creating boxplot for categorical data, antibiotics vs F15
## 2024-07-16 19:26:26.050567 INFO::Creating boxplot for categorical data, antibiotics vs F419
## 2024-07-16 19:26:26.312923 INFO::Creating boxplot for categorical data, antibiotics vs F701
## 2024-07-16 19:26:26.567004 INFO::Creating boxplot for categorical data, antibiotics vs F176
## 2024-07-16 19:26:26.837132 INFO::Creating boxplot for categorical data, antibiotics vs F203
## 2024-07-16 19:26:27.149442 INFO::Creating boxplot for categorical data, antibiotics vs F501
## 2024-07-16 19:26:27.479543 INFO::Creating boxplot for categorical data, antibiotics vs F772
## 2024-07-16 19:26:27.736148 INFO::Creating boxplot for categorical data, antibiotics vs F488
## 2024-07-16 19:26:27.961156 INFO::Creating boxplot for categorical data, antibiotics vs F600
## 2024-07-16 19:26:28.260568 INFO::Creating boxplot for categorical data, antibiotics vs F768
## 2024-07-16 19:26:28.566673 INFO::Creating boxplot for categorical data, antibiotics vs F432
## 2024-07-16 19:26:28.860147 INFO::Creating boxplot for categorical data, antibiotics vs F26
## 2024-07-16 19:26:29.048601 INFO::Creating boxplot for categorical data, antibiotics vs F189
## 2024-07-16 19:26:29.296652 INFO::Creating boxplot for categorical data, antibiotics vs F200
## 2024-07-16 19:26:29.504755 INFO::Creating boxplot for categorical data, antibiotics vs F121
## 2024-07-16 19:26:29.697844 INFO::Creating boxplot for categorical data, antibiotics vs F624
## 2024-07-16 19:26:29.932554 INFO::Creating boxplot for categorical data, antibiotics vs F855
## 2024-07-16 19:26:30.263106 INFO::Creating boxplot for categorical data, antibiotics vs F380
## 2024-07-16 19:26:30.528323 INFO::Creating boxplot for categorical data, antibiotics vs F734
## 2024-07-16 19:26:30.740938 INFO::Creating boxplot for categorical data, antibiotics vs F16
## 2024-07-16 19:26:30.958724 INFO::Creating boxplot for categorical data, antibiotics vs F602
## 2024-07-16 19:26:31.23624 INFO::Creating boxplot for categorical data, antibiotics vs F210
## 2024-07-16 19:26:31.529954 INFO::Creating boxplot for categorical data, antibiotics vs F217
## 2024-07-16 19:26:31.781564 INFO::Creating boxplot for categorical data, antibiotics vs F640
## 2024-07-16 19:26:31.970688 INFO::Creating boxplot for categorical data, antibiotics vs F631
## 2024-07-16 19:26:32.165119 INFO::Creating boxplot for categorical data, antibiotics vs F32
## 2024-07-16 19:26:32.450543 INFO::Creating boxplot for categorical data, antibiotics vs F322
## 2024-07-16 19:26:32.667248 INFO::Creating boxplot for categorical data, antibiotics vs F476
## 2024-07-16 19:26:32.969059 INFO::Creating boxplot for categorical data, antibiotics vs F265
## 2024-07-16 19:26:33.252484 INFO::Creating boxplot for categorical data, antibiotics vs F283
## 2024-07-16 19:26:33.551995 INFO::Creating boxplot for categorical data, antibiotics vs F316
## 2024-07-16 19:26:33.8386 INFO::Creating boxplot for categorical data, antibiotics vs F465
## 2024-07-16 19:26:34.129493 INFO::Creating boxplot for categorical data, antibiotics vs F24
## 2024-07-16 19:26:34.423732 INFO::Creating boxplot for categorical data, antibiotics vs F38
## 2024-07-16 19:26:34.614589 INFO::Creating boxplot for categorical data, antibiotics vs F82
## 2024-07-16 19:26:34.806968 INFO::Creating boxplot for categorical data, antibiotics vs F86
## 2024-07-16 19:26:34.990033 INFO::Creating boxplot for categorical data, antibiotics vs F270
## 2024-07-16 19:26:35.203295 INFO::Creating boxplot for categorical data, antibiotics vs F485
## 2024-07-16 19:26:35.3914 INFO::Creating boxplot for categorical data, antibiotics vs F486
## 2024-07-16 19:26:35.584996 INFO::Creating boxplot for categorical data, antibiotics vs F399
## 2024-07-16 19:26:35.770229 INFO::Creating boxplot for categorical data, antibiotics vs F573
## 2024-07-16 19:26:35.957026 INFO::Creating boxplot for categorical data, antibiotics vs F877
## 2024-07-16 19:26:36.173175 INFO::Creating boxplot for categorical data, antibiotics vs F709
## 2024-07-16 19:26:36.361875 INFO::Creating boxplot for categorical data, antibiotics vs F227
## 2024-07-16 19:26:36.568397 INFO::Creating boxplot for categorical data, antibiotics vs F553
## 2024-07-16 19:26:36.750674 INFO::Creating boxplot for categorical data, antibiotics vs F123
## 2024-07-16 19:26:36.93081 INFO::Creating boxplot for categorical data, antibiotics vs F118
## 2024-07-16 19:26:37.14502 INFO::Creating boxplot for categorical data, antibiotics vs F605
## 2024-07-16 19:26:37.365795 INFO::Creating boxplot for categorical data, antibiotics vs F619
## 2024-07-16 19:26:37.639975 INFO::Creating boxplot for categorical data, antibiotics vs F830
## 2024-07-16 19:26:37.827106 INFO::Creating boxplot for categorical data, antibiotics vs F837
## 2024-07-16 19:26:38.144069 INFO::Creating boxplot for categorical data, antibiotics vs F12
## 2024-07-16 19:26:38.454424 INFO::Creating boxplot for categorical data, antibiotics vs F623
## 2024-07-16 19:26:38.743431 INFO::Creating boxplot for categorical data, antibiotics vs F806
## 2024-07-16 19:26:38.932881 INFO::Creating boxplot for categorical data, antibiotics vs F353
## 2024-07-16 19:26:39.127813 INFO::Creating boxplot for categorical data, antibiotics vs F829
## 2024-07-16 19:26:39.322415 INFO::Creating boxplot for categorical data, antibiotics vs F289
## 2024-07-16 19:26:39.56769 INFO::Creating boxplot for categorical data, antibiotics vs F93
## 2024-07-16 19:26:39.753194 INFO::Creating boxplot for categorical data, antibiotics vs F379
## 2024-07-16 19:26:39.94267 INFO::Creating boxplot for categorical data, antibiotics vs F370
## 2024-07-16 19:26:40.136502 INFO::Creating boxplot for categorical data, antibiotics vs F360
## 2024-07-16 19:26:40.332924 INFO::Creating boxplot for categorical data, antibiotics vs F710
## 2024-07-16 19:26:40.648891 INFO::Creating boxplot for categorical data, antibiotics vs F388
## 2024-07-16 19:26:40.926098 INFO::Creating boxplot for categorical data, antibiotics vs F796
## 2024-07-16 19:26:41.118533 INFO::Creating boxplot for categorical data, antibiotics vs F174
## 2024-07-16 19:26:41.308178 INFO::Creating boxplot for categorical data, antibiotics vs F601
## 2024-07-16 19:26:41.490999 INFO::Creating boxplot for categorical data, antibiotics vs F775
## 2024-07-16 19:26:41.733823 INFO::Creating boxplot for categorical data, antibiotics vs F836
## 2024-07-16 19:26:42.062736 INFO::Creating boxplot for categorical data, antibiotics vs F192
## 2024-07-16 19:26:42.326553 INFO::Creating boxplot for categorical data, antibiotics vs F463
## 2024-07-16 19:26:42.606864 INFO::Creating boxplot for categorical data, antibiotics vs F57
## 2024-07-16 19:26:42.901775 INFO::Creating boxplot for categorical data, antibiotics vs F658
## 2024-07-16 19:26:43.279701 INFO::Creating boxplot