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Indentification of significantly activated ligand-receptor interactions across clusters of cells from single-cell RNA sequencing data

Bioconductor version: Release (3.18)

scTHI is an R package to identify active pairs of ligand-receptors from single cells in order to study,among others, tumor-host interactions. scTHI contains a set of signatures to classify cells from the tumor microenvironment.

Author: Francesca Pia Caruso [aut], Michele Ceccarelli [aut, cre]

Maintainer: Michele Ceccarelli <m.ceccarelli at gmail.com>

Citation (from within R, enter citation("scTHI")):


To install this package, start R (version "4.3") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Using scTHI HTML R Script
Reference Manual PDF


biocViews SingleCell, Software
Version 1.14.0
In Bioconductor since BioC 3.11 (R-4.0) (4 years)
License GPL-2
Depends R (>= 4.0)
Imports BiocParallel, Rtsne, grDevices, graphics, stats
System Requirements
Bug Reports https://github.com/miccec/scTHI/issues
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Suggests scTHI.data, knitr, rmarkdown, BiocStyle
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package scTHI_1.14.0.tar.gz
Windows Binary scTHI_1.14.0.zip
macOS Binary (x86_64) scTHI_1.14.0.tgz
macOS Binary (arm64) scTHI_1.14.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/scTHI
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/scTHI
Bioc Package Browser https://code.bioconductor.org/browse/scTHI/
Package Short Url https://bioconductor.org/packages/scTHI/
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