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This package is deprecated. It will probably be removed from Bioconductor. Please refer to the package end-of-life guidelines for more information.

This package is for version 3.18 of Bioconductor. This package has been removed from Bioconductor. For the last stable, up-to-date release version, see SEPIRA.

Systems EPigenomics Inference of Regulatory Activity

Bioconductor version: Release (3.18)

SEPIRA (Systems EPigenomics Inference of Regulatory Activity) is an algorithm that infers sample-specific transcription factor activity from the genome-wide expression or DNA methylation profile of the sample.

Author: Yuting Chen [aut, cre], Andrew Teschendorff [aut]

Maintainer: Yuting Chen <cytwarmmay at hotmail.com>

Citation (from within R, enter citation("SEPIRA")):


To install this package, start R (version "4.3") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


Reference Manual PDF


biocViews GeneExpression, GeneRegulation, GeneTarget, Network, NetworkInference, Software, Transcription
Version 1.22.0
In Bioconductor since BioC 3.7 (R-3.5) (6 years)
License GPL-3
Depends R (>= 3.5.0)
Imports limma(>= 3.32.5), corpcor (>= 1.6.9), parallel (>= 3.3.1), stats
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Follow Installation instructions to use this package in your R session.

Source Package
Windows Binary SEPIRA_1.22.0.zip
macOS Binary (x86_64) SEPIRA_1.22.0.tgz
macOS Binary (arm64) SEPIRA_1.22.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/SEPIRA
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/SEPIRA
Package Short Url https://bioconductor.org/packages/SEPIRA/
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