for categorical data, antibiotics vs F596
## 2024-07-16 19:26:43.583901 INFO::Creating boxplot for categorical data, antibiotics vs F218
## 2024-07-16 19:26:43.885519 INFO::Creating boxplot for categorical data, antibiotics vs F104
## 2024-07-16 19:26:44.201978 INFO::Creating boxplot for categorical data, antibiotics vs F466
## 2024-07-16 19:26:44.509281 INFO::Creating boxplot for categorical data, antibiotics vs F737
## 2024-07-16 19:26:44.816729 INFO::Creating boxplot for categorical data, antibiotics vs F487
## 2024-07-16 19:26:45.087594 INFO::Creating boxplot for categorical data, antibiotics vs F369
## 2024-07-16 19:26:45.366861 INFO::Creating boxplot for categorical data, antibiotics vs F584
## 2024-07-16 19:26:45.591488 INFO::Creating boxplot for categorical data, antibiotics vs F166
## 2024-07-16 19:26:45.781485 INFO::Creating boxplot for categorical data, antibiotics vs F822
## 2024-07-16 19:26:46.075506 INFO::Creating boxplot for categorical data, antibiotics vs F416
## 2024-07-16 19:26:46.429303 INFO::Creating boxplot for categorical data, antibiotics vs F70
## 2024-07-16 19:26:46.714759 INFO::Creating boxplot for categorical data, antibiotics vs F243
## 2024-07-16 19:26:47.024127 INFO::Creating boxplot for categorical data, antibiotics vs F498
## 2024-07-16 19:26:47.306928 INFO::Creating boxplot for categorical data, antibiotics vs F272
## 2024-07-16 19:26:47.610008 INFO::Creating boxplot for categorical data, antibiotics vs F846
## 2024-07-16 19:26:47.844534 INFO::Creating boxplot for categorical data, antibiotics vs F881
## 2024-07-16 19:26:48.113798 INFO::Creating boxplot for categorical data, antibiotics vs F280
## 2024-07-16 19:26:48.417345 INFO::Creating boxplot for categorical data, antibiotics vs F761
## 2024-07-16 19:26:48.686054 INFO::Creating boxplot for categorical data, antibiotics vs F781
## 2024-07-16 19:26:48.930249 INFO::Creating boxplot for categorical data, antibiotics vs F697
## 2024-07-16 19:26:49.228166 INFO::Creating boxplot for categorical data, antibiotics vs F890
## 2024-07-16 19:26:49.518584 INFO::Creating boxplot for categorical data, antibiotics vs F197
## 2024-07-16 19:26:49.80853 INFO::Creating boxplot for categorical data, antibiotics vs F826
## 2024-07-16 19:26:50.10145 INFO::Creating boxplot for categorical data, antibiotics vs F641
## 2024-07-16 19:26:50.39345 INFO::Creating boxplot for categorical data, antibiotics vs F700
## 2024-07-16 19:26:50.693035 INFO::Creating boxplot for categorical data, antibiotics vs F531
## 2024-07-16 19:26:51.057762 INFO::Creating boxplot for categorical data, antibiotics vs F660
## 2024-07-16 19:26:51.29804 INFO::Creating boxplot for categorical data, antibiotics vs F257
## 2024-07-16 19:26:51.607444 INFO::Creating boxplot for categorical data, antibiotics vs F136
## 2024-07-16 19:26:51.916525 INFO::Creating boxplot for categorical data, antibiotics vs F875
## 2024-07-16 19:26:52.171339 INFO::Creating boxplot for categorical data, antibiotics vs F160
## 2024-07-16 19:26:52.442832 INFO::Creating boxplot for categorical data, antibiotics vs F782
## 2024-07-16 19:26:52.760492 INFO::Creating boxplot for categorical data, antibiotics vs F642
## 2024-07-16 19:26:53.063848 INFO::Creating boxplot for categorical data, antibiotics vs F730
## 2024-07-16 19:26:53.313083 INFO::Creating boxplot for categorical data, antibiotics vs F679
## 2024-07-16 19:26:53.610138 INFO::Creating boxplot for categorical data, antibiotics vs F713
## 2024-07-16 19:26:53.935525 INFO::Creating boxplot for categorical data, antibiotics vs F821
## 2024-07-16 19:26:54.154237 INFO::Creating boxplot for categorical data, antibiotics vs F443
## 2024-07-16 19:26:54.424268 INFO::Creating boxplot for categorical data, antibiotics vs F729
## 2024-07-16 19:26:54.756026 INFO::Creating boxplot for categorical data, antibiotics vs F25
## 2024-07-16 19:26:55.056409 INFO::Creating boxplot for categorical data, antibiotics vs F338
## 2024-07-16 19:26:55.397819 INFO::Creating boxplot for categorical data, antibiotics vs F647
## 2024-07-16 19:26:55.707649 INFO::Creating boxplot for categorical data, antibiotics vs F817
## 2024-07-16 19:26:55.95708 INFO::Creating boxplot for categorical data, antibiotics vs F535
## 2024-07-16 19:26:56.277077 INFO::Creating boxplot for categorical data, antibiotics vs F634
## 2024-07-16 19:26:56.614983 INFO::Creating boxplot for categorical data, antibiotics vs F533
## 2024-07-16 19:26:56.841747 INFO::Creating boxplot for categorical data, antibiotics vs F808
## 2024-07-16 19:26:57.157204 INFO::Creating boxplot for categorical data, antibiotics vs F571
## 2024-07-16 19:26:57.364605 INFO::Creating boxplot for categorical data, antibiotics vs F529
## 2024-07-16 19:26:57.573998 INFO::Creating boxplot for categorical data, antibiotics vs F827
## 2024-07-16 19:26:57.826164 INFO::Creating boxplot for categorical data, antibiotics vs F107
## 2024-07-16 19:26:58.011336 INFO::Creating boxplot for categorical data, antibiotics vs F515
## 2024-07-16 19:26:58.35117 INFO::Creating boxplot for categorical data, antibiotics vs F305
## 2024-07-16 19:26:58.566934 INFO::Creating boxplot for categorical data, antibiotics vs F662
## 2024-07-16 19:26:58.82874 INFO::Creating boxplot for categorical data, antibiotics vs F310
## 2024-07-16 19:26:59.205005 INFO::Creating boxplot for categorical data, antibiotics vs F430
## 2024-07-16 19:26:59.605834 INFO::Creating boxplot for categorical data, antibiotics vs F173
## 2024-07-16 19:27:00.052778 INFO::Creating boxplot for categorical data, antibiotics vs F820
## 2024-07-16 19:27:00.316834 INFO::Creating boxplot for categorical data, antibiotics vs F743
## 2024-07-16 19:27:00.528699 INFO::Creating boxplot for categorical data, antibiotics vs F63
## 2024-07-16 19:27:00.769311 INFO::Creating boxplot for categorical data, antibiotics vs F215
## 2024-07-16 19:27:01.026397 INFO::Creating boxplot for categorical data, antibiotics vs F216
## 2024-07-16 19:27:01.331857 INFO::Creating boxplot for categorical data, antibiotics vs F245
## 2024-07-16 19:27:01.597119 INFO::Creating boxplot for categorical data, antibiotics vs F862
## 2024-07-16 19:27:01.844665 INFO::Creating boxplot for categorical data, antibiotics vs F541
## 2024-07-16 19:27:02.045131 INFO::Creating boxplot for categorical data, antibiotics vs F558
## 2024-07-16 19:27:02.274644 INFO::Creating boxplot for categorical data, antibiotics vs F633
## 2024-07-16 19:27:02.590805 INFO::Creating boxplot for categorical data, antibiotics vs F94
## 2024-07-16 19:27:02.873408 INFO::Creating boxplot for categorical data, antibiotics vs F574
## 2024-07-16 19:27:03.131913 INFO::Creating boxplot for categorical data, antibiotics vs F238
## 2024-07-16 19:27:03.366595 INFO::Creating boxplot for categorical data, antibiotics vs F815
## 2024-07-16 19:27:03.656512 INFO::Creating boxplot