1 Abstract

Macarron is a workflow to systematically annotate and prioritize potentially bioactive (and often unannotated) small molecules in microbial community metabolomic datasets. Macarron prioritizes metabolic features as potentially bioactive in a phenotype/condition of interest using a combination of (a) covariance with annotated metabolites, (b) ecological properties such as abundance with respect to covarying annotated compounds, and (c) differential abundance in the phenotype/condition of interest.

If you have questions, please direct it to: Macarron Forum

2 Installation

Macarron requires R version 4.2.0 or higher. Install Bioconductor and then install Macarron:

if(!requireNamespace("BiocManager", quietly = TRUE))
    install.packages("BiocManager")
BiocManager::install("Macarron")

3 Running Macarron

Macarron can be run from the command line or as an R function. Both methods require the same arguments, have the same options, and use the same default settings. The package includes the wrapper Macarron() as well as functions which perform different steps in the Macarron framework.

3.1 Input CSV files

Macarron requires 4 comma-separated, appropriately formatted input files. The files and their formatting constraints are described below.

Metabolic features abundances
- Must contain features in rows and samples in columns.
- First column must identify features.
Metabolic features annotations
- Must contain features in rows and annotations in columns.
- First column must identify features.
- Second column must contain either HMDB ID or PubChem Compound Identifier (CID).
- Third column must contain the name of the metabolite.
- Fourth column must contain a continuous chemical property such as m/z or RT or shift/ppm.
- Other annotations such as RT, m/z or other identifiers can be listed column 4 onward.
Sample metadata
- Must contain samples in rows and metadata in columns.
- First column must identify samples.
- Second column must contain categorical metadata relevant to prioritization such as phenotypes, exposures or environments.
Chemical taxonomy
- First column must contain the HMDB ID or PubChem CID. IDs must be consistent between annotation and taxonomy files.
- Second and third columns must contain chemical subclass and class of the respective metabolite.

If you do not have the chemical taxonomy file, you can generate this file using the annotation dataframe and Macarron utility decorate_ID (see Advanced Topics).

3.2 Output Files

By default, all files will be stored in a folder named Macarron_output inside the current working directory. The main prioritization results are stored in prioritized_metabolites_all.csv. Another file, prioritized_metabolites_characterizable.csv is a subset of prioritized_metabolites_all.csv and only contains metabolic features which covary with at least one annotated metabolite. The columns in these output files are:

Feature_index: Lists the identifier of the metabolic feature found in column 1 of abundance and annotation files.
HMDB_ID (or PubChem ID): Public database identifier from column 2 of annotation file (column 1 of annotation dataframe).
Metabolite name: From column 2 of annotation dataframe.
mz: The continuous numerical chemical property from column 3 of the annotation dataframe.
Priority_score: 1 indicates most prioritized. It is the percentile from the meta-rank of AVA, q-value and effect size.
Status: Direction of perturbation (differential abundance) in the phenotype (or environment) of interest compared to reference phenotype.
Module: ID of the covariance module a metabolic feature is a member of. Module = 0 indicates a singleton i.e., a metabolic feature that is not assigned to any module.
Anchor (of a module): Metabolic feature that has the highest abundance in any phenotype.
Related_classes: Chemical taxonomy of the annotated features that covary with a metabolic feature.
Covaries_with_standard: 1 (yes) and 0 (no). Column specifies if the metabolic feature covaries with at least one annotated (standard) metabolite.
AVA: Abundance versus anchor which is a ratio of the highest abundance (in any phenotype) of a metabolic feature and highest abundance of the covarying anchor. Naturally, the AVA of an anchor metabolite is 1.
qvalue: Estimated from multivariate linear model using Maaslin2.
effect_size
Remaining columns from the annotation dataframe are appended.

3.3 Run a demo in R

3.3.1 Using CSV files as inputs

Example (demo) input files can be found under inst/extdata folder of the Macarron source. These files were generated from the PRISM study of stool metabolomes of individuals with inflammatory bowel disease (IBD) and healthy “Control” individuals. Control and IBD are the two phenotypes in this example. Macarron will be applied to prioritize metabolic features with respect to their bioactivity in IBD. Therefore, in this example, the phenotype of interest is “IBD” and the reference phenotype is “Control”. The four input files are demo_abundances.csv, demo_annotations.csv, demo_metadata.csv, and demo_taxonomy.csv.

library(Macarron)

## Loading required package: SummarizedExperiment

## Loading required package: MatrixGenerics

## Loading required package: matrixStats

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## Attaching package: 'MatrixGenerics'

## The following objects are masked from 'package:matrixStats':
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prism_abundances <- system.file(
    'extdata','demo_abundances.csv', package="Macarron")
prism_annotations <-system.file(
    'extdata','demo_annotations.csv', package="Macarron")
prism_metadata <-system.file(
    'extdata','demo_metadata.csv', package="Macarron")
mets_taxonomy <-system.file(
    'extdata','demo_taxonomy.csv', package="Macarron")
prism_prioritized <- Macarron::Macarron(input_abundances = prism_abundances,
                                        input_annotations = prism_annotations,
                                        input_metadata = prism_metadata,
                                        input_taxonomy = mets_taxonomy)

## 2024-12-19 17:42:20.65975 INFO::Creating output folder.
## 2024-12-19 17:42:20.672536 INFO::Writing function arguments to log file

## Samples with both abundances and metadata: 102

## 2024-12-19 17:42:20.732483 INFO::Summarized Experiment created.
## 2024-12-19 17:42:20.734013 INFO::Metadata chosen for prevalence filtering: diagnosis

## 869 features pass chosen minimum prevalence threshold of 0.7.

## Calculating pairwise correlations in phenotype: IBD

##

## Calculating pairwise correlations in phenotype: Control

## Distance matrix with 869 features created.

## 2024-12-19 17:42:25.699244 INFO::Distance matrix with 869 metabolic features created.

## Initiating module detection

## 2024-12-19 17:42:25.7006 INFO::Minimum module size used for this dataset: 10

## Tree constructed

## Evaluating measures of success

##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
## 2024-12-19 17:42:27.00745 INFO::Total number of modules detected: 30

