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Analyze thermal proteome profiling (TPP) experiments

Bioconductor version: Release (3.18)

Analyze thermal proteome profiling (TPP) experiments with varying temperatures (TR) or compound concentrations (CCR).

Author: Dorothee Childs, Nils Kurzawa, Holger Franken, Carola Doce, Mikhail Savitski and Wolfgang Huber

Maintainer: Dorothee Childs <d.childs at posteo.de>

Citation (from within R, enter citation("TPP")):


To install this package, start R (version "4.3") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

TPP_introduction_1D PDF R Script
TPP_introduction_2D PDF R Script
TPP_introduction_NPARC PDF R Script
Reference Manual PDF


biocViews ImmunoOncology, MassSpectrometry, Proteomics, Software
Version 3.30.0
In Bioconductor since BioC 3.1 (R-3.2) (9 years)
License Artistic-2.0
Depends R (>= 3.4), Biobase, dplyr, magrittr, tidyr
Imports biobroom, broom, data.table, doParallel, foreach, futile.logger, ggplot2, grDevices, gridExtra, grid, knitr, limma, MASS, mefa, nls2, openxlsx (>= 2.4.0), parallel, plyr, purrr, RColorBrewer, RCurl, reshape2, rmarkdown, splines, stats, stringr, tibble, utils, VennDiagram, VGAM
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package TPP_3.30.0.tar.gz
Windows Binary TPP_3.30.0.zip
macOS Binary (x86_64) TPP_3.30.0.tgz
macOS Binary (arm64) TPP_3.30.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/TPP
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/TPP
Bioc Package Browser https://code.bioconductor.org/browse/TPP/
Package Short Url https://bioconductor.org/packages/TPP/
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