for categorical data, antibiotics vs F587
## 2024-07-16 19:27:04.002365 INFO::Creating boxplot for categorical data, antibiotics vs F464
## 2024-07-16 19:27:04.233687 INFO::Creating boxplot for categorical data, antibiotics vs F590
## 2024-07-16 19:27:04.452179 INFO::Creating boxplot for categorical data, antibiotics vs F124
## 2024-07-16 19:27:04.696853 INFO::Creating boxplot for categorical data, antibiotics vs F664
## 2024-07-16 19:27:04.992335 INFO::Creating boxplot for categorical data, antibiotics vs F100
## 2024-07-16 19:27:05.208325 INFO::Creating boxplot for categorical data, antibiotics vs F744
## 2024-07-16 19:27:05.484563 INFO::Creating boxplot for categorical data, antibiotics vs F444
## 2024-07-16 19:27:05.718276 INFO::Creating boxplot for categorical data, antibiotics vs F597
## 2024-07-16 19:27:05.99364 INFO::Creating boxplot for categorical data, antibiotics vs F650
## 2024-07-16 19:27:06.205341 INFO::Creating boxplot for categorical data, antibiotics vs F147
## 2024-07-16 19:27:06.386665 INFO::Creating boxplot for categorical data, antibiotics vs F363
## 2024-07-16 19:27:06.615953 INFO::Creating boxplot for categorical data, antibiotics vs F521
## 2024-07-16 19:27:06.908964 INFO::Creating boxplot for categorical data, antibiotics vs F412
## 2024-07-16 19:27:07.193789 INFO::Creating boxplot for categorical data, antibiotics vs F279
## 2024-07-16 19:27:07.474873 INFO::Creating boxplot for categorical data, antibiotics vs F225
## 2024-07-16 19:27:07.748522 INFO::Creating boxplot for categorical data, antibiotics vs F10
## 2024-07-16 19:27:08.075547 INFO::Creating boxplot for categorical data, antibiotics vs F481
## 2024-07-16 19:27:08.282408 INFO::Creating boxplot for categorical data, antibiotics vs F861
## 2024-07-16 19:27:08.472441 INFO::Creating boxplot for categorical data, antibiotics vs F888
## 2024-07-16 19:27:08.659611 INFO::Creating boxplot for categorical data, antibiotics vs F156
## 2024-07-16 19:27:08.844613 INFO::Creating boxplot for categorical data, antibiotics vs F857
## 2024-07-16 19:27:09.065238 INFO::Creating boxplot for categorical data, antibiotics vs F509
## 2024-07-16 19:27:09.256485 INFO::Creating boxplot for categorical data, antibiotics vs F244
## 2024-07-16 19:27:09.468837 INFO::Creating boxplot for categorical data, antibiotics vs F514
## 2024-07-16 19:27:09.693415 INFO::Creating boxplot for categorical data, antibiotics vs F196
## 2024-07-16 19:27:09.897403 INFO::Creating boxplot for categorical data, antibiotics vs F304
## 2024-07-16 19:27:10.145445 INFO::Creating boxplot for categorical data, antibiotics vs F833
## 2024-07-16 19:27:10.403999 INFO::Creating boxplot for categorical data, antibiotics vs F294
## 2024-07-16 19:27:10.696512 INFO::Creating boxplot for categorical data, antibiotics vs F550
## 2024-07-16 19:27:11.027799 INFO::Creating boxplot for categorical data, antibiotics vs F869
## 2024-07-16 19:27:11.30973 INFO::Creating boxplot for categorical data, antibiotics vs F364
## 2024-07-16 19:27:11.629342 INFO::Creating boxplot for categorical data, antibiotics vs F583
## 2024-07-16 19:27:11.870522 INFO::Creating boxplot for categorical data, antibiotics vs F441
## 2024-07-16 19:27:12.168805 INFO::Creating boxplot for categorical data, antibiotics vs F595
## 2024-07-16 19:27:12.444907 INFO::Creating boxplot for categorical data, antibiotics vs F35
## 2024-07-16 19:27:12.698019 INFO::Creating boxplot for categorical data, antibiotics vs F630
## 2024-07-16 19:27:13.867945 INFO::Creating boxplot for categorical data, antibiotics vs F401
## 2024-07-16 19:27:14.06814 INFO::Creating boxplot for categorical data, antibiotics vs F287
## 2024-07-16 19:27:14.3445 INFO::Creating boxplot for categorical data, antibiotics vs F250
## 2024-07-16 19:27:14.565865 INFO::Creating boxplot for categorical data, antibiotics vs F239
## 2024-07-16 19:27:14.779938 INFO::Creating boxplot for categorical data, antibiotics vs F88
## 2024-07-16 19:27:14.999463 INFO::Creating boxplot for categorical data, antibiotics vs F752
## 2024-07-16 19:27:15.179247 INFO::Creating boxplot for categorical data, antibiotics vs F539
## 2024-07-16 19:27:15.353389 INFO::Creating boxplot for categorical data, antibiotics vs F69
## 2024-07-16 19:27:15.565421 INFO::Creating boxplot for categorical data, antibiotics vs F126
## 2024-07-16 19:27:15.854513 INFO::Creating boxplot for categorical data, antibiotics vs F362
## 2024-07-16 19:27:16.057799 INFO::Creating boxplot for categorical data, antibiotics vs F753
## 2024-07-16 19:27:16.245655 INFO::Creating boxplot for categorical data, antibiotics vs F469
## 2024-07-16 19:27:16.433777 INFO::Creating boxplot for categorical data, antibiotics vs F14
## 2024-07-16 19:27:16.62112 INFO::Creating boxplot for categorical data, antibiotics vs F803
## 2024-07-16 19:27:16.906236 INFO::Creating boxplot for categorical data, antibiotics vs F814
## 2024-07-16 19:27:17.199013 INFO::Creating boxplot for categorical data, antibiotics vs F449
## 2024-07-16 19:27:17.509594 INFO::Creating boxplot for categorical data, antibiotics vs F494
## 2024-07-16 19:27:17.67971 INFO::Creating boxplot for categorical data, antibiotics vs F439
## 2024-07-16 19:27:17.886381 INFO::Creating boxplot for categorical data, antibiotics vs F686
## 2024-07-16 19:27:18.1767 INFO::Creating boxplot for categorical data, antibiotics vs F591
## 2024-07-16 19:27:18.474878 INFO::Creating boxplot for categorical data, antibiotics vs F735
## 2024-07-16 19:27:18.740388 INFO::Creating boxplot for categorical data, antibiotics vs F111
## 2024-07-16 19:27:19.005975 INFO::Creating boxplot for categorical data, antibiotics vs F346
## 2024-07-16 19:27:19.253718 INFO::Creating boxplot for categorical data, antibiotics vs F29
## 2024-07-16 19:27:19.506829 INFO::Creating boxplot for categorical data, antibiotics vs F376
## 2024-07-16 19:27:19.804353 INFO::Creating boxplot for categorical data, antibiotics vs F414
## 2024-07-16 19:27:20.048997 INFO::Creating boxplot for categorical data, antibiotics vs F555
## 2024-07-16 19:27:20.31428 INFO::Creating boxplot for categorical data, antibiotics vs F517
## 2024-07-16 19:27:20.561804 INFO::Creating boxplot for categorical data, antibiotics vs F544
## 2024-07-16 19:27:20.811994 INFO::Creating boxplot for categorical data, antibiotics vs F339
## 2024-07-16 19:27:21.063223 INFO::Creating boxplot for categorical data, antibiotics vs F689
## 2024-07-16 19:27:21.337148 INFO::Creating boxplot for categorical data, antibiotics vs F391
## 2024-07-16 19:27:21.654295 INFO::Creating boxplot for categorical data, antibiotics vs F502
## 2024-07-16 19:27:21.949821 INFO::Creating boxplot for categorical data, antibiotics vs F298
## 2024-07-16 19:27:22.236842 INFO::Creating boxplot for categorical data, antibiotics vs F337
## 2024-07-16 19:27:22.505047 INFO::Creating boxplot for categorical