Changes in Version 1.3.1 (2018-11-02) _____________________________________ o dmrseq now requires that input BSseq objects be ordered (as the BSseq() constructor no longer automatically orders loci). Changes in Version 1.1.20 (2018-10-11) _____________________________________ o Minor bug fix for a rare situation that occured in the case of a multi-level covariate of interest if the region level model fitting procedure did not converge. Changes in Version 1.1.2 (2018-05-09) _____________________________________ o The newly added `chrsPerChunk` argument specifies the number of chromosomes to compute at a time (default is 1). Changes in Version 0.99.11 (2018-04-05) ______________________________________ o dmrseq now provides support for detecting large-scale methylation blocks. To use this feature, specify `block=TRUE`, and increase the smoothing span parameters `minInSpan`, `bpSpan`, and `maxGapSmooth`. More details are provided in the documentation and vignette. Changes in Version 0.99.8 (2018-03-21) ______________________________________ o dmrseq no longer requires balanced, two-group comparisons. To run using a continuous or categorial covariate with more than two groups, simply pass in the name of a column in `pData` that contains this covariate. A continuous covariate is assmued if the data type in the `testCovariate` slot is continuous, with the exception of if there are only two unique values (then a two group comparison is carried out). Version 0.99.6 (2018-03-02) ___________________________ o dmrseq is now available on Bioconductor devel (3.7) !