## Initiating AVA calculations

## Finding anchors

## Calculating AVA

## Initiating q-value calculations

## [1] "Creating output folder"
## [1] "Creating output feature tables folder"
## [1] "Creating output fits folder"
## [1] "Creating output figures folder"
## 2024-12-19 17:42:29.100976 INFO::Writing function arguments to log file
## 2024-12-19 17:42:29.109235 INFO::Verifying options selected are valid
## 2024-12-19 17:42:29.172778 INFO::Determining format of input files
## 2024-12-19 17:42:29.174304 INFO::Input format is data samples as columns and metadata samples as rows
## 2024-12-19 17:42:29.20018 INFO::Formula for fixed effects: expr ~  diagnosis + age + antibiotics
## 2024-12-19 17:42:29.20237 INFO::Filter data based on min abundance and min prevalence
## 2024-12-19 17:42:29.203381 INFO::Total samples in data: 102
## 2024-12-19 17:42:29.204346 INFO::Min samples required with min abundance for a feature not to be filtered: 0.000000
## 2024-12-19 17:42:29.218348 INFO::Total filtered features: 0
## 2024-12-19 17:42:29.219236 INFO::Filtered feature names from abundance and prevalence filtering:
## 2024-12-19 17:42:29.235967 INFO::Total filtered features with variance filtering: 0
## 2024-12-19 17:42:29.236884 INFO::Filtered feature names from variance filtering:
## 2024-12-19 17:42:29.237521 INFO::Running selected normalization method: NONE
## 2024-12-19 17:42:29.23816 INFO::Applying z-score to standardize continuous metadata
## 2024-12-19 17:42:29.256602 INFO::Running selected transform method: NONE
## 2024-12-19 17:42:29.257419 INFO::Running selected analysis method: LM
## 2024-12-19 17:42:29.262204 INFO::Fitting model to feature number 1, F1
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## 2024-12-19 17:42:29.81117 INFO::Fitting model to feature number 163, F169
## 2024-12-19 17:42:29.814568 INFO::Fitting model to feature number 164, F170
## 2024-12-19 17:42:29.817955 INFO::Fitting model to feature number 165, F171
## 2024-12-19 17:42:29.821299 INFO::Fitting model to feature number 166, F172
## 2024-12-19 17:42:29.824724 INFO::Fitting model to feature number 167, F173
## 2024-12-19 17:42:29.828143 INFO::Fitting model to feature number 168, F174
## 2024-12-19 17:42:29.831547 INFO::Fitting model to feature number 169, F175
## 2024-12-19 17:42:29.834945 INFO::Fitting model to feature number 170, F176
## 2024-12-19 17:42:29.83854 INFO::Fitting model to feature number 171, F177
## 2024-12-19 17:42:29.841872 INFO::Fitting model to feature number 172, F178
## 2024-12-19 17:42:29.845273 INFO::Fitting model to feature number 173, F179
## 2024-12-19 17:42:29.848678 INFO::Fitting model to feature number 174, F180
## 2024-12-19 17:42:29.852068 INFO::Fitting model to feature number 175, F181
## 2024-12-19 17:42:29.855471 INFO::Fitting model to feature number 176, F182
## 2024-12-19 17:42:29.858851 INFO::Fitting model to feature number 177, F183
## 2024-12-19 17:42:29.862188 INFO::Fitting model to feature number 178, F184
## 2024-12-19 17:42:29.865591 INFO::Fitting model to feature number 179, F185
## 2024-12-19 17:42:29.86899 INFO::Fitting model to feature number 180, F186
## 2024-12-19 17:42:29.872405 INFO::Fitting model to feature number 181, F187
## 2024-12-19 17:42:29.875823 INFO::Fitting model to feature number 182, F188
## 2024-12-19 17:42:29.879238 INFO::Fitting model to feature number 183, F189
## 2024-12-19 17:42:29.882662 INFO::Fitting model to feature number 184, F190
## 2024-12-19 17:42:29.886082 INFO::Fitting model to feature number 185, F191
## 2024-12-19 17:42:29.889512 INFO::Fitting model to feature number 186, F192
## 2024-12-19 17:42:29.892966 INFO::Fitting model to feature number 187, F193
## 2024-12-19 17:42:29.896421 INFO::Fitting model to feature number 188, F194
## 2024-12-19 17:42:29.899833 INFO::Fitting model to feature number 189, F195
## 2024-12-19 17:42:29.903275 INFO::Fitting model to feature number 190, F196
## 2024-12-19 17:42:29.906672 INFO::Fitting model to feature number 191, F197
## 2024-12-19 17:42:29.910054 INFO::Fitting model to feature number 192, F198
## 2024-12-19 17:42:29.913467 INFO::Fitting model to feature number 193, F199
## 2024-12-19 17:42:29.916851 INFO::Fitting model to feature number 194, F200
## 2024-12-19 17:42:29.920253 INFO::Fitting model to feature number 195, F201
## 2024-12-19 17:42:29.923634 INFO::Fitting model to feature number 196, F202
## 2024-12-19 17:42:29.927025 INFO::Fitting model to feature number 197, F203
## 2024-12-19 17:42:29.930418 INFO::Fitting model to feature number 198, F204
## 2024-12-19 17:42:29.933804 INFO::Fitting model to feature number 199, F206
## 2024-12-19 17:42:29.937173 INFO::Fitting model to feature number 200, F207
## 2024-12-19 17:42:29.940503 INFO::Fitting model to feature number 201, F208
## 2024-12-19 17:42:29.943835 INFO::Fitting model to feature number 202, F209
## 2024-12-19 17:42:29.947153 INFO::Fitting model to feature number 203, F210
## 2024-12-19 17:42:29.950558 INFO::Fitting model to feature number 204, F211
## 2024-12-19 17:42:29.953938 INFO::Fitting model to feature number 205, F212
## 2024-12-19 17:42:29.957388 INFO::Fitting model to feature number 206, F213
## 2024-12-19 17:42:29.960835 INFO::Fitting model to feature number 207, F214
## 2024-12-19 17:42:29.964225 INFO::Fitting model to feature number 208, F215
## 2024-12-19 17:42:29.967649 INFO::Fitting model to feature number 209, F216
## 2024-12-19 17:42:29.971086 INFO::Fitting model to feature number 210, F217
## 2024-12-19 17:42:29.97453 INFO::Fitting model to feature number 211, F218
## 2024-12-19 17:42:29.977958 INFO::Fitting model to feature number 212, F219
## 2024-12-19 17:42:29.981568 INFO::Fitting model to feature number 213, F220
## 2024-12-19 17:42:29.985004 INFO::Fitting model to feature number 214, F221
## 2024-12-19 17:42:29.988419 INFO::Fitting model to feature number 215, F222
## 2024-12-19 17:42:29.991741 INFO::Fitting model to feature number 216, F223
## 2024-12-19 17:42:29.995153 INFO::Fitting model to feature number 217, F224
## 2024-12-19 17:42:29.998538 INFO::Fitting model to feature number 218, F225
## 2024-12-19 17:42:30.001938 INFO::Fitting model to feature number 219, F226
## 2024-12-19 17:42:30.00534 INFO::Fitting model to feature number 220, F227
## 2024-12-19 17:42:30.008666 INFO::Fitting model to feature number 221, F228
## 2024-12-19 17:42:30.01205 INFO::Fitting model to feature number 222, F229
## 2024-12-19 17:42:30.015453 INFO::Fitting model to feature number 223, F230
## 2024-12-19 17:42:30.018852 INFO::Fitting model to feature number 224, F231
## 2024-12-19 17:42:30.022244 INFO::Fitting model to feature number 225, F232
## 2024-12-19 17:42:30.02562 INFO::Fitting model to feature number 226, F233
## 2024-12-19 17:42:30.029013 INFO::Fitting model to feature number 227, F234
## 2024-12-19 17:42:30.032429 INFO::Fitting model to feature number 228, F235
## 2024-12-19 17:42:30.03581 INFO::Fitting model to feature number 229, F236
## 2024-12-19 17:42:30.039222 INFO::Fitting model to feature number 230, F237
## 2024-12-19 17:42:30.042531 INFO::Fitting model to feature number 231, F238
## 2024-12-19 17:42:30.045919 INFO::Fitting model to feature number 232, F239
## 2024-12-19 17:42:30.049244 INFO::Fitting model to feature number 233, F240
## 2024-12-19 17:42:30.052619 INFO::Fitting model to feature number 234, F241
## 2024-12-19 17:42:30.055995 INFO::Fitting model to feature number 235, F242
## 2024-12-19 17:42:30.059386 INFO::Fitting model to feature number 236, F243
## 2024-12-19 17:42:30.062773 INFO::Fitting model to feature number 237, F244
## 2024-12-19 17:42:30.066083 INFO::Fitting model to feature number 238, F245
## 2024-12-19 17:42:30.069467 INFO::Fitting model to feature number 239, F246
## 2024-12-19 17:42:30.072779 INFO::Fitting model to feature number 240, F247
## 2024-12-19 17:42:30.076103 INFO::Fitting model to feature number 241, F248
## 2024-12-19 17:42:30.079425 INFO::Fitting model to feature number 242, F249
## 2024-12-19 17:42:30.082805 INFO::Fitting model to feature number 243, F250
## 2024-12-19 17:42:30.086187 INFO::Fitting model to feature number 244, F252
## 2024-12-19 17:42:30.089593 INFO::Fitting model to feature number 245, F253
## 2024-12-19 17:42:30.092909 INFO::Fitting model to feature number 246, F254
## 2024-12-19 17:42:30.096271 INFO::Fitting model to feature number 247, F255
## 2024-12-19 17:42:30.09965 INFO::Fitting model to feature number 248, F256
## 2024-12-19 17:42:30.103025 INFO::Fitting model to feature number 249, F257
## 2024-12-19 17:42:30.10637 INFO::Fitting model to feature number 250, F259
## 2024-12-19 17:42:30.109681 INFO::Fitting model to feature number 251, F260
## 2024-12-19 17:42:30.113075 INFO::Fitting model to feature number 252, F261
## 2024-12-19 17:42:30.116481 INFO::Fitting model to feature number 253, F262
## 2024-12-19 17:42:30.119807 INFO::Fitting model to feature number 254, F263
## 2024-12-19 17:42:30.123348 INFO::Fitting model to feature number 255, F264
## 2024-12-19 17:42:30.126679 INFO::Fitting model to feature number 256, F265
## 2024-12-19 17:42:30.130008 INFO::Fitting model to feature number 257, F266
## 2024-12-19 17:42:30.133398 INFO::Fitting model to feature number 258, F267
## 2024-12-19 17:42:30.136735 INFO::Fitting model to feature number 259, F269
## 2024-12-19 17:42:30.140118 INFO::Fitting model to feature number 260, F270
## 2024-12-19 17:42:30.143441 INFO::Fitting model to feature number 261, F271
## 2024-12-19 17:42:30.146834 INFO::Fitting model to feature number 262, F272
## 2024-12-19 17:42:30.15015 INFO::Fitting model to feature number 263, F273
## 2024-12-19 17:42:30.153548 INFO::Fitting model to feature number 264, F274
## 2024-12-19 17:42:30.156865 INFO::Fitting model to feature number 265, F276
## 2024-12-19 17:42:30.16017 INFO::Fitting model to feature number 266, F277
## 2024-12-19 17:42:30.163503 INFO::Fitting model to feature number 267, F278
## 2024-12-19 17:42:30.166917 INFO::Fitting model to feature number 268, F279
## 2024-12-19 17:42:30.170327 INFO::Fitting model to feature number 269, F280
## 2024-12-19 17:42:30.173748 INFO::Fitting model to feature number 270, F281
## 2024-12-19 17:42:30.177147 INFO::Fitting model to feature number 271, F282
## 2024-12-19 17:42:30.180525 INFO::Fitting model to feature number 272, F283
## 2024-12-19 17:42:30.183918 INFO::Fitting model to feature number 273, F284
## 2024-12-19 17:42:30.187349 INFO::Fitting model to feature number 274, F285
## 2024-12-19 17:42:30.190664 INFO::Fitting model to feature number 275, F286
## 2024-12-19 17:42:30.194116 INFO::Fitting model to feature number 276, F287
## 2024-12-19 17:42:30.197503 INFO::Fitting model to feature number 277, F288
## 2024-12-19 17:42:30.200901 INFO::Fitting model to feature number 278, F289
## 2024-12-19 17:42:30.204311 INFO::Fitting model to feature number 279, F290
## 2024-12-19 17:42:30.207709 INFO::Fitting model to feature number 280, F292
## 2024-12-19 17:42:30.211132 INFO::Fitting model to feature number 281, F293
## 2024-12-19 17:42:30.21456 INFO::Fitting model to feature number 282, F294
## 2024-12-19 17:42:30.218002 INFO::Fitting model to feature number 283, F295
## 2024-12-19 17:42:30.221436 INFO::Fitting model to feature number 284, F296
## 2024-12-19 17:42:30.246873 INFO::Fitting model to feature number 285, F297
## 2024-12-19 17:42:30.250514 INFO::Fitting model to feature number 286, F298
## 2024-12-19 17:42:30.2539 INFO::Fitting model to feature number 287, F299
## 2024-12-19 17:42:30.257239 INFO::Fitting model to feature number 288, F300
## 2024-12-19 17:42:30.260566 INFO::Fitting model to feature number 289, F301
## 2024-12-19 17:42:30.263909 INFO::Fitting model to feature number 290, F302
## 2024-12-19 17:42:30.267187 INFO::Fitting model to feature number 291, F303
## 2024-12-19 17:42:30.270479 INFO::Fitting model to feature number 292, F304
## 2024-12-19 17:42:30.273707 INFO::Fitting model to feature number 293, F305
## 2024-12-19 17:42:30.276923 INFO::Fitting model to feature number 294, F306
## 2024-12-19 17:42:30.280139 INFO::Fitting model to feature number 295, F307
## 2024-12-19 17:42:30.283375 INFO::Fitting model to feature number 296, F308
## 2024-12-19 17:42:30.286519 INFO::Fitting model to feature number 297, F309
## 2024-12-19 17:42:30.289709 INFO::Fitting model to feature number 298, F310
## 2024-12-19 17:42:30.292851 INFO::Fitting model to feature number 299, F311
## 2024-12-19 17:42:30.296062 INFO::Fitting model to feature number 300, F312
## 2024-12-19 17:42:30.29925 INFO::Fitting model to feature number 301, F313
## 2024-12-19 17:42:30.302436 INFO::Fitting model to feature number 302, F315
## 2024-12-19 17:42:30.305544 INFO::Fitting model to feature number 303, F316
## 2024-12-19 17:42:30.308718 INFO::Fitting model to feature number 304, F317
## 2024-12-19 17:42:30.311876 INFO::Fitting model to feature number 305, F318
## 2024-12-19 17:42:30.315069 INFO::Fitting model to feature number 306, F319
## 2024-12-19 17:42:30.318192 INFO::Fitting model to feature number 307, F320
## 2024-12-19 17:42:30.321389 INFO::Fitting model to feature number 308, F321
## 2024-12-19 17:42:30.324585 INFO::Fitting model to feature number 309, F322
## 2024-12-19 17:42:30.327778 INFO::Fitting model to feature number 310, F323
## 2024-12-19 17:42:30.330971 INFO::Fitting model to feature number 311, F324
## 2024-12-19 17:42:30.334164 INFO::Fitting model to feature number 312, F325
## 2024-12-19 17:42:30.337355 INFO::Fitting model to feature number 313, F326
## 2024-12-19 17:42:30.340547 INFO::Fitting model to feature number 314, F327
## 2024-12-19 17:42:30.343735 INFO::Fitting model to feature number 315, F328
## 2024-12-19 17:42:30.346928 INFO::Fitting model to feature number 316, F329
## 2024-12-19 17:42:30.350109 INFO::Fitting model to feature number 317, F330
## 2024-12-19 17:42:30.353289 INFO::Fitting model to feature number 318, F331
## 2024-12-19 17:42:30.35646 INFO::Fitting model to feature number 319, F332
## 2024-12-19 17:42:30.359637 INFO::Fitting model to feature number 320, F333
## 2024-12-19 17:42:30.362816 INFO::Fitting model to feature number 321, F334
## 2024-12-19 17:42:30.366004 INFO::Fitting model to feature number 322, F335
## 2024-12-19 17:42:30.369106 INFO::Fitting model to feature number 323, F336
## 2024-12-19 17:42:30.372298 INFO::Fitting model to feature number 324, F337
## 2024-12-19 17:42:30.375475 INFO::Fitting model to feature number 325, F338
## 2024-12-19 17:42:30.378655 INFO::Fitting model to feature number 326, F339
## 2024-12-19 17:42:30.381764 INFO::Fitting model to feature number 327, F340
## 2024-12-19 17:42:30.384857 INFO::Fitting model to feature number 328, F342
## 2024-12-19 17:42:30.388034 INFO::Fitting model to feature number 329, F343
## 2024-12-19 17:42:30.391242 INFO::Fitting model to feature number 330, F344
## 2024-12-19 17:42:30.394428 INFO::Fitting model to feature number 331, F345
## 2024-12-19 17:42:30.397625 INFO::Fitting model to feature number 332, F346
## 2024-12-19 17:42:30.400799 INFO::Fitting model to feature number 333, F347
## 2024-12-19 17:42:30.403961 INFO::Fitting model to feature number 334, F348
## 2024-12-19 17:42:30.407128 INFO::Fitting model to feature number 335, F350
## 2024-12-19 17:42:30.410315 INFO::Fitting model to feature number 336, F351
## 2024-12-19 17:42:30.413486 INFO::Fitting model to feature number 337, F352
## 2024-12-19 17:42:30.416677 INFO::Fitting model to feature number 338, F353
## 2024-12-19 17:42:30.419875 INFO::Fitting model to feature number 339, F355
## 2024-12-19 17:42:30.423069 INFO::Fitting model to feature number 340, F356
## 2024-12-19 17:42:30.426261 INFO::Fitting model to feature number 341, F357
## 2024-12-19 17:42:30.429433 INFO::Fitting model to feature number 342, F358
## 2024-12-19 17:42:30.432606 INFO::Fitting model to feature number 343, F359
## 2024-12-19 17:42:30.435775 INFO::Fitting model to feature number 344, F360
## 2024-12-19 17:42:30.438949 INFO::Fitting model to feature number 345, F361
## 2024-12-19 17:42:30.442126 INFO::Fitting model to feature number 346, F362
## 2024-12-19 17:42:30.445321 INFO::Fitting model to feature number 347, F363
## 2024-12-19 17:42:30.448507 INFO::Fitting model to feature number 348, F364
## 2024-12-19 17:42:30.451715 INFO::Fitting model to feature number 349, F365
## 2024-12-19 17:42:30.454893 INFO::Fitting model to feature number 350, F366
## 2024-12-19 17:42:30.458088 INFO::Fitting model to feature number 351, F367
## 2024-12-19 17:42:30.461284 INFO::Fitting model to feature number 352, F368
## 2024-12-19 17:42:30.46447 INFO::Fitting model to feature number 353, F369
## 2024-12-19 17:42:30.467666 INFO::Fitting model to feature number 354, F370
## 2024-12-19 17:42:30.470845 INFO::Fitting model to feature number 355, F371
## 2024-12-19 17:42:30.474032 INFO::Fitting model to feature number 356, F372
## 2024-12-19 17:42:30.477231 INFO::Fitting model to feature number 357, F373
## 2024-12-19 17:42:30.480406 INFO::Fitting model to feature number 358, F374
## 2024-12-19 17:42:30.48358 INFO::Fitting model to feature number 359, F375
## 2024-12-19 17:42:30.486764 INFO::Fitting model to feature number 360, F376
## 2024-12-19 17:42:30.489887 INFO::Fitting model to feature number 361, F377
## 2024-12-19 17:42:30.493105 INFO::Fitting model to feature number 362, F378
## 2024-12-19 17:42:30.496323 INFO::Fitting model to feature number 363, F379
## 2024-12-19 17:42:30.499435 INFO::Fitting model to feature number 364, F380
## 2024-12-19 17:42:30.502615 INFO::Fitting model to feature number 365, F381
## 2024-12-19 17:42:30.505774 INFO::Fitting model to feature number 366, F382
## 2024-12-19 17:42:30.508969 INFO::Fitting model to feature number 367, F383
## 2024-12-19 17:42:30.51209 INFO::Fitting model to feature number 368, F384
## 2024-12-19 17:42:30.515292 INFO::Fitting model to feature number 369, F386
## 2024-12-19 17:42:30.518417 INFO::Fitting model to feature number 370, F387
## 2024-12-19 17:42:30.52159 INFO::Fitting model to feature number 371, F388
## 2024-12-19 17:42:30.524756 INFO::Fitting model to feature number 372, F389
## 2024-12-19 17:42:30.527932 INFO::Fitting model to feature number 373, F390
## 2024-12-19 17:42:30.531121 INFO::Fitting model to feature number 374, F391
## 2024-12-19 17:42:30.53432 INFO::Fitting model to feature number 375, F392
## 2024-12-19 17:42:30.537515 INFO::Fitting model to feature number 376, F393
## 2024-12-19 17:42:30.54071 INFO::Fitting model to feature number 377, F394
## 2024-12-19 17:42:30.543847 INFO::Fitting model to feature number 378, F395
## 2024-12-19 17:42:30.546985 INFO::Fitting model to feature number 379, F396
## 2024-12-19 17:42:30.550176 INFO::Fitting model to feature number 380, F397
## 2024-12-19 17:42:30.553382 INFO::Fitting model to feature number 381, F398
## 2024-12-19 17:42:30.556566 INFO::Fitting model to feature number 382, F399
## 2024-12-19 17:42:30.559769 INFO::Fitting model to feature number 383, F400
## 2024-12-19 17:42:30.562949 INFO::Fitting model to feature number 384, F401
## 2024-12-19 17:42:30.566129 INFO::Fitting model to feature number 385, F402
## 2024-12-19 17:42:30.569312 INFO::Fitting model to feature number 386, F403
## 2024-12-19 17:42:30.572441 INFO::Fitting model to feature number 387, F404
## 2024-12-19 17:42:30.575653 INFO::Fitting model to feature number 388, F406
## 2024-12-19 17:42:30.578841 INFO::Fitting model to feature number 389, F407
## 2024-12-19 17:42:30.582036 INFO::Fitting model to feature number 390, F408
## 2024-12-19 17:42:30.58522 INFO::Fitting model to feature number 391, F409
## 2024-12-19 17:42:30.588401 INFO::Fitting model to feature number 392, F410
## 2024-12-19 17:42:30.591609 INFO::Fitting model to feature number 393, F411
## 2024-12-19 17:42:30.594845 INFO::Fitting model to feature number 394, F412
## 2024-12-19 17:42:30.598008 INFO::Fitting model to feature number 395, F413
## 2024-12-19 17:42:30.601184 INFO::Fitting model to feature number 396, F414
## 2024-12-19 17:42:30.60438 INFO::Fitting model to feature number 397, F415
## 2024-12-19 17:42:30.607499 INFO::Fitting model to feature number 398, F416
## 2024-12-19 17:42:30.610627 INFO::Fitting model to feature number 399, F417
## 2024-12-19 17:42:30.613829 INFO::Fitting model to feature number 400, F418
## 2024-12-19 17:42:30.617032 INFO::Fitting model to feature number 401, F419
## 2024-12-19 17:42:30.620257 INFO::Fitting model to feature number 402, F420
## 2024-12-19 17:42:30.623468 INFO::Fitting model to feature number 403, F421
## 2024-12-19 17:42:30.62667 INFO::Fitting model to feature number 404, F422
## 2024-12-19 17:42:30.629911 INFO::Fitting model to feature number 405, F423
## 2024-12-19 17:42:30.633141 INFO::Fitting model to feature number 406, F425
## 2024-12-19 17:42:30.636278 INFO::Fitting model to feature number 407, F426
## 2024-12-19 17:42:30.639483 INFO::Fitting model to feature number 408, F428
## 2024-12-19 17:42:30.642703 INFO::Fitting model to feature number 409, F429
## 2024-12-19 17:42:30.645836 INFO::Fitting model to feature number 410, F430
## 2024-12-19 17:42:30.648972 INFO::Fitting model to feature number 411, F431
## 2024-12-19 17:42:30.652186 INFO::Fitting model to feature number 412, F432
## 2024-12-19 17:42:30.65539 INFO::Fitting model to feature number 413, F433
## 2024-12-19 17:42:30.658609 INFO::Fitting model to feature number 414, F434
## 2024-12-19 17:42:30.661804 INFO::Fitting model to feature number 415, F435
## 2024-12-19 17:42:30.665 INFO::Fitting model to feature number 416, F436
## 2024-12-19 17:42:30.668227 INFO::Fitting model to feature number 417, F437
## 2024-12-19 17:42:30.671448 INFO::Fitting model to feature number 418, F438
## 2024-12-19 17:42:30.674649 INFO::Fitting model to feature number 419, F439
## 2024-12-19 17:42:30.67778 INFO::Fitting model to feature number 420, F440
## 2024-12-19 17:42:30.680979 INFO::Fitting model to feature number 421, F441
## 2024-12-19 17:42:30.684184 INFO::Fitting model to feature number 422, F442
## 2024-12-19 17:42:30.687396 INFO::Fitting model to feature number 423, F443
## 2024-12-19 17:42:30.690626 INFO::Fitting model to feature number 424, F444
## 2024-12-19 17:42:30.693771 INFO::Fitting model to feature number 425, F445
## 2024-12-19 17:42:30.697001 INFO::Fitting model to feature number 426, F446
## 2024-12-19 17:42:30.700183 INFO::Fitting model to feature number 427, F447
## 2024-12-19 17:42:30.703417 INFO::Fitting model to feature number 428, F448
## 2024-12-19 17:42:30.706642 INFO::Fitting model to feature number 429, F449
## 2024-12-19 17:42:30.709888 INFO::Fitting model to feature number 430, F450
## 2024-12-19 17:42:30.713094 INFO::Fitting model to feature number 431, F451
## 2024-12-19 17:42:30.71631 INFO::Fitting model to feature number 432, F452
## 2024-12-19 17:42:30.719689 INFO::Fitting model to feature number 433, F454
## 2024-12-19 17:42:30.722941 INFO::Fitting model to feature number 434, F455
## 2024-12-19 17:42:30.726272 INFO::Fitting model to feature number 435, F456
## 2024-12-19 17:42:30.729599 INFO::Fitting model to feature number 436, F457
## 2024-12-19 17:42:30.732894 INFO::Fitting model to feature number 437, F458
## 2024-12-19 17:42:30.736305 INFO::Fitting model to feature number 438, F459
## 2024-12-19 17:42:30.739629 INFO::Fitting model to feature number 439, F461
## 2024-12-19 17:42:30.742939 INFO::Fitting model to feature number 440, F462
## 2024-12-19 17:42:30.746243 INFO::Fitting model to feature number 441, F463
## 2024-12-19 17:42:30.749518 INFO::Fitting model to feature number 442, F464
## 2024-12-19 17:42:30.752846 INFO::Fitting model to feature number 443, F465
## 2024-12-19 17:42:30.75609 INFO::Fitting model to feature number 444, F466
## 2024-12-19 17:42:30.759444 INFO::Fitting model to feature number 445, F467
## 2024-12-19 17:42:30.76285 INFO::Fitting model to feature number 446, F468
## 2024-12-19 17:42:30.766243 INFO::Fitting model to feature number 447, F469
## 2024-12-19 17:42:30.76955 INFO::Fitting model to feature number 448, F470
## 2024-12-19 17:42:30.772947 INFO::Fitting model to feature number 449, F471
## 2024-12-19 17:42:30.77632 INFO::Fitting model to feature number 450, F474
## 2024-12-19 17:42:30.779679 INFO::Fitting model to feature number 451, F475
## 2024-12-19 17:42:30.782998 INFO::Fitting model to feature number 452, F476
## 2024-12-19 17:42:30.786273 INFO::Fitting model to feature number 453, F477
## 2024-12-19 17:42:30.789598 INFO::Fitting model to feature number 454, F478
## 2024-12-19 17:42:30.792881 INFO::Fitting model to feature number 455, F479
## 2024-12-19 17:42:30.79628 INFO::Fitting model to feature number 456, F480
## 2024-12-19 17:42:30.799577 INFO::Fitting model to feature number 457, F481
## 2024-12-19 17:42:30.802912 INFO::Fitting model to feature number 458, F482
## 2024-12-19 17:42:30.806149 INFO::Fitting model to feature number 459, F483
## 2024-12-19 17:42:30.809416 INFO::Fitting model to feature number 460, F484
## 2024-12-19 17:42:30.81271 INFO::Fitting model to feature number 461, F485
## 2024-12-19 17:42:30.815939 INFO::Fitting model to feature number 462, F486
## 2024-12-19 17:42:30.819239 INFO::Fitting model to feature number 463, F487
## 2024-12-19 17:42:30.822539 INFO::Fitting model to feature number 464, F488
## 2024-12-19 17:42:30.825827 INFO::Fitting model to feature number 465, F489
## 2024-12-19 17:42:30.829101 INFO::Fitting model to feature number 466, F490
## 2024-12-19 17:42:30.832368 INFO::Fitting model to feature number 467, F491
## 2024-12-19 17:42:30.835565 INFO::Fitting model to feature number 468, F492
## 2024-12-19 17:42:30.838764 INFO::Fitting model to feature number 469, F493
## 2024-12-19 17:42:30.842025 INFO::Fitting model to feature number 470, F494
## 2024-12-19 17:42:30.845305 INFO::Fitting model to feature number 471, F495
## 2024-12-19 17:42:30.848574 INFO::Fitting model to feature number 472, F496
## 2024-12-19 17:42:30.851833 INFO::Fitting model to feature number 473, F497
## 2024-12-19 17:42:30.855088 INFO::Fitting model to feature number 474, F498
## 2024-12-19 17:42:30.858361 INFO::Fitting model to feature number 475, F499
## 2024-12-19 17:42:30.861621 INFO::Fitting model to feature number 476, F500
## 2024-12-19 17:42:30.864812 INFO::Fitting model to feature number 477, F501
## 2024-12-19 17:42:30.868072 INFO::Fitting model to feature number 478, F502
## 2024-12-19 17:42:30.87134 INFO::Fitting model to feature number 479, F503
## 2024-12-19 17:42:30.874598 INFO::Fitting model to feature number 480, F504
## 2024-12-19 17:42:30.877858 INFO::Fitting model to feature number 481, F505
## 2024-12-19 17:42:30.881126 INFO::Fitting model to feature number 482, F506
## 2024-12-19 17:42:30.884389 INFO::Fitting model to feature number 483, F507
## 2024-12-19 17:42:30.887655 INFO::Fitting model to feature number 484, F508
## 2024-12-19 17:42:30.890906 INFO::Fitting model to feature number 485, F509
## 2024-12-19 17:42:30.894191 INFO::Fitting model to feature number 486, F510
## 2024-12-19 17:42:30.897472 INFO::Fitting model to feature number 487, F511
## 2024-12-19 17:42:30.900746 INFO::Fitting model to feature number 488, F512
## 2024-12-19 17:42:30.90403 INFO::Fitting model to feature number 489, F513
## 2024-12-19 17:42:30.907345 INFO::Fitting model to feature number 490, F514
## 2024-12-19 17:42:30.910583 INFO::Fitting model to feature number 491, F515
## 2024-12-19 17:42:30.913868 INFO::Fitting model to feature number 492, F516
## 2024-12-19 17:42:30.917149 INFO::Fitting model to feature number 493, F517
## 2024-12-19 17:42:30.920444 INFO::Fitting model to feature number 494, F518
## 2024-12-19 17:42:30.923739 INFO::Fitting model to feature number 495, F519
## 2024-12-19 17:42:30.92702 INFO::Fitting model to feature number 496, F520
## 2024-12-19 17:42:30.93032 INFO::Fitting model to feature number 497, F521
## 2024-12-19 17:42:30.933587 INFO::Fitting model to feature number 498, F522
## 2024-12-19 17:42:30.936873 INFO::Fitting model to feature number 499, F523
## 2024-12-19 17:42:30.940157 INFO::Fitting model to feature number 500, F524
## 2024-12-19 17:42:30.943384 INFO::Fitting model to feature number 501, F525
## 2024-12-19 17:42:30.946665 INFO::Fitting model to feature number 502, F526
## 2024-12-19 17:42:30.949921 INFO::Fitting model to feature number 503, F527
## 2024-12-19 17:42:30.953178 INFO::Fitting model to feature number 504, F528
## 2024-12-19 17:42:30.956449 INFO::Fitting model to feature number 505, F529
## 2024-12-19 17:42:30.959742 INFO::Fitting model to feature number 506, F530
## 2024-12-19 17:42:30.963019 INFO::Fitting model to feature number 507, F531
## 2024-12-19 17:42:30.96632 INFO::Fitting model to feature number 508, F532
## 2024-12-19 17:42:30.96958 INFO::Fitting model to feature number 509, F533
## 2024-12-19 17:42:30.972838 INFO::Fitting model to feature number 510, F534
## 2024-12-19 17:42:30.976106 INFO::Fitting model to feature number 511, F535
## 2024-12-19 17:42:30.979362 INFO::Fitting model to feature number 512, F536
## 2024-12-19 17:42:30.982562 INFO::Fitting model to feature number 513, F537
## 2024-12-19 17:42:30.985766 INFO::Fitting model to feature number 514, F539
## 2024-12-19 17:42:30.989019 