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Interface for the Reactome Graph Database

Bioconductor version: Release (3.18)

Pathways, reactions, and biological entities in Reactome knowledge are systematically represented as an ordered network. Instances are represented as nodes and relationships between instances as edges; they are all stored in the Reactome Graph Database. This package serves as an interface to query the interconnected data from a local Neo4j database, with the aim of minimizing the usage of Neo4j Cypher queries.

Author: Chi-Lam Poon [aut, cre] , Reactome [cph]

Maintainer: Chi-Lam Poon <clpoon807 at gmail.com>

Citation (from within R, enter citation("ReactomeGraph4R")):


To install this package, start R (version "4.3") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Introduction HTML R Script
Reference Manual PDF


biocViews DataImport, GraphAndNetwork, Network, Pathways, Reactome, Software
Version 1.10.0
In Bioconductor since BioC 3.13 (R-4.1) (3 years)
License Apache License (>= 2)
Depends R (>= 4.1)
Imports neo4r, utils, getPass, jsonlite, purrr, magrittr, data.table, rlang, ReactomeContentService4R, doParallel, parallel, foreach
System Requirements
URL https://github.com/reactome/ReactomeGraph4R
Bug Reports https://github.com/reactome/ReactomeGraph4R/issues
See More
Suggests knitr, rmarkdown, testthat, stringr, networkD3, visNetwork, wesanderson
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package ReactomeGraph4R_1.10.0.tar.gz
Windows Binary ReactomeGraph4R_1.10.0.zip
macOS Binary (x86_64) ReactomeGraph4R_1.10.0.tgz
macOS Binary (arm64) ReactomeGraph4R_1.10.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/ReactomeGraph4R
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/ReactomeGraph4R
Bioc Package Browser https://code.bioconductor.org/browse/ReactomeGraph4R/
Package Short Url https://bioconductor.org/packages/ReactomeGraph4R/
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