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Analysis of co-regulation and inference of 'dual regulons'

Bioconductor version: Release (3.19)

RTNduals is a tool that searches for possible co-regulatory loops between regulon pairs generated by the RTN package. It compares the shared targets in order to infer 'dual regulons', a new concept that tests whether regulators can co-operate or compete in influencing targets.

Author: Vinicius S. Chagas, Clarice S. Groeneveld, Gordon Robertson, Kerstin B. Meyer, Mauro A. A. Castro

Maintainer: Mauro Castro <mauro.a.castro at>, Clarice Groeneveld <clari.groeneveld at>

Citation (from within R, enter citation("RTNduals")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

RTNduals: analysis of co-regulation and inference of dual regulons. HTML R Script
Reference Manual PDF


biocViews GeneExpression, GeneRegulation, GraphAndNetwork, NetworkEnrichment, NetworkInference, Software
Version 1.28.0
In Bioconductor since BioC 3.5 (R-3.4) (7 years)
License Artistic-2.0
Depends R (>= 3.6.3), RTN(>= 2.14.1), methods
Imports graphics, grDevices, stats, utils
System Requirements
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Suggests knitr, rmarkdown, BiocStyle, RUnit, BiocGenerics
Linking To
Depends On Me RTNsurvival
Imports Me
Suggests Me
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Follow Installation instructions to use this package in your R session.

Source Package RTNduals_1.28.0.tar.gz
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macOS Binary (x86_64) RTNduals_1.28.0.tgz
macOS Binary (arm64) RTNduals_1.28.0.tgz
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Source Repository (Developer Access) git clone
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