The National Cancer Institute (NCI) has established the Genomic Data Commons (GDC). The GDC provides the cancer research community with an open and unified repository for sharing and accessing data across numerous cancer studies and projects via a high-performance data transfer and query infrastructure. The GenomicDataCommons Bioconductor package provides basic infrastructure for querying, accessing, and mining genomic datasets available from the GDC. We expect that the Bioconductor developer and the larger bioinformatics communities will build on the GenomicDataCommons package to add higher-level functionality and expose cancer genomics data to the plethora of state-of-the-art bioinformatics methods available in Bioconductor.
From the Genomic Data Commons (GDC) website:
The National Cancer Institute’s (NCI’s) Genomic Data Commons (GDC) is a data sharing platform that promotes precision medicine in oncology. It is not just a database or a tool; it is an expandable knowledge network supporting the import and standardization of genomic and clinical data from cancer research programs. The GDC contains NCI-generated data from some of the largest and most comprehensive cancer genomic datasets, including The Cancer Genome Atlas (TCGA) and Therapeutically Applicable Research to Generate Effective Therapies (TARGET). For the first time, these datasets have been harmonized using a common set of bioinformatics pipelines, so that the data can be directly compared. As a growing knowledge system for cancer, the GDC also enables researchers to submit data, and harmonizes these data for import into the GDC. As more researchers add clinical and genomic data to the GDC, it will become an even more powerful tool for making discoveries about the molecular basis of cancer that may lead to better care for patients.
The data model for the GDC is complex, but it worth a quick overview and a graphical representation is included here.