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This is the development version of M3Drop; for the stable release version, see M3Drop.

Michaelis-Menten Modelling of Dropouts in single-cell RNASeq

Bioconductor version: Development (3.19)

This package fits a Michaelis-Menten model to the pattern of dropouts in single-cell RNASeq data. This model is used as a null to identify significantly variable (i.e. differentially expressed) genes for use in downstream analysis, such as clustering cells.

Author: Tallulah Andrews <tallulandrews at gmail.com>

Maintainer: Tallulah Andrews <tallulandrews at gmail.com>

Citation (from within R, enter citation("M3Drop")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Introduction to M3Drop PDF R Script
Reference Manual PDF


biocViews DifferentialExpression, DimensionReduction, FeatureExtraction, GeneExpression, RNASeq, Sequencing, Software, Transcriptomics
Version 1.29.0
In Bioconductor since BioC 3.4 (R-3.3) (7.5 years)
License GPL (>=2)
Depends R (>= 3.4), numDeriv
Imports RColorBrewer, gplots, bbmle, statmod, grDevices, graphics, stats, matrixStats, Matrix, irlba, reldist, Hmisc, methods
System Requirements
URL https://github.com/tallulandrews/M3Drop
Bug Reports https://github.com/tallulandrews/M3Drop/issues
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Suggests ROCR, knitr, M3DExampleData, scater, SingleCellExperiment, monocle, Seurat, Biobase
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Imports Me scMerge
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Follow Installation instructions to use this package in your R session.

Source Package M3Drop_1.29.0.tar.gz
Windows Binary M3Drop_1.29.0.zip
macOS Binary (x86_64) M3Drop_1.29.0.tgz
macOS Binary (arm64) M3Drop_1.29.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/M3Drop
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/M3Drop
Bioc Package Browser https://code.bioconductor.org/browse/M3Drop/
Package Short Url https://bioconductor.org/packages/M3Drop/
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