data, antibiotics vs F773
## 2024-07-16 19:27:22.68191 INFO::Creating boxplot for categorical data, antibiotics vs F592
## 2024-07-16 19:27:22.950441 INFO::Creating boxplot for categorical data, antibiotics vs F307
## 2024-07-16 19:27:23.234173 INFO::Creating boxplot for categorical data, antibiotics vs F115
## 2024-07-16 19:27:23.468226 INFO::Creating boxplot for categorical data, antibiotics vs F739
## 2024-07-16 19:27:23.697643 INFO::Creating boxplot for categorical data, antibiotics vs F433
## 2024-07-16 19:27:23.962777 INFO::Creating boxplot for categorical data, antibiotics vs F384
## 2024-07-16 19:27:24.139103 INFO::Creating boxplot for categorical data, antibiotics vs F750
## 2024-07-16 19:27:24.333065 INFO::Creating boxplot for categorical data, antibiotics vs F762
## 2024-07-16 19:27:24.572427 INFO::Creating boxplot for categorical data, antibiotics vs F277
## 2024-07-16 19:27:24.837487 INFO::Creating boxplot for categorical data, antibiotics vs F871
## 2024-07-16 19:27:25.105065 INFO::Creating boxplot for categorical data, antibiotics vs F839
## 2024-07-16 19:27:25.300943 INFO::Creating boxplot for categorical data, antibiotics vs F127
## 2024-07-16 19:27:25.488424 INFO::Creating boxplot for categorical data, antibiotics vs F554
## 2024-07-16 19:27:25.680897 INFO::Creating boxplot for categorical data, antibiotics vs F676
## 2024-07-16 19:27:25.869067 INFO::Creating boxplot for categorical data, antibiotics vs F568
## 2024-07-16 19:27:26.048059 INFO::Creating boxplot for categorical data, antibiotics vs F137
## 2024-07-16 19:27:26.229477 INFO::Creating boxplot for categorical data, antibiotics vs F131
## 2024-07-16 19:27:26.440014 INFO::Creating boxplot for categorical data, antibiotics vs F60
## 2024-07-16 19:27:26.728672 INFO::Creating boxplot for categorical data, antibiotics vs F98
## 2024-07-16 19:27:26.916922 INFO::Creating boxplot for categorical data, antibiotics vs F672
## 2024-07-16 19:27:27.097982 INFO::Creating boxplot for categorical data, antibiotics vs F530
## 2024-07-16 19:27:27.270907 INFO::Creating boxplot for categorical data, antibiotics vs F809
## 2024-07-16 19:27:27.457678 INFO::Creating boxplot for categorical data, antibiotics vs F894
## 2024-07-16 19:27:27.654902 INFO::Creating boxplot for categorical data, antibiotics vs F22
## 2024-07-16 19:27:27.938254 INFO::Creating boxplot for categorical data, antibiotics vs F818
## 2024-07-16 19:27:28.193883 INFO::Creating boxplot for categorical data, antibiotics vs F559
## 2024-07-16 19:27:28.454624 INFO::Creating boxplot for categorical data, antibiotics vs F741
## 2024-07-16 19:27:28.636157 INFO::Creating boxplot for categorical data, antibiotics vs F398
## 2024-07-16 19:27:28.882206 INFO::Creating boxplot for categorical data, antibiotics vs F357
## 2024-07-16 19:27:29.141784 INFO::Creating boxplot for categorical data, antibiotics vs F119
## 2024-07-16 19:27:29.375742 INFO::Creating boxplot for categorical data, antibiotics vs F426
## 2024-07-16 19:27:29.62596 INFO::Creating boxplot for categorical data, antibiotics vs F204
## 2024-07-16 19:27:29.924815 INFO::Creating boxplot for categorical data, antibiotics vs F851
## 2024-07-16 19:27:30.214181 INFO::Creating boxplot for categorical data, antibiotics vs F657
## 2024-07-16 19:27:30.385082 INFO::Creating boxplot for categorical data, antibiotics vs F801
## 2024-07-16 19:27:30.660333 INFO::Creating boxplot for categorical data, antibiotics vs F754
## 2024-07-16 19:27:30.834966 INFO::Creating boxplot for categorical data, antibiotics vs F859
## 2024-07-16 19:27:31.036508 INFO::Creating boxplot for categorical data, antibiotics vs F480
## 2024-07-16 19:27:31.251242 INFO::Creating boxplot for categorical data, antibiotics vs F507
## 2024-07-16 19:27:31.502599 INFO::Creating boxplot for categorical data, antibiotics vs F207
## 2024-07-16 19:27:34.650802 INFO::Plotting data for metadata number 3, age
## 2024-07-16 19:27:34.655319 INFO::Creating scatter plot for continuous data, age vs F340
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:34.964377 INFO::Creating scatter plot for continuous data, age vs F603
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:35.210316 INFO::Creating scatter plot for continuous data, age vs F356
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:35.42705 INFO::Creating scatter plot for continuous data, age vs F181
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:35.625137 INFO::Creating scatter plot for continuous data, age vs F177
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:35.806625 INFO::Creating scatter plot for continuous data, age vs F390
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:35.99276 INFO::Creating scatter plot for continuous data, age vs F743
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:36.159394 INFO::Creating scatter plot for continuous data, age vs F491
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:36.353947 INFO::Creating scatter plot for continuous data, age vs F436
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:36.636418 INFO::Creating scatter plot for continuous data, age vs F219
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:36.927313 INFO::Creating scatter plot for continuous data, age vs F483
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:37.231497 INFO::Creating scatter plot for continuous data, age vs F878
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:37.480721 INFO::Creating scatter plot for continuous data, age vs F876
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:37.800759 INFO::Creating scatter plot for continuous data, age vs F211
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:38.090475 INFO::Creating scatter plot for continuous data, age vs F732
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:38.381554 INFO::Creating scatter plot for continuous data, age vs F222
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:38.685288 INFO::Creating scatter plot for continuous data, age vs F688
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:38.949938 INFO::Creating scatter plot for continuous data, age vs F170
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:39.169335 INFO::Creating scatter plot for continuous data, age vs F431
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:39.361429 INFO::Creating scatter plot for continuous data, age vs F174
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:39.586324 INFO::Creating scatter plot for continuous data, age vs F17
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:39.772534 INFO::Creating scatter plot for continuous data, age vs F334
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:40.056316 INFO::Creating scatter plot for continuous data, age vs F835
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:40.248182 INFO::Creating scatter plot for continuous data, age vs F223
