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martini

This is the development version of martini; for the stable release version, see martini.

GWAS Incorporating Networks


Bioconductor version: Development (3.22)

martini deals with the low power inherent to GWAS studies by using prior knowledge represented as a network. SNPs are the vertices of the network, and the edges represent biological relationships between them (genomic adjacency, belonging to the same gene, physical interaction between protein products). The network is scanned using SConES, which looks for groups of SNPs maximally associated with the phenotype, that form a close subnetwork.

Author: Hector Climente-Gonzalez [aut, cre] ORCID iD ORCID: 0000-0002-3030-7471 , Chloe-Agathe Azencott [aut] ORCID iD ORCID: 0000-0003-1003-301X

Maintainer: Hector Climente-Gonzalez <hector.climente at a.riken.jp>

Citation (from within R, enter citation("martini")):

Installation

To install this package, start R (version "4.5") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

# The following initializes usage of Bioc devel
BiocManager::install(version='devel')

BiocManager::install("martini")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

Reference Manual PDF

Details

biocViews FeatureExtraction, GeneticVariability, Genetics, GenomeWideAssociation, GraphAndNetwork, Network, SNP, Software
Version 1.29.0
In Bioconductor since BioC 3.7 (R-3.5) (7 years)
License GPL-3
Depends R (>= 4.0)
Imports igraph (>= 1.0.1), Matrix, memoise (>= 2.0.0), methods (>= 3.3.2), Rcpp (>= 0.12.8), snpStats(>= 1.20.0), stats, utils
System Requirements
URL https://github.com/hclimente/martini
Bug Reports https://github.com/hclimente/martini/issues
See More
Suggests biomaRt(>= 2.34.1), circlize (>= 0.4.11), STRINGdb(>= 2.2.0), httr (>= 1.2.1), IRanges(>= 2.8.2), S4Vectors(>= 0.12.2), knitr, testthat, readr, rmarkdown
Linking To Rcpp, RcppEigen (>= 0.3.3.5.0)
Enhances
Depends On Me
Imports Me
Suggests Me
Links To Me
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package
Windows Binary (x86_64)
macOS Binary (x86_64)
macOS Binary (arm64)
Source Repository git clone https://git.bioconductor.org/packages/martini
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/martini
Package Short Url https://bioconductor.org/packages/martini/
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