INFO::Fitting model to feature number 515, F540
## 2024-12-19 17:42:30.992279 INFO::Fitting model to feature number 516, F541
## 2024-12-19 17:42:30.995559 INFO::Fitting model to feature number 517, F543
## 2024-12-19 17:42:30.998838 INFO::Fitting model to feature number 518, F544
## 2024-12-19 17:42:31.002044 INFO::Fitting model to feature number 519, F545
## 2024-12-19 17:42:31.005266 INFO::Fitting model to feature number 520, F546
## 2024-12-19 17:42:31.008482 INFO::Fitting model to feature number 521, F547
## 2024-12-19 17:42:31.011739 INFO::Fitting model to feature number 522, F548
## 2024-12-19 17:42:31.014947 INFO::Fitting model to feature number 523, F549
## 2024-12-19 17:42:31.018215 INFO::Fitting model to feature number 524, F550
## 2024-12-19 17:42:31.021495 INFO::Fitting model to feature number 525, F551
## 2024-12-19 17:42:31.024739 INFO::Fitting model to feature number 526, F552
## 2024-12-19 17:42:31.027993 INFO::Fitting model to feature number 527, F553
## 2024-12-19 17:42:31.031253 INFO::Fitting model to feature number 528, F554
## 2024-12-19 17:42:31.0345 INFO::Fitting model to feature number 529, F555
## 2024-12-19 17:42:31.037742 INFO::Fitting model to feature number 530, F556
## 2024-12-19 17:42:31.040989 INFO::Fitting model to feature number 531, F557
## 2024-12-19 17:42:31.044235 INFO::Fitting model to feature number 532, F558
## 2024-12-19 17:42:31.047471 INFO::Fitting model to feature number 533, F559
## 2024-12-19 17:42:31.050722 INFO::Fitting model to feature number 534, F560
## 2024-12-19 17:42:31.053973 INFO::Fitting model to feature number 535, F561
## 2024-12-19 17:42:31.057234 INFO::Fitting model to feature number 536, F562
## 2024-12-19 17:42:31.06046 INFO::Fitting model to feature number 537, F563
## 2024-12-19 17:42:31.063705 INFO::Fitting model to feature number 538, F564
## 2024-12-19 17:42:31.066949 INFO::Fitting model to feature number 539, F566
## 2024-12-19 17:42:31.070193 INFO::Fitting model to feature number 540, F567
## 2024-12-19 17:42:31.073452 INFO::Fitting model to feature number 541, F568
## 2024-12-19 17:42:31.076687 INFO::Fitting model to feature number 542, F569
## 2024-12-19 17:42:31.079944 INFO::Fitting model to feature number 543, F570
## 2024-12-19 17:42:31.083208 INFO::Fitting model to feature number 544, F571
## 2024-12-19 17:42:31.086394 INFO::Fitting model to feature number 545, F572
## 2024-12-19 17:42:31.089633 INFO::Fitting model to feature number 546, F573
## 2024-12-19 17:42:31.092831 INFO::Fitting model to feature number 547, F574
## 2024-12-19 17:42:31.096094 INFO::Fitting model to feature number 548, F575
## 2024-12-19 17:42:31.099369 INFO::Fitting model to feature number 549, F576
## 2024-12-19 17:42:31.102665 INFO::Fitting model to feature number 550, F577
## 2024-12-19 17:42:31.105948 INFO::Fitting model to feature number 551, F578
## 2024-12-19 17:42:31.109157 INFO::Fitting model to feature number 552, F579
## 2024-12-19 17:42:31.112437 INFO::Fitting model to feature number 553, F580
## 2024-12-19 17:42:31.115626 INFO::Fitting model to feature number 554, F581
## 2024-12-19 17:42:31.118802 INFO::Fitting model to feature number 555, F582
## 2024-12-19 17:42:31.122014 INFO::Fitting model to feature number 556, F583
## 2024-12-19 17:42:31.125279 INFO::Fitting model to feature number 557, F584
## 2024-12-19 17:42:31.128531 INFO::Fitting model to feature number 558, F585
## 2024-12-19 17:42:31.131796 INFO::Fitting model to feature number 559, F586
## 2024-12-19 17:42:31.135002 INFO::Fitting model to feature number 560, F587
## 2024-12-19 17:42:31.138297 INFO::Fitting model to feature number 561, F588
## 2024-12-19 17:42:31.141569 INFO::Fitting model to feature number 562, F589
## 2024-12-19 17:42:31.1546 INFO::Fitting model to feature number 563, F590
## 2024-12-19 17:42:31.158147 INFO::Fitting model to feature number 564, F591
## 2024-12-19 17:42:31.161502 INFO::Fitting model to feature number 565, F592
## 2024-12-19 17:42:31.164793 INFO::Fitting model to feature number 566, F593
## 2024-12-19 17:42:31.168072 INFO::Fitting model to feature number 567, F594
## 2024-12-19 17:42:31.171396 INFO::Fitting model to feature number 568, F595
## 2024-12-19 17:42:31.174718 INFO::Fitting model to feature number 569, F596
## 2024-12-19 17:42:31.178046 INFO::Fitting model to feature number 570, F597
## 2024-12-19 17:42:31.181375 INFO::Fitting model to feature number 571, F598
## 2024-12-19 17:42:31.184647 INFO::Fitting model to feature number 572, F599
## 2024-12-19 17:42:31.187932 INFO::Fitting model to feature number 573, F600
## 2024-12-19 17:42:31.191212 INFO::Fitting model to feature number 574, F601
## 2024-12-19 17:42:31.194428 INFO::Fitting model to feature number 575, F602
## 2024-12-19 17:42:31.197714 INFO::Fitting model to feature number 576, F603
## 2024-12-19 17:42:31.200972 INFO::Fitting model to feature number 577, F605
## 2024-12-19 17:42:31.204249 INFO::Fitting model to feature number 578, F606
## 2024-12-19 17:42:31.207521 INFO::Fitting model to feature number 579, F607
## 2024-12-19 17:42:31.21079 INFO::Fitting model to feature number 580, F608
## 2024-12-19 17:42:31.214074 INFO::Fitting model to feature number 581, F609
## 2024-12-19 17:42:31.217388 INFO::Fitting model to feature number 582, F610
## 2024-12-19 17:42:31.220682 INFO::Fitting model to feature number 583, F611
## 2024-12-19 17:42:31.223912 INFO::Fitting model to feature number 584, F612
## 2024-12-19 17:42:31.227212 INFO::Fitting model to feature number 585, F613
## 2024-12-19 17:42:31.230485 INFO::Fitting model to feature number 586, F614
## 2024-12-19 17:42:31.233768 INFO::Fitting model to feature number 587, F615
## 2024-12-19 17:42:31.237056 INFO::Fitting model to feature number 588, F616
## 2024-12-19 17:42:31.24031 INFO::Fitting model to feature number 589, F617
## 2024-12-19 17:42:31.243596 INFO::Fitting model to feature number 590, F618
## 2024-12-19 17:42:31.246887 INFO::Fitting model to feature number 591, F619
## 2024-12-19 17:42:31.250165 INFO::Fitting model to feature number 592, F620
## 2024-12-19 17:42:31.253444 INFO::Fitting model to feature number 593, F621
## 2024-12-19 17:42:31.256734 INFO::Fitting model to feature number 594, F622
## 2024-12-19 17:42:31.259967 INFO::Fitting model to feature number 595, F623
## 2024-12-19 17:42:31.263263 INFO::Fitting model to feature number 596, F624
## 2024-12-19 17:42:31.266538 INFO::Fitting model to feature number 597, F625
## 2024-12-19 17:42:31.26976 INFO::Fitting model to feature number 598, F626
## 2024-12-19 17:42:31.273037 INFO::Fitting model to feature number 599, F627
## 2024-12-19 17:42:31.276323 INFO::Fitting model to feature number 600, F628
## 2024-12-19 17:42:31.279615 INFO::Fitting model to feature number 601, F629
## 2024-12-19 17:42:31.282867 INFO::Fitting model to feature number 602, F630
## 2024-12-19 17:42:31.286067 INFO::Fitting model to feature number 603, F631
## 2024-12-19 17:42:31.289286 INFO::Fitting model to feature number 604, F632
## 2024-12-19 17:42:31.29251 INFO::Fitting model to feature number 605, F633
## 2024-12-19 17:42:31.324977 INFO::Fitting model to feature number 606, F634
## 2024-12-19 17:42:31.328612 INFO::Fitting model to feature number 607, F635
## 2024-12-19 17:42:31.332009 INFO::Fitting model to feature number 608, F636
## 2024-12-19 17:42:31.335265 INFO::Fitting model to feature number 609, F637
## 2024-12-19 17:42:31.338521 INFO::Fitting model to feature number 610, F638
## 2024-12-19 17:42:31.341784 INFO::Fitting model to feature number 611, F639
## 2024-12-19 17:42:31.34507 INFO::Fitting model to feature number 612, F640
## 2024-12-19 17:42:31.348266 INFO::Fitting model to feature number 613, F641
## 2024-12-19 17:42:31.351472 INFO::Fitting model to feature number 614, F642
## 2024-12-19 17:42:31.354684 INFO::Fitting model to feature number 615, F643
## 2024-12-19 17:42:31.357886 INFO::Fitting model to feature number 616, F644
## 2024-12-19 17:42:31.361087 INFO::Fitting model to feature number 617, F645
## 2024-12-19 17:42:31.364231 INFO::Fitting model to feature number 618, F646
## 2024-12-19 17:42:31.367419 INFO::Fitting model to feature number 619, F647
## 2024-12-19 17:42:31.370605 INFO::Fitting model to feature number 620, F648
## 2024-12-19 17:42:31.373783 INFO::Fitting model to feature number 621, F649
## 2024-12-19 17:42:31.376963 INFO::Fitting model to feature number 622, F650
## 2024-12-19 17:42:31.380139 INFO::Fitting model to feature number 623, F651
## 2024-12-19 17:42:31.383261 INFO::Fitting model to feature number 624, F652
## 2024-12-19 17:42:31.38643 INFO::Fitting model to feature number 625, F653
## 2024-12-19 17:42:31.389617 INFO::Fitting model to feature number 626, F654
## 2024-12-19 17:42:31.392801 INFO::Fitting model to feature number 627, F655
## 2024-12-19 17:42:31.396011 INFO::Fitting model to feature number 628, F656
## 2024-12-19 17:42:31.399229 INFO::Fitting model to feature number 629, F657
## 2024-12-19 17:42:31.402428 INFO::Fitting model to feature number 630, F658
## 2024-12-19 17:42:31.405609 INFO::Fitting model to feature number 631, F659
## 2024-12-19 17:42:31.408737 INFO::Fitting model to feature number 632, F660
## 2024-12-19 17:42:31.411927 INFO::Fitting model to feature number 633, F661
## 2024-12-19 17:42:31.415107 INFO::Fitting model to feature number 634, F662
## 2024-12-19 17:42:31.418231 INFO::Fitting model to feature number 635, F663
## 2024-12-19 17:42:31.421401 INFO::Fitting model to feature number 636, F664
## 2024-12-19 17:42:31.424603 INFO::Fitting model to feature number 637, F665
## 2024-12-19 17:42:31.427805 INFO::Fitting model to feature number 638, F666
## 2024-12-19 17:42:31.431013 INFO::Fitting model to feature number 639, F667
## 2024-12-19 17:42:31.434216 INFO::Fitting model to feature number 640, F668
## 2024-12-19 17:42:31.437429 INFO::Fitting model to feature number 641, F669
## 2024-12-19 17:42:31.440652 INFO::Fitting model to feature number 642, F670
## 2024-12-19 17:42:31.443892 INFO::Fitting model to feature number 643, F671
## 2024-12-19 17:42:31.447109 INFO::Fitting model to feature number 644, F672
## 2024-12-19 17:42:31.450333 INFO::Fitting model to feature number 645, F673
## 2024-12-19 17:42:31.453524 INFO::Fitting model to feature number 646, F674
## 2024-12-19 17:42:31.456709 INFO::Fitting model to feature number 647, F675
## 2024-12-19 17:42:31.459867 INFO::Fitting model to feature number 648, F676
## 2024-12-19 17:42:31.463057 INFO::Fitting model to feature number 649, F677
## 2024-12-19 17:42:31.466257 INFO::Fitting model to feature number 650, F678
## 2024-12-19 17:42:31.46943 INFO::Fitting model to feature number 651, F679
## 2024-12-19 17:42:31.472604 INFO::Fitting model to feature number 652, F680
## 2024-12-19 17:42:31.475716 INFO::Fitting model to feature number 653, F681
## 2024-12-19 17:42:31.47888 INFO::Fitting model to feature number 654, F682
## 2024-12-19 17:42:31.482048 INFO::Fitting model to feature number 655, F683
## 2024-12-19 17:42:31.48523 INFO::Fitting model to feature number 656, F684
## 2024-12-19 17:42:31.488408 INFO::Fitting model to feature number 657, F685
## 2024-12-19 17:42:31.4916 INFO::Fitting model to feature number 658, F686
## 2024-12-19 17:42:31.494802 INFO::Fitting model to feature number 659, F687
## 2024-12-19 17:42:31.49797 INFO::Fitting model to feature number 660, F688
## 2024-12-19 17:42:31.501092 INFO::Fitting model to feature number 661, F689
## 2024-12-19 17:42:31.504277 INFO::Fitting model to feature number 662, F690
## 2024-12-19 17:42:31.507459 INFO::Fitting model to feature number 663, F691
## 2024-12-19 17:42:31.510634 INFO::Fitting model to feature number 664, F692
## 2024-12-19 17:42:31.513814 INFO::Fitting model to feature number 665, F693
## 2024-12-19 17:42:31.517006 INFO::Fitting model to feature number 666, F694
## 2024-12-19 17:42:31.520222 INFO::Fitting model to feature number 667, F695
## 2024-12-19 17:42:31.523458 INFO::Fitting model to feature number 668, F696
## 2024-12-19 17:42:31.526674 INFO::Fitting model to feature number 669, F697
## 2024-12-19 17:42:31.529913 INFO::Fitting model to feature number 670, F698
## 2024-12-19 17:42:31.533132 INFO::Fitting model to feature number 671, F699
## 2024-12-19 17:42:31.536262 INFO::Fitting model to feature number 672, F700
## 2024-12-19 17:42:31.539459 INFO::Fitting model to feature number 673, F701
## 2024-12-19 17:42:31.542678 INFO::Fitting model to feature number 674, F702
## 2024-12-19 17:42:31.545887 INFO::Fitting model to feature number 675, F704
## 2024-12-19 17:42:31.549101 INFO::Fitting model to feature number 676, F705
## 2024-12-19 17:42:31.552339 INFO::Fitting model to feature number 677, F706
## 2024-12-19 17:42:31.555487 INFO::Fitting model to feature number 678, F707
## 2024-12-19 17:42:31.558665 INFO::Fitting model to feature number 679, F708
## 2024-12-19 17:42:31.561855 INFO::Fitting model to feature number 680, F709
## 2024-12-19 17:42:31.565036 INFO::Fitting model to feature number 681, F710
## 2024-12-19 17:42:31.568237 INFO::Fitting model to feature number 682, F711
## 2024-12-19 17:42:31.571439 INFO::Fitting model to feature number 683, F712
## 2024-12-19 17:42:31.574614 INFO::Fitting model to feature number 684, F713
## 2024-12-19 17:42:31.577806 INFO::Fitting model to feature number 685, F714
## 2024-12-19 17:42:31.580987 INFO::Fitting model to feature number 686, F715
## 2024-12-19 17:42:31.584166 INFO::Fitting model to feature number 687, F716
## 2024-12-19 17:42:31.587368 INFO::Fitting model to feature number 688, F717
## 2024-12-19 17:42:31.590534 INFO::Fitting model to feature number 689, F718
## 2024-12-19 17:42:31.593716 INFO::Fitting model to feature number 690, F719
## 2024-12-19 17:42:31.596879 INFO::Fitting model to feature number 691, F720
## 2024-12-19 17:42:31.600061 INFO::Fitting model to feature number 692, F721
## 2024-12-19 17:42:31.603244 INFO::Fitting model to feature number 693, F722
## 2024-12-19 17:42:31.60641 INFO::Fitting model to feature number 694, F723
## 2024-12-19 17:42:31.609578 INFO::Fitting model to feature number 695, F724
## 2024-12-19 17:42:31.612764 INFO::Fitting model to feature number 696, F725
## 2024-12-19 17:42:31.615957 INFO::Fitting model to feature number 697, F726
## 2024-12-19 17:42:31.61911 INFO::Fitting model to feature number 698, F727
## 2024-12-19 17:42:31.622371 INFO::Fitting model to feature number 699, F728
## 2024-12-19 17:42:31.625621 INFO::Fitting model to feature number 700, F729
## 2024-12-19 17:42:31.628837 INFO::Fitting model to feature number 701, F730
## 2024-12-19 17:42:31.63205 INFO::Fitting model to feature number 702, F731
## 2024-12-19 17:42:31.635249 INFO::Fitting model to feature number 703, F732
## 2024-12-19 17:42:31.638461 INFO::Fitting model to feature number 704, F733
## 2024-12-19 17:42:31.641649 INFO::Fitting model to feature number 705, F734
## 2024-12-19 17:42:31.644846 INFO::Fitting model to feature number 706, F735
## 2024-12-19 17:42:31.647993 INFO::Fitting model to feature number 707, F736
## 2024-12-19 17:42:31.651209 INFO::Fitting model to feature number 708, F737
## 2024-12-19 17:42:31.654431 INFO::Fitting model to feature number 709, F739
## 2024-12-19 17:42:31.657572 INFO::Fitting model to feature number 710, F740
## 2024-12-19 17:42:31.660763 INFO::Fitting model to feature number 711, F741
## 2024-12-19 17:42:31.663941 INFO::Fitting model to feature number 712, F742
## 2024-12-19 17:42:31.667125 INFO::Fitting model to feature number 713, F743
## 2024-12-19 17:42:31.670341 INFO::Fitting model to feature number 714, F744
## 2024-12-19 17:42:31.673595 INFO::Fitting model to feature number 715, F745
## 2024-12-19 17:42:31.676795 INFO::Fitting model to feature number 716, F746
## 2024-12-19 17:42:31.679979 INFO::Fitting model to feature number 717, F747
## 2024-12-19 17:42:31.683163 INFO::Fitting model to feature number 718, F748
## 2024-12-19 17:42:31.68635 INFO::Fitting model to feature number 719, F749
## 2024-12-19 17:42:31.689524 INFO::Fitting model to feature number 720, F750
## 2024-12-19 17:42:31.692634 INFO::Fitting model to feature number 721, F751
## 2024-12-19 17:42:31.695816 INFO::Fitting model to feature number 722, F752
## 2024-12-19 17:42:31.698994 INFO::Fitting model to feature number 723, F753
## 2024-12-19 17:42:31.70211 INFO::Fitting model to feature number 724, F754
## 2024-12-19 17:42:31.70525 INFO::Fitting model to feature number 725, F755
## 2024-12-19 17:42:31.708447 INFO::Fitting model to feature number 726, F756
## 2024-12-19 17:42:31.711613 INFO::Fitting model to feature number 727, F757
## 2024-12-19 17:42:31.714776 INFO::Fitting model to feature number 728, F758
## 2024-12-19 17:42:31.717932 INFO::Fitting model to feature number 729, F759
## 2024-12-19 17:42:31.721095 INFO::Fitting model to feature number 730, F760
## 2024-12-19 17:42:31.724273 INFO::Fitting model to feature number 731, F761
## 2024-12-19 17:42:31.727372 INFO::Fitting model to feature number 732, F762
## 2024-12-19 17:42:31.73055 INFO::Fitting model to feature number 733, F763
## 2024-12-19 17:42:31.733745 INFO::Fitting model to feature number 734, F764
## 2024-12-19 17:42:31.736965 INFO::Fitting model to feature number 735, F765
## 2024-12-19 17:42:31.740166 INFO::Fitting model to feature number 736, F766
## 2024-12-19 17:42:31.743367 INFO::Fitting model to feature number 737, F767
## 2024-12-19 17:42:31.746543 INFO::Fitting model to feature number 738, F768
## 2024-12-19 17:42:31.749711 INFO::Fitting model to feature number 739, F769
## 2024-12-19 17:42:31.752896 INFO::Fitting model to feature number 740, F770
## 2024-12-19 17:42:31.756063 INFO::Fitting model to feature number 741, F771
## 2024-12-19 17:42:31.759269 INFO::Fitting model to feature number 742, F772
## 2024-12-19 17:42:31.762499 INFO::Fitting model to feature number 743, F773
## 2024-12-19 17:42:31.765688 INFO::Fitting model to feature number 744, F774
## 2024-12-19 17:42:31.768905 INFO::Fitting model to feature number 745, F775
## 2024-12-19 17:42:31.772125 INFO::Fitting model to feature number 746, F776
## 2024-12-19 17:42:31.775322 INFO::Fitting model to feature number 747, F777
## 2024-12-19 17:42:31.778483 INFO::Fitting model to feature number 748, F778
## 2024-12-19 17:42:31.78168 INFO::Fitting model to feature number 749, F779
## 2024-12-19 17:42:31.784887 INFO::Fitting model to feature number 750, F780
## 2024-12-19 17:42:31.788054 INFO::Fitting model to feature number 751, F781
## 2024-12-19 17:42:31.79124 INFO::Fitting model to feature number 752, F782
## 2024-12-19 17:42:31.794474 INFO::Fitting model to feature number 753, F783
## 2024-12-19 17:42:31.797797 INFO::Fitting model to feature number 754, F784
## 2024-12-19 17:42:31.801034 INFO::Fitting model to feature number 755, F785
## 2024-12-19 17:42:31.804366 INFO::Fitting model to feature number 756, F786
## 2024-12-19 17:42:31.807603 INFO::Fitting model to feature number 757, F787
## 2024-12-19 17:42:31.810849 INFO::Fitting model to feature number 758, F788
## 2024-12-19 17:42:31.814698 INFO::Fitting model to feature number 759, F789
## 2024-12-19 17:42:31.818005 INFO::Fitting model to feature number 760, F790
## 2024-12-19 17:42:31.821235 INFO::Fitting model to feature number 761, F791
## 2024-12-19 17:42:31.82444 INFO::Fitting model to feature number 762, F792
## 2024-12-19 17:42:31.827711 INFO::Fitting model to feature number 763, F793
## 2024-12-19 17:42:31.830998 INFO::Fitting model to feature number 764, F794
## 2024-12-19 17:42:31.8343 INFO::Fitting model to feature number 765, F795
## 2024-12-19 17:42:31.837563 INFO::Fitting model to feature number 766, F796
## 2024-12-19 17:42:31.840811 INFO::Fitting model to feature number 767, F797
## 2024-12-19 17:42:31.844043 INFO::Fitting model to feature number 768, F798
## 2024-12-19 17:42:31.847218 INFO::Fitting model to feature number 769, F799
## 2024-12-19 17:42:31.850482 INFO::Fitting model to feature number 770, F800
## 2024-12-19 17:42:31.853759 INFO::Fitting model to feature number 771, F801
## 2024-12-19 17:42:31.857073 INFO::Fitting model to feature number 772, F802
## 2024-12-19 17:42:31.860333 INFO::Fitting model to feature number 773, F803
## 2024-12-19 17:42:31.863612 INFO::Fitting model to feature number 774, F804
## 2024-12-19 17:42:31.866871 INFO::Fitting model to feature number 775, F805
## 2024-12-19 17:42:31.870142 INFO::Fitting model to feature number 776, F806
## 2024-12-19 17:42:31.873411 INFO::Fitting model to feature number 777, F808
## 2024-12-19 17:42:31.876669 INFO::Fitting model to feature number 778, F809
## 2024-12-19 17:42:31.879929 INFO::Fitting model to feature number 779, F810
## 2024-12-19 17:42:31.883176 INFO::Fitting model to feature number 780, F811
## 2024-12-19 17:42:31.886433 INFO::Fitting model to feature number 781, F812
## 2024-12-19 17:42:31.889689 INFO::Fitting model to feature number 782, F813
## 2024-12-19 17:42:31.892956 INFO::Fitting model to feature number 783, F814
## 2024-12-19 17:42:31.896236 INFO::Fitting model to feature number 784, F815
## 2024-12-19 17:42:31.899508 INFO::Fitting model to feature number 785, F816
## 2024-12-19 17:42:31.902787 INFO::Fitting model to feature number 786, F817
## 2024-12-19 17:42:31.90609 INFO::Fitting model to feature number 787, F818
## 2024-12-19 17:42:31.909394 INFO::Fitting model to feature number 788, F819
## 2024-12-19 17:42:31.912646 INFO::Fitting model to feature number 789, F820
## 2024-12-19 17:42:31.915959 INFO::Fitting model to feature number 790, F821
## 2024-12-19 17:42:31.91922 INFO::Fitting model to feature number 791, F822
## 2024-12-19 17:42:31.922548 INFO::Fitting model to feature number 792, F823
## 2024-12-19 17:42:31.925853 INFO::Fitting model to feature number 793, F824
## 2024-12-19 17:42:31.92916 INFO::Fitting model to feature number 794, F825
## 2024-12-19 17:42:31.932477 INFO::Fitting model to feature number 795, F826
## 2024-12-19 17:42:31.93578 INFO::Fitting model to feature number 796, F827
## 2024-12-19 17:42:31.939056 INFO::Fitting model to feature number 797, F828
## 2024-12-19 17:42:31.942278 INFO::Fitting model to feature number 798, F829
## 2024-12-19 17:42:31.945545 INFO::Fitting model to feature number 799, F830
## 2024-12-19 17:42:31.94882 INFO::Fitting model to feature number 800, F831
## 2024-12-19 17:42:31.952095 INFO::Fitting model to feature number 801, F832
## 2024-12-19 17:42:31.955385 INFO::Fitting model to feature number 802, F833
## 2024-12-19 17:42:31.958601 INFO::Fitting model to feature number 803, F834
## 2024-12-19 17:42:31.961854 INFO::Fitting model to feature number 804, F835
## 2024-12-19 17:42:31.965128 INFO::Fitting model to feature number 805, F836
## 2024-12-19 17:42:31.968396 INFO::Fitting model to feature number 806, F837
## 2024-12-19 17:42:31.971685 INFO::Fitting model to feature number 807, F838
## 2024-12-19 17:42:31.974911 INFO::Fitting model to feature number 808, F839
## 2024-12-19 17:42:31.978223 INFO::Fitting model to feature number 809, F840
## 2024-12-19 17:42:31.98151 INFO::Fitting model to feature number 810, F841
## 2024-12-19 17:42:31.984777 INFO::Fitting model to feature number 811, F842
## 2024-12-19 17:42:31.988108 INFO::Fitting model to feature number 812, F843
## 2024-12-19 17:42:31.991458 INFO::Fitting model to feature number 813, F844
## 2024-12-19 17:42:31.994729 INFO::Fitting model to feature number 814, F845
## 2024-12-19 17:42:31.998071 INFO::Fitting model to feature number 815, F846
## 2024-12-19 17:42:32.001351 INFO::Fitting model to feature number 816, F847
## 2024-12-19 17:42:32.004642 INFO::Fitting model to feature number 817, F848
## 2024-12-19 17:42:32.007936 INFO::Fitting model to feature number 818, F849
## 2024-12-19 17:42:32.011238 INFO::Fitting model to feature number 819, F850
## 2024-12-19 17:42:32.014538 INFO::Fitting model to feature number 820, F851
## 2024-12-19 17:42:32.017815 INFO::Fitting model to feature number 821, F852
## 2024-12-19 17:42:32.021113 INFO::Fitting model to feature number 822, F853
## 2024-12-19 17:42:32.024419 INFO::Fitting model to feature number 823, F854
## 2024-12-19 17:42:32.027692 INFO::Fitting model to feature number 824, F855
## 2024-12-19 17:42:32.030968 INFO::Fitting model to feature number 825, F856
## 2024-12-19 17:42:32.034239 INFO::Fitting model to feature number 826, F857
## 2024-12-19 17:42:32.037499 INFO::Fitting model to feature number 827, F858
## 2024-12-19 17:42:32.040802 INFO::Fitting model to feature number 828, F859
## 2024-12-19 17:42:32.044089 INFO::Fitting model to feature number 829, F860
## 2024-12-19 17:42:32.047373 INFO::Fitting model to feature number 830, F861
## 2024-12-19 17:42:32.051044 INFO::Fitting model to feature number 831, F862
## 2024-12-19 17:42:32.055748 INFO::Fitting model to feature number 832, F863
## 2024-12-19 17:42:32.05932 INFO::Fitting model to feature number 833, F864
## 2024-12-19 17:42:32.06271 INFO::Fitting model to feature number 834, F865
## 2024-12-19 17:42:32.066028 INFO::Fitting model to feature number 835, F866
## 2024-12-19 17:42:32.069392 INFO::Fitting model to feature number 836, F867
## 2024-12-19 17:42:32.072734 INFO::Fitting model to feature number 837, F868
## 2024-12-19 17:42:32.076045 INFO::Fitting model to feature number 838, F869
## 2024-12-19 17:42:32.079294 INFO::Fitting model to feature number 839, F870
## 2024-12-19 17:42:32.082588 INFO::Fitting model to feature number 840, F871
## 2024-12-19 17:42:32.085874 INFO::Fitting model to feature number 841, F872
## 2024-12-19 17:42:32.089168 INFO::Fitting model to feature number 842, F873
## 2024-12-19 17:42:32.092386 INFO::Fitting model to feature number 843, F874
## 2024-12-19 17:42:32.095725 INFO::Fitting model to feature number 844, F875
## 2024-12-19 17:42:32.099024 INFO::Fitting model to feature number 845, F876
## 2024-12-19 17:42:32.102318 INFO::Fitting model to feature number 846, F877
## 2024-12-19 17:42:32.105602 INFO::Fitting model to feature number 847, F878
## 2024-12-19 17:42:32.108897 INFO::Fitting model to feature number 848, F879
## 2024-12-19 17:42:32.112205 INFO::Fitting model to feature number 849, F880
## 2024-12-19 17:42:32.115486 INFO::Fitting model to feature number 850, F881
## 2024-12-19 17:42:32.118757 INFO::Fitting model to feature number 851, F882
## 2024-12-19 17:42:32.12204 INFO::Fitting model to feature number 852, F883
## 2024-12-19 17:42:32.125331 INFO::Fitting model to feature number 853, F884
## 2024-12-19 17:42:32.128656 INFO::Fitting model to feature number 854, F885
## 2024-12-19 17:42:32.131868 INFO::Fitting model to feature number 855, F886
## 2024-12-19 17:42:32.135164 INFO::Fitting model to feature number 856, F887
## 2024-12-19 17:42:32.138461 INFO::Fitting model to feature number 857, F888
## 2024-12-19 17:42:32.141739 INFO::Fitting model to feature number 858, F889
## 2024-12-19 17:42:32.145013 INFO::Fitting model to feature number 859, F890
## 2024-12-19 17:42:32.148307 INFO::Fitting model to feature number 860, F891
## 2024-12-19 17:42:32.151526 INFO::Fitting model to feature number 861, F892
## 2024-12-19 17:42:32.154812 INFO::Fitting model to feature number 862, F893
## 2024-12-19 17:42:32.158023 INFO::Fitting model to feature number 863, F894
## 2024-12-19 17:42:32.161325 INFO::Fitting model to feature number 864, F895
## 2024-12-19 17:42:32.164696 INFO::Fitting model to feature number 865, F896
## 2024-12-19 17:42:32.167927 INFO::Fitting model to feature number 866, F897
## 2024-12-19 17:42:32.17116 INFO::Fitting model to feature number 867, F898
## 2024-12-19 17:42:32.174435 INFO::Fitting model to feature number 868, F899
## 2024-12-19 17:42:32.177725 INFO::Fitting model to feature number 869, F900
## 2024-12-19 17:42:32.351374 INFO::Counting total values for each feature
## 2024-12-19 17:42:32.461213 INFO::Writing filtered data to file Macarron_output/maaslin2_results/features/filtered_data.tsv
## 2024-12-19 17:42:32.568966 INFO::Writing filtered, normalized data to file Macarron_output/maaslin2_results/features/filtered_data_norm.tsv
## 2024-12-19 17:42:32.677136 INFO::Writing filtered, normalized, transformed data to file Macarron_output/maaslin2_results/features/filtered_data_norm_transformed.tsv
## 2024-12-19 17:42:32.784822 INFO::Writing residuals to file Macarron_output/maaslin2_results/fits/residuals.rds
## 2024-12-19 17:42:32.826462 INFO::Writing fitted values to file Macarron_output/maaslin2_results/fits/fitted.rds
## 2024-12-19 17:42:32.861688 INFO::Writing all results to file (ordered by increasing q-values): Macarron_output/maaslin2_results/all_results.tsv
## 2024-12-19 17:42:32.876017 INFO::Writing the significant results (those which are less than or equal to the threshold of 0.250000 ) to file (ordered by increasing q-values): Macarron_output/maaslin2_results/significant_results.tsv
## 2024-12-19 17:42:32.882582 INFO::Writing association plots (one for each significant association) to output folder: Macarron_output/maaslin2_results
## 2024-12-19 17:42:32.897698 INFO::Plotting associations from most to least significant, grouped by metadata
## 2024-12-19 17:42:32.898649 INFO::Plotting data for metadata number 1, diagnosis
## 2024-12-19 17:42:32.940761 INFO::Creating boxplot for categorical data, diagnosis vs F504