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:40.443577 INFO::Creating scatter plot for continuous data, age vs F383
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:40.617432 INFO::Creating scatter plot for continuous data, age vs F623
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:40.805081 INFO::Creating scatter plot for continuous data, age vs F329
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:41.028643 INFO::Creating scatter plot for continuous data, age vs F395
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:41.214608 INFO::Creating scatter plot for continuous data, age vs F528
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:41.395652 INFO::Creating scatter plot for continuous data, age vs F13
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:41.620613 INFO::Creating scatter plot for continuous data, age vs F36
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:41.892755 INFO::Creating scatter plot for continuous data, age vs F285
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:42.162916 INFO::Creating scatter plot for continuous data, age vs F404
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:42.383632 INFO::Creating scatter plot for continuous data, age vs F894
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:42.592255 INFO::Creating scatter plot for continuous data, age vs F300
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:42.786356 INFO::Creating scatter plot for continuous data, age vs F32
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:43.022814 INFO::Creating scatter plot for continuous data, age vs F24
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:43.347508 INFO::Creating scatter plot for continuous data, age vs F97
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:43.525889 INFO::Creating scatter plot for continuous data, age vs F849
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:43.698872 INFO::Creating scatter plot for continuous data, age vs F185
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:43.915804 INFO::Creating scatter plot for continuous data, age vs F513
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:44.155555 INFO::Creating scatter plot for continuous data, age vs F296
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:44.362585 INFO::Creating scatter plot for continuous data, age vs F471
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:44.5645 INFO::Creating scatter plot for continuous data, age vs F793
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:44.781363 INFO::Creating scatter plot for continuous data, age vs F402
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:45.077734 INFO::Creating scatter plot for continuous data, age vs F541
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:45.33941 INFO::Creating scatter plot for continuous data, age vs F496
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:45.50898 INFO::Creating scatter plot for continuous data, age vs F386
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:45.678916 INFO::Creating scatter plot for continuous data, age vs F594
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:45.861683 INFO::Creating scatter plot for continuous data, age vs F704
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:46.068516 INFO::Creating scatter plot for continuous data, age vs F330
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:46.281294 INFO::Creating scatter plot for continuous data, age vs F197
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:46.506669 INFO::Creating scatter plot for continuous data, age vs F735
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:46.794878 INFO::Creating scatter plot for continuous data, age vs F481
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:47.036085 INFO::Creating scatter plot for continuous data, age vs F635
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:47.381462 INFO::Creating scatter plot for continuous data, age vs F687
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:47.702943 INFO::Creating scatter plot for continuous data, age vs F652
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:48.020727 INFO::Creating scatter plot for continuous data, age vs F651
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:48.29527 INFO::Creating scatter plot for continuous data, age vs F82
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:48.564309 INFO::Creating scatter plot for continuous data, age vs F7
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:48.891641 INFO::Creating scatter plot for continuous data, age vs F866
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:49.186794 INFO::Creating scatter plot for continuous data, age vs F593
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:49.437041 INFO::Creating scatter plot for continuous data, age vs F733
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:49.675759 INFO::Creating scatter plot for continuous data, age vs F684
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:49.901324 INFO::Creating scatter plot for continuous data, age vs F410
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:50.100169 INFO::Creating scatter plot for continuous data, age vs F224
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:50.284929 INFO::Creating scatter plot for continuous data, age vs F722
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:50.586703 INFO::Creating scatter plot for continuous data, age vs F856
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:50.874675 INFO::Creating scatter plot for continuous data, age vs F680
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:51.108228 INFO::Creating scatter plot for continuous data, age vs F19
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:51.386135 INFO::Creating scatter plot for continuous data, age vs F860
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:51.66174 INFO::Creating scatter plot for continuous data, age vs F859
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:51.968675 INFO::Creating scatter plot for continuous data, age vs F522
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:52.170262 INFO::Creating scatter plot for continuous data, age vs F372
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:52.381957 INFO::Creating scatter plot for continuous data, age vs F899
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:52.608126 INFO::Creating scatter plot for continuous data, age vs F782
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:52.890544 INFO::Creating scatter plot for continuous data, age vs F839
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:53.075374 INFO::Creating scatter plot for continuous data, age vs F827
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:53.340055 INFO::Creating scatter plot for continuous data, age vs F817
