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This is the development version of genomicInstability; for the stable release version, see genomicInstability.

Genomic Instability estimation for scRNA-Seq

Bioconductor version: Development (3.19)

This package contain functions to run genomic instability analysis (GIA) from scRNA-Seq data. GIA estimates the association between gene expression and genomic location of the coding genes. It uses the aREA algorithm to quantify the enrichment of sets of contiguous genes (loci-blocks) on the gene expression profiles and estimates the Genomic Instability Score (GIS) for each analyzed cell.

Author: Mariano Alvarez [aut, cre], Pasquale Laise [aut], DarwinHealth [cph]

Maintainer: Mariano Alvarez <reef103 at gmail.com>

Citation (from within R, enter citation("genomicInstability")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Using genomicInstability PDF R Script
Reference Manual PDF


biocViews GeneExpression, SingleCell, Software, SystemsBiology
Version 1.9.0
In Bioconductor since BioC 3.14 (R-4.1) (2.5 years)
License file LICENSE
Depends R (>= 4.1.0), checkmate
Imports mixtools, SummarizedExperiment
System Requirements
URL https://github.com/DarwinHealth/genomicInstability
Bug Reports https://github.com/DarwinHealth/genomicInstability
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Suggests SingleCellExperiment, ExperimentHub, pROC
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Follow Installation instructions to use this package in your R session.

Source Package genomicInstability_1.9.0.tar.gz
Windows Binary genomicInstability_1.9.0.zip (64-bit only)
macOS Binary (x86_64) genomicInstability_1.9.0.tgz
macOS Binary (arm64)
Source Repository git clone https://git.bioconductor.org/packages/genomicInstability
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/genomicInstability
Bioc Package Browser https://code.bioconductor.org/browse/genomicInstability/
Package Short Url https://bioconductor.org/packages/genomicInstability/
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