## 2024-12-19 17:42:33.219818 INFO::Creating boxplot for categorical data, diagnosis vs F859

## 2024-12-19 17:42:33.408614 INFO::Creating boxplot for categorical data, diagnosis vs F533

## 2024-12-19 17:42:33.576407 INFO::Creating boxplot for categorical data, diagnosis vs F587

## 2024-12-19 17:42:33.761647 INFO::Creating boxplot for categorical data, diagnosis vs F584

## 2024-12-19 17:42:33.923558 INFO::Creating boxplot for categorical data, diagnosis vs F197

## 2024-12-19 17:42:34.08933 INFO::Creating boxplot for categorical data, diagnosis vs F380

## 2024-12-19 17:42:34.258833 INFO::Creating boxplot for categorical data, diagnosis vs F829

## 2024-12-19 17:42:34.424708 INFO::Creating boxplot for categorical data, diagnosis vs F664

## 2024-12-19 17:42:34.60604 INFO::Creating boxplot for categorical data, diagnosis vs F93

## 2024-12-19 17:42:34.771791 INFO::Creating boxplot for categorical data, diagnosis vs F15

## 2024-12-19 17:42:34.961642 INFO::Creating boxplot for categorical data, diagnosis vs F881

## 2024-12-19 17:42:35.140464 INFO::Creating boxplot for categorical data, diagnosis vs F806

## 2024-12-19 17:42:35.311292 INFO::Creating boxplot for categorical data, diagnosis vs F78

## 2024-12-19 17:42:35.479015 INFO::Creating boxplot for categorical data, diagnosis vs F189

## 2024-12-19 17:42:35.659256 INFO::Creating boxplot for categorical data, diagnosis vs F369

## 2024-12-19 17:42:35.82307 INFO::Creating boxplot for categorical data, diagnosis vs F623

## 2024-12-19 17:42:35.991436 INFO::Creating boxplot for categorical data, diagnosis vs F710

## 2024-12-19 17:42:36.161263 INFO::Creating boxplot for categorical data, diagnosis vs F851

## 2024-12-19 17:42:36.330184 INFO::Creating boxplot for categorical data, diagnosis vs F257

## 2024-12-19 17:42:36.549237 INFO::Creating boxplot for categorical data, diagnosis vs F330

## 2024-12-19 17:42:36.712423 INFO::Creating boxplot for categorical data, diagnosis vs F344

## 2024-12-19 17:42:36.880173 INFO::Creating boxplot for categorical data, diagnosis vs F696

## 2024-12-19 17:42:37.051916 INFO::Creating boxplot for categorical data, diagnosis vs F741

## 2024-12-19 17:42:37.225936 INFO::Creating boxplot for categorical data, diagnosis vs F509

## 2024-12-19 17:42:37.411476 INFO::Creating boxplot for categorical data, diagnosis vs F479

## 2024-12-19 17:42:37.58053 INFO::Creating boxplot for categorical data, diagnosis vs F550

## 2024-12-19 17:42:37.74909 INFO::Creating boxplot for categorical data, diagnosis vs F640

## 2024-12-19 17:42:37.916399 INFO::Creating boxplot for categorical data, diagnosis vs F281

## 2024-12-19 17:42:38.085047 INFO::Creating boxplot for categorical data, diagnosis vs F80

## 2024-12-19 17:42:38.264488 INFO::Creating boxplot for categorical data, diagnosis vs F285

## 2024-12-19 17:42:38.439561 INFO::Creating boxplot for categorical data, diagnosis vs F531

## 2024-12-19 17:42:38.62147 INFO::Creating boxplot for categorical data, diagnosis vs F737

## 2024-12-19 17:42:38.812518 INFO::Creating boxplot for categorical data, diagnosis vs F875

## 2024-12-19 17:42:38.990969 INFO::Creating boxplot for categorical data, diagnosis vs F864

## 2024-12-19 17:42:39.187615 INFO::Creating boxplot for categorical data, diagnosis vs F379

## 2024-12-19 17:42:39.372076 INFO::Creating boxplot for categorical data, diagnosis vs F190

## 2024-12-19 17:42:39.537713 INFO::Creating boxplot for categorical data, diagnosis vs F4

## 2024-12-19 17:42:39.708868 INFO::Creating boxplot for categorical data, diagnosis vs F591

## 2024-12-19 17:42:39.878049 INFO::Creating boxplot for categorical data, diagnosis vs F773

## 2024-12-19 17:42:40.047074 INFO::Creating boxplot for categorical data, diagnosis vs F283

## 2024-12-19 17:42:40.224673 INFO::Creating boxplot for categorical data, diagnosis vs F233

## 2024-12-19 17:42:40.393035 INFO::Creating boxplot for categorical data, diagnosis vs F420

## 2024-12-19 17:42:40.56137 INFO::Creating boxplot for categorical data, diagnosis vs F5

## 2024-12-19 17:42:40.732632 INFO::Creating boxplot for categorical data, diagnosis vs F137

## 2024-12-19 17:42:40.904932 INFO::Creating boxplot for categorical data, diagnosis vs F215

## 2024-12-19 17:42:41.085946 INFO::Creating boxplot for categorical data, diagnosis vs F489

## 2024-12-19 17:42:41.250818 INFO::Creating boxplot for categorical data, diagnosis vs F220

## 2024-12-19 17:42:41.419099 INFO::Creating boxplot for categorical data, diagnosis vs F691

## 2024-12-19 17:42:41.58866 INFO::Creating boxplot for categorical data, diagnosis vs F381

## 2024-12-19 17:42:41.759957 INFO::Creating boxplot for categorical data, diagnosis vs F539

## 2024-12-19 17:42:41.940775 INFO::Creating boxplot for categorical data, diagnosis vs F490

## 2024-12-19 17:42:42.112751 INFO::Creating boxplot for categorical data, diagnosis vs F832

## 2024-12-19 17:42:42.281308 INFO::Creating boxplot for categorical data, diagnosis vs F396

## 2024-12-19 17:42:42.456912 INFO::Creating boxplot for categorical data, diagnosis vs F528

## 2024-12-19 17:42:42.649397 INFO::Creating boxplot for categorical data, diagnosis vs F234

## 2024-12-19 17:42:42.85023 INFO::Creating boxplot for categorical data, diagnosis vs F178

## 2024-12-19 17:42:43.020028 INFO::Creating boxplot for categorical data, diagnosis vs F761

## 2024-12-19 17:42:43.188454 INFO::Creating boxplot for categorical data, diagnosis vs F2

## 2024-12-19 17:42:43.368768 INFO::Creating boxplot for categorical data, diagnosis vs F260

## 2024-12-19 17:42:43.544946 INFO::Creating boxplot for categorical data, diagnosis vs F734

## 2024-12-19 17:42:43.730802 INFO::Creating boxplot for categorical data, diagnosis vs F429

## 2024-12-19 17:42:43.896123 INFO::Creating boxplot for categorical data, diagnosis vs F630

## 2024-12-19 17:42:44.06214 INFO::Creating boxplot for categorical data, diagnosis vs F817

## 2024-12-19 17:42:44.231867 INFO::Creating boxplot for categorical data, diagnosis vs F847

## 2024-12-19 17:42:44.403672 INFO::Creating boxplot for categorical data, diagnosis vs F896

## 2024-12-19 17:42:44.587864 INFO::Creating boxplot for categorical data, diagnosis vs F81

## 2024-12-19 17:42:44.753381 INFO::Creating boxplot for categorical data, diagnosis vs F110

## 2024-12-19 17:42:44.922225 INFO::Creating boxplot for categorical data, diagnosis vs F3

## 2024-12-19 17:42:45.098323 INFO::Creating boxplot for categorical data, diagnosis vs F33

## 2024-12-19 17:42:45.268265 INFO::Creating boxplot for categorical data, diagnosis vs F270

## 2024-12-19 17:42:45.453157 INFO::Creating boxplot for categorical data, diagnosis vs F278

## 2024-12-19 17:42:45.620067 INFO::Creating boxplot for categorical data, diagnosis vs F264

## 2024-12-19 17:42:45.785379 INFO::Creating boxplot for categorical data, diagnosis vs F90

## 2024-12-19 17:42:45.959211 INFO::Creating boxplot for categorical data, diagnosis vs F403

## 2024-12-19 17:42:46.131301 INFO::Creating boxplot for categorical data, diagnosis vs F727

## 2024-12-19 17:42:46.302283 INFO::Creating boxplot for categorical data, diagnosis vs F394

## 2024-12-19 17:42:46.481391 INFO::Creating boxplot for categorical data, diagnosis vs F800

## 2024-12-19 17:42:46.65476 INFO::Creating boxplot for categorical data, diagnosis vs F439

## 2024-12-19 17:42:46.825029 INFO::Creating boxplot for categorical data, diagnosis vs F554

## 2024-12-19 17:42:46.99501 INFO::Creating boxplot for categorical data, diagnosis vs F559

## 2024-12-19 17:42:47.1689 INFO::Creating boxplot for categorical data, diagnosis vs F548

## 2024-12-19 17:42:47.347835 INFO::Creating boxplot for categorical data, diagnosis vs F794

## 2024-12-19 17:42:47.515103 INFO::Creating boxplot for categorical data, diagnosis vs F45

## 2024-12-19 17:42:47.685357 INFO::Creating boxplot for categorical data, diagnosis vs F158

## 2024-12-19 17:42:47.859859 INFO::Creating boxplot for categorical data, diagnosis vs F477

## 2024-12-19 17:42:48.035563 INFO::Creating boxplot for categorical data, diagnosis vs F1

## 2024-12-19 17:42:48.21648 INFO::Creating boxplot for categorical data, diagnosis vs F862

## 2024-12-19 17:42:48.381779 INFO::Creating boxplot for categorical data, diagnosis vs F803

## 2024-12-19 17:42:48.550982 INFO::Creating boxplot for categorical data, diagnosis vs F751

## 2024-12-19 17:42:48.720278 INFO::Creating boxplot for categorical data, diagnosis vs F98

## 2024-12-19 17:42:48.888808 INFO::Creating boxplot for categorical data, diagnosis vs F22

## 2024-12-19 17:42:49.074453 INFO::Creating boxplot for categorical data, diagnosis vs F625

## 2024-12-19 17:42:49.239028 INFO::Creating boxplot for categorical data, diagnosis vs F206

## 2024-12-19 17:42:49.40883 INFO::Creating boxplot for categorical data, diagnosis vs F779

## 2024-12-19 17:42:49.580997 INFO::Creating boxplot for categorical data, diagnosis vs F532

## 2024-12-19 17:42:49.75509 INFO::Creating boxplot for categorical data, diagnosis vs F676

## 2024-12-19 17:42:49.949523 INFO::Creating boxplot for categorical data, diagnosis vs F644

## 2024-12-19 17:42:50.120459 INFO::Creating boxplot for categorical data, diagnosis vs F7

## 2024-12-19 17:42:50.290659 INFO::Creating boxplot for categorical data, diagnosis vs F596

## 2024-12-19 17:42:50.46157 INFO::Creating boxplot for categorical data, diagnosis vs F250

## 2024-12-19 17:42:50.629995 INFO::Creating boxplot for categorical data, diagnosis vs F462

## 2024-12-19 17:42:50.810402 INFO::Creating boxplot for categorical data, diagnosis vs F516

## 2024-12-19 17:42:50.975368 INFO::Creating boxplot for categorical data, diagnosis vs F659

## 2024-12-19 17:42:51.152059 INFO::Creating boxplot for categorical data, diagnosis vs F663

## 2024-12-19 17:42:51.3384 INFO::Creating boxplot for categorical data, diagnosis vs F837

## 2024-12-19 17:42:51.528872 INFO::Creating boxplot for categorical data, diagnosis vs F138

## 2024-12-19 17:42:51.718424 INFO::Creating boxplot for categorical data, diagnosis vs F445

## 2024-12-19 17:42:51.885731 INFO::Creating boxplot for categorical data, diagnosis vs F697

## 2024-12-19 17:42:52.057872 INFO::Creating boxplot for categorical data, diagnosis vs F225

## 2024-12-19 17:42:52.23397 INFO::Creating boxplot for categorical data, diagnosis vs F148

## 2024-12-19 17:42:52.405046 INFO::Creating boxplot for categorical data, diagnosis vs F448

## 2024-12-19 17:42:52.58675 INFO::Creating boxplot for categorical data, diagnosis vs F91

## 2024-12-19 17:42:52.753192 INFO::Creating boxplot for categorical data, diagnosis vs F123

## 2024-12-19 17:42:52.923606 INFO::Creating boxplot for categorical data, diagnosis vs F665

## 2024-12-19 17:42:53.093831 INFO::Creating boxplot for categorical data, diagnosis vs F845

## 2024-12-19 17:42:53.264984 INFO::Creating boxplot for categorical data, diagnosis vs F331

## 2024-12-19 17:42:53.456978 INFO::Creating boxplot for categorical data, diagnosis vs F361

## 2024-12-19 17:42:53.626125 INFO::Creating boxplot for categorical data, diagnosis vs F421

## 2024-12-19 17:42:53.812858 INFO::Creating boxplot for categorical data, diagnosis vs F277

## 2024-12-19 17:42:53.986885 INFO::Creating boxplot for categorical data, diagnosis vs F307

## 2024-12-19 17:42:54.176253 INFO::Creating boxplot for categorical data, diagnosis vs F503

## 2024-12-19 17:42:54.371294 INFO::Creating boxplot for categorical data, diagnosis vs F34

## 2024-12-19 17:42:54.538784 INFO::Creating boxplot for categorical data, diagnosis vs F649

## 2024-12-19 17:42:54.715401 INFO::Creating boxplot for categorical data, diagnosis vs F825

## 2024-12-19 17:42:54.890538 INFO::Creating boxplot for categorical data, diagnosis vs F298

## 2024-12-19 17:42:55.068968 INFO::Creating boxplot for categorical data, diagnosis vs F461

## 2024-12-19 17:42:55.315772 INFO::Creating boxplot for categorical data, diagnosis vs F242

## 2024-12-19 17:42:55.490288 INFO::Creating boxplot for categorical data, diagnosis vs F375

## 2024-12-19 17:42:55.659717 INFO::Creating boxplot for categorical data, diagnosis vs F648

## 2024-12-19 17:42:55.840775 INFO::Creating boxplot for categorical data, diagnosis vs F724

## 2024-12-19 17:42:56.018621 INFO::Creating boxplot for categorical data, diagnosis vs F678

## 2024-12-19 17:42:56.209549 INFO::Creating boxplot for categorical data, diagnosis vs F290

## 2024-12-19 17:42:56.38285 INFO::Creating boxplot for categorical data, diagnosis vs F743

## 2024-12-19 17:42:56.554658 INFO::Creating boxplot for categorical data, diagnosis vs F495

## 2024-12-19 17:42:56.726334 INFO::Creating boxplot for categorical data, diagnosis vs F261

## 2024-12-19 17:42:56.897039 INFO::Creating boxplot for categorical data, diagnosis vs F43

## 2024-12-19 17:42:57.080889 INFO::Creating boxplot for categorical data, diagnosis vs F714

## 2024-12-19 17:42:57.253755 INFO::Creating boxplot for categorical data, diagnosis vs F131

## 2024-12-19 17:42:57.419316 INFO::Creating boxplot for categorical data, diagnosis vs F150

## 2024-12-19 17:42:57.591831 INFO::Creating boxplot for categorical data, diagnosis vs F651

## 2024-12-19 17:42:57.767508 INFO::Creating boxplot for categorical data, diagnosis vs F798

## 2024-12-19 17:42:57.957951 INFO::Creating boxplot for categorical data, diagnosis vs F289

## 2024-12-19 17:42:58.160585 INFO::Creating boxplot for categorical data, diagnosis vs F661

## 2024-12-19 17:42:58.345625 INFO::Creating boxplot for categorical data, diagnosis vs F199

## 2024-12-19 17:42:58.525195 INFO::Creating boxplot for categorical data, diagnosis vs F406

## 2024-12-19 17:42:58.707582 INFO::Creating boxplot for categorical data, diagnosis vs F139

## 2024-12-19 17:42:58.895739 INFO::Creating boxplot for categorical data, diagnosis vs F506

## 2024-12-19 17:42:59.08867 INFO::Creating boxplot for categorical data, diagnosis vs F552

## 2024-12-19 17:42:59.261361 INFO::Creating boxplot for categorical data, diagnosis vs F94

## 2024-12-19 17:42:59.43442 INFO::Creating boxplot for categorical data, diagnosis vs F430

## 2024-12-19 17:42:59.610608 INFO::Creating boxplot for categorical data, diagnosis vs F639

## 2024-12-19 17:42:59.784814 INFO::Creating boxplot for categorical data, diagnosis vs F500

## 2024-12-19 17:42:59.97103 INFO::Creating boxplot for categorical data, diagnosis vs F609

## 2024-12-19 17:43:00.143019 INFO::Creating boxplot for categorical data, diagnosis vs F306

## 2024-12-19 17:43:00.31214 INFO::Creating boxplot for categorical data, diagnosis vs F507

## 2024-12-19 17:43:00.483699 INFO::Creating boxplot for categorical data, diagnosis vs F671

## 2024-12-19 17:43:00.656062 INFO::Creating boxplot for categorical data, diagnosis vs F894

## 2024-12-19 17:43:00.844052 INFO::Creating boxplot for categorical data, diagnosis vs F345

## 2024-12-19 17:43:01.01933 INFO::Creating boxplot for categorical data, diagnosis vs F801

## 2024-12-19 17:43:01.194314 INFO::Creating boxplot for categorical data, diagnosis vs F194

## 2024-12-19 17:43:01.373806 INFO::Creating boxplot for categorical data, diagnosis vs F195

## 2024-12-19 17:43:01.554494 INFO::Creating boxplot for categorical data, diagnosis vs F119

## 2024-12-19 17:43:01.754312 INFO::Creating boxplot for categorical data, diagnosis vs F120

## 2024-12-19 17:43:01.924928 INFO::Creating boxplot for categorical data, diagnosis vs F231

## 2024-12-19 17:43:02.094062 INFO::Creating boxplot for categorical data, diagnosis vs F311

## 2024-12-19 17:43:02.265436 INFO::Creating boxplot for categorical data, diagnosis vs F646

## 2024-12-19 17:43:02.44062 INFO::Creating boxplot for categorical data, diagnosis vs F814

## 2024-12-19 17:43:02.651724 INFO::Creating boxplot for categorical data, diagnosis vs F510

## 2024-12-19 17:43:02.830947 INFO::Creating boxplot for categorical data, diagnosis vs F398

## 2024-12-19 17:43:03.004007 INFO::Creating boxplot for categorical data, diagnosis vs F60

## 2024-12-19 17:43:03.185715 INFO::Creating boxplot for categorical data, diagnosis vs F153

## 2024-12-19 17:43:03.36907 INFO::Creating boxplot for categorical data, diagnosis vs F858

## 2024-12-19 17:43:03.564941 INFO::Creating boxplot for categorical data, diagnosis vs F775

## 2024-12-19 17:43:03.736286 INFO::Creating boxplot for categorical data, diagnosis vs F684

## 2024-12-19 17:43:03.903714 INFO::Creating boxplot for categorical data, diagnosis vs F384

## 2024-12-19 17:43:04.077239 INFO::Creating boxplot for categorical data, diagnosis vs F134

## 2024-12-19 17:43:04.254887 INFO::Creating boxplot for categorical data, diagnosis vs F670

## 2024-12-19 17:43:04.444868 INFO::Creating boxplot for categorical data, diagnosis vs F632

## 2024-12-19 17:43:04.619166 INFO::Creating boxplot for categorical data, diagnosis vs F721

## 2024-12-19 17:43:04.786819 INFO::Creating boxplot for categorical data, diagnosis vs F700

## 2024-12-19 17:43:04.959337 INFO::Creating boxplot for categorical data, diagnosis vs F376

## 2024-12-19 17:43:05.133125 INFO::Creating boxplot for categorical data, diagnosis vs F301

## 2024-12-19 17:43:05.318909 INFO::Creating boxplot for categorical data, diagnosis vs F27

## 2024-12-19 17:43:05.490528 INFO::Creating boxplot for categorical data, diagnosis vs F280

## 2024-12-19 17:43:05.656342 INFO::Creating boxplot for categorical data, diagnosis vs F391

## 2024-12-19 17:43:05.827384 INFO::Creating boxplot for categorical data, diagnosis vs F725

## 2024-12-19 17:43:05.995973 INFO::Creating boxplot for categorical data, diagnosis vs F186

## 2024-12-19 17:43:06.172628 INFO::Creating boxplot for categorical data, diagnosis vs F481

## 2024-12-19 17:43:06.353152 INFO::Creating boxplot for categorical data, diagnosis vs F333

## 2024-12-19 17:43:06.520479 INFO::Creating boxplot for categorical data, diagnosis vs F720

## 2024-12-19 17:43:06.686641 INFO::Creating boxplot for categorical data, diagnosis vs F520

## 2024-12-19 17:43:06.85956 INFO::Creating boxplot for categorical data, diagnosis vs F129

## 2024-12-19 17:43:07.03144 INFO::Creating boxplot for categorical data, diagnosis vs F204

## 2024-12-19 17:43:07.214231 INFO::Creating boxplot for categorical data, diagnosis vs F259

## 2024-12-19 17:43:07.379632 INFO::Creating boxplot for categorical data, diagnosis vs F831

## 2024-12-19 17:43:07.549049 INFO::Creating boxplot for categorical data, diagnosis vs F891

## 2024-12-19 17:43:07.718963 INFO::Creating boxplot for categorical data, diagnosis vs F262

## 2024-12-19 17:43:07.886904 INFO::Creating boxplot for categorical data, diagnosis vs F592

## 2024-12-19 17:43:08.067912 INFO::Creating boxplot for categorical data, diagnosis vs F343

## 2024-12-19 17:43:08.231436 INFO::Creating boxplot for categorical data, diagnosis vs F505

## 2024-12-19 17:43:08.402478 INFO::Creating boxplot for categorical data, diagnosis vs F622

## 2024-12-19 17:43:08.574346 INFO::Creating boxplot for categorical data, diagnosis vs F348

## 2024-12-19 17:43:08.745342 INFO::Creating boxplot for categorical data, diagnosis vs F133

## 2024-12-19 17:43:08.930812 INFO::Creating boxplot for categorical data, diagnosis vs F371

## 2024-12-19 17:43:09.105055 INFO::Creating boxplot for categorical data, diagnosis vs F113

## 2024-12-19 17:43:09.275348 INFO::Creating boxplot for categorical data, diagnosis vs F336

## 2024-12-19 17:43:09.4491 INFO::Creating boxplot for categorical data, diagnosis vs F399

## 2024-12-19 17:43:09.620661 INFO::Creating boxplot for categorical data, diagnosis vs F416

## 2024-12-19 17:43:09.804982 INFO::Creating boxplot for categorical data, diagnosis vs F657

## 2024-12-19 17:43:09.973049 INFO::Creating boxplot for categorical data, diagnosis vs F241

## 2024-12-19 17:43:10.145462 INFO::Creating boxplot for categorical data, diagnosis vs F95

## 2024-12-19 17:43:10.314853 INFO::Creating boxplot for categorical data, diagnosis vs F128

## 2024-12-19 17:43:10.488502 INFO::Creating boxplot for categorical data, diagnosis vs F595

## 2024-12-19 17:43:10.676445 INFO::Creating boxplot for categorical data, diagnosis vs F428

## 2024-12-19 17:43:10.842183 INFO::Creating boxplot for categorical data, diagnosis vs F796

## 2024-12-19 17:43:11.010588 INFO::Creating boxplot for categorical data, diagnosis vs F709

## 2024-12-19 17:43:11.179697 INFO::Creating boxplot for categorical data, diagnosis vs F602

## 2024-12-19 17:43:11.353753 INFO::Creating boxplot for categorical data, diagnosis vs F293

## 2024-12-19 17:43:11.543533 INFO::Creating boxplot for categorical data, diagnosis vs F867

## 2024-12-19 17:43:11.709267 INFO::Creating boxplot for categorical data, diagnosis vs F108

## 2024-12-19 17:43:11.87912 INFO::Creating boxplot for categorical data, diagnosis vs F846

## 2024-12-19 17:43:12.048481 INFO::Creating boxplot for categorical data, diagnosis vs F633

## 2024-12-19 17:43:12.219515 INFO::Creating boxplot for categorical data, diagnosis vs F564

## 2024-12-19 17:43:12.402588 INFO::Creating boxplot for categorical data, diagnosis vs F183

## 2024-12-19 17:43:12.570947 INFO::Creating boxplot for categorical data, diagnosis vs F647

## 2024-12-19 17:43:12.746057 INFO::Creating boxplot for categorical data, diagnosis vs F288

## 2024-12-19 17:43:12.917331 INFO::Creating boxplot for categorical data, diagnosis vs F159

## 2024-12-19 17:43:13.090978 INFO::Creating boxplot for categorical data, diagnosis vs F638

## 2024-12-19 17:43:13.278647 INFO::Creating boxplot for categorical data, diagnosis vs F484

## 2024-12-19 17:43:13.442867 INFO::Creating boxplot for categorical data, diagnosis vs F20

## 2024-12-19 17:43:13.616388 INFO::Creating boxplot for categorical data, diagnosis vs F19

## 2024-12-19 17:43:13.783408 INFO::Creating boxplot for categorical data, diagnosis vs F897

## 2024-12-19 17:43:14.696662 INFO::Creating boxplot for categorical data, diagnosis vs F442

## 2024-12-19 17:43:14.861184 INFO::Creating boxplot for categorical data, diagnosis vs F372

## 2024-12-19 17:43:15.021185 INFO::Creating boxplot for categorical data, diagnosis vs F771

## 2024-12-19 17:43:15.182526 INFO::Creating boxplot for categorical data, diagnosis vs F370

## 2024-12-19 17:43:15.341653 INFO::Creating boxplot for categorical data, diagnosis vs F620

## 2024-12-19 17:43:15.503329 INFO::Creating boxplot for categorical data, diagnosis vs F753

## 2024-12-19 17:43:15.676961 INFO::Creating boxplot for categorical data, diagnosis vs F568

## 2024-12-19 17:43:15.837603 INFO::Creating boxplot for categorical data, diagnosis vs F312

## 2024-12-19 17:43:15.997305 INFO::Creating boxplot for categorical data, diagnosis vs F485

## 2024-12-19 17:43:16.159232 INFO::Creating boxplot for categorical data, diagnosis vs F627

## 2024-12-19 17:43:16.32071 INFO::Creating boxplot for categorical data, diagnosis vs F72

## 2024-12-19 17:43:16.493027 INFO::Creating boxplot for categorical data, diagnosis vs F575

## 2024-12-19 17:43:16.651576 INFO::Creating boxplot for categorical data, diagnosis vs F332

## 2024-12-19 17:43:16.811425 INFO::Creating boxplot for categorical data, diagnosis vs F674

## 2024-12-19 17:43:16.972715 INFO::Creating boxplot for categorical data, diagnosis vs F537

## 2024-12-19 17:43:17.133269 INFO::Creating boxplot for categorical data, diagnosis vs F839

## 2024-12-19 17:43:17.304271 INFO::Creating boxplot for categorical data, diagnosis vs F715

## 2024-12-19 17:43:17.466312 INFO::Creating boxplot for categorical data, diagnosis vs F768

## 2024-12-19 17:43:17.628842 INFO::Creating boxplot for categorical data, diagnosis vs F202

## 2024-12-19 17:43:17.79041 INFO::Creating boxplot for categorical data, diagnosis vs F756

## 2024-12-19 17:43:17.948625 INFO::Creating boxplot for categorical data, diagnosis vs F536

## 2024-12-19 17:43:18.122043 INFO::Creating boxplot for categorical data, diagnosis vs F677

## 2024-12-19 17:43:18.286995 INFO::Creating boxplot for categorical data, diagnosis vs F435

## 2024-12-19 17:43:18.451021 INFO::Creating boxplot for categorical data, diagnosis vs F574

## 2024-12-19 17:43:18.613936 INFO::Creating boxplot for categorical data, diagnosis vs F70

## 2024-12-19 17:43:18.777176 INFO::Creating boxplot for categorical data, diagnosis vs F146

## 2024-12-19 17:43:18.939702 INFO::Creating boxplot for categorical data, diagnosis vs F236

## 2024-12-19 17:43:19.113353 INFO::Creating boxplot for categorical data, diagnosis vs F527

## 2024-12-19 17:43:19.278893 INFO::Creating boxplot for categorical data, diagnosis vs F624

## 2024-12-19 17:43:19.444551 INFO::Creating boxplot for categorical data, diagnosis vs F426

## 2024-12-19 17:43:19.610765 INFO::Creating boxplot for categorical data, diagnosis vs F880

## 2024-12-19 17:43:19.773386 INFO::Creating boxplot for categorical data, diagnosis vs F549

## 2024-12-19 17:43:19.947142 INFO::Creating boxplot for categorical data, diagnosis vs F49

## 2024-12-19 17:43:20.110343 INFO::Creating boxplot for categorical data, diagnosis vs F67

## 2024-12-19 17:43:20.273097 INFO::Creating boxplot for categorical data, diagnosis vs F491

## 2024-12-19 17:43:20.437525 INFO::Creating boxplot for categorical data, diagnosis vs F174

## 2024-12-19 17:43:20.599605 INFO::Creating boxplot for categorical data, diagnosis vs F254

## 2024-12-19 17:43:20.771966 INFO::Creating boxplot for categorical data, diagnosis vs F112

## 2024-12-19 17:43:20.932663 INFO::Creating boxplot for categorical data, diagnosis vs F235

## 2024-12-19 17:43:21.092568 INFO::Creating boxplot for categorical data, diagnosis vs F833

## 2024-12-19 17:43:21.25603 INFO::Creating boxplot for categorical data, diagnosis vs F752

## 2024-12-19 17:43:21.419423 INFO::Creating boxplot for categorical data, diagnosis vs F792

## 2024-12-19 17:43:21.595021 INFO::Creating boxplot for categorical data, diagnosis vs F422

## 2024-12-19 17:43:21.757016 INFO::Creating boxplot for categorical data, diagnosis vs F6

## 2024-12-19 17:43:21.9205 INFO::Creating boxplot for categorical data, diagnosis vs F463

## 2024-12-19 17:43:22.087619 INFO::Creating boxplot for categorical data, diagnosis vs F706

## 2024-12-19 17:43:22.257058 INFO::Creating boxplot for categorical data, diagnosis vs F642