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:53.655462 INFO::Creating scatter plot for continuous data, age vs F345
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:53.89371 INFO::Creating scatter plot for continuous data, age vs F127
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:54.146782 INFO::Creating scatter plot for continuous data, age vs F749
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:54.363106 INFO::Creating scatter plot for continuous data, age vs F877
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:54.607122 INFO::Creating scatter plot for continuous data, age vs F150
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:54.806895 INFO::Creating scatter plot for continuous data, age vs F752
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:54.983031 INFO::Creating scatter plot for continuous data, age vs F848
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:55.237319 INFO::Creating scatter plot for continuous data, age vs F809
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:55.429412 INFO::Creating scatter plot for continuous data, age vs F751
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:55.633289 INFO::Creating scatter plot for continuous data, age vs F15
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:55.875441 INFO::Creating scatter plot for continuous data, age vs F521
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:56.139399 INFO::Creating scatter plot for continuous data, age vs F842
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:56.439307 INFO::Creating scatter plot for continuous data, age vs F319
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:56.62326 INFO::Creating scatter plot for continuous data, age vs F96
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:56.83773 INFO::Creating scatter plot for continuous data, age vs F171
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:57.018262 INFO::Creating scatter plot for continuous data, age vs F241
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:57.187719 INFO::Creating scatter plot for continuous data, age vs F582
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:57.358906 INFO::Creating scatter plot for continuous data, age vs F822
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:57.624773 INFO::Creating scatter plot for continuous data, age vs F748
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:57.865168 INFO::Creating scatter plot for continuous data, age vs F147
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:58.147118 INFO::Creating scatter plot for continuous data, age vs F16
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:58.339479 INFO::Creating scatter plot for continuous data, age vs F212
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:58.536461 INFO::Creating scatter plot for continuous data, age vs F718
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:58.755068 INFO::Creating scatter plot for continuous data, age vs F663
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:59.007576 INFO::Creating scatter plot for continuous data, age vs F690
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:59.308828 INFO::Creating scatter plot for continuous data, age vs F865
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:59.518396 INFO::Creating scatter plot for continuous data, age vs F421
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:27:59.697994 INFO::Creating scatter plot for continuous data, age vs F110
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:27:59.914957 INFO::Creating scatter plot for continuous data, age vs F857
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:00.156663 INFO::Creating scatter plot for continuous data, age vs F84
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:00.345891 INFO::Creating scatter plot for continuous data, age vs F123
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:00.543861 INFO::Creating scatter plot for continuous data, age vs F566
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:00.756288 INFO::Creating scatter plot for continuous data, age vs F370
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:00.926835 INFO::Creating scatter plot for continuous data, age vs F65
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:01.143092 INFO::Creating scatter plot for continuous data, age vs F119
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:01.32924 INFO::Creating scatter plot for continuous data, age vs F263
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:01.625184 INFO::Creating scatter plot for continuous data, age vs F630
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:01.874912 INFO::Creating scatter plot for continuous data, age vs F628
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:02.102703 INFO::Creating scatter plot for continuous data, age vs F711
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:02.309682 INFO::Creating scatter plot for continuous data, age vs F152
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:02.56702 INFO::Creating scatter plot for continuous data, age vs F324
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:02.971742 INFO::Creating scatter plot for continuous data, age vs F575
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:03.261562 INFO::Creating scatter plot for continuous data, age vs F699
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:03.518782 INFO::Creating scatter plot for continuous data, age vs F846
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:03.739307 INFO::Creating scatter plot for continuous data, age vs F380
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:03.931003 INFO::Creating scatter plot for continuous data, age vs F172
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:04.145957 INFO::Creating scatter plot for continuous data, age vs F504
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:04.322557 INFO::Creating scatter plot for continuous data, age vs F34
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:04.520376 INFO::Creating scatter plot for continuous data, age vs F199
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:04.764075 INFO::Creating scatter plot for continuous data, age vs F198
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:04.950812 INFO::Creating scatter plot for continuous data, age vs F479
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:05.173189 INFO::Creating scatter plot for continuous data, age vs F673
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:05.421912 INFO::Creating scatter plot for continuous data, age vs F508
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:05.720755 INFO::Creating scatter plot for continuous data, age vs F337
