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This is the development version of HERON; for the stable release version, see HERON.

Hierarchical Epitope pROtein biNding

Bioconductor version: Development (3.19)

HERON is a software package for analyzing peptide binding array data. In addition to identifying significant binding probes, HERON also provides functions for finding epitopes (string of consecutive peptides within a protein). HERON also calculates significance on the probe, epitope, and protein level by employing meta p-value methods. HERON is designed for obtaining calls on the sample level and calculates fractions of hits for different conditions.

Author: Sean McIlwain [aut, cre] , Irene Ong [aut]

Maintainer: Sean McIlwain <sean.mcilwain at wisc.edu>

Citation (from within R, enter citation("HERON")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Analyzing High Density Peptide Array Data using HERON HTML R Script
Reference Manual PDF


biocViews Coverage, Microarray, Sequencing, Software
Version 1.1.1
In Bioconductor since BioC 3.18 (R-4.3) (< 6 months)
License GPL (>= 3)
Depends R (>= 4.3.0), SummarizedExperiment(>= 1.1.6), GenomicRanges, IRanges, S4Vectors
Imports matrixStats, stats, data.table, harmonicmeanp, metap, cluster, spdep, Matrix, limma, methods
System Requirements
URL https://github.com/Ong-Research/HERON
Bug Reports https://github.com/Ong-Research/HERON/issues
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Suggests knitr, rmarkdown, testthat (>= 3.0.0)
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package HERON_1.1.1.tar.gz
Windows Binary HERON_1.1.1.zip
macOS Binary (x86_64) HERON_1.1.1.tgz
macOS Binary (arm64) HERON_1.1.1.tgz
Source Repository git clone https://git.bioconductor.org/packages/HERON
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/HERON
Bioc Package Browser https://code.bioconductor.org/browse/HERON/
Package Short Url https://bioconductor.org/packages/HERON/
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