## 2024-12-19 17:43:22.433595 INFO::Creating boxplot for categorical data, diagnosis vs F65

## 2024-12-19 17:43:22.59959 INFO::Creating boxplot for categorical data, diagnosis vs F102

## 2024-12-19 17:43:22.760833 INFO::Creating boxplot for categorical data, diagnosis vs F783

## 2024-12-19 17:43:22.922128 INFO::Creating boxplot for categorical data, diagnosis vs F478

## 2024-12-19 17:43:23.084853 INFO::Creating boxplot for categorical data, diagnosis vs F889

## 2024-12-19 17:43:23.26335 INFO::Creating boxplot for categorical data, diagnosis vs F350

## 2024-12-19 17:43:23.428099 INFO::Creating boxplot for categorical data, diagnosis vs F681

## 2024-12-19 17:43:23.593841 INFO::Creating boxplot for categorical data, diagnosis vs F748

## 2024-12-19 17:43:23.758615 INFO::Creating boxplot for categorical data, diagnosis vs F762

## 2024-12-19 17:43:23.924779 INFO::Creating boxplot for categorical data, diagnosis vs F852

## 2024-12-19 17:43:24.110192 INFO::Creating boxplot for categorical data, diagnosis vs F180

## 2024-12-19 17:43:24.282535 INFO::Creating boxplot for categorical data, diagnosis vs F248

## 2024-12-19 17:43:24.456098 INFO::Creating boxplot for categorical data, diagnosis vs F759

## 2024-12-19 17:43:24.616575 INFO::Creating boxplot for categorical data, diagnosis vs F824

## 2024-12-19 17:43:24.778475 INFO::Creating boxplot for categorical data, diagnosis vs F145

## 2024-12-19 17:43:24.944907 INFO::Creating boxplot for categorical data, diagnosis vs F16

## 2024-12-19 17:43:25.121234 INFO::Creating boxplot for categorical data, diagnosis vs F169

## 2024-12-19 17:43:25.28826 INFO::Creating boxplot for categorical data, diagnosis vs F392

## 2024-12-19 17:43:25.455315 INFO::Creating boxplot for categorical data, diagnosis vs F468

## 2024-12-19 17:43:25.62075 INFO::Creating boxplot for categorical data, diagnosis vs F476

## 2024-12-19 17:43:25.788819 INFO::Creating boxplot for categorical data, diagnosis vs F699

## 2024-12-19 17:43:25.967469 INFO::Creating boxplot for categorical data, diagnosis vs F735

## 2024-12-19 17:43:26.130617 INFO::Creating boxplot for categorical data, diagnosis vs F182

## 2024-12-19 17:43:26.292094 INFO::Creating boxplot for categorical data, diagnosis vs F64

## 2024-12-19 17:43:26.451288 INFO::Creating boxplot for categorical data, diagnosis vs F203

## 2024-12-19 17:43:26.61284 INFO::Creating boxplot for categorical data, diagnosis vs F877

## 2024-12-19 17:43:26.784478 INFO::Creating boxplot for categorical data, diagnosis vs F433

## 2024-12-19 17:43:26.948124 INFO::Creating boxplot for categorical data, diagnosis vs F739

## 2024-12-19 17:43:27.114715 INFO::Creating boxplot for categorical data, diagnosis vs F749

## 2024-12-19 17:43:27.278077 INFO::Creating boxplot for categorical data, diagnosis vs F382

## 2024-12-19 17:43:27.438985 INFO::Creating boxplot for categorical data, diagnosis vs F162

## 2024-12-19 17:43:27.611334 INFO::Creating boxplot for categorical data, diagnosis vs F438

## 2024-12-19 17:43:27.771381 INFO::Creating boxplot for categorical data, diagnosis vs F360

## 2024-12-19 17:43:27.934806 INFO::Creating boxplot for categorical data, diagnosis vs F56

## 2024-12-19 17:43:28.096625 INFO::Creating boxplot for categorical data, diagnosis vs F529

## 2024-12-19 17:43:28.261156 INFO::Creating boxplot for categorical data, diagnosis vs F48

## 2024-12-19 17:43:28.439087 INFO::Creating boxplot for categorical data, diagnosis vs F826

## 2024-12-19 17:43:28.60036 INFO::Creating boxplot for categorical data, diagnosis vs F488

## 2024-12-19 17:43:28.761837 INFO::Creating boxplot for categorical data, diagnosis vs F309

## 2024-12-19 17:43:28.923252 INFO::Creating boxplot for categorical data, diagnosis vs F834

## 2024-12-19 17:43:29.088672 INFO::Creating boxplot for categorical data, diagnosis vs F449

## 2024-12-19 17:43:29.264056 INFO::Creating boxplot for categorical data, diagnosis vs F77

## 2024-12-19 17:43:29.425803 INFO::Creating boxplot for categorical data, diagnosis vs F365

## 2024-12-19 17:43:29.588534 INFO::Creating boxplot for categorical data, diagnosis vs F346

## 2024-12-19 17:43:29.75256 INFO::Creating boxplot for categorical data, diagnosis vs F654

## 2024-12-19 17:43:29.916358 INFO::Creating boxplot for categorical data, diagnosis vs F79

## 2024-12-19 17:43:30.088801 INFO::Creating boxplot for categorical data, diagnosis vs F785

## 2024-12-19 17:43:30.249816 INFO::Creating boxplot for categorical data, diagnosis vs F415

## 2024-12-19 17:43:30.41093 INFO::Creating boxplot for categorical data, diagnosis vs F466

## 2024-12-19 17:43:30.575726 INFO::Creating boxplot for categorical data, diagnosis vs F643

## 2024-12-19 17:43:30.740791 INFO::Creating boxplot for categorical data, diagnosis vs F160

## 2024-12-19 17:43:30.918677 INFO::Creating boxplot for categorical data, diagnosis vs F69

## 2024-12-19 17:43:31.082919 INFO::Creating boxplot for categorical data, diagnosis vs F498

## 2024-12-19 17:43:31.24612 INFO::Creating boxplot for categorical data, diagnosis vs F207

## 2024-12-19 17:43:31.41058 INFO::Creating boxplot for categorical data, diagnosis vs F679

## 2024-12-19 17:43:31.5708 INFO::Creating boxplot for categorical data, diagnosis vs F618

## 2024-12-19 17:43:31.745804 INFO::Creating boxplot for categorical data, diagnosis vs F255

## 2024-12-19 17:43:31.906694 INFO::Creating boxplot for categorical data, diagnosis vs F267

## 2024-12-19 17:43:32.071175 INFO::Creating boxplot for categorical data, diagnosis vs F143

## 2024-12-19 17:43:32.23606 INFO::Creating boxplot for categorical data, diagnosis vs F286

## 2024-12-19 17:43:32.397304 INFO::Creating boxplot for categorical data, diagnosis vs F562

## 2024-12-19 17:43:32.622302 INFO::Creating boxplot for categorical data, diagnosis vs F100

## 2024-12-19 17:43:32.791507 INFO::Creating boxplot for categorical data, diagnosis vs F374

## 2024-12-19 17:43:32.95951 INFO::Creating boxplot for categorical data, diagnosis vs F535

## 2024-12-19 17:43:33.129856 INFO::Creating boxplot for categorical data, diagnosis vs F658

## 2024-12-19 17:43:33.299427 INFO::Creating boxplot for categorical data, diagnosis vs F707

## 2024-12-19 17:43:33.483808 INFO::Creating boxplot for categorical data, diagnosis vs F325

## 2024-12-19 17:43:33.647766 INFO::Creating boxplot for categorical data, diagnosis vs F89

## 2024-12-19 17:43:33.810116 INFO::Creating boxplot for categorical data, diagnosis vs F214

## 2024-12-19 17:43:33.976046 INFO::Creating boxplot for categorical data, diagnosis vs F578

## 2024-12-19 17:43:34.144292 INFO::Creating boxplot for categorical data, diagnosis vs F790

## 2024-12-19 17:43:34.325073 INFO::Creating boxplot for categorical data, diagnosis vs F265

## 2024-12-19 17:43:34.494144 INFO::Creating boxplot for categorical data, diagnosis vs F253

## 2024-12-19 17:43:34.659253 INFO::Creating boxplot for categorical data, diagnosis vs F294

## 2024-12-19 17:43:34.828933 INFO::Creating boxplot for categorical data, diagnosis vs F410

## 2024-12-19 17:43:35.000873 INFO::Creating boxplot for categorical data, diagnosis vs F614

## 2024-12-19 17:43:35.179917 INFO::Creating boxplot for categorical data, diagnosis vs F764

## 2024-12-19 17:43:35.348063 INFO::Creating boxplot for categorical data, diagnosis vs F59

## 2024-12-19 17:43:35.510461 INFO::Creating boxplot for categorical data, diagnosis vs F675

## 2024-12-19 17:43:35.677157 INFO::Creating boxplot for categorical data, diagnosis vs F441

## 2024-12-19 17:43:35.845344 INFO::Creating boxplot for categorical data, diagnosis vs F193

## 2024-12-19 17:43:36.010308 INFO::Creating boxplot for categorical data, diagnosis vs F689

## 2024-12-19 17:43:36.198014 INFO::Creating boxplot for categorical data, diagnosis vs F249

## 2024-12-19 17:43:36.364614 INFO::Creating boxplot for categorical data, diagnosis vs F821

## 2024-12-19 17:43:36.534667 INFO::Creating boxplot for categorical data, diagnosis vs F351

## 2024-12-19 17:43:36.706276 INFO::Creating boxplot for categorical data, diagnosis vs F66

## 2024-12-19 17:43:36.874779 INFO::Creating boxplot for categorical data, diagnosis vs F413

## 2024-12-19 17:43:37.057237 INFO::Creating boxplot for categorical data, diagnosis vs F172

## 2024-12-19 17:43:37.223824 INFO::Creating boxplot for categorical data, diagnosis vs F317

## 2024-12-19 17:43:37.3887 INFO::Creating boxplot for categorical data, diagnosis vs F167

## 2024-12-19 17:43:37.556814 INFO::Creating boxplot for categorical data, diagnosis vs F229

## 2024-12-19 17:43:37.722435 INFO::Creating boxplot for categorical data, diagnosis vs F243

## 2024-12-19 17:43:37.904266 INFO::Creating boxplot for categorical data, diagnosis vs F732

## 2024-12-19 17:43:38.067602 INFO::Creating boxplot for categorical data, diagnosis vs F467

## 2024-12-19 17:43:38.23074 INFO::Creating boxplot for categorical data, diagnosis vs F474

## 2024-12-19 17:43:38.400787 INFO::Creating boxplot for categorical data, diagnosis vs F156

## 2024-12-19 17:43:38.568726 INFO::Creating boxplot for categorical data, diagnosis vs F786

## 2024-12-19 17:43:38.748922 INFO::Creating boxplot for categorical data, diagnosis vs F216

## 2024-12-19 17:43:38.91485 INFO::Creating boxplot for categorical data, diagnosis vs F85

## 2024-12-19 17:43:39.080788 INFO::Creating boxplot for categorical data, diagnosis vs F621

## 2024-12-19 17:43:39.248316 INFO::Creating boxplot for categorical data, diagnosis vs F558

## 2024-12-19 17:43:39.414741 INFO::Creating boxplot for categorical data, diagnosis vs F582

## 2024-12-19 17:43:39.593651 INFO::Creating boxplot for categorical data, diagnosis vs F898

## 2024-12-19 17:43:39.759302 INFO::Creating boxplot for categorical data, diagnosis vs F402

## 2024-12-19 17:43:39.921856 INFO::Creating boxplot for categorical data, diagnosis vs F71

## 2024-12-19 17:43:40.086038 INFO::Creating boxplot for categorical data, diagnosis vs F99

## 2024-12-19 17:43:40.252634 INFO::Creating boxplot for categorical data, diagnosis vs F366

## 2024-12-19 17:43:40.435963 INFO::Creating boxplot for categorical data, diagnosis vs F778

## 2024-12-19 17:43:40.598676 INFO::Creating boxplot for categorical data, diagnosis vs F188

## 2024-12-19 17:43:40.760831 INFO::Creating boxplot for categorical data, diagnosis vs F857

## 2024-12-19 17:43:40.924548 INFO::Creating boxplot for categorical data, diagnosis vs F440

## 2024-12-19 17:43:41.089642 INFO::Creating boxplot for categorical data, diagnosis vs F799

## 2024-12-19 17:43:41.271394 INFO::Creating boxplot for categorical data, diagnosis vs F482

## 2024-12-19 17:43:41.434045 INFO::Creating boxplot for categorical data, diagnosis vs F212

## 2024-12-19 17:43:41.592908 INFO::Creating boxplot for categorical data, diagnosis vs F882

## 2024-12-19 17:43:41.75912 INFO::Creating boxplot for categorical data, diagnosis vs F599

## 2024-12-19 17:43:41.930308 INFO::Creating boxplot for categorical data, diagnosis vs F302

## 2024-12-19 17:43:42.098462 INFO::Creating boxplot for categorical data, diagnosis vs F543

## 2024-12-19 17:43:42.284224 INFO::Creating boxplot for categorical data, diagnosis vs F269

## 2024-12-19 17:43:42.453788 INFO::Creating boxplot for categorical data, diagnosis vs F650

## 2024-12-19 17:43:42.618084 INFO::Creating boxplot for categorical data, diagnosis vs F456

## 2024-12-19 17:43:42.781411 INFO::Creating boxplot for categorical data, diagnosis vs F573

## 2024-12-19 17:43:42.947897 INFO::Creating boxplot for categorical data, diagnosis vs F8

## 2024-12-19 17:43:43.12816 INFO::Creating boxplot for categorical data, diagnosis vs F810

## 2024-12-19 17:43:43.290004 INFO::Creating boxplot for categorical data, diagnosis vs F401

## 2024-12-19 17:43:43.457928 INFO::Creating boxplot for categorical data, diagnosis vs F606

## 2024-12-19 17:43:43.626779 INFO::Creating boxplot for categorical data, diagnosis vs F662

## 2024-12-19 17:43:43.799374 INFO::Creating boxplot for categorical data, diagnosis vs F765

## 2024-12-19 17:43:43.984088 INFO::Creating boxplot for categorical data, diagnosis vs F887

## 2024-12-19 17:43:44.150698 INFO::Creating boxplot for categorical data, diagnosis vs F770

## 2024-12-19 17:43:44.317405 INFO::Creating boxplot for categorical data, diagnosis vs F469

## 2024-12-19 17:43:44.488295 INFO::Creating boxplot for categorical data, diagnosis vs F86

## 2024-12-19 17:43:44.661694 INFO::Creating boxplot for categorical data, diagnosis vs F400

## 2024-12-19 17:43:44.85271 INFO::Creating boxplot for categorical data, diagnosis vs F579

## 2024-12-19 17:43:45.017927 INFO::Creating boxplot for categorical data, diagnosis vs F871

## 2024-12-19 17:43:45.183899 INFO::Creating boxplot for categorical data, diagnosis vs F37

## 2024-12-19 17:43:45.35963 INFO::Creating boxplot for categorical data, diagnosis vs F446

## 2024-12-19 17:43:45.533417 INFO::Creating boxplot for categorical data, diagnosis vs F218

## 2024-12-19 17:43:45.727218 INFO::Creating boxplot for categorical data, diagnosis vs F321

## 2024-12-19 17:43:45.890333 INFO::Creating boxplot for categorical data, diagnosis vs F487

## 2024-12-19 17:43:46.056366 INFO::Creating boxplot for categorical data, diagnosis vs F740

## 2024-12-19 17:43:46.225559 INFO::Creating boxplot for categorical data, diagnosis vs F141

## 2024-12-19 17:43:46.393311 INFO::Creating boxplot for categorical data, diagnosis vs F327

## 2024-12-19 17:43:46.576899 INFO::Creating boxplot for categorical data, diagnosis vs F196

## 2024-12-19 17:43:46.742662 INFO::Creating boxplot for categorical data, diagnosis vs F883

## 2024-12-19 17:43:46.911076 INFO::Creating boxplot for categorical data, diagnosis vs F279

## 2024-12-19 17:43:47.081271 INFO::Creating boxplot for categorical data, diagnosis vs F838

## 2024-12-19 17:43:47.251781 INFO::Creating boxplot for categorical data, diagnosis vs F451

## 2024-12-19 17:43:47.436073 INFO::Creating boxplot for categorical data, diagnosis vs F854

## 2024-12-19 17:43:47.597687 INFO::Creating boxplot for categorical data, diagnosis vs F434

## 2024-12-19 17:43:47.761894 INFO::Creating boxplot for categorical data, diagnosis vs F519

## 2024-12-19 17:43:47.925842 INFO::Creating boxplot for categorical data, diagnosis vs F694

## 2024-12-19 17:43:48.096549 INFO::Creating boxplot for categorical data, diagnosis vs F561

## 2024-12-19 17:43:48.283514 INFO::Creating boxplot for categorical data, diagnosis vs F10

## 2024-12-19 17:43:48.452418 INFO::Creating boxplot for categorical data, diagnosis vs F303

## 2024-12-19 17:43:48.619855 INFO::Creating boxplot for categorical data, diagnosis vs F512

## 2024-12-19 17:43:48.794729 INFO::Creating boxplot for categorical data, diagnosis vs F645

## 2024-12-19 17:43:48.968653 INFO::Creating boxplot for categorical data, diagnosis vs F793

## 2024-12-19 17:43:49.163891 INFO::Creating boxplot for categorical data, diagnosis vs F404

## 2024-12-19 17:43:49.330351 INFO::Creating boxplot for categorical data, diagnosis vs F362

## 2024-12-19 17:43:49.50065 INFO::Creating boxplot for categorical data, diagnosis vs F525

## 2024-12-19 17:43:49.674145 INFO::Creating boxplot for categorical data, diagnosis vs F742

## 2024-12-19 17:43:49.849651 INFO::Creating boxplot for categorical data, diagnosis vs F276

## 2024-12-19 17:43:50.042156 INFO::Creating boxplot for categorical data, diagnosis vs F499

## 2024-12-19 17:43:50.212054 INFO::Creating boxplot for categorical data, diagnosis vs F328

## 2024-12-19 17:43:50.394126 INFO::Creating boxplot for categorical data, diagnosis vs F787

## 2024-12-19 17:43:50.574248 INFO::Creating boxplot for categorical data, diagnosis vs F30

## 2024-12-19 17:43:50.745534 INFO::Creating boxplot for categorical data, diagnosis vs F122

## 2024-12-19 17:43:50.961633 INFO::Creating boxplot for categorical data, diagnosis vs F619

## 2024-12-19 17:43:51.130115 INFO::Creating boxplot for categorical data, diagnosis vs F572

## 2024-12-19 17:43:51.295913 INFO::Creating boxplot for categorical data, diagnosis vs F47

## 2024-12-19 17:43:51.466481 INFO::Creating boxplot for categorical data, diagnosis vs F570

## 2024-12-19 17:43:51.633696 INFO::Creating boxplot for categorical data, diagnosis vs F26

## 2024-12-19 17:43:51.823207 INFO::Creating boxplot for categorical data, diagnosis vs F252

## 2024-12-19 17:43:51.99542 INFO::Creating boxplot for categorical data, diagnosis vs F117

## 2024-12-19 17:43:52.159804 INFO::Creating boxplot for categorical data, diagnosis vs F683

## 2024-12-19 17:43:52.326459 INFO::Creating boxplot for categorical data, diagnosis vs F395

## 2024-12-19 17:43:52.494889 INFO::Creating boxplot for categorical data, diagnosis vs F822

## 2024-12-19 17:43:52.683388 INFO::Creating boxplot for categorical data, diagnosis vs F46

## 2024-12-19 17:43:52.849335 INFO::Creating boxplot for categorical data, diagnosis vs F154

## 2024-12-19 17:43:53.013383 INFO::Creating boxplot for categorical data, diagnosis vs F540

## 2024-12-19 17:43:53.182601 INFO::Creating boxplot for categorical data, diagnosis vs F884

## 2024-12-19 17:43:53.346005 INFO::Creating boxplot for categorical data, diagnosis vs F368

## 2024-12-19 17:43:53.536052 INFO::Creating boxplot for categorical data, diagnosis vs F607

## 2024-12-19 17:43:53.705839 INFO::Creating boxplot for categorical data, diagnosis vs F111

## 2024-12-19 17:43:53.870815 INFO::Creating boxplot for categorical data, diagnosis vs F745

## 2024-12-19 17:43:54.035697 INFO::Creating boxplot for categorical data, diagnosis vs F673

## 2024-12-19 17:43:54.207727 INFO::Creating boxplot for categorical data, diagnosis vs F92

## 2024-12-19 17:43:54.397569 INFO::Creating boxplot for categorical data, diagnosis vs F493

## 2024-12-19 17:43:54.576251 INFO::Creating boxplot for categorical data, diagnosis vs F835

## 2024-12-19 17:43:54.74974 INFO::Creating boxplot for categorical data, diagnosis vs F872

## 2024-12-19 17:43:54.9184 INFO::Creating boxplot for categorical data, diagnosis vs F879

## 2024-12-19 17:43:55.090631 INFO::Creating boxplot for categorical data, diagnosis vs F432

## 2024-12-19 17:43:55.264572 INFO::Creating boxplot for categorical data, diagnosis vs F518

## 2024-12-19 17:43:55.4651 INFO::Creating boxplot for categorical data, diagnosis vs F44

## 2024-12-19 17:43:55.636047 INFO::Creating boxplot for categorical data, diagnosis vs F240

## 2024-12-19 17:43:55.80213 INFO::Creating boxplot for categorical data, diagnosis vs F819

## 2024-12-19 17:43:55.974764 INFO::Creating boxplot for categorical data, diagnosis vs F411

## 2024-12-19 17:43:56.153249 INFO::Creating boxplot for categorical data, diagnosis vs F353

## 2024-12-19 17:43:56.357194 INFO::Creating boxplot for categorical data, diagnosis vs F763

## 2024-12-19 17:43:56.52971 INFO::Creating boxplot for categorical data, diagnosis vs F97

## 2024-12-19 17:43:56.695308 INFO::Creating boxplot for categorical data, diagnosis vs F40

## 2024-12-19 17:43:56.864424 INFO::Creating boxplot for categorical data, diagnosis vs F652

## 2024-12-19 17:43:57.033645 INFO::Creating boxplot for categorical data, diagnosis vs F789

## 2024-12-19 17:43:57.224988 INFO::Creating boxplot for categorical data, diagnosis vs F25

## 2024-12-19 17:43:57.391275 INFO::Creating boxplot for categorical data, diagnosis vs F256

## 2024-12-19 17:43:57.556329 INFO::Creating boxplot for categorical data, diagnosis vs F423

## 2024-12-19 17:43:57.731412 INFO::Creating boxplot for categorical data, diagnosis vs F594

## 2024-12-19 17:43:57.905329 INFO::Creating boxplot for categorical data, diagnosis vs F201

## 2024-12-19 17:43:58.10309 INFO::Creating boxplot for categorical data, diagnosis vs F813

## 2024-12-19 17:43:58.277855 INFO::Creating boxplot for categorical data, diagnosis vs F653

## 2024-12-19 17:43:58.445999 INFO::Creating boxplot for categorical data, diagnosis vs F524

## 2024-12-19 17:43:58.616225 INFO::Creating boxplot for categorical data, diagnosis vs F777

## 2024-12-19 17:43:58.78877 INFO::Creating boxplot for categorical data, diagnosis vs F226

## 2024-12-19 17:43:58.984999 INFO::Creating boxplot for categorical data, diagnosis vs F227

## 2024-12-19 17:43:59.159175 INFO::Creating boxplot for categorical data, diagnosis vs F521

## 2024-12-19 17:43:59.327612 INFO::Creating boxplot for categorical data, diagnosis vs F14

## 2024-12-19 17:43:59.496628 INFO::Creating boxplot for categorical data, diagnosis vs F310

## 2024-12-19 17:43:59.666894 INFO::Creating boxplot for categorical data, diagnosis vs F452

## 2024-12-19 17:43:59.860056 INFO::Creating boxplot for categorical data, diagnosis vs F52

## 2024-12-19 17:44:00.031041 INFO::Creating boxplot for categorical data, diagnosis vs F53

## 2024-12-19 17:44:00.200477 INFO::Creating boxplot for categorical data, diagnosis vs F844

## 2024-12-19 17:44:00.372398 INFO::Creating boxplot for categorical data, diagnosis vs F31

## 2024-12-19 17:44:00.548316 INFO::Creating boxplot for categorical data, diagnosis vs F795

## 2024-12-19 17:44:00.759912 INFO::Creating boxplot for categorical data, diagnosis vs F766

## 2024-12-19 17:44:00.941389 INFO::Creating boxplot for categorical data, diagnosis vs F342

## 2024-12-19 17:44:01.122033 INFO::Creating boxplot for categorical data, diagnosis vs F408

## 2024-12-19 17:44:01.304117 INFO::Creating boxplot for categorical data, diagnosis vs F282

## 2024-12-19 17:44:01.493333 INFO::Creating boxplot for categorical data, diagnosis vs F508

## 2024-12-19 17:44:01.70434 INFO::Creating boxplot for categorical data, diagnosis vs F805

## 2024-12-19 17:44:01.887125 INFO::Creating boxplot for categorical data, diagnosis vs F337

## 2024-12-19 17:44:02.068389 INFO::Creating boxplot for categorical data, diagnosis vs F820

## 2024-12-19 17:44:02.247877 INFO::Creating boxplot for categorical data, diagnosis vs F593

## 2024-12-19 17:44:02.42626 INFO::Creating boxplot for categorical data, diagnosis vs F701

## 2024-12-19 17:44:02.623521 INFO::Creating boxplot for categorical data, diagnosis vs F459

## 2024-12-19 17:44:02.794627 INFO::Creating boxplot for categorical data, diagnosis vs F305

## 2024-12-19 17:44:02.964804 INFO::Creating boxplot for categorical data, diagnosis vs F142

## 2024-12-19 17:44:03.133347 INFO::Creating boxplot for categorical data, diagnosis vs F534

## 2024-12-19 17:44:03.306055 INFO::Creating boxplot for categorical data, diagnosis vs F135

## 2024-12-19 17:44:03.506613 INFO::Creating boxplot for categorical data, diagnosis vs F702

## 2024-12-19 17:44:03.683182 INFO::Creating boxplot for categorical data, diagnosis vs F776

## 2024-12-19 17:44:03.852669 INFO::Creating boxplot for categorical data, diagnosis vs F295

## 2024-12-19 17:44:04.025436 INFO::Creating boxplot for categorical data, diagnosis vs F355

## 2024-12-19 17:44:04.195087 INFO::Creating boxplot for categorical data, diagnosis vs F797

## 2024-12-19 17:44:04.394055 INFO::Creating boxplot for categorical data, diagnosis vs F13

## 2024-12-19 17:44:04.568814 INFO::Creating boxplot for categorical data, diagnosis vs F356

## 2024-12-19 17:44:04.745495 INFO::Creating boxplot for categorical data, diagnosis vs F359

## 2024-12-19 17:44:04.918903 INFO::Creating boxplot for categorical data, diagnosis vs F121

## 2024-12-19 17:44:05.094934 INFO::Creating boxplot for categorical data, diagnosis vs F850

## 2024-12-19 17:44:05.288247 INFO::Creating boxplot for categorical data, diagnosis vs F899

## 2024-12-19 17:44:05.460459 INFO::Creating boxplot for categorical data, diagnosis vs F628

## 2024-12-19 17:44:05.624575 INFO::Creating boxplot for categorical data, diagnosis vs F843

## 2024-12-19 17:44:05.796076 INFO::Creating boxplot for categorical data, diagnosis vs F107

## 2024-12-19 17:44:05.967466 INFO::Creating boxplot for categorical data, diagnosis vs F287

## 2024-12-19 17:44:06.168233 INFO::Creating boxplot for categorical data, diagnosis vs F165

## 2024-12-19 17:44:06.340682 INFO::Creating boxplot for categorical data, diagnosis vs F557

## 2024-12-19 17:44:06.517232 INFO::Creating boxplot for categorical data, diagnosis vs F127

## 2024-12-19 17:44:06.692766 INFO::Creating boxplot for categorical data, diagnosis vs F299

## 2024-12-19 17:44:06.864168 INFO::Creating boxplot for categorical data, diagnosis vs F497

## 2024-12-19 17:44:07.063748 INFO::Creating boxplot for categorical data, diagnosis vs F711

## 2024-12-19 17:44:07.240539 INFO::Creating boxplot for categorical data, diagnosis vs F319

## 2024-12-19 17:44:07.411545 INFO::Creating boxplot for categorical data, diagnosis vs F271

## 2024-12-19 17:44:07.576375 INFO::Creating boxplot for categorical data, diagnosis vs F157

## 2024-12-19 17:44:07.74467 INFO::Creating boxplot for categorical data, diagnosis vs F560

## 2024-12-19 17:44:07.937912 INFO::Creating boxplot for categorical data, diagnosis vs F680

## 2024-12-19 17:44:08.109373 INFO::Creating boxplot for categorical data, diagnosis vs F580

## 2024-12-19 17:44:08.276828 INFO::Creating boxplot for categorical data, diagnosis vs F152

## 2024-12-19 17:44:08.443926 INFO::Creating boxplot for categorical data, diagnosis vs F12

## 2024-12-19 17:44:08.614774 INFO::Creating boxplot for categorical data, diagnosis vs F324

## 2024-12-19 17:44:08.814721 INFO::Creating boxplot for categorical data, diagnosis vs F893

## 2024-12-19 17:44:08.991674 INFO::Creating boxplot for categorical data, diagnosis vs F318

## 2024-12-19 17:44:09.161368 INFO::Creating boxplot for categorical data, diagnosis vs F784

## 2024-12-19 17:44:09.330716 INFO::Creating boxplot for categorical data, diagnosis vs F567

## 2024-12-19 17:44:09.504337 INFO::Creating boxplot for categorical data, diagnosis vs F457

## 2024-12-19 17:44:09.756762 INFO::Creating boxplot for categorical data, diagnosis vs F708

## 2024-12-19 17:44:09.928569 INFO::Creating boxplot for categorical data, diagnosis vs F669

## 2024-12-19 17:44:10.101177 INFO::Creating boxplot for categorical data, diagnosis vs F87

## 2024-12-19 17:44:12.445955 INFO::Plotting data for metadata number 2, antibiotics
## 2024-12-19 17:44:12.448021 INFO::Creating boxplot for categorical data, antibiotics vs F663