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:05.915534 INFO::Creating scatter plot for continuous data, age vs F737
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:06.124521 INFO::Creating scatter plot for continuous data, age vs F609
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:06.317675 INFO::Creating scatter plot for continuous data, age vs F40
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:06.54739 INFO::Creating scatter plot for continuous data, age vs F821
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:06.733612 INFO::Creating scatter plot for continuous data, age vs F643
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:06.902691 INFO::Creating scatter plot for continuous data, age vs F759
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:07.097289 INFO::Creating scatter plot for continuous data, age vs F417
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:07.292853 INFO::Creating scatter plot for continuous data, age vs F58
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:07.512218 INFO::Creating scatter plot for continuous data, age vs F267
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:07.698825 INFO::Creating scatter plot for continuous data, age vs F101
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:07.97517 INFO::Creating scatter plot for continuous data, age vs F890
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:08.254115 INFO::Creating scatter plot for continuous data, age vs F655
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:08.459227 INFO::Creating scatter plot for continuous data, age vs F95
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:08.63382 INFO::Creating scatter plot for continuous data, age vs F775
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:08.80926 INFO::Creating scatter plot for continuous data, age vs F93
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:08.999517 INFO::Creating scatter plot for continuous data, age vs F353
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:09.200424 INFO::Creating scatter plot for continuous data, age vs F480
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:09.398623 INFO::Creating scatter plot for continuous data, age vs F567
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:09.605818 INFO::Creating scatter plot for continuous data, age vs F871
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:09.847877 INFO::Creating scatter plot for continuous data, age vs F295
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:10.151168 INFO::Creating scatter plot for continuous data, age vs F459
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:10.42393 INFO::Creating scatter plot for continuous data, age vs F812
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:10.620089 INFO::Creating scatter plot for continuous data, age vs F146
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:10.821812 INFO::Creating scatter plot for continuous data, age vs F239
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:11.015612 INFO::Creating scatter plot for continuous data, age vs F754
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:11.232197 INFO::Creating scatter plot for continuous data, age vs F443
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:11.434257 INFO::Creating scatter plot for continuous data, age vs F5
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:11.673184 INFO::Creating scatter plot for continuous data, age vs F864
## `geom_smooth()` using formula = 'y ~ x'
## 2024-07-16 19:28:11.965486 INFO::Creating scatter plot for continuous data, age vs F477
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:12.225257 INFO::Creating scatter plot for continuous data, age vs F571
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-07-16 19:28:12.5807 INFO::Creating scatter plot for continuous data, age vs F715
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Initiating effect size calculations
##
## Calculating mean abundance in: IBD
##
## Calculating mean abundance in: Control
##
## Calculating effect size in: IBD
##
## Initiating prioritization
##
## Calculating meta-rank and prioritizing metabolic features
## 2024-07-16 19:28:15.982192 INFO::Writing all prioritized metabolites to file: Macarron_output/prioritized_metabolites_all.csv
## 2024-07-16 19:28:16.008557 INFO::Writing characterizable prioritized metabolites to file: Macarron_output/prioritized_metabolites_characterizable.csv
## 2024-07-16 19:28:16.039796 INFO::Writing highly prioritized metabolites in IBD to file: Macarron_output/highly_prioritized_per_module_in_IBD.csv
abundances_df = read.csv(file = prism_abundances, row.names = 1) # setting features as rownames
annotations_df = read.csv(file = prism_annotations, row.names = 1) # setting features as rownames
metadata_df = read.csv(file = prism_metadata, row.names = 1) # setting samples as rownames
taxonomy_df = read.csv(file = mets_taxonomy)
# Running Macarron
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df,
input_taxonomy = taxonomy_df)
The Macarron::Macarron()
function is a wrapper for the Macarron framework. Users can also apply individual functions on the input dataframes to achieve same results as the wrapper with the added benefit of storing output from each function for other analyses. There are seven steps:
# Step 1: Storing input data in a summarized experiment object
prism_mbx <- prepInput(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df)
# Step 2: Creating a distance matrix from pairwise correlations in abundances of metabolic features
prism_w <- makeDisMat(se = prism_mbx)
# Step 3: Finding covariance modules
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df)
# The output is a list containing two dataframes- module assignments and measures of success
# if evaluateMOS=TRUE. To write modules to a separate dataframe, do:
prism_module_assignments <- prism_modules[[1]]
prism_modules_mos <- prism_modules[[2]]
# Step 4: Calculating AVA
prism_ava <- calAVA(se = prism_mbx,
mod.assn = prism_modules)
# Step 5: Calculating q-value
prism_qval <- calQval(se = prism_mbx,
mod.assn = prism_modules)
# Step 6: Calculating effect size
prism_es <- calES(se = prism_mbx,
mac.qval = prism_qval)
# Step 7: Prioritizing metabolic features
prism_prioritized <- prioritize(se = prism_mbx,
mod.assn = prism_modules,
mac.ava = prism_ava,
mac.qval = prism_qval,
mac.es = prism_es)
# The output is a list containing two dataframes- all prioritized metabolic features and
# only characterizable metabolic features.
all_prioritized <- prism_prioritized[[1]]
char_prioritized <- prism_prioritized[[2]]
# Step 8 (optional): View only the highly prioritized metabolic features in each module
prism_highly_prioritized <- showBest(prism_prioritized)
Session info from running the demo in R can be displayed with the following command.
