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This package is deprecated. It will probably be removed from Bioconductor. Please refer to the package end-of-life guidelines for more information.

This package is for version 3.18 of Bioconductor. This package has been removed from Bioconductor. For the last stable, up-to-date release version, see LPEadj.

A correction of the local pooled error (LPE) method to replace the asymptotic variance adjustment with an unbiased adjustment based on sample size.

Bioconductor version: Release (3.18)

Two options are added to the LPE algorithm. The original LPE method sets all variances below the max variance in the ordered distribution of variances to the maximum variance. in LPEadj this option is turned off by default. The second option is to use a variance adjustment based on sample size rather than pi/2. By default the LPEadj uses the sample size based variance adjustment.

Author: Carl Murie <carl.murie at mcgill.ca>, Robert Nadon <robert.nadon at mcgill.ca>

Maintainer: Carl Murie <carl.murie at mcgill.ca>

Citation (from within R, enter citation("LPEadj")):


To install this package, start R (version "4.3") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

LPEadj test for microarray data with small number of replicates PDF R Script
Reference Manual PDF


biocViews Microarray, Proteomics, Software
Version 1.62.0
In Bioconductor since BioC 2.3 (R-2.8) (15.5 years)
License LGPL
Depends LPE
Imports LPE, stats
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Follow Installation instructions to use this package in your R session.

Source Package LPEadj_1.62.0.tar.gz
Windows Binary LPEadj_1.62.0.zip (64-bit only)
macOS Binary (x86_64) LPEadj_1.62.0.tgz
macOS Binary (arm64) LPEadj_1.62.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/LPEadj
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/LPEadj
Package Short Url https://bioconductor.org/packages/LPEadj/
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