## 2024-12-19 17:44:12.631276 INFO::Creating boxplot for categorical data, antibiotics vs F838

## 2024-12-19 17:44:12.811544 INFO::Creating boxplot for categorical data, antibiotics vs F764

## 2024-12-19 17:44:12.991654 INFO::Creating boxplot for categorical data, antibiotics vs F880

## 2024-12-19 17:44:13.191249 INFO::Creating boxplot for categorical data, antibiotics vs F751

## 2024-12-19 17:44:13.374136 INFO::Creating boxplot for categorical data, antibiotics vs F288

## 2024-12-19 17:44:13.558861 INFO::Creating boxplot for categorical data, antibiotics vs F65

## 2024-12-19 17:44:13.739898 INFO::Creating boxplot for categorical data, antibiotics vs F742

## 2024-12-19 17:44:13.932315 INFO::Creating boxplot for categorical data, antibiotics vs F528

## 2024-12-19 17:44:14.117193 INFO::Creating boxplot for categorical data, antibiotics vs F790

## 2024-12-19 17:44:14.293573 INFO::Creating boxplot for categorical data, antibiotics vs F777

## 2024-12-19 17:44:14.472224 INFO::Creating boxplot for categorical data, antibiotics vs F178

## 2024-12-19 17:44:14.651018 INFO::Creating boxplot for categorical data, antibiotics vs F139

## 2024-12-19 17:44:14.852589 INFO::Creating boxplot for categorical data, antibiotics vs F202

## 2024-12-19 17:44:15.034875 INFO::Creating boxplot for categorical data, antibiotics vs F220

## 2024-12-19 17:44:15.215067 INFO::Creating boxplot for categorical data, antibiotics vs F397

## 2024-12-19 17:44:15.398945 INFO::Creating boxplot for categorical data, antibiotics vs F882

## 2024-12-19 17:44:15.57616 INFO::Creating boxplot for categorical data, antibiotics vs F446

## 2024-12-19 17:44:15.778091 INFO::Creating boxplot for categorical data, antibiotics vs F418

## 2024-12-19 17:44:15.958011 INFO::Creating boxplot for categorical data, antibiotics vs F133

## 2024-12-19 17:44:16.137295 INFO::Creating boxplot for categorical data, antibiotics vs F696

## 2024-12-19 17:44:16.316634 INFO::Creating boxplot for categorical data, antibiotics vs F548

## 2024-12-19 17:44:16.497446 INFO::Creating boxplot for categorical data, antibiotics vs F536

## 2024-12-19 17:44:16.701508 INFO::Creating boxplot for categorical data, antibiotics vs F194

## 2024-12-19 17:44:16.887814 INFO::Creating boxplot for categorical data, antibiotics vs F34

## 2024-12-19 17:44:17.070892 INFO::Creating boxplot for categorical data, antibiotics vs F153

## 2024-12-19 17:44:17.250153 INFO::Creating boxplot for categorical data, antibiotics vs F400

## 2024-12-19 17:44:17.43337 INFO::Creating boxplot for categorical data, antibiotics vs F794

## 2024-12-19 17:44:17.635068 INFO::Creating boxplot for categorical data, antibiotics vs F396

## 2024-12-19 17:44:17.816287 INFO::Creating boxplot for categorical data, antibiotics vs F182

## 2024-12-19 17:44:17.999962 INFO::Creating boxplot for categorical data, antibiotics vs F719

## 2024-12-19 17:44:18.180374 INFO::Creating boxplot for categorical data, antibiotics vs F109

## 2024-12-19 17:44:18.382513 INFO::Creating boxplot for categorical data, antibiotics vs F180

## 2024-12-19 17:44:18.564964 INFO::Creating boxplot for categorical data, antibiotics vs F552

## 2024-12-19 17:44:18.745433 INFO::Creating boxplot for categorical data, antibiotics vs F789

## 2024-12-19 17:44:18.927321 INFO::Creating boxplot for categorical data, antibiotics vs F893

## 2024-12-19 17:44:19.110787 INFO::Creating boxplot for categorical data, antibiotics vs F834

## 2024-12-19 17:44:19.317678 INFO::Creating boxplot for categorical data, antibiotics vs F889

## 2024-12-19 17:44:19.502342 INFO::Creating boxplot for categorical data, antibiotics vs F143

## 2024-12-19 17:44:19.689843 INFO::Creating boxplot for categorical data, antibiotics vs F224

## 2024-12-19 17:44:19.877328 INFO::Creating boxplot for categorical data, antibiotics vs F5

## 2024-12-19 17:44:20.06149 INFO::Creating boxplot for categorical data, antibiotics vs F873

## 2024-12-19 17:44:20.27073 INFO::Creating boxplot for categorical data, antibiotics vs F452

## 2024-12-19 17:44:20.455615 INFO::Creating boxplot for categorical data, antibiotics vs F681

## 2024-12-19 17:44:20.633304 INFO::Creating boxplot for categorical data, antibiotics vs F468

## 2024-12-19 17:44:20.812754 INFO::Creating boxplot for categorical data, antibiotics vs F731

## 2024-12-19 17:44:21.010633 INFO::Creating boxplot for categorical data, antibiotics vs F479

## 2024-12-19 17:44:21.200339 INFO::Creating boxplot for categorical data, antibiotics vs F520

## 2024-12-19 17:44:21.384081 INFO::Creating boxplot for categorical data, antibiotics vs F649

## 2024-12-19 17:44:21.56675 INFO::Creating boxplot for categorical data, antibiotics vs F259

## 2024-12-19 17:44:21.750858 INFO::Creating boxplot for categorical data, antibiotics vs F186

## 2024-12-19 17:44:21.95614 INFO::Creating boxplot for categorical data, antibiotics vs F312

## 2024-12-19 17:44:22.138628 INFO::Creating boxplot for categorical data, antibiotics vs F477

## 2024-12-19 17:44:22.319818 INFO::Creating boxplot for categorical data, antibiotics vs F4

## 2024-12-19 17:44:22.503423 INFO::Creating boxplot for categorical data, antibiotics vs F632

## 2024-12-19 17:44:22.686197 INFO::Creating boxplot for categorical data, antibiotics vs F31

## 2024-12-19 17:44:22.894569 INFO::Creating boxplot for categorical data, antibiotics vs F184

## 2024-12-19 17:44:23.081206 INFO::Creating boxplot for categorical data, antibiotics vs F7

## 2024-12-19 17:44:23.26322 INFO::Creating boxplot for categorical data, antibiotics vs F213

## 2024-12-19 17:44:23.442109 INFO::Creating boxplot for categorical data, antibiotics vs F691

## 2024-12-19 17:44:23.63859 INFO::Creating boxplot for categorical data, antibiotics vs F828

## 2024-12-19 17:44:23.822824 INFO::Creating boxplot for categorical data, antibiotics vs F831

## 2024-12-19 17:44:24.001948 INFO::Creating boxplot for categorical data, antibiotics vs F315

## 2024-12-19 17:44:24.180549 INFO::Creating boxplot for categorical data, antibiotics vs F159

## 2024-12-19 17:44:24.361105 INFO::Creating boxplot for categorical data, antibiotics vs F331

## 2024-12-19 17:44:24.567044 INFO::Creating boxplot for categorical data, antibiotics vs F757

## 2024-12-19 17:44:24.752024 INFO::Creating boxplot for categorical data, antibiotics vs F167

## 2024-12-19 17:44:24.935228 INFO::Creating boxplot for categorical data, antibiotics vs F85

## 2024-12-19 17:44:25.115145 INFO::Creating boxplot for categorical data, antibiotics vs F80

## 2024-12-19 17:44:25.295689 INFO::Creating boxplot for categorical data, antibiotics vs F105

## 2024-12-19 17:44:25.500278 INFO::Creating boxplot for categorical data, antibiotics vs F674

## 2024-12-19 17:44:25.687559 INFO::Creating boxplot for categorical data, antibiotics vs F50

## 2024-12-19 17:44:25.869725 INFO::Creating boxplot for categorical data, antibiotics vs F164

## 2024-12-19 17:44:26.052731 INFO::Creating boxplot for categorical data, antibiotics vs F840

## 2024-12-19 17:44:26.272088 INFO::Creating boxplot for categorical data, antibiotics vs F232

## 2024-12-19 17:44:26.471492 INFO::Creating boxplot for categorical data, antibiotics vs F872

## 2024-12-19 17:44:26.654769 INFO::Creating boxplot for categorical data, antibiotics vs F54

## 2024-12-19 17:44:26.836666 INFO::Creating boxplot for categorical data, antibiotics vs F365

## 2024-12-19 17:44:27.015018 INFO::Creating boxplot for categorical data, antibiotics vs F499

## 2024-12-19 17:44:27.219794 INFO::Creating boxplot for categorical data, antibiotics vs F510

## 2024-12-19 17:44:27.401616 INFO::Creating boxplot for categorical data, antibiotics vs F716

## 2024-12-19 17:44:27.583578 INFO::Creating boxplot for categorical data, antibiotics vs F454

## 2024-12-19 17:44:27.775979 INFO::Creating boxplot for categorical data, antibiotics vs F52

## 2024-12-19 17:44:27.978003 INFO::Creating boxplot for categorical data, antibiotics vs F273

## 2024-12-19 17:44:28.172192 INFO::Creating boxplot for categorical data, antibiotics vs F474

## 2024-12-19 17:44:28.352739 INFO::Creating boxplot for categorical data, antibiotics vs F267

## 2024-12-19 17:44:28.534335 INFO::Creating boxplot for categorical data, antibiotics vs F253

## 2024-12-19 17:44:28.714536 INFO::Creating boxplot for categorical data, antibiotics vs F247

## 2024-12-19 17:44:28.955947 INFO::Creating boxplot for categorical data, antibiotics vs F708

## 2024-12-19 17:44:29.140133 INFO::Creating boxplot for categorical data, antibiotics vs F438

## 2024-12-19 17:44:29.329172 INFO::Creating boxplot for categorical data, antibiotics vs F450

## 2024-12-19 17:44:29.514168 INFO::Creating boxplot for categorical data, antibiotics vs F666

## 2024-12-19 17:44:29.697779 INFO::Creating boxplot for categorical data, antibiotics vs F720

## 2024-12-19 17:44:29.90731 INFO::Creating boxplot for categorical data, antibiotics vs F48

## 2024-12-19 17:44:30.098694 INFO::Creating boxplot for categorical data, antibiotics vs F371

## 2024-12-19 17:44:30.294254 INFO::Creating boxplot for categorical data, antibiotics vs F423

## 2024-12-19 17:44:30.4929 INFO::Creating boxplot for categorical data, antibiotics vs F190

## 2024-12-19 17:44:30.691813 INFO::Creating boxplot for categorical data, antibiotics vs F351

## 2024-12-19 17:44:30.909118 INFO::Creating boxplot for categorical data, antibiotics vs F394

## 2024-12-19 17:44:31.095587 INFO::Creating boxplot for categorical data, antibiotics vs F581

## 2024-12-19 17:44:31.285776 INFO::Creating boxplot for categorical data, antibiotics vs F276

## 2024-12-19 17:44:31.476331 INFO::Creating boxplot for categorical data, antibiotics vs F608

## 2024-12-19 17:44:31.696136 INFO::Creating boxplot for categorical data, antibiotics vs F28

## 2024-12-19 17:44:31.909404 INFO::Creating boxplot for categorical data, antibiotics vs F805

## 2024-12-19 17:44:32.132852 INFO::Creating boxplot for categorical data, antibiotics vs F249

## 2024-12-19 17:44:32.341367 INFO::Creating boxplot for categorical data, antibiotics vs F776

## 2024-12-19 17:44:32.532533 INFO::Creating boxplot for categorical data, antibiotics vs F755

## 2024-12-19 17:44:32.769732 INFO::Creating boxplot for categorical data, antibiotics vs F68

## 2024-12-19 17:44:32.964239 INFO::Creating boxplot for categorical data, antibiotics vs F78

## 2024-12-19 17:44:33.166925 INFO::Creating boxplot for categorical data, antibiotics vs F381

## 2024-12-19 17:44:33.380895 INFO::Creating boxplot for categorical data, antibiotics vs F644

## 2024-12-19 17:44:33.595323 INFO::Creating boxplot for categorical data, antibiotics vs F358

## 2024-12-19 17:44:33.828434 INFO::Creating boxplot for categorical data, antibiotics vs F344

## 2024-12-19 17:44:34.012698 INFO::Creating boxplot for categorical data, antibiotics vs F209

## 2024-12-19 17:44:34.200645 INFO::Creating boxplot for categorical data, antibiotics vs F898

## 2024-12-19 17:44:34.386937 INFO::Creating boxplot for categorical data, antibiotics vs F51

## 2024-12-19 17:44:34.571761 INFO::Creating boxplot for categorical data, antibiotics vs F149

## 2024-12-19 17:44:34.780454 INFO::Creating boxplot for categorical data, antibiotics vs F108

## 2024-12-19 17:44:34.963705 INFO::Creating boxplot for categorical data, antibiotics vs F255

## 2024-12-19 17:44:35.147329 INFO::Creating boxplot for categorical data, antibiotics vs F823

## 2024-12-19 17:44:35.331906 INFO::Creating boxplot for categorical data, antibiotics vs F864

## 2024-12-19 17:44:35.538955 INFO::Creating boxplot for categorical data, antibiotics vs F214

## 2024-12-19 17:44:35.734306 INFO::Creating boxplot for categorical data, antibiotics vs F76

## 2024-12-19 17:44:35.918605 INFO::Creating boxplot for categorical data, antibiotics vs F575

## 2024-12-19 17:44:36.102075 INFO::Creating boxplot for categorical data, antibiotics vs F13

## 2024-12-19 17:44:36.280527 INFO::Creating boxplot for categorical data, antibiotics vs F389

## 2024-12-19 17:44:36.491905 INFO::Creating boxplot for categorical data, antibiotics vs F556

## 2024-12-19 17:44:36.681265 INFO::Creating boxplot for categorical data, antibiotics vs F49

## 2024-12-19 17:44:36.86625 INFO::Creating boxplot for categorical data, antibiotics vs F436

## 2024-12-19 17:44:37.049588 INFO::Creating boxplot for categorical data, antibiotics vs F378

## 2024-12-19 17:44:37.231725 INFO::Creating boxplot for categorical data, antibiotics vs F682

## 2024-12-19 17:44:37.449501 INFO::Creating boxplot for categorical data, antibiotics vs F47

## 2024-12-19 17:44:37.630261 INFO::Creating boxplot for categorical data, antibiotics vs F429

## 2024-12-19 17:44:37.81371 INFO::Creating boxplot for categorical data, antibiotics vs F588

## 2024-12-19 17:44:37.996595 INFO::Creating boxplot for categorical data, antibiotics vs F616

## 2024-12-19 17:44:38.177692 INFO::Creating boxplot for categorical data, antibiotics vs F323

## 2024-12-19 17:44:38.434776 INFO::Creating boxplot for categorical data, antibiotics vs F409

## 2024-12-19 17:44:38.632018 INFO::Creating boxplot for categorical data, antibiotics vs F326

## 2024-12-19 17:44:38.821452 INFO::Creating boxplot for categorical data, antibiotics vs F698

## 2024-12-19 17:44:39.011416 INFO::Creating boxplot for categorical data, antibiotics vs F567

## 2024-12-19 17:44:39.226805 INFO::Creating boxplot for categorical data, antibiotics vs F179

## 2024-12-19 17:44:39.41627 INFO::Creating boxplot for categorical data, antibiotics vs F787

## 2024-12-19 17:44:39.599215 INFO::Creating boxplot for categorical data, antibiotics vs F79

## 2024-12-19 17:44:39.780879 INFO::Creating boxplot for categorical data, antibiotics vs F335

## 2024-12-19 17:44:39.963729 INFO::Creating boxplot for categorical data, antibiotics vs F576

## 2024-12-19 17:44:40.177889 INFO::Creating boxplot for categorical data, antibiotics vs F667

## 2024-12-19 17:44:40.361295 INFO::Creating boxplot for categorical data, antibiotics vs F694

## 2024-12-19 17:44:40.547591 INFO::Creating boxplot for categorical data, antibiotics vs F297

## 2024-12-19 17:44:40.732328 INFO::Creating boxplot for categorical data, antibiotics vs F569

## 2024-12-19 17:44:40.918699 INFO::Creating boxplot for categorical data, antibiotics vs F138

## 2024-12-19 17:44:41.121928 INFO::Creating boxplot for categorical data, antibiotics vs F611

## 2024-12-19 17:44:41.303459 INFO::Creating boxplot for categorical data, antibiotics vs F810

## 2024-12-19 17:44:41.488445 INFO::Creating boxplot for categorical data, antibiotics vs F746

## 2024-12-19 17:44:41.672453 INFO::Creating boxplot for categorical data, antibiotics vs F23

## 2024-12-19 17:44:41.885767 INFO::Creating boxplot for categorical data, antibiotics vs F135

## 2024-12-19 17:44:42.073139 INFO::Creating boxplot for categorical data, antibiotics vs F411

## 2024-12-19 17:44:42.258285 INFO::Creating boxplot for categorical data, antibiotics vs F489

## 2024-12-19 17:44:42.443094 INFO::Creating boxplot for categorical data, antibiotics vs F492

## 2024-12-19 17:44:42.628957 INFO::Creating boxplot for categorical data, antibiotics vs F844

## 2024-12-19 17:44:42.841918 INFO::Creating boxplot for categorical data, antibiotics vs F586

## 2024-12-19 17:44:43.024774 INFO::Creating boxplot for categorical data, antibiotics vs F11

## 2024-12-19 17:44:43.206424 INFO::Creating boxplot for categorical data, antibiotics vs F900

## 2024-12-19 17:44:43.386927 INFO::Creating boxplot for categorical data, antibiotics vs F21

## 2024-12-19 17:44:43.591525 INFO::Creating boxplot for categorical data, antibiotics vs F736

## 2024-12-19 17:44:43.780384 INFO::Creating boxplot for categorical data, antibiotics vs F408

## 2024-12-19 17:44:43.965408 INFO::Creating boxplot for categorical data, antibiotics vs F788

## 2024-12-19 17:44:44.159539 INFO::Creating boxplot for categorical data, antibiotics vs F66

## 2024-12-19 17:44:44.362489 INFO::Creating boxplot for categorical data, antibiotics vs F493

## 2024-12-19 17:44:44.589009 INFO::Creating boxplot for categorical data, antibiotics vs F343

## 2024-12-19 17:44:44.774816 INFO::Creating boxplot for categorical data, antibiotics vs F352

## 2024-12-19 17:44:44.964854 INFO::Creating boxplot for categorical data, antibiotics vs F677

## 2024-12-19 17:44:45.157682 INFO::Creating boxplot for categorical data, antibiotics vs F816

## 2024-12-19 17:44:45.338682 INFO::Creating boxplot for categorical data, antibiotics vs F457

## 2024-12-19 17:44:45.544447 INFO::Creating boxplot for categorical data, antibiotics vs F330

## 2024-12-19 17:44:45.727355 INFO::Creating boxplot for categorical data, antibiotics vs F293

## 2024-12-19 17:44:45.911662 INFO::Creating boxplot for categorical data, antibiotics vs F725

## 2024-12-19 17:44:46.098223 INFO::Creating boxplot for categorical data, antibiotics vs F813

## 2024-12-19 17:44:46.32207 INFO::Creating boxplot for categorical data, antibiotics vs F295

## 2024-12-19 17:44:46.51906 INFO::Creating boxplot for categorical data, antibiotics vs F656

## 2024-12-19 17:44:46.721157 INFO::Creating boxplot for categorical data, antibiotics vs F669

## 2024-12-19 17:44:46.90908 INFO::Creating boxplot for categorical data, antibiotics vs F15

## 2024-12-19 17:44:47.087488 INFO::Creating boxplot for categorical data, antibiotics vs F419

## 2024-12-19 17:44:47.294575 INFO::Creating boxplot for categorical data, antibiotics vs F701

## 2024-12-19 17:44:47.478097 INFO::Creating boxplot for categorical data, antibiotics vs F176

## 2024-12-19 17:44:47.667537 INFO::Creating boxplot for categorical data, antibiotics vs F203

## 2024-12-19 17:44:47.85306 INFO::Creating boxplot for categorical data, antibiotics vs F501

## 2024-12-19 17:44:48.125029 INFO::Creating boxplot for categorical data, antibiotics vs F772

## 2024-12-19 17:44:48.317759 INFO::Creating boxplot for categorical data, antibiotics vs F488

## 2024-12-19 17:44:48.504329 INFO::Creating boxplot for categorical data, antibiotics vs F600

## 2024-12-19 17:44:48.699209 INFO::Creating boxplot for categorical data, antibiotics vs F768

## 2024-12-19 17:44:48.884394 INFO::Creating boxplot for categorical data, antibiotics vs F432

## 2024-12-19 17:44:49.09299 INFO::Creating boxplot for categorical data, antibiotics vs F26

## 2024-12-19 17:44:49.279925 INFO::Creating boxplot for categorical data, antibiotics vs F189

## 2024-12-19 17:44:49.461839 INFO::Creating boxplot for categorical data, antibiotics vs F200

## 2024-12-19 17:44:49.647275 INFO::Creating boxplot for categorical data, antibiotics vs F121

## 2024-12-19 17:44:49.829463 INFO::Creating boxplot for categorical data, antibiotics vs F624

## 2024-12-19 17:44:50.038595 INFO::Creating boxplot for categorical data, antibiotics vs F855

## 2024-12-19 17:44:50.223949 INFO::Creating boxplot for categorical data, antibiotics vs F380

## 2024-12-19 17:44:50.417359 INFO::Creating boxplot for categorical data, antibiotics vs F734

## 2024-12-19 17:44:50.612738 INFO::Creating boxplot for categorical data, antibiotics vs F16

## 2024-12-19 17:44:50.796857 INFO::Creating boxplot for categorical data, antibiotics vs F602

## 2024-12-19 17:44:51.007687 INFO::Creating boxplot for categorical data, antibiotics vs F210

## 2024-12-19 17:44:51.192479 INFO::Creating boxplot for categorical data, antibiotics vs F217

## 2024-12-19 17:44:51.380088 INFO::Creating boxplot for categorical data, antibiotics vs F640

## 2024-12-19 17:44:51.562902 INFO::Creating boxplot for categorical data, antibiotics vs F631

## 2024-12-19 17:44:51.764025 INFO::Creating boxplot for categorical data, antibiotics vs F32

## 2024-12-19 17:44:51.951522 INFO::Creating boxplot for categorical data, antibiotics vs F322

## 2024-12-19 17:44:52.134421 INFO::Creating boxplot for categorical data, antibiotics vs F476

## 2024-12-19 17:44:52.325094 INFO::Creating boxplot for categorical data, antibiotics vs F265

## 2024-12-19 17:44:52.510174 INFO::Creating boxplot for categorical data, antibiotics vs F283

## 2024-12-19 17:44:52.715448 INFO::Creating boxplot for categorical data, antibiotics vs F316

## 2024-12-19 17:44:52.903462 INFO::Creating boxplot for categorical data, antibiotics vs F465

## 2024-12-19 17:44:53.089356 INFO::Creating boxplot for categorical data, antibiotics vs F24

## 2024-12-19 17:44:53.282438 INFO::Creating boxplot for categorical data, antibiotics vs F38

## 2024-12-19 17:44:53.471843 INFO::Creating boxplot for categorical data, antibiotics vs F82

## 2024-12-19 17:44:53.686359 INFO::Creating boxplot for categorical data, antibiotics vs F86

## 2024-12-19 17:44:53.871316 INFO::Creating boxplot for categorical data, antibiotics vs F270

## 2024-12-19 17:44:54.055226 INFO::Creating boxplot for categorical data, antibiotics vs F485

## 2024-12-19 17:44:54.240916 INFO::Creating boxplot for categorical data, antibiotics vs F486

## 2024-12-19 17:44:54.421778 INFO::Creating boxplot for categorical data, antibiotics vs F399