sessionInfo()
## R version 4.4.1 (2024-06-14 ucrt)
## Platform: x86_64-w64-mingw32/x64
## Running under: Windows Server 2022 x64 (build 20348)
##
## Matrix products: default
##
##
## locale:
## [1] LC_COLLATE=C
## [2] LC_CTYPE=English_United States.utf8
## [3] LC_MONETARY=English_United States.utf8
## [4] LC_NUMERIC=C
## [5] LC_TIME=English_United States.utf8
##
## time zone: America/New_York
## tzcode source: internal
##
## attached base packages:
## [1] stats4 stats graphics grDevices utils datasets methods
## [8] base
##
## other attached packages:
## [1] Macarron_1.9.1 SummarizedExperiment_1.35.1
## [3] Biobase_2.65.0 GenomicRanges_1.57.1
## [5] GenomeInfoDb_1.41.1 IRanges_2.39.1
## [7] S4Vectors_0.43.1 BiocGenerics_0.51.0
## [9] MatrixGenerics_1.17.0 matrixStats_1.3.0
## [11] BiocStyle_2.33.1
##
## loaded via a namespace (and not attached):
## [1] mnormt_2.1.1 DBI_1.2.3 pbapply_1.7-2
## [4] gridExtra_2.3 rlang_1.1.4 magrittr_2.0.3
## [7] compiler_4.4.1 RSQLite_2.3.7 mgcv_1.9-1
## [10] png_0.1-8 vctrs_0.6.5 stringr_1.5.1
## [13] pkgconfig_2.0.3 crayon_1.5.3 fastmap_1.2.0
## [16] backports_1.5.0 XVector_0.45.0 labeling_0.4.3
## [19] utf8_1.2.4 rmarkdown_2.27 preprocessCore_1.67.0
## [22] UCSC.utils_1.1.0 bit_4.0.5 xfun_0.45
## [25] zlibbioc_1.51.1 cachem_1.1.0 jsonlite_1.8.8
## [28] blob_1.2.4 DelayedArray_0.31.8 BiocParallel_1.39.0
## [31] psych_2.4.6.26 Maaslin2_1.19.0 parallel_4.4.1
## [34] cluster_2.1.6 biglm_0.9-3 R6_2.5.1
## [37] RColorBrewer_1.1-3 stringi_1.8.4 bslib_0.7.0
## [40] rpart_4.1.23 jquerylib_0.1.4 Rcpp_1.0.12
## [43] bookdown_0.40 iterators_1.0.14 knitr_1.48
## [46] WGCNA_1.72-5 base64enc_0.1-3 Matrix_1.7-0
## [49] splines_4.4.1 nnet_7.3-19 tidyselect_1.2.1
## [52] rstudioapi_0.16.0 abind_1.4-5 yaml_2.3.9
## [55] doParallel_1.0.17 codetools_0.2-20 plyr_1.8.9
## [58] lattice_0.22-6 tibble_3.2.1 withr_3.0.0
## [61] KEGGREST_1.45.1 evaluate_0.24.0 foreign_0.8-87
## [64] survival_3.7-0 getopt_1.20.4 Biostrings_2.73.1
## [67] pillar_1.9.0 BiocManager_1.30.23 checkmate_2.3.1
## [70] foreach_1.5.2 pcaPP_2.0-4 generics_0.1.3
## [73] ggplot2_3.5.1 munsell_0.5.1 scales_1.3.0
## [76] glue_1.7.0 Hmisc_5.1-3 tools_4.4.1
## [79] robustbase_0.99-3 data.table_1.15.4 mvtnorm_1.2-5
## [82] fastcluster_1.2.6 grid_4.4.1 optparse_1.7.5
## [85] impute_1.79.0 AnnotationDbi_1.67.0 colorspace_2.1-0
## [88] nlme_3.1-165 GenomeInfoDbData_1.2.12 htmlTable_2.4.2
## [91] Formula_1.2-5 cli_3.6.3 fansi_1.0.6
## [94] S4Arrays_1.5.4 dplyr_1.1.4 DEoptimR_1.1-3
## [97] gtable_0.3.5 hash_2.2.6.3 logging_0.10-108
## [100] dynamicTreeCut_1.63-1 sass_0.4.9 digest_0.6.36
## [103] SparseArray_1.5.21 farver_2.1.2 htmlwidgets_1.6.4
## [106] memoise_2.0.1 htmltools_0.5.8.1 lifecycle_1.0.4
## [109] httr_1.4.7 GO.db_3.19.1 bit64_4.0.5
The input taxonomy dataframe can be generated using the input metabolic features annotation dataframe using Macarron::decorateID()
. This function annotates an HMDB ID or a PubChem CID with the chemical class and subclass of the metabolite.
taxonomy_df <- decorateID(input_annotations = annotations_df)
write.csv(taxonomy_df, file="demo_taxonomy.csv", row.names = FALSE)
A record of all chosen parameters and steps that were followed during execution.
This file provides information about the properties of covariance modules used in the analysis. By default, modules are generated using a minimum module size (MMS) (argument: min_module_size
) equal to cube root of the total number of prevalent metabolic features. Macarron evaluates 9 measures of success (MOS) that collectively capture the “correctness” and chemical homogeneity of the modules. The MOS are as follows:
This folder contains the Maaslin2 log file (maaslin2.log), significant associations found by Maaslin2 (significant_results.tsv) and the linear model residuals file (residuals.rds). For more information, see Maaslin2.
Ideally, at least 50% metabolic features must be retained after prevalence filtering. By default, Macarron uses the union of metabolic features observed (non-zero abundance) in at least 70% samples of any phenotype for further analysis. This prevalence threshold may be high for some metabolomics datasets and can be changed using the min_prevalence
argument.
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df,
input_taxonomy = taxonomy_df,
min_prevalence = 0.5)
# or
prism_w <- makeDisMat(se = prism_mbx,
min_prevalence = 0.5)
By default, cube root of the total number of prevalent features is used as the minimum module size (MMS) (argument: min_module_size
) for module detection and generation. We expect this to work for most real world datasets. To determine if the modules are optimal for further analysis, Macarron evaluates several measures of success (MOS) as described above. In addition to evaluating MOS for modules generated using the default MMS, Macarron also evaluates MOS for MMS values that are larger (MMS+5, MMS+10) and smaller (MMS-5, MMS-10) than the default MMS. If you find that the MOS improve with larger or smaller MMS, you may change the default accordingly. For more details about module detection, please see WGCNA
and dynamicTreeCut
.
# See MOS of modules generated using default
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df)
prism_modules_mos <- prism_modules[[2]]
View(prism_modules_mos)
# Change MMS
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df,
min_module_size = 10)
Macarron uses Maaslin2 for determining the q-value of differential abundance in a phenotype of interest. For default execution, the phenotype of interest must be a category in column 1 of the metadata dataframe e.g. IBD in diagnosis in the demo. This is also the column that is picked by the metadata_variable
argument for identifying the main phenotypes/conditions in any dataset (see Macarron.log file). Further, in the default execution, all columns in the metadata table are considered as fixed effects and the alphabetically first categorical variable in each covariate with two categories is considered as the reference. Maaslin2 requires reference categories to be explicitly defined for all categorical metadata with more than two categories.
Defaults can be changed with the arguments fixed_effects
, random_effects
and reference
. In the demo example, fixed effects
and reference
can be defined as follows:
prism_qval <- calQval(se = prism_mbx,
mod.assn = prism_modules,
metadata_variable = "diagnosis",
fixed_effects = c("diagnosis","age","antibiotics"),
reference = c("diagnosis,Control";"antibiotics,No"))
The package source contains a script MacarronCMD.R
in inst/scripts
to invoke Macarron in the command line using Rscript.
The inst/scripts
folder also contains a README file that comprehensively documents the usage of the script.