## 2024-12-19 17:44:54.636922 INFO::Creating boxplot for categorical data, antibiotics vs F573

## 2024-12-19 17:44:54.821664 INFO::Creating boxplot for categorical data, antibiotics vs F877

## 2024-12-19 17:44:55.008987 INFO::Creating boxplot for categorical data, antibiotics vs F709

## 2024-12-19 17:44:55.192323 INFO::Creating boxplot for categorical data, antibiotics vs F227

## 2024-12-19 17:44:55.401056 INFO::Creating boxplot for categorical data, antibiotics vs F553

## 2024-12-19 17:44:55.58852 INFO::Creating boxplot for categorical data, antibiotics vs F123

## 2024-12-19 17:44:55.781182 INFO::Creating boxplot for categorical data, antibiotics vs F118

## 2024-12-19 17:44:55.982409 INFO::Creating boxplot for categorical data, antibiotics vs F605

## 2024-12-19 17:44:56.167002 INFO::Creating boxplot for categorical data, antibiotics vs F619

## 2024-12-19 17:44:56.385145 INFO::Creating boxplot for categorical data, antibiotics vs F830

## 2024-12-19 17:44:56.568071 INFO::Creating boxplot for categorical data, antibiotics vs F837

## 2024-12-19 17:44:56.75278 INFO::Creating boxplot for categorical data, antibiotics vs F12

## 2024-12-19 17:44:56.936378 INFO::Creating boxplot for categorical data, antibiotics vs F623

## 2024-12-19 17:44:57.115473 INFO::Creating boxplot for categorical data, antibiotics vs F806

## 2024-12-19 17:44:57.318049 INFO::Creating boxplot for categorical data, antibiotics vs F353

## 2024-12-19 17:44:57.496885 INFO::Creating boxplot for categorical data, antibiotics vs F829

## 2024-12-19 17:44:57.680121 INFO::Creating boxplot for categorical data, antibiotics vs F289

## 2024-12-19 17:44:57.858938 INFO::Creating boxplot for categorical data, antibiotics vs F93

## 2024-12-19 17:44:58.051474 INFO::Creating boxplot for categorical data, antibiotics vs F379

## 2024-12-19 17:44:58.240269 INFO::Creating boxplot for categorical data, antibiotics vs F370

## 2024-12-19 17:44:58.422812 INFO::Creating boxplot for categorical data, antibiotics vs F360

## 2024-12-19 17:44:58.612475 INFO::Creating boxplot for categorical data, antibiotics vs F710

## 2024-12-19 17:44:58.805342 INFO::Creating boxplot for categorical data, antibiotics vs F388

## 2024-12-19 17:44:59.009975 INFO::Creating boxplot for categorical data, antibiotics vs F796

## 2024-12-19 17:44:59.18912 INFO::Creating boxplot for categorical data, antibiotics vs F174

## 2024-12-19 17:44:59.370961 INFO::Creating boxplot for categorical data, antibiotics vs F601

## 2024-12-19 17:44:59.554545 INFO::Creating boxplot for categorical data, antibiotics vs F775

## 2024-12-19 17:44:59.734081 INFO::Creating boxplot for categorical data, antibiotics vs F836

## 2024-12-19 17:44:59.938855 INFO::Creating boxplot for categorical data, antibiotics vs F192

## 2024-12-19 17:45:00.122083 INFO::Creating boxplot for categorical data, antibiotics vs F463

## 2024-12-19 17:45:00.307747 INFO::Creating boxplot for categorical data, antibiotics vs F57

## 2024-12-19 17:45:00.489772 INFO::Creating boxplot for categorical data, antibiotics vs F658

## 2024-12-19 17:45:00.686357 INFO::Creating boxplot for categorical data, antibiotics vs F596

## 2024-12-19 17:45:00.876772 INFO::Creating boxplot for categorical data, antibiotics vs F218

## 2024-12-19 17:45:01.05586 INFO::Creating boxplot for categorical data, antibiotics vs F104

## 2024-12-19 17:45:01.242601 INFO::Creating boxplot for categorical data, antibiotics vs F466

## 2024-12-19 17:45:01.425296 INFO::Creating boxplot for categorical data, antibiotics vs F737

## 2024-12-19 17:45:01.629871 INFO::Creating boxplot for categorical data, antibiotics vs F487

## 2024-12-19 17:45:01.810768 INFO::Creating boxplot for categorical data, antibiotics vs F369

## 2024-12-19 17:45:01.991484 INFO::Creating boxplot for categorical data, antibiotics vs F584

## 2024-12-19 17:45:02.173151 INFO::Creating boxplot for categorical data, antibiotics vs F166

## 2024-12-19 17:45:02.356626 INFO::Creating boxplot for categorical data, antibiotics vs F822

## 2024-12-19 17:45:02.561639 INFO::Creating boxplot for categorical data, antibiotics vs F416

## 2024-12-19 17:45:02.742136 INFO::Creating boxplot for categorical data, antibiotics vs F70

## 2024-12-19 17:45:02.930119 INFO::Creating boxplot for categorical data, antibiotics vs F243

## 2024-12-19 17:45:03.115236 INFO::Creating boxplot for categorical data, antibiotics vs F498

## 2024-12-19 17:45:03.339753 INFO::Creating boxplot for categorical data, antibiotics vs F272

## 2024-12-19 17:45:03.523005 INFO::Creating boxplot for categorical data, antibiotics vs F846

## 2024-12-19 17:45:03.708251 INFO::Creating boxplot for categorical data, antibiotics vs F881

## 2024-12-19 17:45:03.893765 INFO::Creating boxplot for categorical data, antibiotics vs F280

## 2024-12-19 17:45:04.079131 INFO::Creating boxplot for categorical data, antibiotics vs F761

## 2024-12-19 17:45:04.287637 INFO::Creating boxplot for categorical data, antibiotics vs F781

## 2024-12-19 17:45:04.469487 INFO::Creating boxplot for categorical data, antibiotics vs F697

## 2024-12-19 17:45:04.658994 INFO::Creating boxplot for categorical data, antibiotics vs F890

## 2024-12-19 17:45:04.840468 INFO::Creating boxplot for categorical data, antibiotics vs F197

## 2024-12-19 17:45:05.035095 INFO::Creating boxplot for categorical data, antibiotics vs F826

## 2024-12-19 17:45:05.224193 INFO::Creating boxplot for categorical data, antibiotics vs F641

## 2024-12-19 17:45:05.407848 INFO::Creating boxplot for categorical data, antibiotics vs F700

## 2024-12-19 17:45:05.593156 INFO::Creating boxplot for categorical data, antibiotics vs F531

## 2024-12-19 17:45:05.778592 INFO::Creating boxplot for categorical data, antibiotics vs F660

## 2024-12-19 17:45:05.993686 INFO::Creating boxplot for categorical data, antibiotics vs F257

## 2024-12-19 17:45:06.178159 INFO::Creating boxplot for categorical data, antibiotics vs F136

## 2024-12-19 17:45:06.370458 INFO::Creating boxplot for categorical data, antibiotics vs F875

## 2024-12-19 17:45:06.570017 INFO::Creating boxplot for categorical data, antibiotics vs F160

## 2024-12-19 17:45:06.772629 INFO::Creating boxplot for categorical data, antibiotics vs F782

## 2024-12-19 17:45:07.704625 INFO::Creating boxplot for categorical data, antibiotics vs F642

## 2024-12-19 17:45:07.874961 INFO::Creating boxplot for categorical data, antibiotics vs F730

## 2024-12-19 17:45:08.043269 INFO::Creating boxplot for categorical data, antibiotics vs F679

## 2024-12-19 17:45:08.212838 INFO::Creating boxplot for categorical data, antibiotics vs F713

## 2024-12-19 17:45:08.393213 INFO::Creating boxplot for categorical data, antibiotics vs F821

## 2024-12-19 17:45:08.568053 INFO::Creating boxplot for categorical data, antibiotics vs F443

## 2024-12-19 17:45:08.739131 INFO::Creating boxplot for categorical data, antibiotics vs F729

## 2024-12-19 17:45:08.912862 INFO::Creating boxplot for categorical data, antibiotics vs F25

## 2024-12-19 17:45:09.083764 INFO::Creating boxplot for categorical data, antibiotics vs F338

## 2024-12-19 17:45:09.265255 INFO::Creating boxplot for categorical data, antibiotics vs F647

## 2024-12-19 17:45:09.436983 INFO::Creating boxplot for categorical data, antibiotics vs F817

## 2024-12-19 17:45:09.608045 INFO::Creating boxplot for categorical data, antibiotics vs F535

## 2024-12-19 17:45:09.781362 INFO::Creating boxplot for categorical data, antibiotics vs F634

## 2024-12-19 17:45:09.95587 INFO::Creating boxplot for categorical data, antibiotics vs F533

## 2024-12-19 17:45:10.136323 INFO::Creating boxplot for categorical data, antibiotics vs F808

## 2024-12-19 17:45:10.312133 INFO::Creating boxplot for categorical data, antibiotics vs F571

## 2024-12-19 17:45:10.482628 INFO::Creating boxplot for categorical data, antibiotics vs F529

## 2024-12-19 17:45:10.657017 INFO::Creating boxplot for categorical data, antibiotics vs F827

## 2024-12-19 17:45:10.861875 INFO::Creating boxplot for categorical data, antibiotics vs F107

## 2024-12-19 17:45:11.057494 INFO::Creating boxplot for categorical data, antibiotics vs F515

## 2024-12-19 17:45:11.239806 INFO::Creating boxplot for categorical data, antibiotics vs F305

## 2024-12-19 17:45:11.42786 INFO::Creating boxplot for categorical data, antibiotics vs F662

## 2024-12-19 17:45:11.618404 INFO::Creating boxplot for categorical data, antibiotics vs F310

## 2024-12-19 17:45:11.795363 INFO::Creating boxplot for categorical data, antibiotics vs F430

## 2024-12-19 17:45:11.979827 INFO::Creating boxplot for categorical data, antibiotics vs F173

## 2024-12-19 17:45:12.156169 INFO::Creating boxplot for categorical data, antibiotics vs F820

## 2024-12-19 17:45:12.33774 INFO::Creating boxplot for categorical data, antibiotics vs F743

## 2024-12-19 17:45:12.512096 INFO::Creating boxplot for categorical data, antibiotics vs F63

## 2024-12-19 17:45:12.687765 INFO::Creating boxplot for categorical data, antibiotics vs F215

## 2024-12-19 17:45:12.871297 INFO::Creating boxplot for categorical data, antibiotics vs F216

## 2024-12-19 17:45:13.04836 INFO::Creating boxplot for categorical data, antibiotics vs F245

## 2024-12-19 17:45:13.22584 INFO::Creating boxplot for categorical data, antibiotics vs F862

## 2024-12-19 17:45:13.400677 INFO::Creating boxplot for categorical data, antibiotics vs F541

## 2024-12-19 17:45:13.579555 INFO::Creating boxplot for categorical data, antibiotics vs F558

## 2024-12-19 17:45:13.76654 INFO::Creating boxplot for categorical data, antibiotics vs F633

## 2024-12-19 17:45:13.938735 INFO::Creating boxplot for categorical data, antibiotics vs F94

## 2024-12-19 17:45:14.113144 INFO::Creating boxplot for categorical data, antibiotics vs F574

## 2024-12-19 17:45:14.285284 INFO::Creating boxplot for categorical data, antibiotics vs F238

## 2024-12-19 17:45:14.470219 INFO::Creating boxplot for categorical data, antibiotics vs F815

## 2024-12-19 17:45:14.645178 INFO::Creating boxplot for categorical data, antibiotics vs F587

## 2024-12-19 17:45:14.815316 INFO::Creating boxplot for categorical data, antibiotics vs F464

## 2024-12-19 17:45:14.990692 INFO::Creating boxplot for categorical data, antibiotics vs F590

## 2024-12-19 17:45:15.164115 INFO::Creating boxplot for categorical data, antibiotics vs F124

## 2024-12-19 17:45:15.348377 INFO::Creating boxplot for categorical data, antibiotics vs F664

## 2024-12-19 17:45:15.519509 INFO::Creating boxplot for categorical data, antibiotics vs F100

## 2024-12-19 17:45:15.694363 INFO::Creating boxplot for categorical data, antibiotics vs F744

## 2024-12-19 17:45:15.867023 INFO::Creating boxplot for categorical data, antibiotics vs F444

## 2024-12-19 17:45:16.042608 INFO::Creating boxplot for categorical data, antibiotics vs F597

## 2024-12-19 17:45:16.224927 INFO::Creating boxplot for categorical data, antibiotics vs F650

## 2024-12-19 17:45:16.397328 INFO::Creating boxplot for categorical data, antibiotics vs F147

## 2024-12-19 17:45:16.569485 INFO::Creating boxplot for categorical data, antibiotics vs F363

## 2024-12-19 17:45:16.743193 INFO::Creating boxplot for categorical data, antibiotics vs F521

## 2024-12-19 17:45:16.916886 INFO::Creating boxplot for categorical data, antibiotics vs F412

## 2024-12-19 17:45:17.097724 INFO::Creating boxplot for categorical data, antibiotics vs F279

## 2024-12-19 17:45:17.267449 INFO::Creating boxplot for categorical data, antibiotics vs F225

## 2024-12-19 17:45:17.436985 INFO::Creating boxplot for categorical data, antibiotics vs F10

## 2024-12-19 17:45:17.608038 INFO::Creating boxplot for categorical data, antibiotics vs F481

## 2024-12-19 17:45:17.789081 INFO::Creating boxplot for categorical data, antibiotics vs F861

## 2024-12-19 17:45:17.958383 INFO::Creating boxplot for categorical data, antibiotics vs F888

## 2024-12-19 17:45:18.128911 INFO::Creating boxplot for categorical data, antibiotics vs F156

## 2024-12-19 17:45:18.300268 INFO::Creating boxplot for categorical data, antibiotics vs F857

## 2024-12-19 17:45:18.479419 INFO::Creating boxplot for categorical data, antibiotics vs F509

## 2024-12-19 17:45:18.668336 INFO::Creating boxplot for categorical data, antibiotics vs F244

## 2024-12-19 17:45:18.856454 INFO::Creating boxplot for categorical data, antibiotics vs F514

## 2024-12-19 17:45:19.039837 INFO::Creating boxplot for categorical data, antibiotics vs F196

## 2024-12-19 17:45:19.218765 INFO::Creating boxplot for categorical data, antibiotics vs F304

## 2024-12-19 17:45:19.392761 INFO::Creating boxplot for categorical data, antibiotics vs F833

## 2024-12-19 17:45:19.576686 INFO::Creating boxplot for categorical data, antibiotics vs F294

## 2024-12-19 17:45:19.745042 INFO::Creating boxplot for categorical data, antibiotics vs F550

## 2024-12-19 17:45:19.916209 INFO::Creating boxplot for categorical data, antibiotics vs F869

## 2024-12-19 17:45:20.088313 INFO::Creating boxplot for categorical data, antibiotics vs F364

## 2024-12-19 17:45:20.261444 INFO::Creating boxplot for categorical data, antibiotics vs F583

## 2024-12-19 17:45:20.445378 INFO::Creating boxplot for categorical data, antibiotics vs F441

## 2024-12-19 17:45:20.620359 INFO::Creating boxplot for categorical data, antibiotics vs F595

## 2024-12-19 17:45:20.791832 INFO::Creating boxplot for categorical data, antibiotics vs F35

## 2024-12-19 17:45:20.965011 INFO::Creating boxplot for categorical data, antibiotics vs F630

## 2024-12-19 17:45:21.148587 INFO::Creating boxplot for categorical data, antibiotics vs F401

## 2024-12-19 17:45:21.318901 INFO::Creating boxplot for categorical data, antibiotics vs F287

## 2024-12-19 17:45:21.489638 INFO::Creating boxplot for categorical data, antibiotics vs F250

## 2024-12-19 17:45:21.663312 INFO::Creating boxplot for categorical data, antibiotics vs F239

## 2024-12-19 17:45:21.835326 INFO::Creating boxplot for categorical data, antibiotics vs F88

## 2024-12-19 17:45:22.020661 INFO::Creating boxplot for categorical data, antibiotics vs F752

## 2024-12-19 17:45:22.192442 INFO::Creating boxplot for categorical data, antibiotics vs F539

## 2024-12-19 17:45:22.364267 INFO::Creating boxplot for categorical data, antibiotics vs F69

## 2024-12-19 17:45:22.533632 INFO::Creating boxplot for categorical data, antibiotics vs F126

## 2024-12-19 17:45:22.705586 INFO::Creating boxplot for categorical data, antibiotics vs F362

## 2024-12-19 17:45:22.886231 INFO::Creating boxplot for categorical data, antibiotics vs F753

## 2024-12-19 17:45:23.057823 INFO::Creating boxplot for categorical data, antibiotics vs F469

## 2024-12-19 17:45:23.230187 INFO::Creating boxplot for categorical data, antibiotics vs F14

## 2024-12-19 17:45:23.401259 INFO::Creating boxplot for categorical data, antibiotics vs F803

## 2024-12-19 17:45:23.583159 INFO::Creating boxplot for categorical data, antibiotics vs F814

## 2024-12-19 17:45:23.753379 INFO::Creating boxplot for categorical data, antibiotics vs F449

## 2024-12-19 17:45:23.927678 INFO::Creating boxplot for categorical data, antibiotics vs F494

## 2024-12-19 17:45:24.099898 INFO::Creating boxplot for categorical data, antibiotics vs F439

## 2024-12-19 17:45:24.27164 INFO::Creating boxplot for categorical data, antibiotics vs F686

## 2024-12-19 17:45:24.453739 INFO::Creating boxplot for categorical data, antibiotics vs F591

## 2024-12-19 17:45:24.624125 INFO::Creating boxplot for categorical data, antibiotics vs F735

## 2024-12-19 17:45:24.795101 INFO::Creating boxplot for categorical data, antibiotics vs F111

## 2024-12-19 17:45:24.966186 INFO::Creating boxplot for categorical data, antibiotics vs F346

## 2024-12-19 17:45:25.141369 INFO::Creating boxplot for categorical data, antibiotics vs F29

## 2024-12-19 17:45:25.379826 INFO::Creating boxplot for categorical data, antibiotics vs F376

## 2024-12-19 17:45:25.552999 INFO::Creating boxplot for categorical data, antibiotics vs F414

## 2024-12-19 17:45:25.728847 INFO::Creating boxplot for categorical data, antibiotics vs F555

## 2024-12-19 17:45:25.908747 INFO::Creating boxplot for categorical data, antibiotics vs F517

## 2024-12-19 17:45:26.088679 INFO::Creating boxplot for categorical data, antibiotics vs F544

## 2024-12-19 17:45:26.286262 INFO::Creating boxplot for categorical data, antibiotics vs F339

## 2024-12-19 17:45:26.462206 INFO::Creating boxplot for categorical data, antibiotics vs F689

## 2024-12-19 17:45:26.641 INFO::Creating boxplot for categorical data, antibiotics vs F391

## 2024-12-19 17:45:26.818829 INFO::Creating boxplot for categorical data, antibiotics vs F502

## 2024-12-19 17:45:27.012024 INFO::Creating boxplot for categorical data, antibiotics vs F298

## 2024-12-19 17:45:27.192256 INFO::Creating boxplot for categorical data, antibiotics vs F337

## 2024-12-19 17:45:27.370273 INFO::Creating boxplot for categorical data, antibiotics vs F773

## 2024-12-19 17:45:27.548432 INFO::Creating boxplot for categorical data, antibiotics vs F592

## 2024-12-19 17:45:27.727426 INFO::Creating boxplot for categorical data, antibiotics vs F307

## 2024-12-19 17:45:27.92115 INFO::Creating boxplot for categorical data, antibiotics vs F115

## 2024-12-19 17:45:28.099239 INFO::Creating boxplot for categorical data, antibiotics vs F739

## 2024-12-19 17:45:28.276184 INFO::Creating boxplot for categorical data, antibiotics vs F433

## 2024-12-19 17:45:28.459936 INFO::Creating boxplot for categorical data, antibiotics vs F384

## 2024-12-19 17:45:28.640392 INFO::Creating boxplot for categorical data, antibiotics vs F750

## 2024-12-19 17:45:28.835966 INFO::Creating boxplot for categorical data, antibiotics vs F762

## 2024-12-19 17:45:29.009751 INFO::Creating boxplot for categorical data, antibiotics vs F277

## 2024-12-19 17:45:29.184174 INFO::Creating boxplot for categorical data, antibiotics vs F871

## 2024-12-19 17:45:29.362795 INFO::Creating boxplot for categorical data, antibiotics vs F839

## 2024-12-19 17:45:29.544021 INFO::Creating boxplot for categorical data, antibiotics vs F127

## 2024-12-19 17:45:29.739452 INFO::Creating boxplot for categorical data, antibiotics vs F554

## 2024-12-19 17:45:29.912246 INFO::Creating boxplot for categorical data, antibiotics vs F676

## 2024-12-19 17:45:30.086253 INFO::Creating boxplot for categorical data, antibiotics vs F568

## 2024-12-19 17:45:30.264421 INFO::Creating boxplot for categorical data, antibiotics vs F137

## 2024-12-19 17:45:30.439415 INFO::Creating boxplot for categorical data, antibiotics vs F131

## 2024-12-19 17:45:30.63428 INFO::Creating boxplot for categorical data, antibiotics vs F60

## 2024-12-19 17:45:30.80935 INFO::Creating boxplot for categorical data, antibiotics vs F98

## 2024-12-19 17:45:30.984131 INFO::Creating boxplot for categorical data, antibiotics vs F672

## 2024-12-19 17:45:31.165658 INFO::Creating boxplot for categorical data, antibiotics vs F530

## 2024-12-19 17:45:31.345651 INFO::Creating boxplot for categorical data, antibiotics vs F809

## 2024-12-19 17:45:31.542018 INFO::Creating boxplot for categorical data, antibiotics vs F894

## 2024-12-19 17:45:31.719503 INFO::Creating boxplot for categorical data, antibiotics vs F22

## 2024-12-19 17:45:31.898148 INFO::Creating boxplot for categorical data, antibiotics vs F818

## 2024-12-19 17:45:32.077411 INFO::Creating boxplot for categorical data, antibiotics vs F559

## 2024-12-19 17:45:32.270544 INFO::Creating boxplot for categorical data, antibiotics vs F741

## 2024-12-19 17:45:32.453264 INFO::Creating boxplot for categorical data, antibiotics vs F398

## 2024-12-19 17:45:32.630219 INFO::Creating boxplot for categorical data, antibiotics vs F357

## 2024-12-19 17:45:32.81733 INFO::Creating boxplot for categorical data, antibiotics vs F119

## 2024-12-19 17:45:32.999445 INFO::Creating boxplot for categorical data, antibiotics vs F426

## 2024-12-19 17:45:33.198359 INFO::Creating boxplot for categorical data, antibiotics vs F204

## 2024-12-19 17:45:33.374265 INFO::Creating boxplot for categorical data, antibiotics vs F851

## 2024-12-19 17:45:33.547485 INFO::Creating boxplot for categorical data, antibiotics vs F657

## 2024-12-19 17:45:33.7279 INFO::Creating boxplot for categorical data, antibiotics vs F801

## 2024-12-19 17:45:33.905647 INFO::Creating boxplot for categorical data, antibiotics vs F754

## 2024-12-19 17:45:34.101186 INFO::Creating boxplot for categorical data, antibiotics vs F859

## 2024-12-19 17:45:34.276761 INFO::Creating boxplot for categorical data, antibiotics vs F480

## 2024-12-19 17:45:34.45673 INFO::Creating boxplot for categorical data, antibiotics vs F507

## 2024-12-19 17:45:34.632097 INFO::Creating boxplot for categorical data, antibiotics vs F207

## 2024-12-19 17:45:36.928009 INFO::Plotting data for metadata number 3, age
## 2024-12-19 17:45:36.929721 INFO::Creating scatter plot for continuous data, age vs F340

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:37.186172 INFO::Creating scatter plot for continuous data, age vs F603

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:37.44411 INFO::Creating scatter plot for continuous data, age vs F356

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:37.632978 INFO::Creating scatter plot for continuous data, age vs F181

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:37.809719 INFO::Creating scatter plot for continuous data, age vs F177

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:38.017783 INFO::Creating scatter plot for continuous data, age vs F390

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:38.204891 INFO::Creating scatter plot for continuous data, age vs F743

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:38.386331 INFO::Creating scatter plot for continuous data, age vs F491

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:38.578915 INFO::Creating scatter plot for continuous data, age vs F436

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:38.776277 INFO::Creating scatter plot for continuous data, age vs F219

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:38.953195 INFO::Creating scatter plot for continuous data, age vs F483

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:39.142095 INFO::Creating scatter plot for continuous data, age vs F878

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:39.334371 INFO::Creating scatter plot for continuous data, age vs F876

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:39.555227 INFO::Creating scatter plot for continuous data, age vs F211

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:39.746628 INFO::Creating scatter plot for continuous data, age vs F732

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:39.935585 INFO::Creating scatter plot for continuous data, age vs F222

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:40.140587 INFO::Creating scatter plot for continuous data, age vs F688

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:40.363742 INFO::Creating scatter plot for continuous data, age vs F170

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:40.564134 INFO::Creating scatter plot for continuous data, age vs F431

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:40.760387 INFO::Creating scatter plot for continuous data, age vs F174

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:40.937027 INFO::Creating scatter plot for continuous data, age vs F17

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:41.112168 INFO::Creating scatter plot for continuous data, age vs F334

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:41.314209 INFO::Creating scatter plot for continuous data, age vs F835

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:41.481946 INFO::Creating scatter plot for continuous data, age vs F223

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:41.669068 INFO::Creating scatter plot for continuous data, age vs F383

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:41.841522 INFO::Creating scatter plot for continuous data, age vs F623

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:42.041674 INFO::Creating scatter plot for continuous data, age vs F329

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:42.226002 INFO::Creating scatter plot for continuous data, age vs F395

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:42.410769 INFO::Creating scatter plot for continuous data, age vs F528

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:42.582817 INFO::Creating scatter plot for continuous data, age vs F13

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:42.774629 INFO::Creating scatter plot for continuous data, age vs F36

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:42.941181 INFO::Creating scatter plot for continuous data, age vs F285

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:43.125633 INFO::Creating scatter plot for continuous data, age vs F404

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:43.302181 INFO::Creating scatter plot for continuous data, age vs F894

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:43.559168 INFO::Creating scatter plot for continuous data, age vs F300

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:43.749778 INFO::Creating scatter plot for continuous data, age vs F32

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:43.932899 INFO::Creating scatter plot for continuous data, age vs F24

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:44.122849 INFO::Creating scatter plot for continuous data, age vs F97

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:44.312584 INFO::Creating scatter plot for continuous data, age vs F849

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:44.492883 INFO::Creating scatter plot for continuous data, age vs F185

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:44.678404 INFO::Creating scatter plot for continuous data, age vs F513

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:44.864247 INFO::Creating scatter plot for continuous data, age vs F296

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:45.050833 INFO::Creating scatter plot for continuous data, age vs F471

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:45.262503 INFO::Creating scatter plot for continuous data, age vs F793

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:45.450173 INFO::Creating scatter plot for continuous data, age vs F402

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:45.642279 INFO::Creating scatter plot for continuous data, age vs F541

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:45.838994 INFO::Creating scatter plot for continuous data, age vs F496

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:46.045748 INFO::Creating scatter plot for continuous data, age vs F386

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:46.220672 INFO::Creating scatter plot for continuous data, age vs F594

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:46.412141 INFO::Creating scatter plot for continuous data, age vs F704

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:46.593168 INFO::Creating scatter plot for continuous data, age vs F330

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:46.808136 INFO::Creating scatter plot for continuous data, age vs F197

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:46.998005 INFO::Creating scatter plot for continuous data, age vs F735

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:47.185084 INFO::Creating scatter plot for continuous data, age vs F481

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:47.359135 INFO::Creating scatter plot for continuous data, age vs F635

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:47.546518 INFO::Creating scatter plot for continuous data, age vs F687

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:47.755135 INFO::Creating scatter plot for continuous data, age vs F652

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:47.941866 INFO::Creating scatter plot for continuous data, age vs F651

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:48.131086 INFO::Creating scatter plot for continuous data, age vs F82

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:48.30725 INFO::Creating scatter plot for continuous data, age vs F7

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:48.509148 INFO::Creating scatter plot for continuous data, age vs F866

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:48.697014 INFO::Creating scatter plot for continuous data, age vs F593

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:48.86772 INFO::Creating scatter plot for continuous data, age vs F733

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:49.042257 INFO::Creating scatter plot for continuous data, age vs F684

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:49.252522 INFO::Creating scatter plot for continuous data, age vs F410

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:49.432205 INFO::Creating scatter plot for continuous data, age vs F224

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:49.616926 INFO::Creating scatter plot for continuous data, age vs F722

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:49.804052 INFO::Creating scatter plot for continuous data, age vs F856

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:49.995347 INFO::Creating scatter plot for continuous data, age vs F680

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:50.180773 INFO::Creating scatter plot for continuous data, age vs F19

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:50.369039 INFO::Creating scatter plot for continuous data, age vs F860

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:50.543622 INFO::Creating scatter plot for continuous data, age vs F859

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:50.731262 INFO::Creating scatter plot for continuous data, age vs F522

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:50.941944 INFO::Creating scatter plot for continuous data, age vs F372

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:51.125829 INFO::Creating scatter plot for continuous data, age vs F899

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:51.299875 INFO::Creating scatter plot for continuous data, age vs F782

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:51.491728 INFO::Creating scatter plot for continuous data, age vs F839

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:51.703871 INFO::Creating scatter plot for continuous data, age vs F827

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:51.891061 INFO::Creating scatter plot for continuous data, age vs F817

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:52.074936 INFO::Creating scatter plot for continuous data, age vs F345

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:52.247937 INFO::Creating scatter plot for continuous data, age vs F127

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:52.456006 INFO::Creating scatter plot for continuous data, age vs F749

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:52.642113 INFO::Creating scatter plot for continuous data, age vs F877

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:52.827216 INFO::Creating scatter plot for continuous data, age vs F150

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:53.017905 INFO::Creating scatter plot for continuous data, age vs F752

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:53.215676 INFO::Creating scatter plot for continuous data, age vs F848

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:53.392226 INFO::Creating scatter plot for continuous data, age vs F809

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:53.580727 INFO::Creating scatter plot for continuous data, age vs F751

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:53.760945 INFO::Creating scatter plot for continuous data, age vs F15

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:53.938347 INFO::Creating scatter plot for continuous data, age vs F521

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:54.144465 INFO::Creating scatter plot for continuous data, age vs F842

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:54.335853 INFO::Creating scatter plot for continuous data, age vs F319

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:54.522178 INFO::Creating scatter plot for continuous data, age vs F96

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:54.71245 INFO::Creating scatter plot for continuous data, age vs F171

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:54.930946 INFO::Creating scatter plot for continuous data, age vs F241

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:55.10807 INFO::Creating scatter plot for continuous data, age vs F582

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:55.281108 INFO::Creating scatter plot for continuous data, age vs F822

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:55.45628 INFO::Creating scatter plot for continuous data, age vs F748

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:55.660289 INFO::Creating scatter plot for continuous data, age vs F147

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:55.850833 INFO::Creating scatter plot for continuous data, age vs F16

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:56.022342 INFO::Creating scatter plot for continuous data, age vs F212

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:56.215307 INFO::Creating scatter plot for continuous data, age vs F718

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:56.440445 INFO::Creating scatter plot for continuous data, age vs F663

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:56.623159 INFO::Creating scatter plot for continuous data, age vs F690

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:56.811435 INFO::Creating scatter plot for continuous data, age vs F865

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:56.989395 INFO::Creating scatter plot for continuous data, age vs F421

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:57.164779 INFO::Creating scatter plot for continuous data, age vs F110

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:57.377072 INFO::Creating scatter plot for continuous data, age vs F857

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:57.561641 INFO::Creating scatter plot for continuous data, age vs F84

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:57.752398 INFO::Creating scatter plot for continuous data, age vs F123

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:57.928154 INFO::Creating scatter plot for continuous data, age vs F566

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:58.129749 INFO::Creating scatter plot for continuous data, age vs F370

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:58.305321 INFO::Creating scatter plot for continuous data, age vs F65

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:58.478069 INFO::Creating scatter plot for continuous data, age vs F119

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:58.650898 INFO::Creating scatter plot for continuous data, age vs F263

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:58.849319 INFO::Creating scatter plot for continuous data, age vs F630

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:59.03603 INFO::Creating scatter plot for continuous data, age vs F628

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:59.207431 INFO::Creating scatter plot for continuous data, age vs F711

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:59.395334 INFO::Creating scatter plot for continuous data, age vs F152

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:59.610147 INFO::Creating scatter plot for continuous data, age vs F324

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:45:59.797925 INFO::Creating scatter plot for continuous data, age vs F575

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:45:59.969515 INFO::Creating scatter plot for continuous data, age vs F699

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:00.160744 INFO::Creating scatter plot for continuous data, age vs F846

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:00.439152 INFO::Creating scatter plot for continuous data, age vs F380

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:00.628314 INFO::Creating scatter plot for continuous data, age vs F172

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:00.821826 INFO::Creating scatter plot for continuous data, age vs F504

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:46:00.999885 INFO::Creating scatter plot for continuous data, age vs F34

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:46:01.175185 INFO::Creating scatter plot for continuous data, age vs F199

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:01.384549 INFO::Creating scatter plot for continuous data, age vs F198

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:01.575833 INFO::Creating scatter plot for continuous data, age vs F479

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:01.769124 INFO::Creating scatter plot for continuous data, age vs F673

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:46:01.944916 INFO::Creating scatter plot for continuous data, age vs F508

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:02.157146 INFO::Creating scatter plot for continuous data, age vs F337

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:02.349531 INFO::Creating scatter plot for continuous data, age vs F737

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:02.540093 INFO::Creating scatter plot for continuous data, age vs F609

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:02.728832 INFO::Creating scatter plot for continuous data, age vs F40

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:46:02.928334 INFO::Creating scatter plot for continuous data, age vs F821

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:03.118695 INFO::Creating scatter plot for continuous data, age vs F643

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:46:03.294238 INFO::Creating scatter plot for continuous data, age vs F759

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:46:03.468279 INFO::Creating scatter plot for continuous data, age vs F417

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:03.671996 INFO::Creating scatter plot for continuous data, age vs F58

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:03.87276 INFO::Creating scatter plot for continuous data, age vs F267

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:04.065676 INFO::Creating scatter plot for continuous data, age vs F101

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:46:04.243742 INFO::Creating scatter plot for continuous data, age vs F890

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:04.43456 INFO::Creating scatter plot for continuous data, age vs F655

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:04.645271 INFO::Creating scatter plot for continuous data, age vs F95

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:46:04.818521 INFO::Creating scatter plot for continuous data, age vs F775

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:46:04.99835 INFO::Creating scatter plot for continuous data, age vs F93

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:05.189595 INFO::Creating scatter plot for continuous data, age vs F353

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:46:05.391556 INFO::Creating scatter plot for continuous data, age vs F480

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:05.596104 INFO::Creating scatter plot for continuous data, age vs F567

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:05.800333 INFO::Creating scatter plot for continuous data, age vs F871

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:05.986936 INFO::Creating scatter plot for continuous data, age vs F295

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:46:06.186665 INFO::Creating scatter plot for continuous data, age vs F459

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:06.377822 INFO::Creating scatter plot for continuous data, age vs F812

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:06.571362 INFO::Creating scatter plot for continuous data, age vs F146

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:46:06.749102 INFO::Creating scatter plot for continuous data, age vs F239

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:06.956097 INFO::Creating scatter plot for continuous data, age vs F754

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:07.160509 INFO::Creating scatter plot for continuous data, age vs F443

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:46:07.340389 INFO::Creating scatter plot for continuous data, age vs F5

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:07.538864 INFO::Creating scatter plot for continuous data, age vs F864

## `geom_smooth()` using formula = 'y ~ x'

## 2024-12-19 17:46:07.71625 INFO::Creating scatter plot for continuous data, age vs F477

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:07.92732 INFO::Creating scatter plot for continuous data, age vs F571

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2024-12-19 17:46:08.114661 INFO::Creating scatter plot for continuous data, age vs F715

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## `geom_smooth()` using formula = 'y ~ x'

## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Initiating effect size calculations
## 
## Calculating mean abundance in: IBD
## 
## Calculating mean abundance in: Control
## 
## Calculating effect size in: IBD
## 
## Initiating prioritization
## 
## Calculating meta-rank and prioritizing metabolic features

## 2024-12-19 17:46:10.581847 INFO::Writing all prioritized metabolites to file: Macarron_output/prioritized_metabolites_all.csv
## 2024-12-19 17:46:10.590032 INFO::Writing characterizable prioritized metabolites to file: Macarron_output/prioritized_metabolites_characterizable.csv
## 2024-12-19 17:46:10.611389 INFO::Writing highly prioritized metabolites in IBD to file: Macarron_output/highly_prioritized_per_module_in_IBD.csv

3.3.2 Using dataframes as inputs

abundances_df = read.csv(file = prism_abundances, row.names = 1) # setting features as rownames
annotations_df = read.csv(file = prism_annotations, row.names = 1) # setting features as rownames
metadata_df = read.csv(file = prism_metadata, row.names = 1) # setting samples as rownames 
taxonomy_df = read.csv(file = mets_taxonomy)

# Running Macarron
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
                                        input_annotations = annotations_df,
                                        input_metadata = metadata_df,
                                        input_taxonomy = taxonomy_df)

3.3.3 Running Macarron as individual functions

The Macarron::Macarron() function is a wrapper for the Macarron framework. Users can also apply individual functions on the input dataframes to achieve same results as the wrapper with the added benefit of storing output from each function for other analyses. There are seven steps:

# Step 1: Storing input data in a summarized experiment object
prism_mbx <- prepInput(input_abundances = abundances_df,
                       input_annotations = annotations_df,
                       input_metadata = metadata_df)

# Step 2: Creating a distance matrix from pairwise correlations in abundances of metabolic features
prism_w <- makeDisMat(se = prism_mbx)

# Step 3: Finding covariance modules
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df)
# The output is a list containing two dataframes- module assignments and measures of success
# if evaluateMOS=TRUE. To write modules to a separate dataframe, do:
prism_module_assignments <- prism_modules[[1]]
prism_modules_mos <- prism_modules[[2]]

# Step 4: Calculating AVA
prism_ava <- calAVA(se = prism_mbx,
                    mod.assn = prism_modules)

# Step 5: Calculating q-value
prism_qval <- calQval(se = prism_mbx,
                      mod.assn = prism_modules)

# Step 6: Calculating effect size
prism_es <- calES(se = prism_mbx,
                   mac.qval = prism_qval)

# Step 7: Prioritizing metabolic features
prism_prioritized <- prioritize(se = prism_mbx,
                                mod.assn = prism_modules,
                                mac.ava = prism_ava,
                                mac.qval = prism_qval,
                                mac.es = prism_es)
# The output is a list containing two dataframes- all prioritized metabolic features and
# only characterizable metabolic features.
all_prioritized <- prism_prioritized[[1]]
char_prioritized <- prism_prioritized[[2]]

# Step 8 (optional): View only the highly prioritized metabolic features in each module
prism_highly_prioritized <- showBest(prism_prioritized)

Session info from running the demo in R can be displayed with the following command.

sessionInfo()

## R Under development (unstable) (2024-10-21 r87258)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.1 LTS
## 
## Matrix products: default
## BLAS:   /home/biocbuild/bbs-3.21-bioc/R/lib/libRblas.so 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_GB              LC_COLLATE=C              
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: America/New_York
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] Macarron_1.11.0             SummarizedExperiment_1.37.0
##  [3] Biobase_2.67.0              GenomicRanges_1.59.1       
##  [5] GenomeInfoDb_1.43.2         IRanges_2.41.2             
##  [7] S4Vectors_0.45.2            BiocGenerics_0.53.3        
##  [9] generics_0.1.3              MatrixGenerics_1.19.0      
## [11] matrixStats_1.4.1           BiocStyle_2.35.0           
## 
## loaded via a namespace (and not attached):
##   [1] mnormt_2.1.1            DBI_1.2.3               pbapply_1.7-2          
##   [4] gridExtra_2.3           rlang_1.1.4             magrittr_2.0.3         
##   [7] compiler_4.5.0          RSQLite_2.3.9           mgcv_1.9-1             
##  [10] png_0.1-8               vctrs_0.6.5             stringr_1.5.1          
##  [13] pkgconfig_2.0.3         crayon_1.5.3            fastmap_1.2.0          
##  [16] backports_1.5.0         XVector_0.47.0          labeling_0.4.3         
##  [19] rmarkdown_2.29          preprocessCore_1.69.0   UCSC.utils_1.3.0       
##  [22] bit_4.5.0.1             xfun_0.49               zlibbioc_1.53.0        
##  [25] cachem_1.1.0            jsonlite_1.8.9          blob_1.2.4             
##  [28] DelayedArray_0.33.3     BiocParallel_1.41.0     psych_2.4.6.26         
##  [31] Maaslin2_1.21.0         parallel_4.5.0          cluster_2.1.8          
##  [34] biglm_0.9-3             R6_2.5.1                RColorBrewer_1.1-3     
##  [37] bslib_0.8.0             stringi_1.8.4           rpart_4.1.23           
##  [40] jquerylib_0.1.4         Rcpp_1.0.13-1           bookdown_0.41          
##  [43] iterators_1.0.14        knitr_1.49              WGCNA_1.73             
##  [46] base64enc_0.1-3         Matrix_1.7-1            splines_4.5.0          
##  [49] nnet_7.3-19             tidyselect_1.2.1        rstudioapi_0.17.1      
##  [52] abind_1.4-8             yaml_2.3.10             doParallel_1.0.17      
##  [55] codetools_0.2-20        plyr_1.8.9              lattice_0.22-6         
##  [58] tibble_3.2.1            withr_3.0.2             KEGGREST_1.47.0        
##  [61] evaluate_1.0.1          foreign_0.8-87          survival_3.8-3         
##  [64] getopt_1.20.4           Biostrings_2.75.3       pillar_1.10.0          
##  [67] BiocManager_1.30.25     checkmate_2.3.2         foreach_1.5.2          
##  [70] pcaPP_2.0-5             ggplot2_3.5.1           munsell_0.5.1          
##  [73] scales_1.3.0            glue_1.8.0              Hmisc_5.2-1            
##  [76] tools_4.5.0             robustbase_0.99-4-1     data.table_1.16.4      
##  [79] mvtnorm_1.3-2           fastcluster_1.2.6       grid_4.5.0             
##  [82] optparse_1.7.5          impute_1.81.0           AnnotationDbi_1.69.0   
##  [85] colorspace_2.1-1        nlme_3.1-166            GenomeInfoDbData_1.2.13
##  [88] htmlTable_2.4.3         Formula_1.2-5           cli_3.6.3              
##  [91] S4Arrays_1.7.1          dplyr_1.1.4             DEoptimR_1.1-3-1       
##  [94] gtable_0.3.6            hash_2.2.6.3            logging_0.10-108       
##  [97] dynamicTreeCut_1.63-1   sass_0.4.9              digest_0.6.37          
## [100] SparseArray_1.7.2       farver_2.1.2            htmlwidgets_1.6.4      
## [103] memoise_2.0.1           htmltools_0.5.8.1       lifecycle_1.0.4        
## [106] httr_1.4.7              GO.db_3.20.0            bit64_4.5.2

3.4 Advanced Topics

3.4.1 Generating the input chemical taxonomy file

The input taxonomy dataframe can be generated using the input metabolic features annotation dataframe using Macarron::decorateID(). This function annotates an HMDB ID or a PubChem CID with the chemical class and subclass of the metabolite.

taxonomy_df <- decorateID(input_annotations = annotations_df)
write.csv(taxonomy_df, file="demo_taxonomy.csv", row.names = FALSE)

3.4.2 Accessory output files

3.4.2.1 Macarron.log

A record of all chosen parameters and steps that were followed during execution.

3.4.2.2 modules_measures_of_success.csv

This file provides information about the properties of covariance modules used in the analysis. By default, modules are generated using a minimum module size (MMS) (argument: min_module_size) equal to cube root of the total number of prevalent metabolic features. Macarron evaluates 9 measures of success (MOS) that collectively capture the “correctness” and chemical homogeneity of the modules. The MOS are as follows:

Total modules: Number of modules.
Singletons: Number of metabolic features that were not assigned to any module at MMS.
% Annotated modules: Percentage of modules that contained at least one annotated metabolic feature.
% Consistent assignments: Percentage of times the same metabolic feature was assigned to the same module e.g. if three metabolic features represent glucose, they should all be in the same module. This percentage must be high.
Max classes per module: The highest number of chemical classes observed in any module. This is evaluated using the chemical taxonomy of covarying annotated features.
90p classes per module: 90th percentile of classes per module; captures the chemical homogeneity of the modules.
Max subclasses per module: The highest number of chemical subclasses observed in any module.
90p subclasses per module: 90th percentile of subclasses per module; captures the chemical homogeneity of the modules.
% Features in HAM: Macarron first finds homogeneously annoted modules (HAMs): These are modules in which >75% annotated features have the same chemical class indicating that they are chemically homogeneous. It then calculates how many features the HAMs account for.

3.4.2.3 Maaslin2 results

This folder contains the Maaslin2 log file (maaslin2.log), significant associations found by Maaslin2 (significant_results.tsv) and the linear model residuals file (residuals.rds). For more information, see Maaslin2.

3.4.3 Changing defaults

3.4.3.1 Filtering metabolic features based on prevalence

Ideally, at least 50% metabolic features must be retained after prevalence filtering. By default, Macarron uses the union of metabolic features observed (non-zero abundance) in at least 70% samples of any phenotype for further analysis. This prevalence threshold may be high for some metabolomics datasets and can be changed using the min_prevalence argument.

prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
                                        input_annotations = annotations_df,
                                        input_metadata = metadata_df,
                                        input_taxonomy = taxonomy_df,
                                        min_prevalence = 0.5)
# or
prism_w <- makeDisMat(se = prism_mbx,
                      min_prevalence = 0.5)

3.4.4 Minimum module size

By default, cube root of the total number of prevalent features is used as the minimum module size (MMS) (argument: min_module_size) for module detection and generation. We expect this to work for most real world datasets. To determine if the modules are optimal for further analysis, Macarron evaluates several measures of success (MOS) as described above. In addition to evaluating MOS for modules generated using the default MMS, Macarron also evaluates MOS for MMS values that are larger (MMS+5, MMS+10) and smaller (MMS-5, MMS-10) than the default MMS. If you find that the MOS improve with larger or smaller MMS, you may change the default accordingly. For more details about module detection, please see WGCNA and dynamicTreeCut.

# See MOS of modules generated using default
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df)
prism_modules_mos <- prism_modules[[2]]
View(prism_modules_mos)

# Change MMS
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df,
                            min_module_size = 10)

3.4.5 Specifying fixed effects, random effects and reference

Macarron uses Maaslin2 for determining the q-value of differential abundance in a phenotype of interest. For default execution, the phenotype of interest must be a category in column 1 of the metadata dataframe e.g. IBD in diagnosis in the demo. This is also the column that is picked by the metadata_variable argument for identifying the main phenotypes/conditions in any dataset (see Macarron.log file). Further, in the default execution, all columns in the metadata table are considered as fixed effects and the alphabetically first categorical variable in each covariate with two categories is considered as the reference. Maaslin2 requires reference categories to be explicitly defined for all categorical metadata with more than two categories. Defaults can be changed with the arguments fixed_effects, random_effects and reference. In the demo example, fixed effects and reference can be defined as follows:

prism_qval <- calQval(se = prism_mbx,
                      mod.assn = prism_modules,
                      metadata_variable = "diagnosis",
                      fixed_effects = c("diagnosis","age","antibiotics"),
                      reference = c("diagnosis,Control";"antibiotics,No"))

4 Command line invocation

The package source contains a script MacarronCMD.R in inst/scripts to invoke Macarron in the command line using Rscript. The inst/scripts folder also contains a README file that comprehensively documents the usage of the script.

Macarron User Manual

19 December 2024